KR101778036B1 - 전립선암 마커로서의 포스포디에스테라제 4ｄ7 - Google Patents

전립선암 마커로서의 포스포디에스테라제 4ｄ7 Download PDF

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KR101778036B1
KR101778036B1 KR1020117029715A KR20117029715A KR101778036B1 KR 101778036 B1 KR101778036 B1 KR 101778036B1 KR 1020117029715 A KR1020117029715 A KR 1020117029715A KR 20117029715 A KR20117029715 A KR 20117029715A KR 101778036 B1 KR101778036 B1 KR 101778036B1
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pde4d7
prostate cancer
expression
sample
hormone
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KR20120034651A (ko
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랄프 호프만
마일즈 디. 하우스레이
피. 헨더슨 데이비드 제이.
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코닌클리케 필립스 엔.브이.
더 유니버시티 코트 오브 더 유니버시티 오브 글래스고우
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KR1020117029715A 2009-05-12 2010-05-11 전립선암 마커로서의 포스포디에스테라제 4ｄ7 Active KR101778036B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09159960 2009-05-12
EP09159960.5 2009-05-12
PCT/IB2010/052073 WO2010131195A1 (en) 2009-05-12 2010-05-11 Phosphodiesterase 4d7 as prostate cancer marker

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KR20120034651A KR20120034651A (ko) 2012-04-12
KR101778036B1 true KR101778036B1 (ko) 2017-09-14

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US (1) US8753892B2 (enExample)
EP (2) EP2430191B1 (enExample)
JP (4) JP6148007B2 (enExample)
KR (1) KR101778036B1 (enExample)
CN (2) CN102549167B (enExample)
BR (1) BRPI1007093A2 (enExample)
DK (1) DK2430191T3 (enExample)
ES (1) ES2700877T3 (enExample)
RU (1) RU2651474C2 (enExample)
WO (1) WO2010131195A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3343647B2 (ja) 1997-07-22 2002-11-11 株式会社岡田建築デザインルーム 木造軸組在来構法による既存建物を、外部より鋼製受け梁と鋼製筋かいフレームにより耐震補強をなす架構
WO2010131195A1 (en) * 2009-05-12 2010-11-18 Koninklijke Philips Electronics N.V. Phosphodiesterase 4d7 as prostate cancer marker
ES2707598T3 (es) * 2009-05-12 2019-04-04 Koninklijke Philips Nv Fosfodiesterasa 4D7 como marcador para cáncer maligno de próstata sensible a hormonas
AU2011241423A1 (en) 2010-04-13 2012-11-08 Gan Systems Inc. High density gallium nitride devices using island topology
GB201322034D0 (en) 2013-12-12 2014-01-29 Almac Diagnostics Ltd Prostate cancer classification
GB201504763D0 (en) 2015-03-20 2015-05-06 Mironid Ltd Compounds and uses
WO2016193110A1 (en) 2015-05-29 2016-12-08 Koninklijke Philips N.V. Methods of prostate cancer prognosis
CN105893782A (zh) * 2016-05-26 2016-08-24 江苏省人民医院 前列腺癌风险预测装置
GB201616439D0 (en) 2016-09-28 2016-11-09 Mironid Limited Compounds and uses
CN106544430A (zh) * 2016-11-04 2017-03-29 叶伟亮 一种检测前列腺癌的分子标记物及其应用
RU2766885C2 (ru) * 2016-12-01 2022-03-16 Конинклейке Филипс Н.В. Оценки риска на основе экспрессии варианта 7 фосфодиэстеразы 4d человека
EP3450981A1 (en) * 2017-08-28 2019-03-06 Trizell GmbH Btnl8 as a marker for tregs
HUE066292T2 (hu) 2017-11-03 2024-07-28 Oxford BioDynamics PLC Az immunválasz genetikai szabályozása kromoszóma-kölcsönhatások által
DE102017125780B3 (de) * 2017-11-05 2018-12-13 Dimo Dietrich Verfahren zur Bestimmung des Ansprechens einer malignen Erkrankung auf eine Immuntherapie
KR102080887B1 (ko) * 2017-11-07 2020-02-24 고려대학교 산학협력단 Gcc2 유전자 또는 단백질을 과발현하는 엑소좀 기반 폐암 진단 또는 예후 예측용 마커 조성물
WO2019158825A1 (en) * 2018-02-16 2019-08-22 Tampereen Korkeakoulusäätiö SR Xrcc5 as biomarker for prostate cancer
GB201805527D0 (en) 2018-04-04 2018-05-16 Mironid Ltd Compounds and their use as pde4 activators
KR20220008175A (ko) * 2020-07-13 2022-01-20 가톨릭대학교 산학협력단 전립선암 환자의 예후 진단 및 치료 전략 결정용 병리등급 특이적 마커
CN112779348B (zh) * 2020-12-31 2022-05-20 四川农业大学 一种小麦单位面积穗数主效qtl位点及紧密连锁的kasp引物和应用
CN120187446A (zh) 2022-10-27 2025-06-20 皇家飞利浦有限公司 通过促进pde4d7治疗前列腺癌
EP4360711A1 (en) * 2022-10-27 2024-05-01 Koninklijke Philips N.V. Treatment of prostate cancer by promoting pde4d7
EP4600377A1 (en) 2024-02-12 2025-08-13 Koninklijke Philips N.V. Prediction of an outcome of a subject suffering from a glioma
WO2025016918A1 (en) 2023-07-18 2025-01-23 Koninklijke Philips N.V. Prediction of an outcome of a subject suffering from a glioma
EP4620461A1 (en) 2024-03-22 2025-09-24 Koninklijke Philips N.V. Treatment of prostate cancer by inhibiting short pde4d isoforms

