KR101670852B1 - A powder complex meterials with a efficacy improving skin aging, and a bath preparation using the meterials - Google Patents

A powder complex meterials with a efficacy improving skin aging, and a bath preparation using the meterials Download PDF

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KR101670852B1
KR101670852B1 KR1020150177977A KR20150177977A KR101670852B1 KR 101670852 B1 KR101670852 B1 KR 101670852B1 KR 1020150177977 A KR1020150177977 A KR 1020150177977A KR 20150177977 A KR20150177977 A KR 20150177977A KR 101670852 B1 KR101670852 B1 KR 101670852B1
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mixed material
composite material
mixing
leaf
skin aging
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손미례
김도연
김영수
홍충의
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재단법인 금산국제인삼약초연구소
금산군
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216Solid or semisolid forms
    • A61K8/022Powders; Compacted Powders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Cosmetics (AREA)

Abstract

The present invention relates to a composite material having an efficacy to improve skin aging by using as a main composition a mulberry leaf, a cucumber leaf, a roundwood leaf and a ginseng flower, and by using the composite material as a powder form, Which is capable of improving antioxidative, anti-aging, anti-wrinkle, anti-inflammatory and whitening functions of skin, and has the effect of improving skin aging, and a bath agent using the above material.
The present invention relates to a method for manufacturing a leaf spring, Washing and drying, and then crushing each of the dried materials; Pulverizing each of the crushed materials after the crushing step; And mixing the finely pulverized respective materials to obtain a mixed material,
Further comprising the steps of: after mixing, increasing the mixed material; A step of inoculating and adding fermented Hwang Guk, to the mixed material, And a second drying step of obtaining a composite material by secondary drying the fermented mixed material after the fermentation step.
At this time, the antioxidant ability is improved by mixing with the mixture of 3: 1: 1: 1, and the antioxidant ability can be further improved by fermenting the mixed material, By decreasing the content of total sugar, it is possible to improve skin aging by enhancing the antioxidant, anti-aging, anti-wrinkle, anti-inflammatory and whitening effect of skin when used as a bathing agent.
In addition, the present invention is characterized in that the DPPH radical scavenging activity is maintained at 45 to 67% for up to 36 hours after bathing when used as a bathing agent.

Description

TECHNICAL FIELD [0001] The present invention relates to a composite material in powder form having an effect of improving skin aging and a bath material utilizing the above material. BACKGROUND OF THE INVENTION 1. Field of the Invention [0002]

The present invention relates to a composite material having an efficacy to improve skin aging by using as a main composition a mulberry leaf, a cucumber leaf, a roundwood leaf and a ginseng flower, and by using the composite material as a powder form, Which is capable of improving antioxidative, anti-aging, anti-wrinkle, anti-inflammatory and whitening functions of skin, and has an effect of improving skin aging, and a bath agent using the above material.

The present invention relates to a method for manufacturing a leaf spring, Washing and drying, and then crushing each of the dried materials; Pulverizing each of the crushed materials after the crushing step; And mixing the finely pulverized respective materials to obtain a mixed material,

Further comprising the steps of: after mixing, increasing the mixed material; A step of inoculating and adding fermented Hwang Guk, to the mixed material, And a second drying step of obtaining a composite material by secondary drying the fermented mixed material after the fermentation step.

At this time, the antioxidant ability is improved by mixing with the mixture of 3: 1: 1: 1, and the antioxidant ability can be further improved by fermenting the mixed material, By decreasing the content of total sugar, it is possible to improve skin aging by enhancing the antioxidant, anti-aging, anti-wrinkle, anti-inflammatory and whitening effect of skin when used as a bathing agent.

In addition, the present invention is characterized in that the DPPH radical scavenging activity is maintained at 45 to 67% during the bath for 36 hours after bathing.

With the increase in the desire to maintain the visual youth with the health of the skin, consumers are increasingly interested in skin beauty.

These skin cosmetics began with women, and in recent years they became objects of interest, both men and women.

Skin cosmetics as described above may be supplemented with nutrients through the ingestion of functional foods, or may be obtained by direct application of cosmetics to the skin, or bathing with water when bathing. As a result, there is a tendency that a method of administering bath salts is popular.

