KR101645640B1

KR101645640B1 - Composition for reducing hair loss or promoting hair growth or regrowth and Method for preparing the same

Info

Publication number: KR101645640B1
Application number: KR1020160009222A
Authority: KR
Inventors: 이재도
Original assignee: 이재도
Priority date: 2016-01-26
Filing date: 2016-01-26
Publication date: 2016-08-05
Also published as: WO2017131403A1

Abstract

The present invention relates to a composition for preventing hair loss and promoting hair growth or hair regrowth containing Pericon, manzanilla, sulfur, and yeast, and a method for preparing the same. According to the present invention, the composition has the advantages of effectively preventing hair loss and promoting hair growth or hair regrowth, and having excellent preservation and preparation convenience. In addition, the method for preparing the same has the advantage of effectively preparing the composition for preventing hair loss and promoting hair growth or hair regrowth.

Description

[0001] The present invention relates to a composition for preventing hair loss, promoting hair growth, or promoting hair growth, and a method for preparing the same,

The present invention relates to a composition for preventing hair loss, promoting hair growth, or promoting wool, and more particularly, to a composition effective for preventing hair loss, promoting hair growth, or promoting wool, and a process for producing the composition.

Hair loss is increasing due to various chemicals and stress, and more and more people suffer from hair loss as well as aesthetic and psychological problems.

Minoxidil and the like are known as conventional hair growth stimulating drugs for treating such alopecia (U.S. Patent No. 4,596,812), but they are not completely satisfying those suffering from hair loss.

Therefore, it is necessary to develop technology related to hair loss.

U.S. Patent No. 4,596,182, claims

One of the problems to be solved by the present invention is to provide a composition capable of effectively preventing hair loss, promoting hair growth, or promoting wool.

Another problem to be solved by the present invention is to provide a method for effectively preventing hair loss, promoting hair growth, or promoting wool.

The object of the present invention is not limited to the above-mentioned problems, and other matters not mentioned can be clearly understood by those skilled in the art from the following description.

The composition for preventing hair loss, accelerating hair growth or promoting wool of the present invention is a peric

n, manzanilla, sulfur, and yeast.

The pericellular and the mannania may be in the form of an extract or a solvent extracted together.

10 to 1000 parts by weight of the mannania may be added to 100 parts by weight of the periclone.

The solvent may be at least one selected from a lower alcohol having 1 to 5 carbon atoms or water.

The solvent may be 100 to 10,000,000 parts by weight based on at least one 100 parts by weight of the pericellulose or the mannania.

The sulfur and the yeast may be dispersed or dissolved in a solvent.

The yeast may be 10 to 500 parts by weight based on 100 parts by weight of the sulfur.

The solvent may be 100 to 10,000,000 parts by weight based on 100 parts by weight of the sulfur.

The sulfur may be 10 to 500 parts by weight per 100 parts by weight of the periclone.

The composition may be external to the skin.

The composition may be a pharmaceutical composition, or a cosmetic composition.

The pharmaceutical composition may be in the form of a spray, an external liquid, an oil, a suspension, a cream, a gel, a patch, an ointment, an alarm, a lotion, a liniment, a pasta or a cataract.

The cosmetic composition may be at least one selected from the group consisting of hair spray, hair tonic, hair conditioner, hair essence, hair lotion, hair lotion, hair shampoo, hair conditioner, hair treatment, hair cream, It can be a form of wax, hair aerosol, hair pack, hair nutrition pack, hair soap, hair cleansing foam, hair oil, hair drying agent, hair preservative, hair dye, hair wave agent, hair bleaching agent, hair gel, hair glaze, have.

The method for producing a composition for preventing hair loss, promoting hair growth or promoting wool according to the present invention comprises the steps of: (A) preparing an extract obtained by solvent extraction of pericellulose and manzanilla, respectively; (B) preparing a mixed solution by mixing sulfur and yeast with a solvent; And (C) contacting the mixture with the extract.

The solvent extraction may include heating in the solvent for 20 to 60 minutes.

The extraction solvent may be at least one selected from a lower alcohol having 1 to 5 carbon atoms or water.

