JP5537675B2 - ジスルフィド結合により安定化された機能的可溶性ｍｈｃクラスｉｉヘテロ二量体 - Google Patents
ジスルフィド結合により安定化された機能的可溶性ｍｈｃクラスｉｉヘテロ二量体 Download PDFInfo
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- C—CHEMISTRY; METALLURGY
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- C—CHEMISTRY; METALLURGY
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- C07K14/70503—Immunoglobulin superfamily
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Landscapes
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| PCT/GB2011/050325 WO2011101681A2 (en) | 2010-02-18 | 2011-02-18 | Disulphide bond-stabilized functional soluble mhc class ii heterodimers |
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| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| ES3011307T3 (en) | 2012-02-23 | 2025-04-07 | Juno Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| EP4592400A3 (en) | 2012-10-17 | 2025-10-29 | 10x Genomics Sweden AB | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| GB201309469D0 (en) | 2013-05-28 | 2013-07-10 | Imcyse Sa | Detection of CD4+ T lymphocytes |
| JP6748061B2 (ja) * | 2014-07-09 | 2020-08-26 | ルピン・リミテッド | 二重シストロン細菌発現システム |
| US11059880B2 (en) | 2015-06-30 | 2021-07-13 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Redirected cells with MHC chimeric receptors and methods of use in immunotherapy |
| US12577289B2 (en) | 2015-06-30 | 2026-03-17 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Surrogate co-receptors for t cells and methods of use |
| MX2018004875A (es) | 2015-10-22 | 2018-08-01 | Juno Therapeutics Gmbh | Metodos para cultivar celulas y kits y aparatos para ello. |
| EP3365453A2 (en) | 2015-10-22 | 2018-08-29 | Juno Therapeutics GmbH | Methods, kits, agents and apparatuses for transduction |
| US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
| US20180127481A1 (en) * | 2016-11-09 | 2018-05-10 | Uti Limited Partnership | RECOMBINANT pMHC CLASS II MOLECULES |
| JP7339160B2 (ja) | 2017-04-27 | 2023-09-05 | ジュノ セラピューティクス ゲーエムベーハー | オリゴマー粒子試薬およびその使用方法 |
| DE102018122546B3 (de) | 2018-09-14 | 2019-12-05 | Immatics Biotechnologies Gmbh | Verfahren zum Hochdurchsatz-Peptid-MHC-Affinitätsscreening für TCR-Liganden |
| EP4345453B1 (en) * | 2018-09-28 | 2025-11-12 | 10X Genomics, Inc. | High throughput epitope identification and t cell receptor specificity determination using loadable detection molecules |
| SG11202104355SA (en) | 2018-10-31 | 2021-05-28 | Juno Therapeutics Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| EP3719033A1 (en) * | 2019-04-02 | 2020-10-07 | imusyn GmbH & Co. KG | Stabilized mhc i |
| WO2021035049A1 (en) * | 2019-08-21 | 2021-02-25 | Uti Limited Partnership | Improved recombinant pmhc molecules |
| EP4028412A2 (en) * | 2019-09-13 | 2022-07-20 | The Regents of The University of California | Systems and methods for the preparation of peptide-mhc-i complexes with native glycan modifications |
| US20220409732A1 (en) * | 2019-12-02 | 2022-12-29 | Regeneron Pharmaceuticals, Inc. | Peptide-mhc ii protein constructs and uses thereof |
| TW202144389A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在多發性骨髓瘤中表現之新抗原及其用途 |
| TW202144388A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在卵巢癌中表現之新抗原及其用途 |
| DE102020109447A1 (de) | 2020-04-03 | 2021-10-07 | Jacobs University Bremen Ggmbh | Synthetisches mhc-klasse-ii-protein |
| US12534510B2 (en) | 2020-04-16 | 2026-01-27 | The Regents Of The University Of California | Peptide-receptive MHC-I complex compositions and methods |
| EP4175664A2 (en) | 2020-07-06 | 2023-05-10 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| CN118813436A (zh) * | 2023-07-24 | 2024-10-22 | 佳吾益(北京)科技有限公司 | 展示单mhc等位基因功能蛋白的工程化细胞 |
| CN119220425A (zh) * | 2023-07-28 | 2024-12-31 | 佳吾益(北京)科技有限公司 | 发现mhc新抗原肽表位的工程化细胞 |
| WO2025137580A1 (en) * | 2023-12-22 | 2025-06-26 | Antiger Therapeutics, Inc. | Class ii hla with inter-chain disulfide bond |
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| CA2302779C (en) * | 1997-09-16 | 2010-02-02 | Oregon Health Sciences University | Recombinant mhc molecules useful for manipulation of antigen-specific t-cells |
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| RU2303264C2 (ru) * | 2001-02-19 | 2007-07-20 | Мерк Патент Гмбх | Способ идентификации эпитопов т-клеток и его применение для получения молекул со сниженной иммуногенностью |
| GB2392158B (en) * | 2002-08-21 | 2005-02-16 | Proimmune Ltd | Chimeric MHC protein and oligomer thereof |
| US8377447B2 (en) * | 2003-09-05 | 2013-02-19 | Oregon Health & Science University | Monomeric recombinant MHC molecules useful for manipulation of antigen-specific T cells |
| CA2638892A1 (en) | 2005-03-18 | 2006-09-28 | Oregon Health & Science University | Recombinant mhc molecules useful for manipulation of antigen-specific t cells |
| ES2709176T3 (es) | 2006-08-11 | 2019-04-15 | Life Sciences Res Partners Vzw | Péptidos inmunogénicos y su uso en trastornos inmunitarios |
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20130009782A (ko) | 2013-01-23 |
| GB201002730D0 (en) | 2010-04-07 |
| WO2011101681A2 (en) | 2011-08-25 |
| AU2011217027B2 (en) | 2015-02-05 |
| CA2789492C (en) | 2017-04-18 |
| ES2572388T3 (es) | 2016-05-31 |
| KR101647176B1 (ko) | 2016-08-09 |
| US8828379B2 (en) | 2014-09-09 |
| PL2536746T3 (pl) | 2016-08-31 |
| RS54744B1 (sr) | 2016-10-31 |
| SI2536746T1 (sl) | 2016-09-30 |
| RU2012138302A (ru) | 2014-03-27 |
| RU2604813C2 (ru) | 2016-12-10 |
| WO2011101681A3 (en) | 2011-12-08 |
| US20130171668A1 (en) | 2013-07-04 |
| US9056920B2 (en) | 2015-06-16 |
| JP2013519721A (ja) | 2013-05-30 |
| HUE027952T2 (en) | 2016-11-28 |
| EP2536746A2 (en) | 2012-12-26 |
| US20140349315A1 (en) | 2014-11-27 |
| HRP20160475T1 (hr) | 2016-06-03 |
| CN102947330B (zh) | 2015-09-16 |
| CY1117697T1 (el) | 2017-05-17 |
| CA2789492A1 (en) | 2011-08-25 |
| AU2011217027A1 (en) | 2012-09-06 |
| EP2536746B1 (en) | 2016-04-20 |
| CN102947330A (zh) | 2013-02-27 |
| DK2536746T3 (en) | 2016-05-30 |
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