AU2010278777B2 - Nitroimidazooxazines and their uses in anti-tubercular therapy - Google Patents

Nitroimidazooxazines and their uses in anti-tubercular therapy Download PDF

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Publication number
AU2010278777B2
AU2010278777B2 AU2010278777A AU2010278777A AU2010278777B2 AU 2010278777 B2 AU2010278777 B2 AU 2010278777B2 AU 2010278777 A AU2010278777 A AU 2010278777A AU 2010278777 A AU2010278777 A AU 2010278777A AU 2010278777 B2 AU2010278777 B2 AU 2010278777B2
Authority
AU
Australia
Prior art keywords
oxazine
imidazo
nitro
dihydro
trifluoromethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010278777A
Other languages
English (en)
Other versions
AU2010278777A1 (en
Inventor
Adrian Blaser
William Alexander Denny
Iveta Kmentova
Zhenkun Ma
Brian Desmond Palmer
Hamish Scott Sutherland
Andrew M. Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TB Alliance
Original Assignee
TB Alliance
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TB Alliance filed Critical TB Alliance
Publication of AU2010278777A1 publication Critical patent/AU2010278777A1/en
Application granted granted Critical
Publication of AU2010278777B2 publication Critical patent/AU2010278777B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2010278777A 2009-07-31 2010-07-30 Nitroimidazooxazines and their uses in anti-tubercular therapy Ceased AU2010278777B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23039609P 2009-07-31 2009-07-31
US61/230,396 2009-07-31
PCT/US2010/043906 WO2011014774A1 (en) 2009-07-31 2010-07-30 Nitroimidazooxazines and their uses in anti-tubercular therapy

Publications (2)

Publication Number Publication Date
AU2010278777A1 AU2010278777A1 (en) 2012-03-01
AU2010278777B2 true AU2010278777B2 (en) 2015-05-07

Family

ID=42937154

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010278777A Ceased AU2010278777B2 (en) 2009-07-31 2010-07-30 Nitroimidazooxazines and their uses in anti-tubercular therapy

Country Status (12)

Country Link
EP (1) EP2459571B1 (cg-RX-API-DMAC10.html)
JP (1) JP5781072B2 (cg-RX-API-DMAC10.html)
KR (1) KR101746482B1 (cg-RX-API-DMAC10.html)
CN (1) CN102753558B (cg-RX-API-DMAC10.html)
AU (1) AU2010278777B2 (cg-RX-API-DMAC10.html)
BR (1) BR112012002278A2 (cg-RX-API-DMAC10.html)
CA (1) CA2769359C (cg-RX-API-DMAC10.html)
ES (1) ES2536997T3 (cg-RX-API-DMAC10.html)
IN (1) IN2012DN01414A (cg-RX-API-DMAC10.html)
NZ (1) NZ598121A (cg-RX-API-DMAC10.html)
RU (1) RU2542988C2 (cg-RX-API-DMAC10.html)
WO (1) WO2011014774A1 (cg-RX-API-DMAC10.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9051333B2 (en) 2011-04-15 2015-06-09 Otsuka Pharmaceutical Co., Ltd. 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides
CN104059082B (zh) * 2013-03-21 2016-08-03 苏州迈泰生物技术有限公司 硝基咪唑杂环类化合物及其在制备治疗结核病药物中的应用
KR101682356B1 (ko) 2014-11-04 2016-12-06 한국화학연구원 이미다조 옥사진 유도체, 이의 약학적으로 허용 가능한 염 또는 이의 광학이성질체 및 이를 유효성분으로 함유하는 약제학적 조성물
EP3252059A4 (en) 2015-01-29 2018-07-11 Medshine Discovery Inc. Anti-pulmonary tuberculosis nitroimidazole derivative
CN108047248A (zh) * 2018-02-12 2018-05-18 丹诺医药(苏州）有限公司 噁唑烷酮-硝基咪唑类偶联分子的应用
CN113527331B (zh) * 2020-04-17 2024-05-28 南京长澳医药科技有限公司 硝基咪唑类衍生物及其制备方法和用途
CN113355439A (zh) * 2021-06-07 2021-09-07 深圳市普瑞康生物技术有限公司 一种结核分枝杆菌潜伏感染及发病的新型组合检测方法
CN114469946B (zh) * 2022-02-24 2023-10-24 首都医科大学附属北京胸科医院 德拉马尼作为cxcl10抑制剂的用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007075872A2 (en) * 2005-12-23 2007-07-05 Novartis Ag Nitroimidazole compounds
WO2009120789A1 (en) * 2008-03-26 2009-10-01 Global Alliance For Tb Drug Development Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK280914B6 (sk) 1994-03-08 2000-09-12 American Home Products Corporation Tiazolidíndiónové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie
US5668127A (en) * 1995-06-26 1997-09-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
US6087358A (en) * 1995-06-26 2000-07-11 Pathogenesis Corporation Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof
AR041198A1 (es) * 2002-10-11 2005-05-04 Otsuka Pharma Co Ltd Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen
CN100497345C (zh) * 2003-10-31 2009-06-10 大塚制药株式会社 治疗结核病的2,3-二氢-6-硝基咪唑并[2,1-b]唑化合物
DE602005004040T2 (de) 2004-01-16 2008-12-11 Sumitomo Chemical Co., Ltd. Malononitrilverbindungen als Pestizide
TWI300409B (en) * 2004-02-18 2008-09-01 Otsuka Pharma Co Ltd Method for producing 4-nitroimidazole compound
WO2006043121A1 (en) * 2004-10-20 2006-04-27 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
KR20080038369A (ko) * 2005-07-28 2008-05-06 버텍스 파마슈티칼스 인코포레이티드 카스파제 억제제 프로드럭

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007075872A2 (en) * 2005-12-23 2007-07-05 Novartis Ag Nitroimidazole compounds
WO2009120789A1 (en) * 2008-03-26 2009-10-01 Global Alliance For Tb Drug Development Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PALMER, B.D. et al, Journal of Medicinal Chemistry, 2010, vol. 53, pp. 282-294 *
SUTHERLAND, H.S. et al, Journal of Medicinal Chemistry, 2010, vol. 53, pp. 855-866 *
THOMPSON, A.M. et al, Journal of Medicinal Chemistry, 2008, vol. 52, pp. 637-645 *

Also Published As

Publication number Publication date
JP5781072B2 (ja) 2015-09-16
KR20120084713A (ko) 2012-07-30
JP2013500996A (ja) 2013-01-10
AU2010278777A1 (en) 2012-03-01
WO2011014774A1 (en) 2011-02-03
CA2769359C (en) 2017-03-07
RU2012107176A (ru) 2013-09-10
EP2459571A1 (en) 2012-06-06
IN2012DN01414A (cg-RX-API-DMAC10.html) 2015-06-05
BR112012002278A2 (pt) 2020-09-15
EP2459571B1 (en) 2015-03-11
CA2769359A1 (en) 2011-02-03
KR101746482B1 (ko) 2017-06-27
RU2542988C2 (ru) 2015-02-27
NZ598121A (en) 2013-04-26
CN102753558B (zh) 2014-10-15
CN102753558A (zh) 2012-10-24
ES2536997T3 (es) 2015-06-01

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired