KR101510308B1 - Damaged hair recovering composition containing transglutaminase and extract of Zanthoxylum bungeanum Maxim - Google Patents

Abstract

The present invention relates to a composition capable of restoring and strengthening damaged hair by providing beneficial characteristics using biomolecule reaction of amino acids constituting hair, and capable of providing gloss, moisturizing elasticity, thickness increase, volume, smoothness and softness to hair The present invention relates to a transglutaminase and a herb extract. The composition and hair treatment method according to the present invention increases the bio-bonding formed on the proteins inside and outside the hair, ultimately enhances the inner and outer structure of the hair, restores the inner and outer protein structures eluted by the damage, and provides the hair with shine, moisturizing elasticity, Increase, volume, smoothness, smoothness, and the like.

Transglutaminase, celecoxib, hair

Description

[0001] The present invention relates to a damaged hair recovery composition containing transglutaminase and extract of Zanthoxylum bungeanum,

The present invention relates to a hair cosmetic and hair treatment method for restoring and strengthening damaged hair due to physical / chemical factors before the hair is damaged.

In general, amide bonds between amino acid residues in proteins and peptides (in addition to the amino acids at both ends of the peptide, in which amino acids are lost in one molecule of water) are referred to as peptide bonds. That is, one mole of water is removed between the alpha-carboxyl of the amino acid and the alpha-amino of the next amino acid, and it is combined as shown in the following figure. A peptide in which two or more amino acids are bound by dehydration is referred to as a peptide.

Depending on the number of amino acids (number of constituent amino acids) bound to the peptide, the peptide may be an oligopeptide of 10 to 50 amino acids, a polypeptide of 2 to 10 amino acids, and a protein of more than 50 amino acids. Although it is not an absolute criterion, depending on the kind of substances constituting these proteins and peptides, only amino acids are referred to as homopeptides and those containing non-amino acid components are referred to as heteropeptides. The bond that forms the primary structure of a protein is a peptide bond (Amide Bond, -CONH-) that is connected to amino acids. Amino acids, the building blocks of proteins, are present in all the cells, even in very small amounts, and are also precursors of proteins.

In general, the hair is composed of a protein called keratin. Specifically, hair is a keratin protein containing 14-18% of cysteine among 18 kinds of amino acids. These keratin proteins are a very strong protein in mild conditions such as water or neutral solvents, but they can easily be damaged by physicochemical treatments for hair, such as combing in daily life, dry heat, dyeing, perm and the like. In recent years, due to various physical, chemical, or environmental factors such as frequent perms, staining, etc., the hair is damaged and the protein in the hair is eluted and becomes porous. As a result, hair becomes rough and loses its gloss and softness and softening effect are decreased. The hair is difficult to be trimmed, the hair is easily cut off, the end is cracked, and the hair tends to be thin and the elasticity is lost.

To solve these problems, there has been continuous research on hair cosmetics to improve the softness of hair after washing or washing and to restore and strengthen damaged hair. As a result, various methods have been attempted and developed to provide a strong and continuous effect of hair conditioning.

Korean Patent Laid-Open No. 10-2007-0038509 discloses a cosmetic agent containing an amino, amino acid or peptide conjugate of retinoic acid to prevent / treat phenomena related to skin aging, but the effect is remarkably deteriorated by washing and is continuous It has the disadvantage that it can not. U.S. Patent No. 5,490,980 discloses the use of transglutaminase, which forms an isopeptide bond between lysine and glutamine among the amino acids that make up the protein component of the human body such as hair, skin, nails and the like, Antibacterial, dye, fragrance, and the like. Japanese Patent Publication No. 3567915 discloses a method of using a peptide having a molecular weight of 203 or more including a lysine and / or glutamine residue in a molecule, a transglutaminase, And a compound having a primary amine structure of a specific chemical formula. Japanese Patent Laid-Open No. 2003-026543 discloses a hair treatment agent comprising a combination of an amphipathic polymer having a weight average molecular weight of 500 to 3,000,000 and transglutaminase And a hair cosmetic composition comprising the hair cosmetic composition.

However, transglutaminase, an enzyme used in the above-mentioned inventions, is an enzyme having a macromolecule with a molecular weight of about 38 kDa, which can easily act on the surface of hair, This effect is very limited because it has a drawback that it is difficult.