The mixed solution may be obtained by mixing the sulfur and the yeast, followed by mixing with the solvent.

The solvent may be from 30 to 40 degrees Celsius per day.

The contacting may include adding the extract to the mixed solution, and then adding and mixing the solvent.

The solvent may be from 30 to 40 degrees Celsius per day.

In addition, the preparation method may further comprise (D) an aging step of aging the contact material obtained in the step (C).

The aging may be carried out at room temperature for 10 to 15 days.

The composition of the present invention can effectively prevent hair loss, promote hair growth, or promote wool. In addition, the composition of the present invention is excellent in preservability and manufacturing convenience. Further, by the production method of the present invention, a composition for preventing hair loss, promoting hair growth or promoting wool can be produced effectively.

FIG. 1 is a photograph showing an example of an experimental result using a composition according to an embodiment of the present invention.
FIG. 2 is a photograph showing another example of an experiment result using a composition according to an embodiment of the present invention.
3 is a flowchart illustrating a manufacturing method according to an embodiment of the present invention.
FIG. 4 is a photograph showing an example of a peri-lace used for preparing a composition according to an embodiment of the present invention.
FIG. 5 is a photograph showing an example of a mannish used in the production of a composition according to an embodiment of the present invention.

BRIEF DESCRIPTION OF THE DRAWINGS The advantages and features of the present invention and the manner of achieving them will be more apparent from the following detailed description taken in conjunction with the accompanying drawings. The present invention may, however, be embodied in many different forms and should not be construed as being limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. But is only provided to fully inform the owner of the scope of the invention, and the present invention is only defined by the scope of the claims.

Throughout the specification, "and / or" include each and every combination of one or more of the components mentioned.

The terminology used herein is for the purpose of illustrating embodiments and is not intended to be limiting of the present invention. In the present specification, the singular form includes plural forms unless otherwise specified in the specification. &Quot; comprises, " and / or "comprising" when used in this specification do not exclude the presence or addition of one or more other components, and / or steps, .

The term "hair loss prevention" means to reduce or suppress the hair loss, and "hair growth promotion" means to promote hair growth and the like. And the like.

1 to 5, a composition for preventing hair loss, promoting hair growth or promoting hair growth according to an embodiment of the present invention, and a method for producing the same will be described in detail.

FIG. 1 is a photograph showing an example of an experiment result of applying a composition according to an embodiment of the present invention, FIG. 2 is a photograph showing another example of an experiment result using a composition according to an embodiment of the present invention, and FIG. 3 FIG. 4 is a photograph showing an example of a perlite used for preparing a composition according to an embodiment of the present invention, and FIG. 5 is a cross- 1 is a photograph showing an example of Manzanian used for preparing a composition according to an embodiment.

According to one embodiment of the present invention, the composition for preventing hair loss, promoting hair growth, or promoting wool is a peric

n, manzanilla, sulfur, and yeast.

Peric

n and manzanilla, respectively, can be harvested or marketed in Guatemala and include all of the plants referred to in Guatemala as Pericum and Manzanilla, respectively. The harvesting time may be, for example, when the buds are opened, and the harvesting part may be, for example, a seedling, or a ground part with the roots removed. Also, peric

n) and manzanilla may each be a dried product. The dried material was collected from peric

n) and manzanilla, respectively, in the shade for 8 to 15 days.

Pericons include plants such as Tagetes lucida and their relatives. Manzanilla also includes plants such as chamomile and related plants. Chamomile includes Matricaria chamomilla, and / or Chamaemelum nobile, and includes fiele chamomile (Anthemis arvensis), stinking chamomile (Anthemis cotula), Moroccan chamomile ; And also includes Cladanthus mixtus, yellow chamomile (Cota tinctoria), cape chamomile (Eriocephalus punctulatus), wile chamomile (Matricaria discoidea), and / or false chamomile (Tripleurospermum inodorum) .

Such pericellin and manzanil may be included in the composition together or in the form of a solvent extracted extract. The extraction solvent may be one or more selected from lower alcohols having 1 to 5 carbon atoms, or water.