Regarding such a bath bath, Patent Document 10-1232817 discloses a bath bath containing an aqueous extract.

The above-described technology relates to a bathing agent. According to Claim 1 of the present invention, 850 to 860 parts by weight of purified water, 0.8 to 1.2 parts by weight of Disodium EDTA 55 to 65 parts by weight of glycerin, 550 to 650 parts by weight of sodium laureth sulfate, 95 to 105 parts by weight of Cocamido Propyl Betaine, 65 to 75 parts by weight of Cocamide DEA, 14 to 18 parts by weight of Glycol Distearate, 0.8 to 1.2 parts by weight of Methylchloroisothiazolinone or Methylisothiazolinone 2 to 3 parts by weight of citric acid, 8 to 12 parts by weight of sodium chloride, 55 to 65 parts by weight of potassium cocoyl glutamate, 1.8 to 2.2 parts by weight of allantoin, 0.8 to 1.2 parts by weight of dipotassium glycyrrhizate, 18 to 22 parts by weight of Perfume, 1.8 to 2.2 parts by weight of Sinensis Leaf Extract, 1.8 to 2.2 parts by weight of Beta-Glucan, 1.8 to 2.2 parts by weight of Extract of Mulberry bark, 0.8 to 1.2 parts by weight of Tocopheryl Acetate, 4 to 8 parts by weight of Resveratrol (ODI extract- 4 to 8 parts by weight of Berry Fruits Complex, , And a bath composition containing a mixed composition of an oily extract at a composition ratio of 75 to 85 parts by weight of red No. 1 '.

In summary, the above techniques can be applied to a variety of methods including, but not limited to, extracts such as aquatic extract, purified water, Disodium EDTA, Glycerine, Sodium Laureth Sulfate, Cocamido Propyl Betaine, Cocamide DEA, Glycol Distearate, Methylchloroisothiazolinone or Methylisothiazolinone, Sodium Chloride, Potassium Cocoyl Glutamate, Allantoin, Dipotassium Glycyrrhizate, Perfume, Sinensis Leaf Extract, Beta-Glucan, Extract of Cabbage Extract, Tocopheryl Acetate, Tocopheryl Acetate, Resveratrol, BFC-1 and Dust Red 1.

However, when such a composition is contained in a large amount, the manufacturing cost is increased, the selling cost is increased when it is sold to consumers, and a large amount of the composition can not be said to be an excellent effect.

In particular, in order to maintain visual skin health, it is necessary to lower the oxidizing action of the skin. Since the composition of the present invention uses the main composition as an oily extract, antioxidant activity can be expected by the ingredient contained in the oily ingredient. However, But the antioxidant ability is inevitably lowered because it is not produced only as a useful ingredient for the antioxidant ability to lower the oxidative effect.

On the other hand, a cosmetic composition for preventing skin aging is disclosed in Korean Patent Registration No. 10-1059471 for the purpose of reducing the aging of the skin according to the antioxidant ability.

The above-described technique is based on the claim 1 of claim 1, wherein the herbal medicine extract mixture consisting of 'white paper, copper and phosphorus, cinnabar, roundworm, sesquin, tofu, doin, Quot; cosmetic composition for preventing skin aging ".

It has been described that the above-mentioned technology as described above can prevent and improve skin aging through improvement of cell proliferation and metabolism, free radical elimination, improvement of skin wrinkles and improvement of skin elasticity by promoting collagen production by the above composition .

However, the above-mentioned technique is different from that of the first applicant in that it is different from the composition in which the applicant intends to improve the antioxidant ability as an active ingredient, and secondly, when it is intended to improve skin aging, it should not be effective only when it comes into contact with the skin, The efficacy should be maintained. However, there is a lack of description thereof, and it is not known whether the efficacy is maintained because the time for maintaining the efficacy is unknown.

Patent Registration No. 10-1232817 (Announcement of Mar. 23, 2013) Patent Registration No. 10-1059471 (issued on August 25, 2011)

An object of the present invention is to provide a composite material having an effect of improving skin aging by using as a main composition a mulberry leaf, a cucumber leaf, a curd leaf, and a ginseng flower (ginseng flower). The composite material is prepared in powder form, The present invention also provides a powdery composite material capable of improving antioxidant, anti-aging, anti-wrinkle, anti-inflammatory and whitening functions of skin and improving skin aging by using the same and a bath agent using the material.

