BR112013003579A2 - adenovírus, células, e, métodos para tratar câncer - Google Patents
adenovírus, células, e, métodos para tratar câncerInfo
- Publication number
- BR112013003579A2 BR112013003579A2 BR112013003579A BR112013003579A BR112013003579A2 BR 112013003579 A2 BR112013003579 A2 BR 112013003579A2 BR 112013003579 A BR112013003579 A BR 112013003579A BR 112013003579 A BR112013003579 A BR 112013003579A BR 112013003579 A2 BR112013003579 A2 BR 112013003579A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- adenovirus
- cells
- treat cancer
- cancer
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 241000701161 unidentified adenovirus Species 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0679—Cells of the gastro-intestinal tract
- C12N5/068—Stem cells; Progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Developmental Biology & Embryology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37421510P | 2010-08-16 | 2010-08-16 | |
| PCT/US2011/048005 WO2012024350A2 (en) | 2010-08-16 | 2011-08-16 | Anti-cancer adenoviruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013003579A2 true BR112013003579A2 (pt) | 2016-06-07 |
Family
ID=45605646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013003579A BR112013003579A2 (pt) | 2010-08-16 | 2011-08-16 | adenovírus, células, e, métodos para tratar câncer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9187733B2 (https=) |
| EP (1) | EP2606137B1 (https=) |
| JP (1) | JP5905460B2 (https=) |
| KR (1) | KR101667094B1 (https=) |
| CN (1) | CN103180448B (https=) |
| AU (1) | AU2011292119B2 (https=) |
| BR (1) | BR112013003579A2 (https=) |
| CA (1) | CA2807778C (https=) |
| SG (1) | SG187785A1 (https=) |
| WO (1) | WO2012024350A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013003579A2 (pt) * | 2010-08-16 | 2016-06-07 | Salk Inst For Biological Studi | adenovírus, células, e, métodos para tratar câncer |
| CN104411826A (zh) * | 2012-03-13 | 2015-03-11 | 萨克生物研究学院 | 使用腺病毒和化学二聚体的选择性细胞寻靶 |
| SG11201507393TA (en) | 2013-03-14 | 2015-10-29 | Salk Inst For Biological Studi | Oncolytic adenovirus compositions |
| KR102608590B1 (ko) | 2014-09-24 | 2023-12-01 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 종양 살상 바이러스 및 이의 사용방법 |
| EP3359175B1 (en) | 2015-10-05 | 2020-09-16 | Salk Institute for Biological Studies | Synthetic adenoviruses with tropism to damaged tissue for use in promoting wound repair and tissue regeneration |
| WO2017147269A1 (en) | 2016-02-23 | 2017-08-31 | Salk Institute For Biological Studies | Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics |
| WO2017147265A1 (en) | 2016-02-23 | 2017-08-31 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
| EP3532082A4 (en) | 2016-12-12 | 2020-08-26 | Salk Institute for Biological Studies | SYNTHETIC ADENOVIRUS TUMOR TARGETING AND THEIR USES |
| EP3634449A4 (en) | 2017-05-08 | 2021-03-17 | Gritstone Oncology, Inc. | ALPHAVIRUS NEOANTIGEN VECTORS |
| CN112292449A (zh) | 2018-04-09 | 2021-01-29 | 萨克生物研究学院 | 具有增强的复制特性的溶瘤腺病毒组合物 |
| MX2021014525A (es) * | 2019-05-30 | 2022-03-17 | Gritstone Bio Inc | Adenovirus modificados. |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA137094A (en) | 1911-08-31 | 1911-11-28 | Sheppe, Alice L. | Cloth measuring and price calculating machine |
| FR2726285B1 (fr) * | 1994-10-28 | 1996-11-29 | Centre Nat Rech Scient | Adenovirus depourvus de particules contaminantes viables, preparation et utilisation |
| ES2180258T3 (es) * | 1998-07-07 | 2003-02-01 | Transgene Sa | Utilizacion de pautas de lectura abierta adenovirales de e4 para mejorar la expresion de genes. |
| EP1083229A1 (en) * | 1999-09-10 | 2001-03-14 | Introgene B.V. | Modified adenoviral vectors for use in gene therapy |
| US7445929B2 (en) * | 2000-05-26 | 2008-11-04 | Dainippon Sumitomo Pharma Co., Ltd. | Recombinant adenovirus vector having a reduced side effect |
| US20020106382A1 (en) * | 2000-07-14 | 2002-08-08 | Young Charles S.H. | Modified adenovirus and uses thereof |
| US20030220284A1 (en) | 2002-02-22 | 2003-11-27 | Patricia Yotnda | Delivery of adenoviral DNA in a liposomal formulation for treatment of disease |
| AU2003223089A1 (en) | 2002-04-29 | 2003-11-17 | Hadasit Medical Research Services And Development Company Ltd. | Compositions and methods for treating cancer with an oncolytic viral agent |
| WO2004031357A2 (en) | 2002-10-01 | 2004-04-15 | Duke University | Targeted tumor therapy by use of recombinant adenovirus vectors that selectively replicate in hypoxic regions of tumors |
| WO2005048950A2 (en) | 2003-11-17 | 2005-06-02 | Biomune, Inc. | Tumor and infectious disease therapeutic compositions |
| KR20110081222A (ko) * | 2008-09-26 | 2011-07-13 | 어번 유니버시티 | 비복제성 벡터화된 백신의 점막 투여에 의한 조류의 면역화 |
| BR112013003579A2 (pt) * | 2010-08-16 | 2016-06-07 | Salk Inst For Biological Studi | adenovírus, células, e, métodos para tratar câncer |
-
2011
- 2011-08-16 BR BR112013003579A patent/BR112013003579A2/pt not_active Application Discontinuation
- 2011-08-16 KR KR1020137006526A patent/KR101667094B1/ko active Active
- 2011-08-16 CA CA2807778A patent/CA2807778C/en active Active
- 2011-08-16 WO PCT/US2011/048005 patent/WO2012024350A2/en not_active Ceased
- 2011-08-16 EP EP11818698.0A patent/EP2606137B1/en active Active
- 2011-08-16 AU AU2011292119A patent/AU2011292119B2/en active Active
- 2011-08-16 JP JP2013524945A patent/JP5905460B2/ja active Active
- 2011-08-16 SG SG2013009790A patent/SG187785A1/en unknown
- 2011-08-16 CN CN201180050032.7A patent/CN103180448B/zh active Active
-
2013
- 2013-02-15 US US13/768,933 patent/US9187733B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2606137A2 (en) | 2013-06-26 |
| AU2011292119A1 (en) | 2013-02-28 |
| AU2011292119B2 (en) | 2015-06-11 |
| US9187733B2 (en) | 2015-11-17 |
| JP2013537426A (ja) | 2013-10-03 |
| CN103180448A (zh) | 2013-06-26 |
| EP2606137B1 (en) | 2018-08-01 |
| CA2807778C (en) | 2017-03-07 |
| EP2606137A4 (en) | 2014-01-08 |
| WO2012024350A3 (en) | 2012-07-05 |
| CA2807778A1 (en) | 2012-02-23 |
| JP5905460B2 (ja) | 2016-04-20 |
| SG187785A1 (en) | 2013-03-28 |
| CN103180448B (zh) | 2017-04-12 |
| WO2012024350A2 (en) | 2012-02-23 |
| KR20130126590A (ko) | 2013-11-20 |
| KR101667094B1 (ko) | 2016-10-17 |
| US20130243729A1 (en) | 2013-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |