KR101746482B1 - 니트로이미다조옥사진 및 항결핵 치료요법에서의 이의 용도 - Google Patents

니트로이미다조옥사진 및 항결핵 치료요법에서의 이의 용도 Download PDF

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Publication number
KR101746482B1
KR101746482B1 KR1020127005320A KR20127005320A KR101746482B1 KR 101746482 B1 KR101746482 B1 KR 101746482B1 KR 1020127005320 A KR1020127005320 A KR 1020127005320A KR 20127005320 A KR20127005320 A KR 20127005320A KR 101746482 B1 KR101746482 B1 KR 101746482B1
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South Korea
Prior art keywords
oxazine
nitro
imidazo
dihydro
trifluoromethoxy
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Expired - Fee Related
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KR1020127005320A
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English (en)
Korean (ko)
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KR20120084713A (ko
Inventor
윌리엄 알렉산더 데니
앤드류 엠. 톰슨
에이드리언 블레이저
젠쿤 마
브라이언 데스몬드 팔머
하미쉬 스코트 서덜랜드
이베타 크멘토바
Original Assignee
글로벌 알리앙스 포 티비 드럭 디벨롭먼트
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Publication of KR20120084713A publication Critical patent/KR20120084713A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020127005320A 2009-07-31 2010-07-30 니트로이미다조옥사진 및 항결핵 치료요법에서의 이의 용도 Expired - Fee Related KR101746482B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23039609P 2009-07-31 2009-07-31
US61/230,396 2009-07-31
PCT/US2010/043906 WO2011014774A1 (en) 2009-07-31 2010-07-30 Nitroimidazooxazines and their uses in anti-tubercular therapy

Publications (2)

Publication Number Publication Date
KR20120084713A KR20120084713A (ko) 2012-07-30
KR101746482B1 true KR101746482B1 (ko) 2017-06-27

Family

ID=42937154

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127005320A Expired - Fee Related KR101746482B1 (ko) 2009-07-31 2010-07-30 니트로이미다조옥사진 및 항결핵 치료요법에서의 이의 용도

Country Status (12)

Country Link
EP (1) EP2459571B1 (cg-RX-API-DMAC10.html)
JP (1) JP5781072B2 (cg-RX-API-DMAC10.html)
KR (1) KR101746482B1 (cg-RX-API-DMAC10.html)
CN (1) CN102753558B (cg-RX-API-DMAC10.html)
AU (1) AU2010278777B2 (cg-RX-API-DMAC10.html)
BR (1) BR112012002278A2 (cg-RX-API-DMAC10.html)
CA (1) CA2769359C (cg-RX-API-DMAC10.html)
ES (1) ES2536997T3 (cg-RX-API-DMAC10.html)
IN (1) IN2012DN01414A (cg-RX-API-DMAC10.html)
NZ (1) NZ598121A (cg-RX-API-DMAC10.html)
RU (1) RU2542988C2 (cg-RX-API-DMAC10.html)
WO (1) WO2011014774A1 (cg-RX-API-DMAC10.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9051333B2 (en) 2011-04-15 2015-06-09 Otsuka Pharmaceutical Co., Ltd. 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides
CN104059082B (zh) * 2013-03-21 2016-08-03 苏州迈泰生物技术有限公司 硝基咪唑杂环类化合物及其在制备治疗结核病药物中的应用
KR101682356B1 (ko) 2014-11-04 2016-12-06 한국화학연구원 이미다조 옥사진 유도체, 이의 약학적으로 허용 가능한 염 또는 이의 광학이성질체 및 이를 유효성분으로 함유하는 약제학적 조성물
EP3252059A4 (en) 2015-01-29 2018-07-11 Medshine Discovery Inc. Anti-pulmonary tuberculosis nitroimidazole derivative
CN108047248A (zh) * 2018-02-12 2018-05-18 丹诺医药(苏州）有限公司 噁唑烷酮-硝基咪唑类偶联分子的应用
CN113527331B (zh) * 2020-04-17 2024-05-28 南京长澳医药科技有限公司 硝基咪唑类衍生物及其制备方法和用途
CN113355439A (zh) * 2021-06-07 2021-09-07 深圳市普瑞康生物技术有限公司 一种结核分枝杆菌潜伏感染及发病的新型组合检测方法
CN114469946B (zh) * 2022-02-24 2023-10-24 首都医科大学附属北京胸科医院 德拉马尼作为cxcl10抑制剂的用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK280914B6 (sk) 1994-03-08 2000-09-12 American Home Products Corporation Tiazolidíndiónové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie
US5668127A (en) * 1995-06-26 1997-09-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
US6087358A (en) * 1995-06-26 2000-07-11 Pathogenesis Corporation Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof
AR041198A1 (es) * 2002-10-11 2005-05-04 Otsuka Pharma Co Ltd Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen
CN100497345C (zh) * 2003-10-31 2009-06-10 大塚制药株式会社 治疗结核病的2,3-二氢-6-硝基咪唑并[2,1-b]唑化合物
DE602005004040T2 (de) 2004-01-16 2008-12-11 Sumitomo Chemical Co., Ltd. Malononitrilverbindungen als Pestizide
TWI300409B (en) * 2004-02-18 2008-09-01 Otsuka Pharma Co Ltd Method for producing 4-nitroimidazole compound
WO2006043121A1 (en) * 2004-10-20 2006-04-27 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
KR20080038369A (ko) * 2005-07-28 2008-05-06 버텍스 파마슈티칼스 인코포레이티드 카스파제 억제제 프로드럭
JP2009521464A (ja) * 2005-12-23 2009-06-04 ノバルティス アクチエンゲゼルシャフト ニトロイミダゾール化合物
CN101965353B (zh) * 2008-03-26 2014-12-17 丹诺医药(苏州）有限公司 共价连接到取代苯基噁唑烷酮的双环硝基咪唑类

Also Published As

Publication number Publication date
JP5781072B2 (ja) 2015-09-16
KR20120084713A (ko) 2012-07-30
JP2013500996A (ja) 2013-01-10
AU2010278777A1 (en) 2012-03-01
WO2011014774A1 (en) 2011-02-03
CA2769359C (en) 2017-03-07
RU2012107176A (ru) 2013-09-10
EP2459571A1 (en) 2012-06-06
IN2012DN01414A (cg-RX-API-DMAC10.html) 2015-06-05
BR112012002278A2 (pt) 2020-09-15
EP2459571B1 (en) 2015-03-11
CA2769359A1 (en) 2011-02-03
RU2542988C2 (ru) 2015-02-27
AU2010278777B2 (en) 2015-05-07
NZ598121A (en) 2013-04-26
CN102753558B (zh) 2014-10-15
CN102753558A (zh) 2012-10-24
ES2536997T3 (es) 2015-06-01

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