In order to accomplish the above object, the present invention provides a composite material in powder form having an effect of improving skin aging, comprising the steps of washing and drying the material using a material selected from the group consisting of mulberry leaf, cucumber leaf, Washing and drying, and then crushing each of the dried materials; Pulverizing each of the crushed materials after the crushing step; And mixing the finely pulverized respective materials to obtain a mixed material,

Further comprising the steps of: after mixing, increasing the mixed material; A step of inoculating and adding fermented Hwang Guk, to the mixed material, And a second drying step of obtaining a composite material by secondary drying the fermented mixed material after the fermentation step.

At this time, it is a technical feature that the mixture of 3: 1: 1: 1 is mixed with the mulberry leaves, cucumber leaves, roundwood leaves and samhwa.

 Further, by fermenting the mixed material, it is possible to further improve the antioxidant ability compared to that before fermentation, and by reducing the content of total sugar, the efficacy against skin antioxidation, anti-aging, anti-wrinkle, anti- It is a technical feature that aging can be improved.

The composite material having the effect of improving skin aging according to the present invention provides a mixed material having excellent antioxidative ability by mixing with a mixture ratio of 2: 3, 1: 1: 1, It has the effect of being able to.

Further, the present invention has the effect of further enhancing the antioxidant ability compared to the fermentation state by fermenting the mixed mixed material, and by reducing the content of total sugar, the antioxidant, anti-aging, anti-wrinkle, The effect on whitening is enhanced and the skin aging is improved.

In addition, the present invention has an effect of maintaining a DPPH radical scavenging activity of 45 to 67% up to 36 hours after bathing when used as a bathing agent.

FIG. 1 shows the DPPH redical scavenging ability according to the composition ratio of the mixed material before fermentation in a powdery composite material having an effect of improving skin aging according to the present invention.
FIG. 2 shows the iron reducing ability according to the composition ratio of the mixed material before fermentation in a powdery composite material having an effect of improving skin aging according to the present invention.
FIG. 3 is a graph showing the total phenol content according to the composition ratio of a mixed material before fermentation in a powdery composite material having an effect of improving skin aging according to the present invention.
FIG. 4 shows the transformation of Samhwa used in a powdery composite material having an effect of improving skin aging according to the present invention. FIG. 4 (a) shows the results obtained by transgenic experiments of ginsenoside Re and Rg1 (B) is a graph.
FIG. 5 shows flavonoid transformation of a mixed material and a composite material used in a powdery composite material having an effect of improving skin aging according to the present invention, wherein (a) shows a result obtained by a transformation experiment of flavonoids (B) is a graph.
Figure 6 is a graphical representation of the results of Figure 5;
FIG. 7 shows the DPPH redical scavenging ability before and after fermentation in a powdery composite material having the effect of improving skin aging according to the present invention when mixing the respective materials at a mixing ratio of 3: 1: 1: 1 .
8 is a graph showing the relationship between the total phenol content and the total sugar content of the composite material before and after fermentation when each material was mixed at a mixing ratio of 3: 1: 1: 1 in a powdery composite material having an effect of improving skin aging according to the present invention. Respectively.
FIG. 9 is a graph showing the effect of improving the skin aging according to the present invention. FIG. 9 is a graph showing the effect of improving the skin aging according to the present invention. Of DPPH radical scavenging activity.

The terms and words used in the present specification and claims should not be construed as limited to ordinary or dictionary meanings and the inventor can properly define the concept of the term to describe its invention in the best possible way And should be construed in accordance with the principles and meanings and concepts consistent with the technical idea of the present invention.

Therefore, the embodiments described in the present specification and the configurations shown in the drawings are merely the most preferred embodiments of the present invention and are not intended to represent all of the technical ideas of the present invention. Therefore, various equivalents And variations are possible.

Before describing the present invention with reference to the accompanying drawings, it should be noted that the present invention is not described or specifically described with respect to a known configuration that can be easily added by a person skilled in the art, Let the sound be revealed.

