KR101647176B1 - 디설파이드 결합으로 안정화된 기능성 가용성 ｍｈｃ클래스 ⅱ 헤테로다이머류 - Google Patents

디설파이드 결합으로 안정화된 기능성 가용성 ｍｈｃ클래스 ⅱ 헤테로다이머류 Download PDF

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KR101647176B1
KR101647176B1 KR1020127024287A KR20127024287A KR101647176B1 KR 101647176 B1 KR101647176 B1 KR 101647176B1 KR 1020127024287 A KR1020127024287 A KR 1020127024287A KR 20127024287 A KR20127024287 A KR 20127024287A KR 101647176 B1 KR101647176 B1 KR 101647176B1
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게일 에이지 로제트
텔저 프리그스타드
인져 산드리에
브자르네 보겐
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유니버시테테트 아이 오슬로
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin

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  • Biochemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Urology & Nephrology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
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KR1020127024287A 2010-02-18 2011-02-18 디설파이드 결합으로 안정화된 기능성 가용성 ｍｈｃ클래스 ⅱ 헤테로다이머류 Active KR101647176B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US30572810P 2010-02-18 2010-02-18
GB1002730.8 2010-02-18
GBGB1002730.8A GB201002730D0 (en) 2010-02-18 2010-02-18 Product
US61/305,728 2010-02-18
US31657610P 2010-03-23 2010-03-23
US61/316,576 2010-03-23
PCT/GB2011/050325 WO2011101681A2 (en) 2010-02-18 2011-02-18 Disulphide bond-stabilized functional soluble mhc class ii heterodimers

Publications (2)

Publication Number Publication Date
KR20130009782A KR20130009782A (ko) 2013-01-23
KR101647176B1 true KR101647176B1 (ko) 2016-08-09

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US (2) US8828379B2 (https=)
EP (1) EP2536746B1 (https=)
JP (1) JP5537675B2 (https=)
KR (1) KR101647176B1 (https=)
CN (1) CN102947330B (https=)
AU (1) AU2011217027B2 (https=)
CA (1) CA2789492C (https=)
CY (1) CY1117697T1 (https=)
DK (1) DK2536746T3 (https=)
ES (1) ES2572388T3 (https=)
GB (1) GB201002730D0 (https=)
HR (1) HRP20160475T1 (https=)
HU (1) HUE027952T2 (https=)
PL (1) PL2536746T3 (https=)
RS (1) RS54744B1 (https=)
RU (1) RU2604813C2 (https=)
SI (1) SI2536746T1 (https=)
WO (1) WO2011101681A2 (https=)

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US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
ES3011307T3 (en) 2012-02-23 2025-04-07 Juno Therapeutics Gmbh Chromatographic isolation of cells and other complex biological materials
EP4592400A3 (en) 2012-10-17 2025-10-29 10x Genomics Sweden AB Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
GB201309469D0 (en) 2013-05-28 2013-07-10 Imcyse Sa Detection of CD4+ T lymphocytes
JP6748061B2 (ja) * 2014-07-09 2020-08-26 ルピン・リミテッド 二重シストロン細菌発現システム
US11059880B2 (en) 2015-06-30 2021-07-13 Arizona Board Of Regents On Behalf Of The University Of Arizona Redirected cells with MHC chimeric receptors and methods of use in immunotherapy
US12577289B2 (en) 2015-06-30 2026-03-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Surrogate co-receptors for t cells and methods of use
MX2018004875A (es) 2015-10-22 2018-08-01 Juno Therapeutics Gmbh Metodos para cultivar celulas y kits y aparatos para ello.
EP3365453A2 (en) 2015-10-22 2018-08-29 Juno Therapeutics GmbH Methods, kits, agents and apparatuses for transduction
US10294454B2 (en) 2016-08-24 2019-05-21 General Electric Company Methods and kits for cell activation
US20180127481A1 (en) * 2016-11-09 2018-05-10 Uti Limited Partnership RECOMBINANT pMHC CLASS II MOLECULES
JP7339160B2 (ja) 2017-04-27 2023-09-05 ジュノ セラピューティクス ゲーエムベーハー オリゴマー粒子試薬およびその使用方法
DE102018122546B3 (de) 2018-09-14 2019-12-05 Immatics Biotechnologies Gmbh Verfahren zum Hochdurchsatz-Peptid-MHC-Affinitätsscreening für TCR-Liganden
EP4345453B1 (en) * 2018-09-28 2025-11-12 10X Genomics, Inc. High throughput epitope identification and t cell receptor specificity determination using loadable detection molecules
SG11202104355SA (en) 2018-10-31 2021-05-28 Juno Therapeutics Gmbh Methods for selection and stimulation of cells and apparatus for same
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
EP3719033A1 (en) * 2019-04-02 2020-10-07 imusyn GmbH & Co. KG Stabilized mhc i
WO2021035049A1 (en) * 2019-08-21 2021-02-25 Uti Limited Partnership Improved recombinant pmhc molecules
EP4028412A2 (en) * 2019-09-13 2022-07-20 The Regents of The University of California Systems and methods for the preparation of peptide-mhc-i complexes with native glycan modifications
US20220409732A1 (en) * 2019-12-02 2022-12-29 Regeneron Pharmaceuticals, Inc. Peptide-mhc ii protein constructs and uses thereof
TW202144389A (zh) 2020-02-14 2021-12-01 美商健生生物科技公司 在多發性骨髓瘤中表現之新抗原及其用途
TW202144388A (zh) 2020-02-14 2021-12-01 美商健生生物科技公司 在卵巢癌中表現之新抗原及其用途
DE102020109447A1 (de) 2020-04-03 2021-10-07 Jacobs University Bremen Ggmbh Synthetisches mhc-klasse-ii-protein
US12534510B2 (en) 2020-04-16 2026-01-27 The Regents Of The University Of California Peptide-receptive MHC-I complex compositions and methods
EP4175664A2 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Prostate neoantigens and their uses
CN118813436A (zh) * 2023-07-24 2024-10-22 佳吾益(北京)科技有限公司 展示单mhc等位基因功能蛋白的工程化细胞
CN119220425A (zh) * 2023-07-28 2024-12-31 佳吾益(北京)科技有限公司 发现mhc新抗原肽表位的工程化细胞
WO2025137580A1 (en) * 2023-12-22 2025-06-26 Antiger Therapeutics, Inc. Class ii hla with inter-chain disulfide bond

