KR101672223B1 - 아이코티닙, 아이코티닙 하이드로클로라이드 및 이의 중간체의 제조방법 - Google Patents

아이코티닙, 아이코티닙 하이드로클로라이드 및 이의 중간체의 제조방법 Download PDF

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KR101672223B1
KR101672223B1 KR1020147013874A KR20147013874A KR101672223B1 KR 101672223 B1 KR101672223 B1 KR 101672223B1 KR 1020147013874 A KR1020147013874 A KR 1020147013874A KR 20147013874 A KR20147013874 A KR 20147013874A KR 101672223 B1 KR101672223 B1 KR 101672223B1
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compound
reaction
icotinib
methanol
mmol
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Korean (ko)
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KR20140112007A (ko
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샤오징 후
웨이 롱
페이 왕
종퀘안 리
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베타 파머수티컬 컴퍼니 리미티드
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Priority claimed from PCT/CN2012/087802 external-priority patent/WO2013064128A1/zh
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
KR1020147013874A 2012-12-28 2012-12-28 아이코티닙, 아이코티닙 하이드로클로라이드 및 이의 중간체의 제조방법 Active KR101672223B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2012/087802 WO2013064128A1 (zh) 2011-10-31 2012-12-28 埃克替尼和盐酸埃克替尼的制备方法及其中间体

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KR20140112007A KR20140112007A (ko) 2014-09-22
KR101672223B1 true KR101672223B1 (ko) 2016-11-04

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JP (1) JP5955396B2 (enrdf_load_stackoverflow)
KR (1) KR101672223B1 (enrdf_load_stackoverflow)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007138613A2 (en) * 2006-05-25 2007-12-06 Vittal Mallya Scientific Research Foundation A process for synthesis of [6,7-bis-(2-methoxyethoxy)-quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride
US20110182882A1 (en) * 2008-07-08 2011-07-28 Beta Pharma, Inc. Icotinib Hydrochloride, Synthesis, Crystalline Forms, Pharmaceutical Compositions, and Uses Thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102180844B (zh) * 2011-03-25 2014-07-09 浙江海正药业股份有限公司 吉非替尼中间体及吉非替尼的制备方法
CN102659716B (zh) * 2012-05-02 2014-09-10 北京国联诚辉医药技术有限公司 4-甲氧基-2-胺基-3-[3-(4-吗啉基)丙氧基]苯腈的制备方法及吉非替尼的制备工艺

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007138613A2 (en) * 2006-05-25 2007-12-06 Vittal Mallya Scientific Research Foundation A process for synthesis of [6,7-bis-(2-methoxyethoxy)-quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride
US20110182882A1 (en) * 2008-07-08 2011-07-28 Beta Pharma, Inc. Icotinib Hydrochloride, Synthesis, Crystalline Forms, Pharmaceutical Compositions, and Uses Thereof

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KR20140112007A (ko) 2014-09-22
JP2015504846A (ja) 2015-02-16
JP5955396B2 (ja) 2016-07-20

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