KR101570446B1 - 혈액 특히 말초 혈액으로부터 얻은 성체 줄기세포의 증대 방법 및 의학 분야의 관련 적용 - Google Patents

혈액 특히 말초 혈액으로부터 얻은 성체 줄기세포의 증대 방법 및 의학 분야의 관련 적용 Download PDF

Info

Publication number
KR101570446B1
KR101570446B1 KR1020097007818A KR20097007818A KR101570446B1 KR 101570446 B1 KR101570446 B1 KR 101570446B1 KR 1020097007818 A KR1020097007818 A KR 1020097007818A KR 20097007818 A KR20097007818 A KR 20097007818A KR 101570446 B1 KR101570446 B1 KR 101570446B1
Authority
KR
South Korea
Prior art keywords
blood
stem cells
cells
mcsf
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020097007818A
Other languages
English (en)
Korean (ko)
Other versions
KR20090074044A (ko
Inventor
감바쿠르타 알레산드라
폴레티니 마르코
Original Assignee
땡스템 에스알엘
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 땡스템 에스알엘 filed Critical 땡스템 에스알엘
Publication of KR20090074044A publication Critical patent/KR20090074044A/ko
Application granted granted Critical
Publication of KR101570446B1 publication Critical patent/KR101570446B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
KR1020097007818A 2006-09-20 2007-09-11 혈액 특히 말초 혈액으로부터 얻은 성체 줄기세포의 증대 방법 및 의학 분야의 관련 적용 Active KR101570446B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM2006A000498 2006-09-20
IT000498A ITRM20060498A1 (it) 2006-09-20 2006-09-20 Metodo di espansione di cellule staminali adulte da sangue periferico e relativi usi in campo medico

Publications (2)

Publication Number Publication Date
KR20090074044A KR20090074044A (ko) 2009-07-03
KR101570446B1 true KR101570446B1 (ko) 2015-11-27

Family

ID=38126399

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097007818A Active KR101570446B1 (ko) 2006-09-20 2007-09-11 혈액 특히 말초 혈액으로부터 얻은 성체 줄기세포의 증대 방법 및 의학 분야의 관련 적용

Country Status (20)

Country Link
US (2) US8263400B2 (https=)
EP (1) EP2076588B1 (https=)
JP (1) JP5340941B2 (https=)
KR (1) KR101570446B1 (https=)
CN (1) CN101553565B (https=)
AU (1) AU2007299043B2 (https=)
BR (1) BRPI0715036A2 (https=)
CA (1) CA2663072C (https=)
DK (1) DK2076588T3 (https=)
EA (1) EA019305B1 (https=)
ES (1) ES2435080T3 (https=)
HR (1) HRP20131104T1 (https=)
IL (1) IL197575A (https=)
IT (1) ITRM20060498A1 (https=)
MX (1) MX2009003059A (https=)
PL (1) PL2076588T3 (https=)
RS (1) RS53039B (https=)
SI (1) SI2076588T1 (https=)
WO (1) WO2008034740A1 (https=)
ZA (1) ZA200901748B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9132116B2 (en) 2004-08-02 2015-09-15 Willowcroft Pharm Inc. Mast cell stabilizers to prevent or treat laminitis
ITUD20080058A1 (it) * 2008-03-18 2009-09-19 Thankstem S R L Kit per la raccolta di sangue, preferibilmente periferico, per la produzione di cellule staminali
WO2010126544A1 (en) * 2009-04-29 2010-11-04 Willowcroft Pharm, Llc Mast cell stabilizers to prevent or treat laminitis
KR101202836B1 (ko) * 2010-08-27 2012-11-20 서울대학교산학협력단 세포응집을 이용한 인간 혈액 유래 혈구 세포괴의 유도와 이를 이용한 혈중 성체줄기세포 및 전구세포의 증폭방법 및 상기의 방법에 의해 제조된 줄기세포
WO2012106367A2 (en) * 2011-01-31 2012-08-09 Royal Daniel F Pluripotent stem cells and method of stimulating and extracting non-embryonic pluripotent stem cells from mammal blood and using reconstituted pluripotent stem cells to treat diseases including chronic obstructive pulmonary disease
BE1020480A5 (nl) * 2012-10-01 2013-11-05 Global Stem Cell Technology Werkwijze voor de isolatie van mesenchymale stamcellen uit bloed van zoogdieren, en gebruik ervan.
AR101442A1 (es) * 2014-05-09 2016-12-21 Thankstem S R L Método para la expansión de células madre de adultos de sangre
RU2644650C2 (ru) 2014-12-01 2018-02-13 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток и способ его получения
WO2016204230A1 (ja) * 2015-06-17 2016-12-22 仁幸 小林 幹細胞投与方法、競走馬または競技馬の症状改善方法、注射用容器および幹細胞注射セット
RU2708329C2 (ru) 2016-05-31 2019-12-05 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток, композиции и способы применения
CA3028422A1 (en) * 2016-06-23 2017-12-28 Tithon Biotech, Inc. Cells expressing parathyroid hormone 1 receptor and uses thereof
US11103537B2 (en) 2016-06-23 2021-08-31 Tithon Biotech Inc. Cells expressing parathyroid hormone 1 receptor and uses thereof
AU2020277774A1 (en) * 2019-05-22 2021-12-09 Thankstem S.R.L. Method for expanding adult stem cells from whole blood

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004043990A2 (en) 2002-11-07 2004-05-27 University Of Chicago Human stem cell materials and methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1436843A (zh) * 2002-02-08 2003-08-20 刘颉 脐血造血干细胞的制作方法
TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
CN1667119A (zh) * 2004-03-11 2005-09-14 中国人民解放军第二军医大学 一种成体干细胞及其培养方法和用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004043990A2 (en) 2002-11-07 2004-05-27 University Of Chicago Human stem cell materials and methods

