KR101716011B1 - Btk 활성의 억제제인 알킬화된 피페라진 화합물 - Google Patents
Btk 활성의 억제제인 알킬화된 피페라진 화합물 Download PDFInfo
- Publication number
- KR101716011B1 KR101716011B1 KR1020147014782A KR20147014782A KR101716011B1 KR 101716011 B1 KR101716011 B1 KR 101716011B1 KR 1020147014782 A KR1020147014782 A KR 1020147014782A KR 20147014782 A KR20147014782 A KR 20147014782A KR 101716011 B1 KR101716011 B1 KR 101716011B1
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- South Korea
- Prior art keywords
- mmol
- fluoro
- methyl
- phenyl
- pyridin
- Prior art date
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- Expired - Fee Related
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- 0 CC=C(N)N=CC(N1CCN(*)CC1)=* Chemical compound CC=C(N)N=CC(N1CCN(*)CC1)=* 0.000 description 3
- IYFYLBRGTQCCGW-UHFFFAOYSA-N CC1(C)OB(c2cc(F)cc(N(C3=O)N=Cc4c3[s]c3c4CCCC3)c2COC(C)=O)OC1(C)C Chemical compound CC1(C)OB(c2cc(F)cc(N(C3=O)N=Cc4c3[s]c3c4CCCC3)c2COC(C)=O)OC1(C)C IYFYLBRGTQCCGW-UHFFFAOYSA-N 0.000 description 1
- LCKGWMCJLOFBAO-UHFFFAOYSA-N CCC(CN(CC1)C2COC2)N1c1ccc(NC2=CC(c3cc(F)cc(N(CCc4c5cc6[n]4CCCC6)C5=O)c3COC(C)=O)=CN(C)C2=O)nc1 Chemical compound CCC(CN(CC1)C2COC2)N1c1ccc(NC2=CC(c3cc(F)cc(N(CCc4c5cc6[n]4CCCC6)C5=O)c3COC(C)=O)=CN(C)C2=O)nc1 LCKGWMCJLOFBAO-UHFFFAOYSA-N 0.000 description 1
- GYPZSDXMAZSJRF-OYRHEFFESA-N CCOC([C@@H](CN(C1)S(c2ccccc2)(=O)=O)N(Cc2ccccc2)[C@@H]1C(OCC)=O)=O Chemical compound CCOC([C@@H](CN(C1)S(c2ccccc2)(=O)=O)N(Cc2ccccc2)[C@@H]1C(OCC)=O)=O GYPZSDXMAZSJRF-OYRHEFFESA-N 0.000 description 1
- VGRKPWHLVRPNAO-CYBMUJFWSA-N C[C@H](CN(CC1)C2COC2)N1c1ccc(NC2=CC(Br)=CN(C)C2=O)nc1 Chemical compound C[C@H](CN(CC1)C2COC2)N1c1ccc(NC2=CC(Br)=CN(C)C2=O)nc1 VGRKPWHLVRPNAO-CYBMUJFWSA-N 0.000 description 1
- SHEGBLQFOSBVPT-JOCHJYFZSA-N C[C@H](CN(CC1)C2COC2)N1c1ccc(NC2=CC(c3cc(F)cc(N(C4=O)N=Cc5c4[s]c4c5CCCC4)c3COC(C)=O)=CN(C)C2=O)nc1 Chemical compound C[C@H](CN(CC1)C2COC2)N1c1ccc(NC2=CC(c3cc(F)cc(N(C4=O)N=Cc5c4[s]c4c5CCCC4)c3COC(C)=O)=CN(C)C2=O)nc1 SHEGBLQFOSBVPT-JOCHJYFZSA-N 0.000 description 1
- YVIXIVOKRYMFMD-NWDGAFQWSA-N C[C@H](CN([C@@H](C)C1)c(cn2)ccc2[N+]([O-])=O)N1C(OC(C)(C)C)=O Chemical compound C[C@H](CN([C@@H](C)C1)c(cn2)ccc2[N+]([O-])=O)N1C(OC(C)(C)C)=O YVIXIVOKRYMFMD-NWDGAFQWSA-N 0.000 description 1
- FYYRXKIAVBUGCF-LOSJGSFVSA-N C[C@H](CN([C@@H](C)C1)c2ccc(NC3=CC(c4cc(F)cc(N(CC[n]5c6cc7c5CCCC7)C6=O)c4COC(C)=O)=CN(C)C3=O)nc2)N1C1COC1 Chemical compound C[C@H](CN([C@@H](C)C1)c2ccc(NC3=CC(c4cc(F)cc(N(CC[n]5c6cc7c5CCCC7)C6=O)c4COC(C)=O)=CN(C)C3=O)nc2)N1C1COC1 FYYRXKIAVBUGCF-LOSJGSFVSA-N 0.000 description 1
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- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
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- Hematology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161555395P | 2011-11-03 | 2011-11-03 | |
| US61/555,395 | 2011-11-03 | ||
| PCT/US2012/063198 WO2013067277A1 (en) | 2011-11-03 | 2012-11-02 | Alkylated piperazine compounds as inhibitors of btk activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140090227A KR20140090227A (ko) | 2014-07-16 |
| KR101716011B1 true KR101716011B1 (ko) | 2017-03-13 |
Family
ID=47146780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147014782A Expired - Fee Related KR101716011B1 (ko) | 2011-11-03 | 2012-11-02 | Btk 활성의 억제제인 알킬화된 피페라진 화합물 |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US8729072B2 (https=) |
| EP (1) | EP2773639B1 (https=) |
| JP (2) | JP5976828B2 (https=) |
| KR (1) | KR101716011B1 (https=) |
| CN (1) | CN104024255B (https=) |
| AR (1) | AR088642A1 (https=) |
| AU (1) | AU2012332368A1 (https=) |
| BR (1) | BR112014010439A2 (https=) |
| CA (1) | CA2853970A1 (https=) |
| CL (1) | CL2014001158A1 (https=) |
| CO (1) | CO6950475A2 (https=) |
| CR (1) | CR20140187A (https=) |
| EA (1) | EA027561B1 (https=) |
| IL (1) | IL232280A0 (https=) |
| IN (1) | IN2014CN03265A (https=) |
| MA (1) | MA35725B1 (https=) |
| MX (1) | MX2014005289A (https=) |
| PE (1) | PE20141686A1 (https=) |
| PH (1) | PH12014500966A1 (https=) |
| SG (1) | SG11201401993RA (https=) |
| TW (1) | TW201326171A (https=) |
| WO (1) | WO2013067277A1 (https=) |
| ZA (1) | ZA201403158B (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013021374A2 (en) | 2011-08-05 | 2013-02-14 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
| MX2014005289A (es) * | 2011-11-03 | 2014-05-30 | Hoffmann La Roche | Compuestos de piperazina alquilados. |
| UA111756C2 (uk) | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
| RU2016101548A (ru) | 2013-07-03 | 2017-08-08 | Ф. Хоффманн-Ля Рош Аг | Соединения амидов гетероарилпиридона и азапиридона |
| WO2015082583A1 (en) | 2013-12-05 | 2015-06-11 | F. Hoffmann-La Roche Ag | Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality |
| EP3079682A4 (en) | 2013-12-13 | 2017-08-30 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| US9856223B2 (en) | 2013-12-13 | 2018-01-02 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| WO2015151006A1 (en) | 2014-03-29 | 2015-10-08 | Lupin Limited | Substituted purine compounds as btk inhibitors |
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