The present invention relates to a composite material having an efficacy to improve skin aging by using as a main composition a mulberry leaf, a cucumber leaf, a roundwood leaf and a ginseng flower, and by using the composite material as a powder form, Which is capable of improving antioxidative, anti-aging, anti-wrinkle, anti-inflammatory and whitening functions of skin, and has an effect of improving skin aging, and a bath agent using the above material.

Example  However, Cedar leaf , Roundwood leaves  And Samhwa  Composite materials in powder form as the main composition

(1) washing and drying the material

It is a step of washing the mulberry leaf, the cucumber leaf, the roundwood leaf and the samhwa.

In the following description, the term " material " is interpreted as meaning that the material includes dicotyledonous leaf, cedarwood leaf, roundwood leaf, and samhwa.

Where the cleaning of the material takes place in running water and the cleaning time can be suitably between 5 and 20 minutes.

Drying is also preferred because the material is dried to such an extent that the material can be easily broken prior to breaking the washed material.

(2) shredding the material

Washing and drying the material, and crushing the dried material, respectively.

At this time, the crushing can use various conventional crushers, and in particular, an ultrasonic crusher can be applied to efficiently extract the components of the materials.

The ultrasonic wave crusher induces molecular motion due to cavity-specific cavitation, and the molecular motion acts as an activation energy, so that extraction or concentration has an effect of improving the reactivity during the process.

Among the materials used in the present invention, Eucommia ulmoides Oliv leaves are leaves of deciduous arboreous trees belonging to Quercus mongolica, which is one of the first species in the world and 30 years old is 20 m in height, which is one of the widely known medicinal plants.

According to the Dongbu Gong, these leaves have anti-aging, cholesterol strengthening, anti-inflammation, sedation, analgesia, immune control, blood coagulation and antibacterial activity.

Cucumis japonica leaf is a leaf of Cudrania tricuspidata (silkworm thorn). Cucumber japonica is easy to grow on hard land and is resistant to insect pests. Edible part is leaf and fruit.

According to a study by Jeonbuk Agricultural Research and Extension Services, it is known that the most abundant antioxidant component in the edible parts of the cucumber tree is that it is effective for nourishment, tenderness, weakness of the body, weakness of the tongue, insomnia, have.

Polygonatum odoratum (MILER) var. Pluriflorum Ohwi is a multi-year-old plant with a monocotyledonous lily of the valley. It is edible in spring and has a height of 30 to 60 meters.

According to Dong-Bok-gyung, these ginseng leaves are known to be effective for cough and diabetes due to nourishment, tonic, weakness, malnutrition, pulmonary tuberculosis and the like.

Panax ginseng (C.A.Meyer) is a perennial herbaceous ginseng flower belonging to the Araliaceae family. It is pale green in April.

It is known that Samhwa is superior to ginseng because its content of ginsenoside is 2 to 3 times higher than that of ginseng. Therefore, it is known that ginseng has an excellent ability to improve permanent memory, improvement of memory, improvement of fatigue, and improvement of blood circulation .

(3) pulverizing the crushed material

After the step of crushing the material, finely pulverizing each of the crushed materials.

Here, the fine pulverization is a method of obtaining fine pulverized material in the size of micrometer unit of the pulverized herb, and can be performed by a method such as ball mill processing, attrition mill processing or pin mill processing .

(4) mixing the pulverized material

After the step of pulverizing the crushed material, and mixing each of the finely pulverized materials to obtain a mixed material.

At this time, each of the materials can be produced in the form of powder through the step of pulverizing the above-mentioned crushed material. In this step, powdery form is mixed, and the mixing ratio is 3, 3, : 1: 1: 1.

The mixed material described below can be understood as a powder form prepared by pulverizing each material.

Example  However, Cedar leaf , Roundwood leaves  And Samhwa  A powdery composite material which is mixed and fermented after mixing

(1) washing and drying the material

The procedure of Example 1 was repeated.

(2) shredding the material

The procedure of Example 1 was repeated.

(3) pulverizing the crushed material

The procedure of Example 1 was repeated.

(4) mixing the pulverized material

The procedure of Example 1 was repeated.

(5) Steps to increase capital

And the step of mixing the finely pulverized material is a step of increasing the mixed material.

Here, the enhancement may be carried out at a temperature of 85 to 100 DEG C for 150 to 300 minutes after the herbicide crushed into fumigant by boiling it with fumigation, but it is not limited thereto and may be changed according to design conditions.

