JP5677945B2 - ジアザカルバゾール及びその使用方法 - Google Patents

ジアザカルバゾール及びその使用方法 Download PDF

Info

Publication number
JP5677945B2
JP5677945B2 JP2011513493A JP2011513493A JP5677945B2 JP 5677945 B2 JP5677945 B2 JP 5677945B2 JP 2011513493 A JP2011513493 A JP 2011513493A JP 2011513493 A JP2011513493 A JP 2011513493A JP 5677945 B2 JP5677945 B2 JP 5677945B2
Authority
JP
Japan
Prior art keywords
alkyl
groups
membered
compound
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2011513493A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011522888A5 (enExample
JP2011522888A (ja
Inventor
ヘイゼル， ジョーン ダイク，
ヘイゼル， ジョーン ダイク，
エマヌエラ ガンチア，
エマヌエラ ガンチア，
ルイス， ジェイ． ギャザード，
ルイス， ジェイ． ギャザード，
サイモン， チャールズ グッドエーカー，
サイモン， チャールズ グッドエーカー，
ジョゼフ， ピー． リッシカトス，
ジョゼフ， ピー． リッシカトス，
カラム マクレオウド，
カラム マクレオウド，
カレン ウィリアムズ，
カレン ウィリアムズ，
フイフェン チェン，
フイフェン チェン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of JP2011522888A publication Critical patent/JP2011522888A/ja
Publication of JP2011522888A5 publication Critical patent/JP2011522888A5/ja
Application granted granted Critical
Publication of JP5677945B2 publication Critical patent/JP5677945B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011513493A 2008-06-11 2009-06-10 ジアザカルバゾール及びその使用方法 Expired - Fee Related JP5677945B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6075008P 2008-06-11 2008-06-11
US61/060,750 2008-06-11
US14800409P 2009-01-28 2009-01-28
US61/148,004 2009-01-28
PCT/US2009/003481 WO2009151589A1 (en) 2008-06-11 2009-06-10 Diazacarbazoles and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014103195A Division JP2014196309A (ja) 2008-06-11 2014-05-19 ジアザカルバゾール及びその使用方法

Publications (3)

Publication Number Publication Date
JP2011522888A JP2011522888A (ja) 2011-08-04
JP2011522888A5 JP2011522888A5 (enExample) 2012-07-26
JP5677945B2 true JP5677945B2 (ja) 2015-02-25

Family

ID=41066268

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011513493A Expired - Fee Related JP5677945B2 (ja) 2008-06-11 2009-06-10 ジアザカルバゾール及びその使用方法
JP2014103195A Pending JP2014196309A (ja) 2008-06-11 2014-05-19 ジアザカルバゾール及びその使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014103195A Pending JP2014196309A (ja) 2008-06-11 2014-05-19 ジアザカルバゾール及びその使用方法

Country Status (12)

