KR101661825B1 - Src 상동성-2 함유 단백질 티로신 포스파타제-1의 작용물질 및 그를 사용한 치료방법 - Google Patents
Src 상동성-2 함유 단백질 티로신 포스파타제-1의 작용물질 및 그를 사용한 치료방법 Download PDFInfo
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- KR101661825B1 KR101661825B1 KR1020147003923A KR20147003923A KR101661825B1 KR 101661825 B1 KR101661825 B1 KR 101661825B1 KR 1020147003923 A KR1020147003923 A KR 1020147003923A KR 20147003923 A KR20147003923 A KR 20147003923A KR 101661825 B1 KR101661825 B1 KR 101661825B1
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- BFFJJVCZFBHMCO-UHFFFAOYSA-N CNC(c1cc(Oc(cc2)ccc2NC(c2cc(F)ccc2C(F)(F)F)=O)ccn1)=O Chemical compound CNC(c1cc(Oc(cc2)ccc2NC(c2cc(F)ccc2C(F)(F)F)=O)ccn1)=O BFFJJVCZFBHMCO-UHFFFAOYSA-N 0.000 description 1
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- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
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- A—HUMAN NECESSITIES
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- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
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- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
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- C07C275/18—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
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- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
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- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
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- Endocrinology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
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- Rheumatology (AREA)
- Dentistry (AREA)
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- Urology & Nephrology (AREA)
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- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161514555P | 2011-08-03 | 2011-08-03 | |
| US61/514,555 | 2011-08-03 | ||
| PCT/US2012/049446 WO2013020014A1 (en) | 2011-08-03 | 2012-08-03 | Agonists of src homology-2 containing protein tyrosine phosphatase-1 and treatment methods using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140039331A KR20140039331A (ko) | 2014-04-01 |
| KR101661825B1 true KR101661825B1 (ko) | 2016-09-30 |
Family
ID=47629697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147003923A Active KR101661825B1 (ko) | 2011-08-03 | 2012-08-03 | Src 상동성-2 함유 단백질 티로신 포스파타제-1의 작용물질 및 그를 사용한 치료방법 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9216950B2 (https=) |
| EP (1) | EP2739139B1 (https=) |
| JP (1) | JP2014527043A (https=) |
| KR (1) | KR101661825B1 (https=) |
| CN (1) | CN104010501B (https=) |
| AU (1) | AU2012289961C1 (https=) |
| BR (1) | BR112014002363A2 (https=) |
| CA (1) | CA2843330C (https=) |
| ES (1) | ES2762193T3 (https=) |
| IL (1) | IL230601A (https=) |
| IN (1) | IN2014MN00125A (https=) |
| MX (1) | MX353205B (https=) |
| MY (1) | MY175797A (https=) |
| PH (1) | PH12014500246A1 (https=) |
| PL (1) | PL2739139T3 (https=) |
| RU (1) | RU2584986C2 (https=) |
| TW (1) | TWI507191B (https=) |
| WO (1) | WO2013020014A1 (https=) |
| ZA (1) | ZA201400757B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150225369A1 (en) * | 2012-08-29 | 2015-08-13 | Merck Patent Gmbh | Ddr2 inhibitors for the treatment of osteoarthritis |
| US10017823B2 (en) * | 2013-04-25 | 2018-07-10 | Cbs Bioscience, Co., Ltd | Analytical method for increasing susceptibility of molecular targeted therapy in hepatocellular carcinoma |
| WO2015051149A1 (en) * | 2013-10-04 | 2015-04-09 | The Trustees Of Columbia University In The City Of New York | Sorafenib analogs and uses thereof |
| TW201718474A (zh) * | 2015-08-31 | 2017-06-01 | 東麗股份有限公司 | 尿素衍生物及其用途 |