With respect to 100 parts by weight of periclane, mannish is preferably 10 to 1000 parts by weight, more preferably 50 to 200 parts by weight. It means on a weight basis, preferably periclinic: manzanil = 100: 10 to 1000.

When the solvent is extracted, the extraction solvent is preferably 100 to 10000000 parts by weight, more preferably 100 to 1000000 parts by weight, still more preferably 1000 to 500000 parts by weight, per 100 parts by weight of the periclase or mannania, . This indicates that it is possible to extract at least one selected from pericellular or manzanil as an extraction solvent which is preferably at least one to 100,000 times selected from pericellulosic or manzanil on the basis of weight.

Sulfur can be collected from nature or sold commercially, for example, it can be mineral sulfur. Mineral sulfur may be collected in a volcanic area or it may be commercially available.

In addition, the yeast may be commercially available as a food additive used for confectionery or bakery.

The sulfur and the yeast may be dispersed or dissolved in the solvent. The sulfur can be more effectively dispersed or dissolved in the solvent by the yeast, and can be more easily applied to the composition of the present invention. As described above, the composition of the present invention can be easily manufactured by the combination of the respective constituents. Therefore, the composition of the present invention is excellent in convenience of production.

Further, the composition of the present invention appears to be preserved without decaying for a certain period of time by the combination of the respective constitutions. Therefore, the composition of the present invention is excellent in preservability.

As described above, each constitution of the present invention is combined organically so as to effectively prevent hair loss, promote hair growth, or promote wool, and is also excellent in ease of manufacture and storage stability.

The yeast may be preferably 10 to 500 parts by weight, more preferably 50 to 300 parts by weight based on 100 parts by weight of sulfur.

The solvent may be one or more selected from lower alcohols having 1 to 5 carbon atoms, or water.

The solvent may preferably be 100 to 10000000 parts by weight, more preferably 100 to 1000000 parts by weight, and even more preferably 1000 to 500000 parts by weight based on 100 parts by weight of sulfur. This indicates that sulfur and yeast can be dispersed or dissolved in a solvent which is preferably 1 to 100000 times as much as sulfur. Thus, sulfur and yeast dispersed or dissolved in a solvent can be mixed with a solvent and referred to as a mixed solution.

The mixed solution may be 10 to 1000 parts by weight based on 100 parts by weight of the extract.

The sulfur may be 10 to 500 parts by weight, more preferably 20 to 200 parts by weight, per 100 parts by weight of the periclate.

In addition, a pharmaceutical additive or an additive for cosmetic can be added to the composition.

As to the total weight of the composition, peric

n, manzanilla, sulfur, and yeast may be from 0.00001 to 99 wt% (w / w). Such composition may vary depending on the state of hair loss and progression.

Further, the composition may be added with a solvent in addition to the extract and / or the mixture, and the solvent may be at least one selected from a lower alcohol having 1 to 5 carbon atoms, or water.

Such a composition may be an external dermatological composition. The composition for external use on skin means a composition externally applied directly to the skin. Such a composition can be applied by a method such as direct application to the skin or by spraying, and includes a skin external preparation.

In addition, the composition may specifically be a pharmaceutical composition, or a cosmetic composition.

The pharmaceutical composition may be in the form of a spray, an external liquid, an oil, a suspension, a cream, a gel, a patch, an ointment, a warning agent, a lotion, a liniment, a pasta or a cataract.

In addition, the cosmetic composition can be used as a hair cosmetic composition such as hair spray, hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair nutrition cream, Hair gels, hair glazes, or hair mousses, in the form of hair waxes, hair waxes, hair aerosols, hair packs, hair nutrition packs, hair soaps, hair cleansing foams, hair oils, hair drying agents, hair preservatives, hair dyes, .

In this case, the cosmetic composition or the pharmaceutical composition is meant to include an article other than a medicament.

The preferred dosage of the composition, which is an embodiment of the present invention, varies depending on the condition of the patient, the body weight, the degree of hair loss, the formulation, the administration route and the period, but can be appropriately selected by those skilled in the art. For example, it can be administered in a manner such that it is applied to the skin (e.g., scalp) at a dose of 0.001 to 1000 mg / kg per day. The administration may be carried out once a day or divided into several doses. Such dosages do not limit the scope of the invention.