Accordingly, the technical problem to be solved by the present invention is to provide a hair restoration method and a hair restoration method for restoring damaged hair, restoring the inner and outer parts of the hair including providing volume feeling by increasing the thickness of hair, , A conditioning effect such as softness, styling of hair, prevention of static electricity, and the like.

In order to accomplish the above object, the present invention provides a transglutaminase and PPAR (Peroxisome Proliferator Activated Receptor) alpha that activate the binding between lysine and glutamine in hair, Wherein the cosmetic composition is useful as a hair treatment or a hair conditioning cosmetic composition.

In addition to the cosmetic properties of the existing transglutaminase-containing hair surface, the present invention synergizes the effect of transglutaminase, such as increasing the expression of transglutaminase by using a mulberry tree extract Thereby enhancing the binding between the amino acids present between the keratin, the internal protein of the hair formed by the hair follicle cell surface protein, and ultimately damaging the inside and the outside of the damaged hair by the action of these two substances to bind the hair amino acid, peptide or protein The hair can be effectively restored inside and outside of the damaged hair and strengthened with damaged hair or skin to improve the conditioning effect such as hair shine, moisturizing, smoothness, and softness, styling of hair, Amazing discovery that can provide beneficial traits Based.

The transglutaminase (TGase, EC 2.3.2.1.3) used in the present invention is an enzyme that cross-links peptides or proteins existing in the inside or outside of the hair or supplied from the outside, and is used in animals, plants, Widely distributed. When these transglutaminases act on proteins or peptides, they can form cross-linking between glutamine and lysine by acyl exchange, cross-linking, and deamination. Transglutaminase can provide beneficial properties such as gloss, elasticity, thickness, flexibility, softness, moisturizing, etc. to the hair by such binding.

Although the activity of a general enzyme including transglutaminase varies depending on an enzyme, it has a property of being easily denatured due to various factors such as moisture, sunlight, heat, temperature and the like. Therefore, the application of transglutaminase, an enzyme in the composition or cosmetic of the present invention, can be carried out by various coating, encapsulating, dispersing, dissolving, emulsifying and the like methods generally known in the art for the purpose of preventing degradation of enzymes It is preferable to modify the enzyme so that the activity of the enzyme can be maintained.

Also, Zanthoxylum bungeanum Maxim, which is included in the composition of the present invention, is also referred to as anthracnose or zygomycetes, and is a perianth of Zanthoxylum piperitum De Candolle or an inbred plant, which means the seed is removed as much as possible. It is distributed in Korea, Japan, China, etc., and it has a characteristic odor, it is known to be spicy, temperate and poisonous.

Such chrysanthemum can be readily obtained commercially, and such extracts of natural products can be extracted by extraction methods well known to those skilled in the art. For example, it can be obtained by heat extraction of water with a solvent such as water, anhydrous or hydrous alcohol having 1 to 4 carbon atoms, ethyl acetate, acetone or chloroform, concentration under reduced pressure, and freeze drying or spray drying. To obtain a high purity extract, the extract may be further extracted one or more times in the same manner. The extract is preferably extracted with at least one solvent selected from the group consisting of water, alcohols having 1 to 4 carbon atoms, ethyl acetate and acetone.

It is preferable that the dry matter content of the municipal wood extract is 0.0001 to 10% by weight based on the total weight of the composition.

The compositions according to the present invention may be formulated so as to aid in achieving the objects of the present invention to the extent that they do not impair the object of the present invention or to provide formulations of pH adjusting agents, Such as thickeners, stabilizers, surfactants, conditioning agents, appearance enhancers, fragrances, preservatives, dyes and pigments, sequestering agents, and the like.

The composition and treatment method of the present invention simultaneously imparts shine, softness, and smoothness to the surface of hair by using transglutaminase and chestnut tree extract at the same time, The structure can be reinforced to provide a variety of properties beneficial to hair, such as hair damage recovery, hair conditioning and treatment effects, hair styling ease, and anti-static.

Hereinafter, embodiments of the present invention will be described in detail to facilitate understanding of the present invention. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the following embodiments. Embodiments of the invention are provided to more fully describe the present invention to those skilled in the art.

≪ Preparation of chestnut tree extract >

100 g of pulverized pulverized product obtained by purchasing a commercially available pulverized product was added to 3 liters of hexane, and the mixture was boiled for 3 hours in a reflux condenser equipped with a condenser. Thereafter, the resultant was filtered through a 100-mesh filter cloth, and the residue was further extracted once more by the same method. The extracts were combined and filtered through a filter paper of Whatman No. 2 at room temperature to remove insoluble matter. The extracts were concentrated under reduced pressure at 60 ° C in a distillation apparatus equipped with a cooling condenser, and then lyophilized to prepare chestnut tree extract.

