KR101758583B1 - 통증을 치료 또는 완화하기 위한 설파메이트 유도체 화합물 - Google Patents

통증을 치료 또는 완화하기 위한 설파메이트 유도체 화합물 Download PDF

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KR101758583B1
KR101758583B1 KR1020167013586A KR20167013586A KR101758583B1 KR 101758583 B1 KR101758583 B1 KR 101758583B1 KR 1020167013586 A KR1020167013586 A KR 1020167013586A KR 20167013586 A KR20167013586 A KR 20167013586A KR 101758583 B1 KR101758583 B1 KR 101758583B1
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KR
South Korea
Prior art keywords
benzo
dioxin
chloro
sulfamate
dimethyl
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KR1020167013586A
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English (en)
Korean (ko)
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KR20160065984A (ko
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최용문
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(주)바이오팜솔루션즈
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Publication of KR20160065984A publication Critical patent/KR20160065984A/ko
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Publication of KR101758583B1 publication Critical patent/KR101758583B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020167013586A 2013-12-12 2014-12-12 통증을 치료 또는 완화하기 위한 설파메이트 유도체 화합물 KR101758583B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361915042P 2013-12-12 2013-12-12
US61/915,042 2013-12-12
PCT/KR2014/012260 WO2015088272A1 (en) 2013-12-12 2014-12-12 Sulfamate derivative compounds for use in treating or alleviating pain

Publications (2)

Publication Number Publication Date
KR20160065984A KR20160065984A (ko) 2016-06-09
KR101758583B1 true KR101758583B1 (ko) 2017-07-14

Family

ID=53371494

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167013586A KR101758583B1 (ko) 2013-12-12 2014-12-12 통증을 치료 또는 완화하기 위한 설파메이트 유도체 화합물

Country Status (7)

Country Link
US (1) US10081615B2 (de)
EP (1) EP3079687B1 (de)
JP (1) JP6311025B2 (de)
KR (1) KR101758583B1 (de)
CN (1) CN105979942B (de)
ES (1) ES2663804T3 (de)
WO (1) WO2015088272A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106456599B (zh) * 2013-12-12 2019-05-14 比皮艾思药物研发有限公司 用于治疗或减轻疼痛的氨基磺酸酯衍生化合物
KR102121680B1 (ko) * 2016-02-29 2020-06-10 (주)바이오팜솔루션즈 설파메이트 유도체 화합물, 이의 제조 방법 및 용도
CN114350340B (zh) * 2022-01-13 2023-01-17 陕西科技大学 一种压裂用增渗剂及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100063138A1 (en) 2008-07-22 2010-03-11 Mccomsey David F Novel substituted sulfamide derivatives

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582916A (en) 1983-09-26 1986-04-15 Mcneilab, Inc. Chlorosulfate and azidosulfate esters of tetrahydro-2H-pyran-2-yl-methanol
US4591601A (en) * 1985-04-12 1986-05-27 Mcneilab, Inc. Anticonvulsant dioxolane methane sulfamates
ES2039260T3 (es) * 1987-02-05 1993-09-16 Farmaceutici Caber S.P.A. Derivado de 4-oxo-1,3-benzodioxano.
US4792569A (en) 1987-08-27 1988-12-20 Mcneilab, Inc. Anticonvulsant phenethyl sulfamates
US5998380A (en) * 1995-10-13 1999-12-07 New England Medical Center Hospitals, Inc. Treatment of migraine
MY147767A (en) 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
TW200823196A (en) * 2006-11-01 2008-06-01 Astrazeneca Ab New use
CA2722986A1 (en) * 2008-04-29 2009-11-05 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Modulators of dopamine neurotransmission
US20130252924A1 (en) * 2010-11-11 2013-09-26 Akron Molecules Gmbh Compounds and Methods for Treating Pain
ES2635067T3 (es) 2012-06-15 2017-10-02 Bio-Pharm Solutions Co., Ltd. Compuesto de sulfamato de fenilalquilo y composición de relajante muscular que comprende el mismo

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100063138A1 (en) 2008-07-22 2010-03-11 Mccomsey David F Novel substituted sulfamide derivatives

Also Published As

Publication number Publication date
EP3079687A4 (de) 2017-04-26
ES2663804T3 (es) 2018-04-17
WO2015088272A1 (en) 2015-06-18
US10081615B2 (en) 2018-09-25
WO2015088272A9 (en) 2015-10-01
CN105979942A (zh) 2016-09-28
JP2017509582A (ja) 2017-04-06
KR20160065984A (ko) 2016-06-09
JP6311025B2 (ja) 2018-04-11
EP3079687B1 (de) 2018-02-28
US20160311792A1 (en) 2016-10-27
EP3079687A1 (de) 2016-10-19
CN105979942B (zh) 2018-12-07

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