BRPI1007093A2 - fosfodiesterase 4d7 uso de pde4d7; composição metodo, metodo de aquisição de dados imunoensaio para detectar diagnosticar, monitorar ou prognosticar cancer de prostata ou para diagnosticar, detectar monitorar ou prognosticar progressao do cancer - Google Patents
fosfodiesterase 4d7 uso de pde4d7; composição metodo, metodo de aquisição de dados imunoensaio para detectar diagnosticar, monitorar ou prognosticar cancer de prostata ou para diagnosticar, detectar monitorar ou prognosticar progressao do cancerInfo
- Publication number
- BRPI1007093A2 BRPI1007093A2 BRPI1007093A BRPI1007093A BRPI1007093A2 BR PI1007093 A2 BRPI1007093 A2 BR PI1007093A2 BR PI1007093 A BRPI1007093 A BR PI1007093A BR PI1007093 A BRPI1007093 A BR PI1007093A BR PI1007093 A2 BRPI1007093 A2 BR PI1007093A2
- Authority
- BR
- Brazil
- Prior art keywords
- diagnose
- monitor
- detect
- predict
- pde4d7
- Prior art date
Links
- 238000000034 method Methods 0.000 title 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 title 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 title 1
- 206010060862 Prostate cancer Diseases 0.000 title 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 238000003018 immunoassay Methods 0.000 title 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12N15/09—Recombinant DNA-technology
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- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/04—Phosphoric diester hydrolases (3.1.4)
- C12Y301/04017—3',5'-Cyclic-nucleotide phosphodiesterase (3.1.4.17)
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C12N2310/141—MicroRNAs, miRNAs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/54—Determining the risk of relapse
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/813—Cancer
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- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
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- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Food Science & Technology (AREA)
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- Cell Biology (AREA)
- Virology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09159960 | 2009-05-12 | ||
| PCT/IB2010/052073 WO2010131195A1 (en) | 2009-05-12 | 2010-05-11 | Phosphodiesterase 4d7 as prostate cancer marker |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1007093A2 true BRPI1007093A2 (pt) | 2017-06-06 |
Family
ID=40843709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1007093A BRPI1007093A2 (pt) | 2009-05-12 | 2010-05-11 | fosfodiesterase 4d7 uso de pde4d7; composição metodo, metodo de aquisição de dados imunoensaio para detectar diagnosticar, monitorar ou prognosticar cancer de prostata ou para diagnosticar, detectar monitorar ou prognosticar progressao do cancer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8753892B2 (enExample) |
| EP (2) | EP2430191B1 (enExample) |
| JP (4) | JP6148007B2 (enExample) |
| KR (1) | KR101778036B1 (enExample) |
| CN (2) | CN107267482A (enExample) |
| BR (1) | BRPI1007093A2 (enExample) |
| DK (1) | DK2430191T3 (enExample) |
| ES (1) | ES2700877T3 (enExample) |
| RU (1) | RU2651474C2 (enExample) |
| WO (1) | WO2010131195A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3343647B2 (ja) | 1997-07-22 | 2002-11-11 | 株式会社岡田建築デザインルーム | 木造軸組在来構法による既存建物を、外部より鋼製受け梁と鋼製筋かいフレームにより耐震補強をなす架構 |
| KR20120036842A (ko) * | 2009-05-12 | 2012-04-18 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 악성의 호르몬 민감성 전립선 암에 대한 마커로서의 포스포디에스테라제 4d7 |