Such extensions may be non-pressurized, pressurized or normal pressure type, and preferably pressureless.

As a result, pressure can be applied to prevent the mixed material from being damaged, so that a good quality workpiece can be manufactured, and the effective ingredient of the material can be prevented from leaking through excessive humidity.

(6) Hwang Kook-jun  Step of inoculation and fermentation

This step is carried out after the above-mentioned step of increasing, and fermentation is performed by inoculating Hwang Kook-gum into the mixed material.

As used herein, Hwang guk gyon is a representative domestic fungus, and is a domestic fungus used for manufacturing miso, soy sauce, and the like.

At this time, Isobacteria are fungal molds, which are divided into yellowish green spores forming yellowish green spores and black spores forming blackish brown spores, which decompose starch and decompose proteins into low molecular weight monosaccharides such as glucose and fructose.

And serves to activate the monosaccharide produced by the Mycobacterium tuberculosis as food for other microorganisms.

The specific gravity of the germs of the germs of the germs is inoculated here in an amount of 0.01 to 0.05 parts by weight per 100 parts by weight of the added material.

And the fermentation can be performed for 5 to 18 hours, but is not limited thereto.

(7) Secondary drying step

The step of fermenting the fermented mixed material is followed by a second step of drying the fermented mixed material to obtain a powdery composite material.

Here, drying can be carried out by spray-drying to obtain a powder form.

That is, in the crushing and pulverizing step, the liquid discharged from the herb is absorbed by each fermented mixed material and evaporated. The heating temperature used for the drying is such that the material can be dried without lowering the effective ingredient of the material For example, a temperature of 30 to 50 DEG C may be preferable, but the present invention is not limited thereto and may be variously applied.

On the other hand, according to the design conditions, the above-described Embodiment 1 and / or Embodiment 2 may further include a cosmetic salt and / or herbal scent.

At this time, the cosmetic salt and / or herbal flavor may be used as a bathing agent by mixing the water and the mixed material and / or the composite material according to the above-described embodiments in powder form, but the present invention is not limited thereto. Or may be manufactured together.

On the other hand, depending on other design conditions, other compositions may be further used as a bathing agent, wherein the other composition may include all of the compositions useful for skin care, which can be obtained by a person skilled in the art.

Such cosmetic salts, herbal fragrances and / or other compositions are preferably used according to the preference of the user.

Example  3. Mixed materials and composite materials

In Embodiment 3, the mixed powder can be obtained by mixing the powdery mixed material obtained in the above-described first embodiment and the powdery composite obtained in the second embodiment.

For this, the third embodiment may further include a step of mixing the mixed material and the composite material, wherein the mixing ratio of the mixed material and the composite material is 1: 1.

Experimental Example  1. Antioxidant capacity test according to mixing ratio: DPPH  radical Scatters  Measure

1-1. Experimental sample

Experimental samples were prepared from the group consisting of Leptinopsis lanceolata, Lentinus edulis L., Leucocyte lentil, and Samhwa based on Example 1.

At this time, the samples of the five groups are as follows.

First sample: a mixture of each material at a mixing ratio of 1: 1: 1: 1

Second sample: a mixture of each material at a mixing ratio of 3: 1: 1: 1

Third Sample: A mixture of each material at a mixing ratio of 1: 3: 1: 1

Fourth sample: a mixture of each material at a mixing ratio of 1: 1: 3: 1

Fifth sample: a mixture of each material at a mixing ratio of 1: 1: 1: 3

1-2. Experimental Method

Experiments were performed using a method commonly used to measure the DPPH radical scavenging ability of an object.

1-3. Experiment result

The results shown in accordance with Experimental Example 1 refer to FIG. 1 of the accompanying drawings.

FIG. 1 shows the DPPH redical scavenging ability according to the composition ratio of the mixed material before fermentation in a powdery composite material having an effect of improving skin aging according to the present invention.

1 of the accompanying drawings, the second sample obtained by mixing the two groups of the above five samples in a mixing ratio of 3: 1: 1: 1 in the ratio of 2: 3, 1: 1: 1 DPPH radical scavenging ability was the highest at 75.0%.

