JP5677945B2 - ジアザカルバゾール及びその使用方法 - Google Patents

ジアザカルバゾール及びその使用方法 Download PDF

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Publication number
JP5677945B2
JP5677945B2 JP2011513493A JP2011513493A JP5677945B2 JP 5677945 B2 JP5677945 B2 JP 5677945B2 JP 2011513493 A JP2011513493 A JP 2011513493A JP 2011513493 A JP2011513493 A JP 2011513493A JP 5677945 B2 JP5677945 B2 JP 5677945B2
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Japan
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alkyl
groups
membered
compound
substituted
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JP2011513493A
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English (en)
Japanese (ja)
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JP2011522888A (ja
JP2011522888A5 (enExample
Inventor
ヘイゼル， ジョーン ダイク，
ヘイゼル， ジョーン ダイク，
エマヌエラ ガンチア，
エマヌエラ ガンチア，
ルイス， ジェイ． ギャザード，
ルイス， ジェイ． ギャザード，
サイモン， チャールズ グッドエーカー，
サイモン， チャールズ グッドエーカー，
ジョゼフ， ピー． リッシカトス，
ジョゼフ， ピー． リッシカトス，
カラム マクレオウド，
カラム マクレオウド，
カレン ウィリアムズ，
カレン ウィリアムズ，
フイフェン チェン，
フイフェン チェン，
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Genentech Inc
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Genentech Inc
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011513493A 2008-06-11 2009-06-10 ジアザカルバゾール及びその使用方法 Expired - Fee Related JP5677945B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6075008P 2008-06-11 2008-06-11
US61/060,750 2008-06-11
US14800409P 2009-01-28 2009-01-28
US61/148,004 2009-01-28
PCT/US2009/003481 WO2009151589A1 (en) 2008-06-11 2009-06-10 Diazacarbazoles and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014103195A Division JP2014196309A (ja) 2008-06-11 2014-05-19 ジアザカルバゾール及びその使用方法

Publications (3)

Publication Number Publication Date
JP2011522888A JP2011522888A (ja) 2011-08-04
JP2011522888A5 JP2011522888A5 (enExample) 2012-07-26
JP5677945B2 true JP5677945B2 (ja) 2015-02-25

Family

ID=41066268

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011513493A Expired - Fee Related JP5677945B2 (ja) 2008-06-11 2009-06-10 ジアザカルバゾール及びその使用方法
JP2014103195A Pending JP2014196309A (ja) 2008-06-11 2014-05-19 ジアザカルバゾール及びその使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014103195A Pending JP2014196309A (ja) 2008-06-11 2014-05-19 ジアザカルバゾール及びその使用方法

Country Status (12)