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WO1998006749A2 (en) 1996-08-16 1998-02-19 President And Fellows Of Harvard College Soluble monovalent and multivalent mhc class ii fusion proteins, and uses therefor
WO2006102170A2 (en) 2005-03-18 2006-09-28 Oregon Health & Science University Recombinant mhc molecules useful for manipulation of antigen-specific t cells
US20080064859A1 (en) 1997-09-16 2008-03-13 Vandenbark Arthur A Recombinant MHC molecules useful for manipulation of antigen-specific T-cells
EP2476435A2 (en) 2006-08-11 2012-07-18 Life Sciences Research Partners VZW Immunogenic peptides and their use in immune disorders

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WO1998006749A2 (en) 1996-08-16 1998-02-19 President And Fellows Of Harvard College Soluble monovalent and multivalent mhc class ii fusion proteins, and uses therefor
US20080064859A1 (en) 1997-09-16 2008-03-13 Vandenbark Arthur A Recombinant MHC molecules useful for manipulation of antigen-specific T-cells
WO2006102170A2 (en) 2005-03-18 2006-09-28 Oregon Health & Science University Recombinant mhc molecules useful for manipulation of antigen-specific t cells
EP2476435A2 (en) 2006-08-11 2012-07-18 Life Sciences Research Partners VZW Immunogenic peptides and their use in immune disorders

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KR20130009782A (ko) 2013-01-23
GB201002730D0 (en) 2010-04-07
WO2011101681A2 (en) 2011-08-25
JP5537675B2 (ja) 2014-07-02
AU2011217027B2 (en) 2015-02-05
CA2789492C (en) 2017-04-18
ES2572388T3 (es) 2016-05-31
US8828379B2 (en) 2014-09-09
PL2536746T3 (pl) 2016-08-31
RS54744B1 (sr) 2016-10-31
SI2536746T1 (sl) 2016-09-30
RU2012138302A (ru) 2014-03-27
RU2604813C2 (ru) 2016-12-10
WO2011101681A3 (en) 2011-12-08
US20130171668A1 (en) 2013-07-04
US9056920B2 (en) 2015-06-16
JP2013519721A (ja) 2013-05-30
HUE027952T2 (en) 2016-11-28
EP2536746A2 (en) 2012-12-26
US20140349315A1 (en) 2014-11-27
HRP20160475T1 (hr) 2016-06-03
CN102947330B (zh) 2015-09-16
CY1117697T1 (el) 2017-05-17
CA2789492A1 (en) 2011-08-25
AU2011217027A1 (en) 2012-09-06
EP2536746B1 (en) 2016-04-20
CN102947330A (zh) 2013-02-27
DK2536746T3 (en) 2016-05-30

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