In other words, it was found that the antioxidant capacity was highest when the mixing ratio according to the second sample was used as compared with the case of using other mixing ratios.

Experimental Example  2. Antioxidant capacity test: Measurement of iron reduction capacity

1-1. Experimental sample

The same test sample as in Experimental Example 1 was used as an experimental sample.

1-2. Experimental Method

Experiments were conducted using a method commonly used to measure the reducing ability of an iron component of an object.

1-3. Experiment result

The results shown in accordance with Experimental Example 2 refer to FIG. 2 of the accompanying drawings.

FIG. 2 shows the iron reducing ability according to the composition ratio of the mixed material before fermentation in a powdery composite material having an effect of improving skin aging according to the present invention.

According to FIG. 2 of the accompanying drawings, the second sample showed the highest reduction ability of iron compared to the other samples. Since the reducing ability of iron is related to oxidation, the higher the value shown, the more excellent the antioxidant ability .

That is, referring to FIG. 2, it means that the second sample is superior in antioxidant ability to the other samples.

Experimental Example  3. Antioxidant capacity test: Total phenol content measurement

1-1. Experimental sample

The same test sample as in Experimental Example 1 was used as an experimental sample.

1-2. Experimental Method

Experiments were carried out using a method commonly used for analyzing the phenol content of an object. Particularly, the total phenol content to be analyzed is the result that the reagent of the Folin-Ciocalteu phenol reagent was reduced by the polyphenolic compound of the mixed material Analyze based on the development of physical bronze blue.

1-3. Experiment result

The results shown in accordance with Experimental Example 3 refer to FIG. 3 of the accompanying drawings.

FIG. 3 is a graph showing the total phenol content according to the composition ratio of a mixed material before fermentation in a powdery composite material having an effect of improving skin aging according to the present invention.

Referring to FIG. 3 of the accompanying drawings, the second sample obtained by mixing 2: 3, 1: 1: 1, respectively, of the mulberry leaves, .

The above-mentioned polyphenols, especially polyphenolic compounds, are a secondary object widely distributed in plants, fruits, vegetables and the like and have a high free radical scavenging ability and are known to have a preventive effect on inflammation, cancer, arteriosclerosis,

The second sample, which had the highest total phenol content compared to the other samples, showed that the antioxidant capacity was superior to the other samples.

Experimental Example  4. Transformation test of skin-improving agent: Samhwa Ginsenoside: Re  And Rg1, (2) flavonoids: rutin, isoquercitrin and quercetin

Samhwa Ginsenoside: Re  And Rg1

1-1. Experimental sample

Experimental samples were sampled with fermentation based on Experimental Examples 2 and / or 3 and sampled with no fermentation.

1-2. Experimental Method

Experiments were performed using methods commonly used to measure the components of an object.

1-3. Experiment result

The results obtained according to the transfection experiments of ginsenoside Re and Rg1 of Samhwa of Experimental Example 4 are shown in Fig. 4 of the accompanying drawings.

FIG. 4 shows the transformation of Samhwa used in a powdery composite material having an effect of improving skin aging according to the present invention.

Fig. 4 (a) of the accompanying drawings is a molecular formula and (b) is a graphical representation of the results of the transgenic experiments of ginsenosides Re and Rg1.

Referring to FIG. 4 of the accompanying drawings, it is easy to refer to Table 1 below.

Gin Senocide Re Rg1 Before fermentation (mg / g) 41.3 ± 0.7 3.2 ± 0.2 After fermentation (mg / g) 26.1 ± 0.8 14.3 ± 0.3

That is, referring to FIG. 4 of the accompanying drawings, as shown in Table 1, ginsenoside Re was found to be 41.3 ± 0.7 and Rg1 was 3.2 ± 0.2 before fermentation of Samhwa, but after fermentation, Side Re tended to decrease to 26.1 ± 0.8, but Rg1 increased to 14.3 ± 0.3.

According to the above results, it is important that ginsenoside Re has antioxidant activity, so it is important to detect a large amount of Rg1. However, Rg1 may reduce the stress transmitted to skin by anti-thrombotic and anti- It is possible to prevent and prevent skin diseases.

As a result, although the ginsenoside Re component was partially reduced, the Rg1 component was increased in a large amount. Therefore, when the Re component was detected in a large amount due to the organic action of the Re and Rg1 components, , Anti-aging, and anti-wrinkle.

