KR101667094B1 - 항암 아데노바이러스 - Google Patents

항암 아데노바이러스 Download PDF

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KR101667094B1
KR101667094B1 KR1020137006526A KR20137006526A KR101667094B1 KR 101667094 B1 KR101667094 B1 KR 101667094B1 KR 1020137006526 A KR1020137006526 A KR 1020137006526A KR 20137006526 A KR20137006526 A KR 20137006526A KR 101667094 B1 KR101667094 B1 KR 101667094B1
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orf3
cells
infected
cancer
adenovirus
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KR20130126590A (ko
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클로다 오쉐아
콜린 포워즈
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더 솔크 인스티튜트 포 바이올로지칼 스터디즈
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/068—Stem cells; Progenitors
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020137006526A 2010-08-16 2011-08-16 항암 아데노바이러스 Active KR101667094B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37421510P 2010-08-16 2010-08-16
US61/374,215 2010-08-16
PCT/US2011/048005 WO2012024350A2 (en) 2010-08-16 2011-08-16 Anti-cancer adenoviruses

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KR20130126590A KR20130126590A (ko) 2013-11-20
KR101667094B1 true KR101667094B1 (ko) 2016-10-17

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US (1) US9187733B2 (https=)
EP (1) EP2606137B1 (https=)
JP (1) JP5905460B2 (https=)
KR (1) KR101667094B1 (https=)
CN (1) CN103180448B (https=)
AU (1) AU2011292119B2 (https=)
BR (1) BR112013003579A2 (https=)
CA (1) CA2807778C (https=)
SG (1) SG187785A1 (https=)
WO (1) WO2012024350A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG187785A1 (en) * 2010-08-16 2013-03-28 Salk Inst For Biological Studi Anti-cancer adenoviruses
CA3215250A1 (en) * 2012-03-13 2013-09-19 Salk Institute For Biological Studies Selective cell targeting using adenovirus and chemical dimers
AU2014236207B2 (en) 2013-03-14 2019-05-23 Salk Institute For Biological Studies Oncolytic adenovirus compositions
KR20250081944A (ko) 2014-09-24 2025-06-05 솔크 인스티튜트 포 바이올로지칼 스터디즈 종양 살상 바이러스 및 이의 사용방법
EP3359175B1 (en) 2015-10-05 2020-09-16 Salk Institute for Biological Studies Synthetic adenoviruses with tropism to damaged tissue for use in promoting wound repair and tissue regeneration
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
EP4155411A1 (en) 2016-02-23 2023-03-29 Salk Institute for Biological Studies Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
EP3532082A4 (en) 2016-12-12 2020-08-26 Salk Institute for Biological Studies SYNTHETIC ADENOVIRUS TUMOR TARGETING AND THEIR USES
MX2019013259A (es) 2017-05-08 2020-01-13 Gritstone Oncology Inc Vectores de neoantigeno de alfavirus.
MX2020010499A (es) 2018-04-09 2020-10-28 Salk Inst For Biological Studi Composiciones de adenovirus oncoliticas con propiedades aumentadas de replicacion.
MX2021014525A (es) * 2019-05-30 2022-03-17 Gritstone Bio Inc Adenovirus modificados.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA137094A (en) 1911-08-31 1911-11-28 Sheppe, Alice L. Cloth measuring and price calculating machine
FR2726285B1 (fr) * 1994-10-28 1996-11-29 Centre Nat Rech Scient Adenovirus depourvus de particules contaminantes viables, preparation et utilisation
ES2210081T3 (es) * 1998-07-07 2004-07-01 Transgene S.A. Utilizacion de los marcos de lectura de la region e4 para la mejora de la expresion de genes.
EP1083229A1 (en) * 1999-09-10 2001-03-14 Introgene B.V. Modified adenoviral vectors for use in gene therapy
WO2001090392A1 (en) * 2000-05-26 2001-11-29 Sumitomo Pharmaceuticals Company, Limited Novel recombinant adenovirus vector with relieved side effects
US20020106382A1 (en) * 2000-07-14 2002-08-08 Young Charles S.H. Modified adenovirus and uses thereof
US20030220284A1 (en) 2002-02-22 2003-11-27 Patricia Yotnda Delivery of adenoviral DNA in a liposomal formulation for treatment of disease
EP1499332A4 (en) 2002-04-29 2006-12-06 Hadasit Med Res Service COMPOSITIONS AND METHODS FOR TREATING CANCER WITH A VIRAL ONCOLYTIC AGENT
EP1545627A4 (en) 2002-10-01 2006-12-27 Univ Duke TARGETED TUMOR THERAPY THROUGH THE USE OF RECOMBINANT ADENOVIRUS VECTORS FOR SELECTIVE REPLICATION IN HYPOXIC TUMOR REGIONS
US20050201978A1 (en) 2003-11-17 2005-09-15 Lipton James S. Tumor and infectious disease therapeutic compositions
JP2012504140A (ja) * 2008-09-26 2012-02-16 オーバーン・ユニバーシティ 非複製性ベクターワクチンの粘膜投与による鳥類の免疫処置
SG187785A1 (en) * 2010-08-16 2013-03-28 Salk Inst For Biological Studi Anti-cancer adenoviruses

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ALBA, R. et al., Gene Therapy, vol.12, no.suppl.1, 1 October 2005, pp.S18-S27

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Publication number Publication date
WO2012024350A2 (en) 2012-02-23
BR112013003579A2 (pt) 2016-06-07
EP2606137B1 (en) 2018-08-01
CA2807778C (en) 2017-03-07
US20130243729A1 (en) 2013-09-19
KR20130126590A (ko) 2013-11-20
EP2606137A4 (en) 2014-01-08
CN103180448B (zh) 2017-04-12
CN103180448A (zh) 2013-06-26
SG187785A1 (en) 2013-03-28
EP2606137A2 (en) 2013-06-26
JP5905460B2 (ja) 2016-04-20
WO2012024350A3 (en) 2012-07-05
JP2013537426A (ja) 2013-10-03
CA2807778A1 (en) 2012-02-23
AU2011292119A1 (en) 2013-02-28
US9187733B2 (en) 2015-11-17
AU2011292119B2 (en) 2015-06-11

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