Country Link
US (1) US20110124654A1 (enExample)
EP (1) EP2324024B1 (enExample)
JP (2) JP5677945B2 (enExample)
KR (2) KR20110015699A (enExample)
CN (1) CN102119162B (enExample)
AU (1) AU2009258115B2 (enExample)
BR (1) BRPI0909957A2 (enExample)
CA (1) CA2726114A1 (enExample)
ES (1) ES2392489T3 (enExample)
IL (1) IL209548A (enExample)
MX (1) MX2010013606A (enExample)
WO (1) WO2009151589A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014196309A (ja) * 2008-06-11 2014-10-16 ジェネンテック， インコーポレイテッド ジアザカルバゾール及びその使用方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108721284A (zh) 2010-11-16 2018-11-02 阵列生物制药公司 检测点激酶1抑制剂和wee1激酶抑制剂的组合
GB201201566D0 (en) 2012-01-30 2012-03-14 Vernalis R&D Ltd New chemical compounds
RU2635359C2 (ru) * 2012-04-23 2017-11-13 Дженентек Инк. Промежуточные химические соединения и способы получения соединений
EP2948438A4 (en) * 2013-01-23 2016-10-05 Univ Chicago METHOD AND COMPOSITIONS FOR INHIBITING THE HUMAN COPPER TRAFFICKING PROTEIN ATOX1 AND CCS
AU2014293013A1 (en) 2013-07-26 2016-03-17 Race Oncology Ltd. Combinatorial methods to improve the therapeutic benefit of bisantrene
AU2014333996B2 (en) 2013-10-08 2018-03-15 F. Hoffmann-La Roche Ag Diazacarbazole derivatives as tau-pet-ligands
JP6840931B2 (ja) * 2015-03-09 2021-03-10 東ソー株式会社 縮環芳香族化合物の製造方法
US20170067946A1 (en) * 2015-06-08 2017-03-09 Zac WHEELER Monitoring system with low power usage
CN109789143A (zh) 2016-07-01 2019-05-21 G1治疗公司 基于嘧啶的抗增殖剂
WO2018046428A1 (en) 2016-09-09 2018-03-15 F. Hoffmann-La Roche Ag Process for preparation of 2-(6-nitropyridin-3-yl)-9h-dipyrido[2,3-b;3',4'-d]pyrrole
US11760701B2 (en) 2018-02-27 2023-09-19 The Research Foundation For The State University Of New Yrok Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
JP7853532B2 (ja) 2020-05-19 2026-04-30 ファーマコスモス ホールディング エー／エス 医学的障害を治療するためのサイクリン依存性キナーゼ阻害化合物
CN115572282B (zh) * 2021-07-05 2024-07-09 华东理工大学 含芳杂环结构的吡唑酰胺类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1268477B1 (en) 2000-03-15 2010-04-21 Sanofi-Aventis Deutschland GmbH Substituted beta-carbolines with ikb-kinase inhibiting activity
CA2402549A1 (en) * 2000-03-15 2001-09-20 Aventis Pharma Deutschland Gmbh Substituted beta-carbolines
AU5261001A (en) * 2000-04-27 2001-11-12 Imperial Cancer Research Technology Ltd Condensed heteroaryl derivatives
US6608053B2 (en) * 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
BRPI0407544A (pt) * 2003-02-17 2006-02-14 Pharmacia Italia Spa derivados de pirazol tetracìclicos como inibidores da cinase, processo para a sua preparação e composições farmacêuticas que os compreendem
AR049300A1 (es) * 2004-06-15 2006-07-12 Schering Corp Compuestos triciclicos antagonistas de mglur1 como agentes terapeuticos
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US8618121B2 (en) 2007-07-02 2013-12-31 Cancer Research Technology Limited 9H-pyrimido[4,5-B]indoles, 9H-pyrido[4',3':4,5]pyrrolo[2,3-D]pyridines, and 9H 1,3,6,9 tetraaza-fluorenes as CHK1 kinase function inhibitors
CA2726114A1 (en) * 2008-06-11 2009-12-17 Genentech, Inc. Diazacarbazoles and methods of use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014196309A (ja) * 2008-06-11 2014-10-16 ジェネンテック， インコーポレイテッド ジアザカルバゾール及びその使用方法

Also Published As

Publication number Publication date
IL209548A0 (en) 2011-01-31
MX2010013606A (es) 2010-12-21
KR101764556B1 (ko) 2017-08-02
JP2014196309A (ja) 2014-10-16
ES2392489T3 (es) 2012-12-11
CN102119162A (zh) 2011-07-06
IL209548A (en) 2014-03-31
KR20110015699A (ko) 2011-02-16
KR20160074680A (ko) 2016-06-28
CA2726114A1 (en) 2009-12-17
BRPI0909957A2 (pt) 2016-04-19
EP2324024A1 (en) 2011-05-25
US20110124654A1 (en) 2011-05-26
AU2009258115B2 (en) 2015-01-29
CN102119162B (zh) 2014-10-08
AU2009258115A2 (en) 2011-05-12
WO2009151589A1 (en) 2009-12-17
JP2011522888A (ja) 2011-08-04
AU2009258115A1 (en) 2009-12-17
EP2324024B1 (en) 2012-09-26

Similar Documents

Publication Publication Date Title
JP2014196309A (ja) ジアザカルバゾール及びその使用方法
KR101710732B1 (ko) 디아자카르바졸 및 사용 방법
JP5710268B2 (ja) ８−アニリノイミダゾピリジン及びその抗ガン及び／又は抗炎症剤としての使用
JP5689069B2 (ja) ピラゾロピリジンｐｉ３ｋ阻害剤化合物及び使用方法
US20110130406A1 (en) Pyrazolo-pyridines as tyrosine kinase inhibitors
JP2010540458A (ja) チアゾロピリミジンｐｉ３ｋ阻害剤化合物および使用方法
EP2164850A2 (en) N-substituted azaindoles and methods of use
EP2300457B1 (en) Substituted pyrroles and methods of use
US20150368244A1 (en) Diazacarbazoles and methods of use

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110215

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120608

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120608

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131119

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140210

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140218

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140313

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140320

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140519

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140916

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141117

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20141209

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150105

R150 Certificate of patent or registration of utility model

Ref document number: 5677945

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees