KR101764556B1 - 디아자카르바졸 및 사용 방법 - Google Patents

디아자카르바졸 및 사용 방법 Download PDF

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Publication number
KR101764556B1
KR101764556B1 KR1020167015993A KR20167015993A KR101764556B1 KR 101764556 B1 KR101764556 B1 KR 101764556B1 KR 1020167015993 A KR1020167015993 A KR 1020167015993A KR 20167015993 A KR20167015993 A KR 20167015993A KR 101764556 B1 KR101764556 B1 KR 101764556B1
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KR
South Korea
Prior art keywords
alkyl
formula
compound
tetraaza
methyl
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Expired - Fee Related
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KR1020167015993A
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English (en)
Korean (ko)
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KR20160074680A (ko
Inventor
헤이젤 존 다이크
엠마누엘라 간치아
루이스 제이. 가자드
사이먼 찰스 굿에이커
조세프 피. 라이시카토스
칼럼 맥레오드
카렌 윌리엄스
후이펜 첸
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제넨테크, 인크.
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Publication of KR20160074680A publication Critical patent/KR20160074680A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020167015993A 2008-06-11 2009-06-10 디아자카르바졸 및 사용 방법 Expired - Fee Related KR101764556B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6075008P 2008-06-11 2008-06-11
US61/060,750 2008-06-11
US14800409P 2009-01-28 2009-01-28
US61/148,004 2009-01-28
PCT/US2009/003481 WO2009151589A1 (en) 2008-06-11 2009-06-10 Diazacarbazoles and methods of use

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020117000608A Division KR20110015699A (ko) 2008-06-11 2009-06-10 디아자카르바졸 및 사용 방법

Publications (2)

Publication Number Publication Date
KR20160074680A KR20160074680A (ko) 2016-06-28
KR101764556B1 true KR101764556B1 (ko) 2017-08-02

Family

ID=41066268

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020167015993A Expired - Fee Related KR101764556B1 (ko) 2008-06-11 2009-06-10 디아자카르바졸 및 사용 방법
KR1020117000608A Withdrawn KR20110015699A (ko) 2008-06-11 2009-06-10 디아자카르바졸 및 사용 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020117000608A Withdrawn KR20110015699A (ko) 2008-06-11 2009-06-10 디아자카르바졸 및 사용 방법

Country Status (12)

Country Link
US (1) US20110124654A1 (enExample)
EP (1) EP2324024B1 (enExample)
JP (2) JP5677945B2 (enExample)
KR (2) KR101764556B1 (enExample)
CN (1) CN102119162B (enExample)
AU (1) AU2009258115B2 (enExample)
BR (1) BRPI0909957A2 (enExample)
CA (1) CA2726114A1 (enExample)
ES (1) ES2392489T3 (enExample)
IL (1) IL209548A (enExample)
MX (1) MX2010013606A (enExample)
WO (1) WO2009151589A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2392489T3 (es) * 2008-06-11 2012-12-11 Genentech, Inc. Dicarbazoles y procedimientos de uso
KR101884960B1 (ko) 2010-11-16 2018-08-30 어레이 바이오파마 인크. 체크포인트 키나제 1 억제제 및 wee 1 키나제 억제제의 조합
GB201201566D0 (en) * 2012-01-30 2012-03-14 Vernalis R&D Ltd New chemical compounds
JP6370772B2 (ja) * 2012-04-23 2018-08-08 ジェネンテック， インコーポレイテッド 化合物の調製のための中間体及び方法
JP2016506929A (ja) * 2013-01-23 2016-03-07 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ ヒト銅輸送タンパク質ａｔｏｘ１およびｃｃｓを阻害するための方法および組成物
CN105764502A (zh) 2013-07-26 2016-07-13 现代化制药公司 改善比生群及其类似物及衍生物的治疗益处的组合方法
PT3055308T (pt) 2013-10-08 2018-01-18 Hoffmann La Roche Resumo
JP6840931B2 (ja) * 2015-03-09 2021-03-10 東ソー株式会社 縮環芳香族化合物の製造方法
US20170067946A1 (en) * 2015-06-08 2017-03-09 Zac WHEELER Monitoring system with low power usage
WO2018005860A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Pyrimidine-based antiproliferative agents
SG11201901983PA (en) 2016-09-09 2019-04-29 Hoffmann La Roche Process for preparation of 2-(6-nitropyridin-3-yl)-9h-dipyrido[2,3-b;3',4'-d]pyrrole
US11760701B2 (en) 2018-02-27 2023-09-19 The Research Foundation For The State University Of New Yrok Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
MX2022014573A (es) 2020-05-19 2022-12-15 G1 Therapeutics Inc Compuestos inhibidores de cinasa dependiente de ciclina para el tratamiento de trastornos medicos.
CN115572282B (zh) * 2021-07-05 2024-07-09 华东理工大学 含芳杂环结构的吡唑酰胺类化合物及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007044779A1 (en) * 2005-10-07 2007-04-19 Takeda San Diego, Inc. Kinase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5000828B2 (ja) * 2000-03-15 2012-08-15 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ＩｋＢキナーゼ阻害活性を有する置換ベーターカルボリン
WO2001068648A1 (en) 2000-03-15 2001-09-20 Aventis Pharma Deutschland Gmbh Substituted beta-carbolines with ikb-kinase inhibiting activity
JP3649395B2 (ja) * 2000-04-27 2005-05-18 山之内製薬株式会社 縮合ヘテロアリール誘導体
US6608053B2 (en) * 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
US20060264493A1 (en) 2003-02-17 2006-11-23 Ermes Vanotti Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
AR049300A1 (es) * 2004-06-15 2006-07-12 Schering Corp Compuestos triciclicos antagonistas de mglur1 como agentes terapeuticos
EP2170886A1 (en) 2007-07-02 2010-04-07 Cancer Research Technology Limited 9h-pyrimido[4,5-b]indoles, 9h-pyrido[4',3':4,5]pyrrolo[2,3-d]pyridines, and 9h-1,3,6,9-tetraaza-fluorenes as chk1 kinase function inhibitors
ES2392489T3 (es) * 2008-06-11 2012-12-11 Genentech, Inc. Dicarbazoles y procedimientos de uso

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007044779A1 (en) * 2005-10-07 2007-04-19 Takeda San Diego, Inc. Kinase inhibitors

Also Published As

Publication number Publication date
CN102119162B (zh) 2014-10-08
CN102119162A (zh) 2011-07-06
IL209548A (en) 2014-03-31
EP2324024B1 (en) 2012-09-26
JP5677945B2 (ja) 2015-02-25
ES2392489T3 (es) 2012-12-11
MX2010013606A (es) 2010-12-21
AU2009258115A1 (en) 2009-12-17
US20110124654A1 (en) 2011-05-26
KR20110015699A (ko) 2011-02-16
WO2009151589A1 (en) 2009-12-17
JP2011522888A (ja) 2011-08-04
CA2726114A1 (en) 2009-12-17
BRPI0909957A2 (pt) 2016-04-19
KR20160074680A (ko) 2016-06-28
AU2009258115A2 (en) 2011-05-12
AU2009258115B2 (en) 2015-01-29
IL209548A0 (en) 2011-01-31
EP2324024A1 (en) 2011-05-25
JP2014196309A (ja) 2014-10-16

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