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003044170A2 (en) * 2001-11-15 2003-05-30 Memory Pharmaceuticals Corporation Cyclic amp phosphodiesterase 4d7 isoforms and methods of use

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932465A (en) * 1997-10-16 1999-08-03 Icos Corporation Phosphodiesterase 8A
US20090176722A9 (en) 2000-01-28 2009-07-09 Shiv Srivastava Androgen-regulated PMEPA1 gene and polypeptides
PL364135A1 (en) * 2001-01-31 2004-12-13 Pfizer Products Inc. Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
US20030220273A1 (en) 2002-05-15 2003-11-27 Isis Pharmaceuticals Inc. Antisense modulation of phosphodiesterase 4D expression
AU2003283303A1 (en) 2002-11-08 2004-06-07 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4b (pde4b)
WO2004042389A2 (en) * 2002-11-08 2004-05-21 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4d (pde4d)
EP1426767A1 (en) 2002-12-04 2004-06-09 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4c (PDE4C)
CA2458085A1 (en) * 2003-03-21 2004-09-21 F. Hoffmann-La Roche Ag Transcriptional activity assay
CN100372944C (zh) * 2003-04-10 2008-03-05 弗·哈夫曼-拉罗切有限公司 Pde4d在筛选治疗动脉粥样硬化的药物中的用途
US7250416B2 (en) * 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
US7982028B2 (en) * 2006-05-19 2011-07-19 Topigen Pharmaceuticals, Inc. Oligonucleotides affecting expression of phosphodiesterases
US9939441B2 (en) * 2006-07-21 2018-04-10 Epigenomics Ag Methods and nucleic acids for analyses for cellular proliferative disorders
EP2074225B1 (en) 2006-10-10 2014-12-03 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Prostate cancer-specific alterations in erg gene expression and detection and treatment methods based on those alterations
ES2694284T3 (es) * 2007-11-23 2018-12-19 Epigenomics Ag Métodos y usos de los ácidos nucleicos para el análisis de la metilación y la expresión de genes, en particular de NFATC3, asociados con trastornos proliferativos de células de la próstata
ES2707598T3 (es) * 2009-05-12 2019-04-04 Koninklijke Philips Nv Fosfodiesterasa 4D7 como marcador para cáncer maligno de próstata sensible a hormonas
WO2010131195A1 (en) * 2009-05-12 2010-11-18 Koninklijke Philips Electronics N.V. Phosphodiesterase 4d7 as prostate cancer marker
WO2014146030A1 (en) * 2013-03-15 2014-09-18 Iris International, Inc. Flowcell systems and methods for particle analysis in blood samples

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003044170A2 (en) * 2001-11-15 2003-05-30 Memory Pharmaceuticals Corporation Cyclic amp phosphodiesterase 4d7 isoforms and methods of use

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JP6148007B2 (ja) 2017-06-14
JP2012526545A (ja) 2012-11-01
DK2430191T3 (en) 2018-12-10
CN107267482A (zh) 2017-10-20
CN102549167A (zh) 2012-07-04
US20120065148A1 (en) 2012-03-15
RU2651474C2 (ru) 2018-04-19
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JP2016034277A (ja) 2016-03-17
EP3434787B1 (en) 2024-10-09
JP6105012B2 (ja) 2017-03-29
KR20120034651A (ko) 2012-04-12
US8753892B2 (en) 2014-06-17
EP3434787A1 (en) 2019-01-30
JP2019059733A (ja) 2019-04-18
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