The pharmaceutical composition may further comprise a pharmaceutically acceptable base and, if necessary, additives, and may be easily formulated by known or publicly known methods.

By way of example, spraying or hair spraying agents can be formulated in such a manner that the compositions on a solution (including liquid or solid tablet) are sprayed with the pressure of the gas, in a known spray container in the manner of filling the composition.

It goes without saying that the composition on the solution (including liquid or suspension) itself may be a preparation such as a solution for external use, a suspension, a liniment, or a hair preservative.

And may be formulated into a formulation described in the Korean Pharmacopoeia or the like at the time of formulation, and may be formulated by a suitable method in the art. See, for example, Remington's Pharmaceutical Science (recent edition), Mack Publishing Company, Easton PA.

The cosmetic composition may further comprise additives acceptable to cosmetics.

Additives that can be added to the cosmetic composition of the present invention may include ingredients conventionally used in cosmetic compositions and include conventional adjuvants and carriers such as, for example, stabilizers, solubilizers, vitamins, pigments and / or fragrances do.

Examples of additives that can be added to the cosmetic composition include a preservative component, a moisturizing agent, an emollient agent, a surfactant, an organic and inorganic pigment, an organic powder, a preservative, a bactericide, an antioxidant, a pH adjuster, an alcohol, a pigment, and / .

The cosmetic composition of the present invention can be prepared into any formulation conventionally produced in the art, and examples thereof include emulsions, creams, lotions, packs, foundations, lotions, essences, and hair cosmetics.

When the formulation of the present invention is a paste, cream or gel, animal fibers, plant fibers, wax, paraffin, starch, tragacanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide .

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as the carrier component. In particular, in the case of a spray, Propellants such as fluorohydrocarbons, propane / butane or dimethyl ether.

Solvents, solubilizing agents or emulsifying agents are used as carrier components in the case of solutions or emulsions of the present invention, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, Glycol, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid esters of sorbitan.

When the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tragacanth.

Hereinafter, the method for producing a composition for preventing hair loss, promoting hair growth or promoting hair growth of the present invention will be described in detail. As shown in FIG. 3, the method of the present invention comprises the steps of: (A) preparing an extract obtained by solvent extraction of pericellulose and manzanilla, respectively; (B) preparing a mixed solution by mixing sulfur and yeast with a solvent; And (C) contacting the mixture with the extract.

In the step (A), periclone and manzanilla may be respectively extracted together with or together with the solvent, and the plant extract may be obtained by heating the peri-lace and manzanilla in a solvent for 20 to 60 minutes have. For example, by heating, plant extracts can be obtained at 100 degrees Centigrade.

In the step (B), the mixed solution may be obtained by mixing sulfur and yeast, followed by mixing with a solvent at 30 to 40 degrees Celsius. For example, sulfur and yeast may be pulverized together and mixed, and then a solvent of 30 to 40 degrees Celsius may be poured and mixed to prepare a mixture in a dispersed or dissolved state.

Thus, by mixing sulfur and yeast, sulfur can be effectively dispersed or dissolved in the solvent. In other words, it appears that a mixed solution in which the dispersibility or solubility of sulfur to the solvent is increased by the yeast is formed. Such yeast improves applicability of the sulfur to the composition of the present invention.

In step (C), the contacting may include adding the extract to the mixed solution and then mixing. Further, the method may further comprise adding the extract to the mixed solution, and then adding and mixing the solvent at 30 to 40 degrees Celsius. At this time, the remaining amount of the composition can be adjusted by the added solvent. The added solvent may be 100 to 5000 parts by weight, more preferably 100 to 4000 parts by weight, based on 100 parts by weight of the mixed solution.

Further, after the mixing step, (D) may further include an aging step. (D) is a step of aging the contact material obtained in the step (C). Such aging may be carried out for 10 to 15 days, for example. The aging can be carried out at normal temperature (15 to 25 degrees Celsius). By passing through the aging step, the sulfur smell and other odors are reduced, so that the usability can be further improved. During aging, the contact material can be allowed to stand at room temperature for a period of aging while being stirred once or twice a day.