| WO2010131195A1 (en) * | 2009-05-12 | 2010-11-18 | Koninklijke Philips Electronics N.V. | Phosphodiesterase 4d7 as prostate cancer marker |
| CN102893392B (zh) | 2010-04-13 | 2015-08-05 | Gan系统公司 | 采用孤岛拓扑结构的高密度氮化镓器件 |
| GB201322034D0 (en) | 2013-12-12 | 2014-01-29 | Almac Diagnostics Ltd | Prostate cancer classification |
| GB201504763D0 (en) | 2015-03-20 | 2015-05-06 | Mironid Ltd | Compounds and uses |
| JP6745820B2 (ja) | 2015-05-29 | 2020-08-26 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 前立腺がん予後判定の方法 |
| CN105893782A (zh) * | 2016-05-26 | 2016-08-24 | 江苏省人民医院 | 前列腺癌风险预测装置 |
| GB201616439D0 (en) | 2016-09-28 | 2016-11-09 | Mironid Limited | Compounds and uses |
| CN106544430A (zh) * | 2016-11-04 | 2017-03-29 | 叶伟亮 | 一种检测前列腺癌的分子标记物及其应用 |
| US20210277479A1 (en) * | 2016-12-01 | 2021-09-09 | Koninklijke Philips N.V. | Risk scores based on human phosphodiesterase 4 d variant 7 expression |
| EP3450981A1 (en) * | 2017-08-28 | 2019-03-06 | Trizell GmbH | Btnl8 as a marker for tregs |
| SG11202003233YA (en) * | 2017-11-03 | 2020-05-28 | Oxford BioDynamics PLC | Genetic regulation of immunoresponse by chromosome interactions |
| DE102017125780B3 (de) * | 2017-11-05 | 2018-12-13 | Dimo Dietrich | Verfahren zur Bestimmung des Ansprechens einer malignen Erkrankung auf eine Immuntherapie |
| KR102080887B1 (ko) * | 2017-11-07 | 2020-02-24 | 고려대학교 산학협력단 | Gcc2 유전자 또는 단백질을 과발현하는 엑소좀 기반 폐암 진단 또는 예후 예측용 마커 조성물 |
| WO2019158825A1 (en) * | 2018-02-16 | 2019-08-22 | Tampereen Korkeakoulusäätiö SR | Xrcc5 as biomarker for prostate cancer |
| GB201805527D0 (en) | 2018-04-04 | 2018-05-16 | Mironid Ltd | Compounds and their use as pde4 activators |
| KR20220008175A (ko) * | 2020-07-13 | 2022-01-20 | 가톨릭대학교 산학협력단 | 전립선암 환자의 예후 진단 및 치료 전략 결정용 병리등급 특이적 마커 |
| CN112779348B (zh) * | 2020-12-31 | 2022-05-20 | 四川农业大学 | 一种小麦单位面积穗数主效qtl位点及紧密连锁的kasp引物和应用 |
| EP4360711A1 (en) * | 2022-10-27 | 2024-05-01 | Koninklijke Philips N.V. | Treatment of prostate cancer by promoting pde4d7 |
| WO2024088865A1 (en) | 2022-10-27 | 2024-05-02 | Koninklijke Philips N.V. | Treatment of prostate cancer by promoting pde4d7 |
| WO2025016918A1 (en) | 2023-07-18 | 2025-01-23 | Koninklijke Philips N.V. | Prediction of an outcome of a subject suffering from a glioma |
| EP4600377A1 (en) | 2024-02-12 | 2025-08-13 | Koninklijke Philips N.V. | Prediction of an outcome of a subject suffering from a glioma |
| EP4620461A1 (en) | 2024-03-22 | 2025-09-24 | Koninklijke Philips N.V. | Treatment of prostate cancer by inhibiting short pde4d isoforms |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5932465A (en) * | 1997-10-16 | 1999-08-03 | Icos Corporation | Phosphodiesterase 8A |
| US20090176722A9 (en) | 2000-01-28 | 2009-07-09 | Shiv Srivastava | Androgen-regulated PMEPA1 gene and polypeptides |
| PL364135A1 (en) | 2001-01-31 | 2004-12-13 | Pfizer Products Inc. | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
| IS7221A (is) * | 2001-11-15 | 2004-04-15 | Memory Pharmaceuticals Corporation | Hringlaga adenosínmónófosfat fosfódíesterasa 4D7 ísóform og aðferðir til notkunar þeirra |
| US20030220273A1 (en) | 2002-05-15 | 2003-11-27 | Isis Pharmaceuticals Inc. | Antisense modulation of phosphodiesterase 4D expression |
| WO2004042390A2 (en) | 2002-11-08 | 2004-05-21 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4b (pde4b) |
| WO2004042389A2 (en) * | 2002-11-08 | 2004-05-21 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4d (pde4d) |
| EP1426767A1 (en) | 2002-12-04 | 2004-06-09 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4c (PDE4C) |
