KR101527334B1 - 자가면역 질병의 치료 및 진단용 tcr-v-베타 관련 펩티드 - Google Patents

자가면역 질병의 치료 및 진단용 tcr-v-베타 관련 펩티드 Download PDF

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KR101527334B1
KR101527334B1 KR1020147008188A KR20147008188A KR101527334B1 KR 101527334 B1 KR101527334 B1 KR 101527334B1 KR 1020147008188 A KR1020147008188 A KR 1020147008188A KR 20147008188 A KR20147008188 A KR 20147008188A KR 101527334 B1 KR101527334 B1 KR 101527334B1
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disease
gpi
insulin
peptide
cells
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KR20140048338A (ko
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알피 마토씨안-로저스
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알피 마토씨안-로저스
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Priority claimed from GB0609920A external-priority patent/GB0609920D0/en
Priority claimed from GB0609921A external-priority patent/GB0609921D0/en
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/39541Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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KR1020147008188A 2005-08-11 2006-08-09 자가면역 질병의 치료 및 진단용 tcr-v-베타 관련 펩티드 Expired - Fee Related KR101527334B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0516527.9 2005-08-11
GB0516527A GB0516527D0 (en) 2005-08-11 2005-08-11 Peptides
GB0609920A GB0609920D0 (en) 2006-05-18 2006-05-18 Peptides
GB0609920.4 2006-05-18
GB0609921.2 2006-05-18
GB0609921A GB0609921D0 (en) 2006-05-18 2006-05-18 Peptides
PCT/GB2006/002977 WO2007017686A2 (en) 2005-08-11 2006-08-09 Tcr-v-beta related peptides for treatment and diagnosis of autoimmune disease

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020087005824A Division KR20080039978A (ko) 2005-08-11 2006-08-09 자가면역 질병의 치료 및 진단용 tcr-v-베타 관련펩티드

Publications (2)

Publication Number Publication Date
KR20140048338A KR20140048338A (ko) 2014-04-23
KR101527334B1 true KR101527334B1 (ko) 2015-06-09

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KR1020147008188A Expired - Fee Related KR101527334B1 (ko) 2005-08-11 2006-08-09 자가면역 질병의 치료 및 진단용 tcr-v-베타 관련 펩티드
KR1020087005824A Ceased KR20080039978A (ko) 2005-08-11 2006-08-09 자가면역 질병의 치료 및 진단용 tcr-v-베타 관련펩티드

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KR1020087005824A Ceased KR20080039978A (ko) 2005-08-11 2006-08-09 자가면역 질병의 치료 및 진단용 tcr-v-베타 관련펩티드