Flavonoids: Routine , Isoquercitrin  And Quercetin

1-1. Experimental sample

Experimental samples were prepared from mixed materials and composite materials based on Experimental Examples 1 to 3.

1-2. Experimental Method

Experiments were performed using methods commonly used to measure the components of an object.

1-3. Experiment result

The results shown in accordance with the experiment of transforming the flavonoid of Experimental Example 4 are shown in Figures 5 and 6 of the accompanying drawings.

FIG. 5 shows flavonoid transformation of a mixed material and a composite material used in a powdery composite material having an effect of improving skin aging according to the present invention, wherein (a) shows a result obtained by a transformation experiment of flavonoids (B) is a graph.

6 is a graphical representation of the results of FIG.

Referring to FIGS. 5 and 6 of the accompanying drawings, rutin and isoquercitrin are shown to be reduced in content after fermentation before fermentation, but quercetin is increased in content after fermentation appear.

Such quercetin has been known to lower cholesterol and triglycerides which are harmful to human body, to inhibit inflammation in blood vessels, to prevent thrombosis, and to have antioxidant, anti-inflammatory, whitening and anti-wrinkle effects on skin.

The above-mentioned efficacy also has both routine and isoquercitrin, and since these routines and isoquercitrin content tend to be reduced, but not removed, the effects of rutin, isoquercitrin, and quercetin on organically- .

Experimental Example  5. Antioxidant capacity test before and after fermentation: DPPH  radical Scatters  Measure

1-1. Experimental sample

Experimental samples were prepared according to Experimental Example 1, except that a second sample having the highest antioxidant capacity (a mixture of dicotyledonous leaf, cedarwood leaf, roundworm leaf, and samphire in a mixing ratio of 3: 1: 1: 1) At a mixing ratio of 1: 1: 1: 1) was used as a sample.

1-2. Experimental Method

Experiments were performed using a method commonly used to measure the DPPH radical scavenging ability of an object.

1-3. Experiment result

The results shown in accordance with Experimental Example 5 refer to FIG. 7 of the accompanying drawings.

FIG. 7 shows the DPPH redical scavenging ability before and after fermentation in a powdery composite material having the effect of improving skin aging according to the present invention when mixing the respective materials at a mixing ratio of 3: 1: 1: 1 .

In FIG. 7 of the accompanying drawings, the mixing ratio is set to 1: 1: 1: 1, but this is for reference only. When the mixing ratio of each material is effectively 3: 1: 1: It can be seen that the post fermentation was improved by about 20%.

1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1 showed a significant difference in the difference between before and after fermentation,

Based on this, it was found that when the mixing ratio based on Experimental Example 1 was fermented, the DPPH radical scavenging ability was further enhanced and the antioxidant capacity was further enhanced.

Experimental Example  6. Total phenol content measurement before and after fermentation

1-1. Experimental sample

As a test sample, a second sample having the highest antioxidant ability (a mixture of a mulberry leaf, a cedar leaf, a roundwood leaf and a samarium mixture at a mixing ratio of 3: 1: 1: 1) was used as a sample.

1-2. Experimental Method

Experiments were carried out using a method commonly used for analyzing the phenol content of an object. Particularly, the total phenol content to be analyzed is the result that the reagent of the Folin-Ciocalteu phenol reagent was reduced by the polyphenolic compound of the mixed material Analyze based on the development of physical bronze blue.

1-3. Experiment result

The results shown in accordance with Experimental Example 6 refer to Fig. 8 of the accompanying drawings.

8 is a graph showing the relationship between the total phenol content and the total sugar content of the composite material before and after fermentation when each material was mixed at a mixing ratio of 3: 1: 1: 1 in a powdery composite material having an effect of improving skin aging according to the present invention. Respectively.

That is, referring to FIG. 8 of the accompanying drawings, the total phenol content was higher after fermentation than before fermentation, and thus the increase in total phenol content means that the antioxidant capacity is increased.

Experimental Example  7. Total before and after fermentation Sugar content  Measurement experiment

1-1. Experimental sample

As a test sample, a second sample having the highest antioxidant ability (a mixture of a mulberry leaf, a cedar leaf, a roundwood leaf and a samarium mixture at a mixing ratio of 3: 1: 1: 1) was used as a sample.