| CN108026035B (zh) * | 2015-09-02 | 2021-03-30 | 陈昆锋 | 具有蛋白酪氨酸磷酸酶shp-1激动剂活性的化合物 |
| EP3500257B1 (en) * | 2016-08-17 | 2025-07-02 | Icahn School of Medicine at Mount Sinai | Kinase inhibitor compounds, compositions, and methods of treating cancer |
| EP3517108B1 (en) * | 2016-09-22 | 2022-04-06 | Kuen-Feng Chen | Application of src homology region 2-containing protein tyrosine phosphatase-1 agonist for improving fibrosis |
| KR20190126074A (ko) * | 2017-02-03 | 2019-11-08 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 레티쿨론 4를 억제하기 위한 조성물 및 방법 |
| RS66727B1 (sr) | 2018-09-10 | 2025-05-30 | Mirati Therapeutics Inc | Kombinacija dasatiniba i adagrasiba za primenu u lečenju nesitnoćelijskog kancera pluća |
| CN113402456B (zh) * | 2020-03-16 | 2023-03-03 | 深圳大学 | 一种抗肿瘤药物以及一种化合物或其药学上可接受的盐在抗肿瘤药物中的应用 |
| CN112084184B (zh) * | 2020-09-15 | 2022-12-16 | 青海省地质测绘地理信息院 | 一种在不同gis平台之间异构数据属性传递的方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1241832B (de) * | 1963-02-23 | 1967-06-08 | Hoechst Ag | Verfahren zur Herstellung von Pyrimidiniumverbindungen |
| IL89029A (en) * | 1988-01-29 | 1993-01-31 | Lilly Co Eli | Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them |
| WO1993015043A1 (fr) * | 1992-01-24 | 1993-08-05 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose arylalkananilide et utilisation pharmaceutique |
| EP0696585B1 (en) * | 1993-04-30 | 1998-12-16 | Yamanouchi Pharmaceutical Co. Ltd. | Novel bisoxadiazolidine derivative |
| BR9814375A (pt) * | 1997-12-22 | 2002-05-21 | Bayer Ag | Inibição de raf cinase usando difenil uréias substituìdas simétricas e assimétricas |
| WO2000042012A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
| CN1237051C (zh) * | 1999-08-20 | 2006-01-18 | 道农业科学公司 | 杀真菌的杂环芳族酰胺和它们的组合物、使用方法和制备 |
| DE19954312A1 (de) * | 1999-11-11 | 2001-05-17 | Bayer Ag | Substituierte Phenyluracile |
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| CN101027283A (zh) * | 2004-04-26 | 2007-08-29 | 阿斯利康(瑞典)有限公司 | 用作血管破坏剂的3,4-二取代马来酰亚胺 |
| SE0401969D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Piperidine derivatives |
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| US9029401B2 (en) | 2011-02-14 | 2015-05-12 | The Regents Of The University Of California | Sorafenib derivatives as sEH inhibitors |
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| Title |
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| European Journal of Medicinal Chemistry, 2011, Vol. 46, pp. 2845-2851 |
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| ES2762193T3 (es) | 2020-05-22 |
| BR112014002363A2 (pt) | 2017-06-13 |
| PH12014500246A1 (en) | 2014-03-24 |
| NZ620434A (en) | 2015-08-28 |
| KR20140039331A (ko) | 2014-04-01 |
| RU2014101953A (ru) | 2015-09-10 |
| AU2012289961A1 (en) | 2014-02-20 |
| MX2014001157A (es) | 2015-02-04 |
| CN104010501A (zh) | 2014-08-27 |
| ZA201400757B (en) | 2015-10-28 |
| AU2012289961C1 (en) | 2016-09-01 |
| AU2012289961B2 (en) | 2016-05-19 |
| JP2014527043A (ja) | 2014-10-09 |
| EP2739139A4 (en) | 2015-06-10 |
| MY175797A (en) | 2020-07-09 |
| WO2013020014A1 (en) | 2013-02-07 |
| IN2014MN00125A (https=) | 2015-06-12 |
| CA2843330C (en) | 2016-09-20 |
| IL230601A0 (en) | 2014-03-31 |
| CN104010501B (zh) | 2016-05-04 |
| EP2739139B1 (en) | 2019-09-25 |
| EP2739139A1 (en) | 2014-06-11 |
| US20140200239A1 (en) | 2014-07-17 |
| US9216950B2 (en) | 2015-12-22 |
| RU2584986C2 (ru) | 2016-05-27 |
| TW201320997A (zh) | 2013-06-01 |
| PL2739139T3 (pl) | 2020-06-15 |
| IL230601A (en) | 2017-07-31 |
| CA2843330A1 (en) | 2013-02-07 |
| TWI507191B (zh) | 2015-11-11 |
| MX353205B (es) | 2018-01-08 |
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