<Preparation of Example 1-2 and Comparative Example 1-2>

Polyquatemium 10 was dispersed or dissolved in distilled water with the composition shown in Table 1 below, and citric acid and sodium citrate were added thereto, followed by completely dissolving cocamidopropyl betaine sodium laureth sulfate. Thereafter, the extracts of chestnut tree and fragrance were added and stirred, and transglutaminase, which was finally coated with a fatty acid and fatty alcohol, was added to prepare a composition.

Component (% by weight) Example 1 Example 2 Comparative Example 1 Comparative Example 2 Distilled water to 100 to 100 to 100 to 100 Polyquaternium 10 0.3 0.3 0.3 0.3 Citric acid 0.05 0.05 0.05 0.05 Citric acid soda 0.2 0.2 0.2 0.2 Cocamidopropyl betaine 5 5 5 5 Sodium laureth sulfate 13 13 13 13 Chestnut tree extract 0.5 One One Spices 0.5 0.5 0.5 0.5 Transglutaminase
(Fatty acid and fatty alcohol coating) 0.5 0.5 0.5

<Test Method and Results of Hair Tensile Strength of Example 1-2 and Comparative Example 1-2>

The effects of the above Example 1-2 and Comparative Example 1-2 on the hair tensile strength were evaluated. The hair tresses of 100 strands were first measured using a 12-cm, 3-g hair tress made of the same hair that was damaged by bleaching twice using a commercial bleaching agent, and the average value of 100 hair was measured as the initial hair tensile strength standard (100) Each of the hair tresses was subjected to shampooing 10 times using the above composition, followed by drying the hair using a hair dryer heat, taking 100 strands of the treated hair, measuring the tensile strength, treating 100 averages, Strength value. Data were processed by determining the increase rate of hair tensile strength after treatment with respect to the average value of tensile strength of 100 strands of initial hair before treatment. The apparatus was measured using a tensile strength measuring apparatus of Diastron, and the results are shown in Table 2 below.

Unit: cN (1 gf = 0.98 cN) Example 1 Example 2 Comparative Example 1 Comparative Example 2 Before treatment (initial) 142 139 143 139 After processing 159 163 146 145 Increase / decrease rate 12 17.3 2.1 4.3

As a result of the above hair tensile strength test, it was confirmed that the rate of increase of the tensile strength of the hair was larger when the transglutaminase and myrrh extract were used simultaneously than in the case of Comparative Example 1-2, as in Example 1-2. Even in the case of Comparative Example 2, a certain level of increase in tensile strength was confirmed by the effect of improving the internal damage of the hair. However, compared with Example 1-2 in which transglutaminase was simultaneously used to restore damage to the outer portion of the hair The effect was not significant.

<Hair Gloss Test Methods and Results of Examples 1-2 and Comparative Examples 1-2>

The effect of Examples 1-2 and 1-2 on hair gloss was evaluated. 100 women who had experienced sensory evaluation of hair products were instructed to use each shampoo for 20 days for each of the prescriptions in Examples 1-2 and 1-2, The evaluation scale was evaluated as 1 point for worse case, 2 points for bad case, 3 points for normal case, 4 points for good case and 5 point for very good condition. The results are shown in Table 3 below.

Example 1 Example 2 Comparative Example 1 Comparative Example 2 burnish 3.9 4.2 3.4 2.8 Softness 4.0 4.4 3.4 3.0 lubricity 4.2 4.5 3.5 3.0

As a result of the glossiness, softness and smoothness of the surface of the hair, when the transglutaminase of Examples 1-2 and Comparative Example 1 was used, superior characteristics were exhibited as compared with those not used. However, as compared with Comparative Example 1, superior results were obtained in Example 1-2, in which damage was restored to the inside of the hair using a chestnut tree extract.

Claims (3)

A cosmetic composition for damaged hair recovery or hair conditioning characterized by containing transglutaminase and chestnut tree extract as active ingredients. The cosmetic composition for damaged hair recovery or hair conditioning according to claim 1, wherein the dry content of the extract is 0.0001 to 10% by weight based on the total weight of the composition. The cosmetic composition for damaged hair recovery or hair conditioning according to claim 1, wherein the transglutaminase is coated for maintaining enzyme activity.