Country Link
US (1) US20110124654A1 (enExample)
EP (1) EP2324024B1 (enExample)
JP (2) JP5677945B2 (enExample)
KR (2) KR101764556B1 (enExample)
CN (1) CN102119162B (enExample)
AU (1) AU2009258115B2 (enExample)
BR (1) BRPI0909957A2 (enExample)
CA (1) CA2726114A1 (enExample)
ES (1) ES2392489T3 (enExample)
IL (1) IL209548A (enExample)
MX (1) MX2010013606A (enExample)
WO (1) WO2009151589A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014196309A (ja) * 2008-06-11 2014-10-16 ジェネンテック， インコーポレイテッド ジアザカルバゾール及びその使用方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6091422B2 (ja) 2010-11-16 2017-03-08 アレイ バイオファーマ、インコーポレイテッド チェックポイントキナーゼ１阻害剤とｗｅｅ１キナーゼ阻害剤の組み合わせ
GB201201566D0 (en) * 2012-01-30 2012-03-14 Vernalis R&D Ltd New chemical compounds
NZ702135A (en) * 2012-04-23 2016-09-30 Genentech Inc Intermediates and processes for preparing 5-bromo-4-chloro-3-nitro-1h-pyrrolo[2,3-b]pyridine
WO2014116859A1 (en) * 2013-01-23 2014-07-31 The University Of Chicago Methods and compositions for inhibiting human copper trafficking proteins atox1 and ccs
AU2014293013A1 (en) 2013-07-26 2016-03-17 Race Oncology Ltd. Combinatorial methods to improve the therapeutic benefit of bisantrene
CA2917191C (en) 2013-10-08 2021-08-10 F. Hoffmann-La Roche Ag Diazacarbazole derivatives as tau-pet-ligands
JP6840931B2 (ja) * 2015-03-09 2021-03-10 東ソー株式会社 縮環芳香族化合物の製造方法
US20170067946A1 (en) * 2015-06-08 2017-03-09 Zac WHEELER Monitoring system with low power usage
WO2018005860A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Pyrimidine-based antiproliferative agents
JP6997769B2 (ja) 2016-09-09 2022-02-10 エフ．ホフマン－ラ ロシュ アーゲー ２－（６－ニトロピリジン－３－イル）－９Ｈ－ジピリド［２，３－ｂ；３’，４’－ｄ］ピロールの製造方法
WO2019168874A1 (en) 2018-02-27 2019-09-06 The Research Foundation For The State University Of New York Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
EP4652997A2 (en) 2020-05-19 2025-11-26 Pharmacosmos Holding A/s Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders
CN115572282B (zh) * 2021-07-05 2024-07-09 华东理工大学 含芳杂环结构的吡唑酰胺类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1268477B1 (en) 2000-03-15 2010-04-21 Sanofi-Aventis Deutschland GmbH Substituted beta-carbolines with ikb-kinase inhibiting activity
ATE465161T1 (de) * 2000-03-15 2010-05-15 Sanofi Aventis Deutschland Substituierte beta-carboline mit ikb-kinase hemmender wirkung
US6608053B2 (en) * 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
KR100774855B1 (ko) * 2000-04-27 2007-11-08 아스텔라스세이야쿠 가부시키가이샤 축합 헤테로아릴 유도체
WO2004071507A1 (en) * 2003-02-17 2004-08-26 Pharmacia Italia S.P.A. Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
PE20060526A1 (es) * 2004-06-15 2006-07-13 Schering Corp Compuestos triciclicos como antagonistas de mglur1
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US8618121B2 (en) 2007-07-02 2013-12-31 Cancer Research Technology Limited 9H-pyrimido[4,5-B]indoles, 9H-pyrido[4',3':4,5]pyrrolo[2,3-D]pyridines, and 9H 1,3,6,9 tetraaza-fluorenes as CHK1 kinase function inhibitors
AU2009258115B2 (en) * 2008-06-11 2015-01-29 Genentech, Inc. Diazacarbazoles and methods of use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014196309A (ja) * 2008-06-11 2014-10-16 ジェネンテック， インコーポレイテッド ジアザカルバゾール及びその使用方法

Also Published As

Publication number Publication date
AU2009258115A1 (en) 2009-12-17
AU2009258115A2 (en) 2011-05-12
AU2009258115B2 (en) 2015-01-29
EP2324024B1 (en) 2012-09-26
IL209548A (en) 2014-03-31
JP2014196309A (ja) 2014-10-16
CN102119162A (zh) 2011-07-06
KR20110015699A (ko) 2011-02-16
MX2010013606A (es) 2010-12-21
WO2009151589A1 (en) 2009-12-17
KR20160074680A (ko) 2016-06-28
CN102119162B (zh) 2014-10-08
CA2726114A1 (en) 2009-12-17
KR101764556B1 (ko) 2017-08-02
BRPI0909957A2 (pt) 2016-04-19
ES2392489T3 (es) 2012-12-11
EP2324024A1 (en) 2011-05-25
IL209548A0 (en) 2011-01-31
US20110124654A1 (en) 2011-05-26
JP2011522888A (ja) 2011-08-04

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