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US (1) US9243062B2 (https=)
EP (3) EP1919952B1 (https=)
JP (2) JP2009505640A (https=)
KR (2) KR101527334B1 (https=)
CN (1) CN105017423B (https=)
AU (1) AU2006277785B2 (https=)
BR (1) BRPI0614366A2 (https=)
CA (1) CA2618796C (https=)
CU (1) CU23793B7 (https=)
CY (1) CY1120640T1 (https=)
DK (1) DK2594591T3 (https=)
EA (1) EA015629B1 (https=)
ES (1) ES2679994T3 (https=)
GB (1) GB2429013C (https=)
IL (3) IL189407A (https=)
NZ (3) NZ566245A (https=)
WO (1) WO2007017686A2 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
HRP20140240T4 (hr) 2005-11-30 2017-02-24 Abbvie Inc. Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
EP2154969B1 (en) * 2007-05-16 2015-11-18 The Brigham and Women's Hospital, Inc. Treatment of synucleinopathies
US8048420B2 (en) 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
NZ581835A (en) * 2007-06-12 2012-09-28 Ac Immune Sa Monoclonal anti beta amyloid antibody
AU2008311367B2 (en) 2007-10-05 2014-11-13 Ac Immune S.A. Use of anti-amyloid beta antibody in ocular diseases
WO2010053209A1 (en) * 2008-11-05 2010-05-14 Fujirebio Inc. Method for sensing a biochemical and/or biomechanical process of a biological material and method for analyzing biological materials
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
EP2598882B1 (en) 2010-07-30 2017-07-26 AC Immune S.A. Safe and functional humanized antibodies for use in treating an amyloidosis
EP3533803B1 (en) 2010-08-14 2021-10-27 AbbVie Inc. Anti-amyloid-beta antibodies
WO2012047732A2 (en) * 2010-09-29 2012-04-12 Genentech, Inc. Antibody compositions and methods of use
CN107831318B (zh) * 2011-01-20 2021-06-18 西瑞斯实验室有限公司 检测谷蛋白敏感性和其区分于乳糜泻的方法和装置
BR112014029417B1 (pt) 2012-05-25 2023-03-07 Cellectis Método ex vivo para a preparação de células t para imunoterapia
JP6153019B2 (ja) 2013-01-31 2017-06-28 国立大学法人 東京大学 リゾホスファチジルセリン受容体機能調節活性を有する化合物
EP3083697B1 (en) * 2013-12-20 2019-04-17 Development Center for Biotechnology Alpha-enolase specific antibodies and methods of uses in cancer therapy
WO2015114576A1 (en) * 2014-01-31 2015-08-06 Universität Zürich Use of heliocbacter pylori extract for treating or preventing inflammatory bowel diseases and coeliac disease
JP6369721B2 (ja) 2014-07-04 2018-08-08 国立大学法人 東京大学 リゾホスファチジルセリン誘導体
GB2532426B (en) * 2014-11-18 2016-11-02 Rogers Arpi Therapeutic homodimer and uses thereof
AU2014415566A1 (en) * 2014-12-31 2017-07-20 Develpment Center For Biotechnology Humanized alpha-enolase specific antibodies and methods of uses in cancer therapy
US9527922B2 (en) 2014-12-31 2016-12-27 Development Center For Biotechnology Humanized alpha-enolase specific antibodies and methods of uses in cancer therapy
KR101802302B1 (ko) 2015-01-21 2017-11-28 가천대학교 산학협력단 포스파티딜이노시톨포스페이트 결합 물질의 세포 사멸 검출 용도
JP6544669B1 (ja) 2018-03-16 2019-07-17 ディヴェロップメント センター フォー バイオテクノロジー アルファエノラーゼに特異的な抗体及びその使用
WO2019197610A1 (en) 2018-04-13 2019-10-17 INSERM (Institut National de la Santé et de la Recherche Médicale) New vaccinal strategy
CN110885778A (zh) * 2018-09-07 2020-03-17 上海益诺思生物技术股份有限公司 从体外培养的细胞中分离Pig-a基因突变细胞的方法
AU2020346886A1 (en) * 2019-09-13 2022-04-14 Memorial Hospital For Cancer And Allied Diseases Anti-CD371 antibodies and uses thereof
GB202015755D0 (en) * 2020-10-05 2020-11-18 Rogers Arpi Coronavirus therapy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005175A2 (en) * 1997-07-21 1999-02-04 Matossian Rogers Arpi Diagnosis and treatment of diseases using anti-anti-t-cell receptor vbeta anti-bodies or peptides which are recognized by said antibodies, and endocrine secretion regulatory protein i (esrp1)
WO2004029093A2 (en) * 2002-09-30 2004-04-08 Immunomedics, Inc. Humanized anti-granulocyte mn-3 antibody and uses thereof

