KR101579993B1 - 이마티닙을 이용한 티로신 키나제 수용체 ｋｉｔ에 의해 매개되는 증식성 질환의 치료를 최적화하는 방법 - Google Patents

이마티닙을 이용한 티로신 키나제 수용체 ｋｉｔ에 의해 매개되는 증식성 질환의 치료를 최적화하는 방법 Download PDF

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KR101579993B1
KR101579993B1 KR1020107018386A KR20107018386A KR101579993B1 KR 101579993 B1 KR101579993 B1 KR 101579993B1 KR 1020107018386 A KR1020107018386 A KR 1020107018386A KR 20107018386 A KR20107018386 A KR 20107018386A KR 101579993 B1 KR101579993 B1 KR 101579993B1
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imatinib
kit
pharmaceutical composition
cmin
pharmaceutically acceptable
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Korean (ko)
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KR20100105778A (ko
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얀펭 왕
엘리자베스 베를레
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노파르티스 아게
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57446—Specifically defined cancers of stomach or intestine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020107018386A 2008-01-23 2009-01-21 이마티닙을 이용한 티로신 키나제 수용체 ｋｉｔ에 의해 매개되는 증식성 질환의 치료를 최적화하는 방법 Expired - Fee Related KR101579993B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2294508P 2008-01-23 2008-01-23
US61/022,945 2008-01-23

Publications (2)

Publication Number Publication Date
KR20100105778A KR20100105778A (ko) 2010-09-29
KR101579993B1 true KR101579993B1 (ko) 2015-12-23

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KR1020107018386A Expired - Fee Related KR101579993B1 (ko) 2008-01-23 2009-01-21 이마티닙을 이용한 티로신 키나제 수용체 ｋｉｔ에 의해 매개되는 증식성 질환의 치료를 최적화하는 방법

Country Status (14)

Country Link
US (3) US20100298338A1 (enExample)
EP (1) EP2237783B1 (enExample)
JP (2) JP5936821B2 (enExample)
KR (1) KR101579993B1 (enExample)
CN (1) CN101951910B (enExample)
AU (1) AU2009206566A1 (enExample)
BR (1) BRPI0906504A2 (enExample)
CA (1) CA2712087A1 (enExample)
ES (1) ES2526537T3 (enExample)
MX (1) MX2010008103A (enExample)
PL (1) PL2237783T3 (enExample)
PT (1) PT2237783E (enExample)
RU (1) RU2537223C2 (enExample)
WO (1) WO2009094360A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2753391C1 (ru) * 2020-09-29 2021-08-13 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ оптимизации лечения стромальных опухолей желудочно-кишечного тракта

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7125875B2 (en) * 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
GB0127922D0 (en) * 2001-11-21 2002-01-16 Novartis Ag Organic compounds
JP4762150B2 (ja) * 2003-11-18 2011-08-31 ノバルティス アーゲー Ｋｉｔの変異体の阻害剤
US7329495B2 (en) * 2004-06-09 2008-02-12 Board Of Regents, The University Of Texas System Mutations in KIT confer imatinib resistance in gastrointestinal stromal tumors
MY148074A (en) * 2005-05-10 2013-02-28 Novartis Ag Pharmaceutical compositions comprising imatinib and a release retardant
EP2068938B1 (en) * 2006-09-22 2011-01-19 Novartis AG Optimization of the treatment of philadelphia-positive leukemia with abl tyrosine kinase inhibitor imatinib
CN101594857B (zh) 2006-11-07 2012-10-31 诺瓦提斯公司 阿利吉仑半富马酸盐的晶形

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Clinical Pharmacokinetics. Vol.44(9), pp.879-894 (2005)*
Journal of Chromatography B. 803(2), pp.285-292 (2004)
Journal of Clinical Oncology. Vol.22(5), pp.935-942 (2004)

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Publication number Publication date
BRPI0906504A2 (pt) 2015-07-14
US20160045501A1 (en) 2016-02-18
CN101951910B (zh) 2013-07-17
PT2237783E (pt) 2014-12-23
JP5881671B2 (ja) 2016-03-09
JP2014094946A (ja) 2014-05-22
US9763944B2 (en) 2017-09-19
RU2537223C2 (ru) 2014-12-27
US20100298338A1 (en) 2010-11-25
ES2526537T3 (es) 2015-01-13
KR20100105778A (ko) 2010-09-29
CN101951910A (zh) 2011-01-19
RU2010134916A (ru) 2012-02-27
PL2237783T3 (pl) 2015-04-30
MX2010008103A (es) 2010-08-23
CA2712087A1 (en) 2009-07-30
EP2237783B1 (en) 2014-11-19
WO2009094360A1 (en) 2009-07-30
EP2237783A1 (en) 2010-10-13
US20170035757A1 (en) 2017-02-09
AU2009206566A1 (en) 2009-07-30
JP5936821B2 (ja) 2016-06-22
JP2011510086A (ja) 2011-03-31

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