Also Published As

Publication number Publication date
BRPI0715036A2 (pt) 2013-05-28
EP2076588B1 (en) 2013-08-21
ZA200901748B (en) 2010-03-31
JP2010504083A (ja) 2010-02-12
KR20090074044A (ko) 2009-07-03
HRP20131104T1 (hr) 2013-12-20
CN101553565B (zh) 2015-05-06
US20120308535A1 (en) 2012-12-06
MX2009003059A (es) 2009-04-01
CN101553565A (zh) 2009-10-07
JP5340941B2 (ja) 2013-11-13
WO2008034740A1 (en) 2008-03-27
IL197575A0 (en) 2011-08-01
EA200970294A1 (ru) 2009-10-30
HK1138315A1 (en) 2010-08-20
ITRM20060498A1 (it) 2008-03-21
PL2076588T3 (pl) 2014-01-31
ES2435080T3 (es) 2013-12-18
CA2663072C (en) 2016-01-19
DK2076588T3 (da) 2013-11-11
SI2076588T1 (sl) 2013-12-31
AU2007299043B2 (en) 2013-06-27
IL197575A (en) 2013-06-27
US8263400B2 (en) 2012-09-11
RS53039B (sr) 2014-04-30
CA2663072A1 (en) 2008-03-27
EA019305B1 (ru) 2014-02-28
EP2076588A1 (en) 2009-07-08
AU2007299043A1 (en) 2008-03-27
US20100068189A1 (en) 2010-03-18

Similar Documents

Publication Publication Date Title
KR101570446B1 (ko) 혈액 특히 말초 혈액으로부터 얻은 성체 줄기세포의 증대 방법 및 의학 분야의 관련 적용
JP2010504083A5 (https=)
Borhani-Haghighi et al. The therapeutic potential of conditioned medium from human breast milk stem cells in treating spinal cord injury
Bombeiro et al. Immunomodulation by dimethyl fumarate treatment improves mouse sciatic nerve regeneration
Angellee et al. Role of platelet-rich plasma to sperm quality in male partners undergoing infertility treatment
CN107970438A (zh) 一种神经再生凝胶及其制备方法和应用
WO2003000871A1 (en) Schwann cells originating in myeloid interstitial cells
US8500712B2 (en) Kit for collecting blood, preferably peripheral blood, for the production of stem cells
Chen et al. Abdominal aortic transplantation of bone marrow mesenchymal stem cells regulates the expression of ciliary neurotrophic factor and inflammatory cytokines in a rat model of spinal cord ischemia-reperfusion injury
US20080197048A1 (en) Use of bone marrow stromal cells for the treatment of tendons and/or ligaments damages
KR101777414B1 (ko) 줄기세포 및/또는 전구세포의 활성화제
CN116925186B (zh) 一种新生儿肺发育不良的间充质干细胞治疗方法
EA035104B1 (ru) Способ размножения взрослых стволовых клеток из цельной крови
Peng et al. Hyperbaric oxygen therapy combined with Schwann cell transplantation promotes spinal cord injury recovery
CN118222496B (zh) 髌下脂肪垫干细胞的培养基及培养方法
CN116920069B (zh) 一种中药提取液及其在促进脐带干细胞分泌vegf中的应用
HK1138315B (en) Expansion method for adult stem cells from blood, particularly peripheral blood, and relative application in medical field
EP3087176B1 (en) Multipotent and immunocompatible stem cell concentrate
Li et al. Lactate drive M2 polarization via OXPHOS and Cebpb and accelerate peripheral nerve regeneration
KR20110017345A (ko) 혈관내피전구세포 이동 촉진제
CN120555339A (zh) 一种治疗神经系统疾病的间充质干细胞的培养方法、用途及检测方法
Zhang Effect of autologous bone mesenchymal stem cell transplantation on neurological function in rehabilitation period of multifocal cerebral hemorrhage
CN120064653A (zh) 一种鉴定脐带间充质干细胞心肌修复特性的方法
WO2013069861A1 (ko) 지방조직유래줄기세포에 ｃｂｍ－１０７８을 처리함으로써 분화 유도된 ｇａｂａ성 신경세포를 유효성분으로 포함하는 신경성 통증 예방 및 치료용 약학적 조성물
CN120437278A (zh) 表皮生长因子在制备修复和/或治疗视网膜损伤中的产品中用途

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20090416

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
N231 Notification of change of applicant
PN2301 Change of applicant

Patent event date: 20110928

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20120906

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20140428

Patent event code: PE09021S01D

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20150225

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20150826

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20151113

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20151116

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
FPAY Annual fee payment

Payment date: 20181107

Year of fee payment: 4

PR1001 Payment of annual fee

Payment date: 20181107

Start annual number: 4

End annual number: 4

FPAY Annual fee payment

Payment date: 20191114

Year of fee payment: 5

PR1001 Payment of annual fee

Payment date: 20191114

Start annual number: 5

End annual number: 5

FPAY Annual fee payment

Payment date: 20201105

Year of fee payment: 6

PR1001 Payment of annual fee

Payment date: 20201105

Start annual number: 6

End annual number: 6

FPAY Annual fee payment

Payment date: 20211102

Year of fee payment: 7

PR1001 Payment of annual fee

Payment date: 20211102

Start annual number: 7

End annual number: 7

FPAY Annual fee payment

Payment date: 20221102

Year of fee payment: 8

PR1001 Payment of annual fee

Payment date: 20221102

Start annual number: 8

End annual number: 8

PR1001 Payment of annual fee

Payment date: 20231101

Start annual number: 9

End annual number: 9

PR1001 Payment of annual fee

Payment date: 20241127

Start annual number: 10

End annual number: 10