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
EP0388186A1 (en) 1989-03-17 1990-09-19 E.I. Du Pont De Nemours And Company External regulation of gene expression
US5795965A (en) * 1991-04-25 1998-08-18 Chugai Seiyaku Kabushiki Kaisha Reshaped human to human interleukin-6 receptor
SE9102074D0 (sv) * 1991-07-03 1991-07-03 Kabi Pharmacia Ab Tomour antigen specific antibody
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
US5891623A (en) * 1992-11-09 1999-04-06 Consorzio Per Le Biotecnologie Diagnosis and treatment of AIDS onset
GB9317423D0 (en) 1993-08-21 1993-10-06 Imp Cancer Res Tech Monoclonal antibodies
US5362865A (en) 1993-09-02 1994-11-08 Monsanto Company Enhanced expression in plants using non-translated leader sequences
US5693506A (en) 1993-11-16 1997-12-02 The Regents Of The University Of California Process for protein production in plants
US6001809A (en) 1994-07-11 1999-12-14 Elan Pharmaceuticals, Inc. Inhibitors of leukocyte adhesion
USRE39048E1 (en) * 1995-06-07 2006-03-28 Pepscan Systems B.V. Peptide, immunogenic composition and vaccine or medical preparation, a method to immunise animals against the hormone LHRH, and analogs of the LHRH tandem repeat peptide and their use as vaccine
US5861260A (en) 1996-11-05 1999-01-19 University Of Massachusetts Diagnostic methods for screening patients for scleroderma
IL121041A0 (en) 1997-06-09 1997-11-20 Yeda Res & Dev Immunogenic compositions for induction of anti-tumor immunity
DE19739685A1 (de) 1997-09-10 1999-03-11 Eichel Streiber Christoph Von Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile
US7083950B2 (en) 1998-09-25 2006-08-01 Regeneron Pharmaceuticals, Inc. High affinity fusion proteins and therapeutic and diagnostic methods for use
US6703491B1 (en) * 1999-03-17 2004-03-09 Exelixis, Inc. Drosophila sequences
EP1212422B1 (en) 1999-08-24 2007-02-21 Medarex, Inc. Human ctla-4 antibodies and their uses
SI1232392T1 (en) * 1999-10-12 2003-10-31 Connex Gesellschaft Zur Optimierung Von Forschung Und Improved method for the detection of acid resistant bacteria of the genus helicobacter in stool
EP1130032A1 (en) * 2000-02-28 2001-09-05 Gesellschaft für biotechnologische Forschung mbH (GBF) Single-chain antibodies recognizing the human vascular endothelial growth factor receptor-2 (VEGFR-2/KDR)
GB0006398D0 (en) * 2000-03-16 2000-05-03 Novartis Ag Organic compounds
JP2001299349A (ja) * 2000-04-19 2001-10-30 Suntory Ltd 新規組換え型抗体とそのcdrのアミノ酸配列およびそれをコードする遺伝子
CU23007A1 (es) 2001-04-06 2004-12-17 Ct De Inmunologia Molecular Ct De Inmunologia Mole Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos
US20040115196A1 (en) * 2001-04-18 2004-06-17 Yoshiaki Fukuda Novel recombinant antibodies, amino acid sequences of cdrs thereof and genes encoding the same
WO2002098897A2 (en) * 2001-06-01 2002-12-12 Cornell Research Foundation, Inc. Modified antibodies to prostate-specific membrane antigen and uses thereof
EP1427377A4 (en) 2001-09-20 2006-04-12 Cornell Res Foundation Inc METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING SKIN DISORDERS USING SPECIFIC BINDING AGENTS FOR A PROSTATE-SPECIFIC MEMBRANE ANTIGEN
CA2478047C (en) * 2002-03-01 2014-01-21 Immunomedics, Inc. Rs7 antibodies
US8038986B2 (en) * 2002-07-26 2011-10-18 The Walter And Eliza Hall Institute Of Medical Research Immunogenic compositions and diagnostic and therapeutic uses thereof
US20040136998A1 (en) * 2002-10-30 2004-07-15 Bander Neil H. Methods and compositions for treating or preventing insulin-related disorders using binding agents specific for prostate specific membrane antigen
US20050009136A1 (en) * 2003-02-19 2005-01-13 Dyax Corporation PAPP-A ligands
KR100500283B1 (ko) 2003-03-25 2005-07-11 이뮤노믹스 주식회사 인간 4-1비비 분자에 대한 인간화 모노클로날 폴리펩티드 및 이를 포함하는 약학 조성물
JP2007525458A (ja) * 2003-04-23 2007-09-06 メダレックス インコーポレイテッド インターフェロンα受容体−1(IFNAR−1)に対するヒト化抗体
JP2007535905A (ja) * 2003-06-06 2007-12-13 オンコマックス アクイジション コーポレイション 癌関連抗原sm5−1の特異抗体およびその用途
EP1648511A1 (en) * 2003-07-29 2006-04-26 Morphotek, Inc. Antibodies and methods for generating genetically altered antibodies with enhanced effector function
US9403908B2 (en) 2003-09-29 2016-08-02 The Regents Of The University Of California Method for altering hematopoietic progenitor cell adhesion, differentiation, and migration
BRPI0922561A2 (pt) * 2008-12-09 2020-08-11 Pfizer Vaccines Llc vacina de peptídeo de ch3 da ige.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005175A2 (en) * 1997-07-21 1999-02-04 Matossian Rogers Arpi Diagnosis and treatment of diseases using anti-anti-t-cell receptor vbeta anti-bodies or peptides which are recognized by said antibodies, and endocrine secretion regulatory protein i (esrp1)
JP2002511765A (ja) * 1997-07-21 2002-04-16 マトシアン−ロジャーズ、アルピ 内分泌細胞に対して反応性を示す、抗体を含むリガンド
WO2004029093A2 (en) * 2002-09-30 2004-04-08 Immunomedics, Inc. Humanized anti-granulocyte mn-3 antibody and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Eur J Immunol. 2002, Vol.29, No. 5 pp449-452. *

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