1-2. Experimental Method

Experiments were conducted using methods commonly used to analyze the sugar content of an object.

1-3. Experiment result

The results shown in accordance with Experimental Example 7 refer to Fig. 8 of the accompanying drawings.

8 is a graph showing the relationship between the total phenol content and the total sugar content of the composite material before and after fermentation when each material was mixed at a mixing ratio of 3: 1: 1: 1 in a powdery composite material having an effect of improving skin aging according to the present invention. Respectively.

That is, referring to FIG. 8 of the accompanying drawings, the content of sugar was found to be further reduced after fermentation compared to before fermentation.

The higher the content of the sugar component, the more sticky, and promotes the aging of the skin by promoting the degeneration of collagen and elastin, the main proteins of the skin tissue, when it touches the skin.

Therefore, based on FIG. 8 of the accompanying drawings, it is possible to reduce the content of total sugar by fermentation, thereby reducing adverse effects on the skin.

Experimental Example  8. DPPH  radical Scarce  Time-lapse experiments to maintain efficacy

1-1. Experimental sample

The test samples were prepared by fermenting a second sample having the highest antioxidant capacity (a mixture of a mixture of 3: 1: 1: 1) Respectively.

1-2. Experimental Method

Experiments were conducted using a method commonly used for analyzing the DPPH radical scavenging ability of an object. Experiments were conducted by measuring the degree of persistence of the DPPH radical scavenging ability at predetermined time intervals.

1-3. Experiment result

The results shown in accordance with Experiment 8 refer to FIG. 9 of the accompanying drawings.

FIG. 9 is a graph showing the effect of improving the skin aging according to the present invention. FIG. 9 is a graph showing the effect of improving the skin aging according to the present invention. Of DPPH radical scavenging activity.

Referring to FIG. 9 of the accompanying drawings, the sample used in Experimental Example 9 maintained 67% DPPH radical scavenging efficacy at 36 hours, and the lowest DPPH radical The scavenging efficacy was maintained.

This means that the sample, that is, the composite material, is used as a bathing agent and has a DPPH radical scavenging effect of 45 to 67% up to 36 hours after the user's bathing, so that the antioxidant capacity is increased by the above- This can be seen as meaning that it is possible.

Claims (8)

It is a powder type bathing agent which utilizes diuched leaves, cucumber leaves, roundwood leaves,
The powdery bath-
Washing and drying the material;
Crushing the dried material;
Milling said shredded material;
Mixing the finely pulverized material to obtain a mixed material by mixing the dicotyledonous leaves, cedarwood leaves, roundwood leaves, and samphas at a mixing ratio of 3: 1: 1: 1;
Growing the mixed material;
Fermenting the fermented mixture material by inoculating the fermented gum;
A second drying step of obtaining a composite material by secondary drying the fermented mixed material; And
Powdering the composite material and preparing a powdered bathing agent using the same,
In the composite material,
- Samhwa, which has increased ginsenoside Rg1 content compared to pre-fermentation,
- The quercetin content and the total phenol content are increased compared with the pre-fermented mixed material,
- The content of total sugar is reduced compared to the pre-fermented mixed material,
Characterized in that the efficacy of DPPH radical scavenging lasts from 45 to 67% up to 36 hours after the user's bathing.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101934789B1 (en) * 2017-01-31 2019-01-03 (주)카낙스바이오 Method for preparing fermentation products of Panax ginseng flower improved contents of low molecular gingenosides and cosmetic compositions comprising fermentation products of Panax ginseng flower prepared thereby

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011522881A (en) * 2008-06-13 2011-08-04 アモーレパシフィック コーポレイション Skin external preparation composition containing ginseng flower or ginseng seed extract

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011522881A (en) * 2008-06-13 2011-08-04 アモーレパシフィック コーポレイション Skin external preparation composition containing ginseng flower or ginseng seed extract

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101934789B1 (en) * 2017-01-31 2019-01-03 (주)카낙스바이오 Method for preparing fermentation products of Panax ginseng flower improved contents of low molecular gingenosides and cosmetic compositions comprising fermentation products of Panax ginseng flower prepared thereby

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