The composition according to one embodiment of the present invention can be manufactured by the manufacturing method according to one embodiment of the present invention. The composition in accordance with an embodiment of the present invention and the contents mentioned in the manufacturing method are applied equally to each other within the same scope unless they are mutually contradictory.

The composition and the manufacturing method according to one embodiment of the present invention will be described in more detail in the first embodiment.

&Lt; Example 1 > Preparation of composition

Peric

n and manzanilla, respectively, were grown in Guatemala at the time of bud budding, and then dried in the shade for 10 days. Fig. 4 is a photograph of the ground surface of the peri-lace before drying, and Fig. 5 is a photograph of the ground surface of Manzaniya before drying.

Five grams of dried perlite and 5 g of Manzaniya were poured, and 5 liters of water was boiled at 100 ° C for 30 minutes. Then, the filtrate was filtrated to prepare Pericellin and Manzania extract.

On the other hand, 3 g of sulfur (collected from the Guatemala volcano area of Puego) and 4 g of yeast (yeast) were pulverized together and mixed. Then, 5 L of water at 30 to 40 degrees C was poured and mixed to prepare a mixed solution.

After that, the extract was added to the mixed solution, and water of 30 to 40 degrees Celsius was added to make the volume to 120 L, and the composition was aged for 15 days while stirring for 1 to 2 times a day.

The composition of Example 1 is packaged in a sterilized container in 100 mL units, and formulated into a solution for external use or a composition for liniment.

&Lt; Formulation Example 2 >

The composition of Example 1 is filled into an empty spray container and formulated as a spray or hair spray.

The composition of Example 1 was subjected to an experiment to prevent hair loss, accelerate hair growth, or confirm the effect of promoting wool on a subject (adult weighing 60 to 80 kg). After washing the hair with soap once a day, the subject was allowed to apply 3 mL of the composition of Example 1 to the hair loss site. Some of the results are shown in Fig. 1 to Fig. FIG. 1 (A) shows the state before the experiment, FIG. 2 (B) shows the state after three weeks, (C) shows the state after four weeks, , And (B) show the state after 8 weeks. As a result, it can be seen that not only the numbers of the subjects' hair increased with the elapse of the treatment time but also their thickness became thicker. It was also confirmed that hair loss was prevented.

Consequently, according to the present invention, it is possible to prevent hair loss, promote hair growth, or promote wool.

Claims

Peric

n), manzanilla, sulfur, and yeast, which are used for preventing hair loss, promoting hair growth, or promoting wool.

delete

2. The composition of claim 1, wherein the pericellent and mannaniya are in the form of an extract or a solvent extracted together.

The composition according to claim 1, wherein the sulfur and the yeast are dispersed or dissolved in a solvent.

The composition of claim 1, wherein the composition is a pharmaceutical composition, or a cosmetic composition.

The composition of claim 5, wherein the pharmaceutical composition is a formulation of a spray, a topical, an emulsion, a suspension, a cream, a gel, a patch, an ointment, a warning agent, a lotion, a liniment, a pasta or a cataract.

[6] The cosmetic composition according to claim 5, wherein the cosmetic composition is selected from the group consisting of a hair spray, a hair tonic, a hair conditioner, a hair essence, a hair lotion, a hair nutrition lotion, a hair shampoo, a hair conditioner, , Hair massage cream, hair wax, hair aerosol, hair pack, hair nutrition pack, hair soap, hair cleansing foam, hair oil, hair drying agent, hair preservative, hair dye, hair wave agent, hair bleaching agent, hair gel, Wherein the composition is a formulation of hair mousse.

(A) preparing an extract obtained by solvent extraction of pericellin and manzanilla, respectively;
(B) preparing a mixed solution by mixing sulfur and yeast with a solvent; And
(C) contacting the mixture with the extract, wherein the composition is used for preventing depilation of hair, promoting hair growth, or promoting wool.

[9] The method of claim 8, further comprising (D) aging the contact material obtained in step (C).