| CA2458085A1 (en) * | 2003-03-21 | 2004-09-21 | F. Hoffmann-La Roche Ag | Transcriptional activity assay |
| CA2521303A1 (en) * | 2003-04-10 | 2004-10-21 | F. Hoffmann-La Roche Ag | The use of pde4d in the screening for medicaments against atherosclerosis |
| US7250416B2 (en) * | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
| JP2009537118A (ja) | 2006-05-19 | 2009-10-29 | トピジェン・ファーマシューティカルズ・インコーポレーテッド | ホスホジエステラーゼの発現に影響するオリゴヌクレオチド |
| US9939441B2 (en) | 2006-07-21 | 2018-04-10 | Epigenomics Ag | Methods and nucleic acids for analyses for cellular proliferative disorders |
| CA2664630C (en) | 2006-10-10 | 2018-11-27 | Shiv Srivastava | Prostate cancer-specific alterations in erg gene expression and detection and treatment methods based on those alterations |
| EP3078751B1 (en) * | 2007-11-23 | 2018-08-01 | Epigenomics AG | Methods and uses of nucleic acids for the analysis of methylation and expression of genes, in particular of nfatc3, associated with prostate cell proliferative disorders |
| WO2010131195A1 (en) * | 2009-05-12 | 2010-11-18 | Koninklijke Philips Electronics N.V. | Phosphodiesterase 4d7 as prostate cancer marker |
| KR20120036842A (ko) * | 2009-05-12 | 2012-04-18 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 악성의 호르몬 민감성 전립선 암에 대한 마커로서의 포스포디에스테라제 4d7 |
| BR112015020098B1 (pt) * | 2013-03-15 | 2020-10-27 | Iris International, Inc. | composição de agente de contraste de partículas para colorir uma amostra de fluido sanguíneo e método para tratar partículas de uma amostra de fluido sanguíneo |
-
2010
- 2010-05-11 WO PCT/IB2010/052073 patent/WO2010131195A1/en not_active Ceased
- 2010-05-11 EP EP10726251.1A patent/EP2430191B1/en active Active
- 2010-05-11 DK DK10726251.1T patent/DK2430191T3/en active
- 2010-05-11 BR BRPI1007093A patent/BRPI1007093A2/pt not_active Application Discontinuation
- 2010-05-11 JP JP2012510424A patent/JP6148007B2/ja active Active
- 2010-05-11 RU RU2011150279A patent/RU2651474C2/ru active
- 2010-05-11 KR KR1020117029715A patent/KR101778036B1/ko active Active
- 2010-05-11 CN CN201710192366.7A patent/CN107267482A/zh active Pending
- 2010-05-11 ES ES10726251T patent/ES2700877T3/es active Active
- 2010-05-11 US US13/320,283 patent/US8753892B2/en active Active
- 2010-05-11 EP EP18187420.7A patent/EP3434787B1/en active Active
- 2010-05-11 CN CN201080033823.4A patent/CN102549167B/zh active Active
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- 2015-09-25 JP JP2015188247A patent/JP6105012B2/ja active Active
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- 2017-03-13 JP JP2017046859A patent/JP6430560B2/ja active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| JP6148007B2 (ja) | 2017-06-14 |
| JP6105012B2 (ja) | 2017-03-29 |
| EP3434787B1 (en) | 2024-10-09 |
| CN102549167A (zh) | 2012-07-04 |
| RU2651474C2 (ru) | 2018-04-19 |
| CN102549167B (zh) | 2017-04-26 |
| RU2011150279A (ru) | 2013-06-20 |
| WO2010131195A1 (en) | 2010-11-18 |
| KR20120034651A (ko) | 2012-04-12 |
| US8753892B2 (en) | 2014-06-17 |
| DK2430191T3 (en) | 2018-12-10 |
| JP6430560B2 (ja) | 2018-11-28 |
| JP2017184729A (ja) | 2017-10-12 |
| EP2430191A1 (en) | 2012-03-21 |
| EP2430191B1 (en) | 2018-09-19 |
| JP2019059733A (ja) | 2019-04-18 |
| US20120065148A1 (en) | 2012-03-15 |
| JP2012526545A (ja) | 2012-11-01 |
| KR101778036B1 (ko) | 2017-09-14 |
| EP3434787A1 (en) | 2019-01-30 |
| JP2016034277A (ja) | 2016-03-17 |
| ES2700877T3 (es) | 2019-02-19 |
| CN107267482A (zh) | 2017-10-20 |
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