KR101042752B1 - Composition for repair or strength of hair and skin using bio-conjugation - Google Patents

Abstract

The present invention relates to cosmetics and methods that can repair and strengthen damaged hair and provide elasticity to the skin. The present invention relates to the use of certain compounds that mediate the binding between amino acids that make up hair or skin. Ultimately, it provides a cosmetic and treatment method that strengthens the structure of the hair or skin by allowing a bond to be formed between peptides and proteins constituting the hair or skin, and repairs the internal and external protein structures eluted by damage in the case of hair.

Hair, skin, protein, peptides, amino acids, biomolecule binding

Description

Composition for repair or strength of hair and skin using bio-conjugation

The present invention relates to cosmetics and methods for repairing and strengthening damaged hair or skin due to physical / chemical factors.

In general, amide bonds between amino acid residues in proteins and peptides (amino acids have lost one molecule of water in addition to amino acids at both ends of the peptide) are called peptide bonds. That is, 1 mole of water is removed between the alpha carboxyl group of the amino acid and the alpha amino group of the next amino acid, and then bonded as shown in the following figure. In this way, two or more amino acids are bound by dehydration to be called peptides.

Peptides are called oligopeptides for 2 to 10, polypeptides for 10 to 50, and proteins for 50 or more depending on the number of peptide-binding amino acids (the number of constituent amino acids). . Although not seen as an absolute standard, the amino acid alone is called a homopeptide, and a non-amino acid component is called a heteropeptide, depending on the kind of substances constituting such proteins and peptides. The bond that forms the primary structure of the protein is a peptide bond (peptide bond, Amide Bond, -CONH-) between amino acids. Amino acids, the building blocks of proteins, are in very small amounts but are present in every cell and are also precursors to proteins.

In general, hair and skin are composed of proteins called keratin and collagen, and specifically, hair is a keratin protein containing 14-18% of cysteine among 18 amino acids. These keratin proteins are very strong proteins under mild conditions such as water or neutral solvents, but they can be easily damaged by physicochemical treatments on hair such as combing, drying heat, dyeing, perming and the like that occur in everyday life. In recent years, the hair is damaged by physical, chemical or environmental factors such as frequent perm and dyeing, and the protein inside the hair is eluted and made porous, resulting in roughness and loss of gloss and softness and softening effect. The problem is that the hair is difficult to clean, the hair is easily cut off or the tip breaks, and the hair becomes thinner and loses its elasticity, resulting in a loss of volume.

In order to solve these problems, there has been a continuous research on hair cosmetics to improve the softness of hair at the time of cleaning or after cleaning and to restore and strengthen damaged hair. As a result, various methods have been tried and developed to be able to impart a strong and lasting hair conditioning effect.

Korean Patent Laid-Open Publication No. 10-2007-0038509 discloses a cosmetic agent containing amino, amino acid or peptide conjugates of retinoic acid to prevent / treat symptoms related to skin aging, but its effect is markedly deteriorated and persistent by washing. There is a drawback to this. U.S. Patent No. 5490980 discloses useful conditioning for hair, skin and nails using transglutase, which forms an isopeptide bond between lysine and glutamine among amino acids constituting protein components of the human body such as hair, skin, nails, A method of using a variety of effective substances, such as antibacterial, dyes, fragrances, etc. is disclosed. Japanese Patent Publication No. 3567915 discloses a peptide having a molecular weight of 203 or higher containing lysine and / or glutamine residues, transglutaminase, And a hair treatment agent containing a compound having a primary amine structure of a specific chemical formula. Japanese Patent Laid-Open No. 2003-026543 discloses an amphiphilic polymer having a weight average molecular weight of 500 to 3,000,000 and a transglutaminase. It discloses the hair cosmetics characterized by being used together.

However, transglutase, an enzyme used in the above inventions, is an enzyme having a macromolecule having a molecular weight of about 38 KDa and can easily act on the surface of the hair, but it acts on the damaged part of the hair that requires substantial structural enhancement. This difficulty has the disadvantage that the effect is very limited.

Therefore, the technical problem to be achieved by the present invention is to have a structure and size that can penetrate into the interior of the hair, using a material capable of forming bonds between amino acids present on proteins or peptides, to close the voids inside the damaged hair / Filled by the formation of bonds between amino acids, peptides and proteins supplied from the skin itself or from the outside, a structure made of biochemical material can be formed in the pores formed inside the damaged hair to repair the damaged hair, and increase the thickness of the hair. Repairs proteins in and out of the hair or skin, including providing a sense of volume, strengthens damaged hair or skin, thereby conditioning the hair and skin, such as shine, moisturizing, smoothing, and softening, hair styling, antistatic, and more A condition that can provide beneficial properties to the skin To provide water and methods.

In order to achieve the above technical problem, the present invention provides a cosmetic for damage recovery or strengthening of hair or skin, characterized in that it comprises a compound capable of forming a chemical bond between the amino acids constituting the protein or peptide.

More preferably, the present invention comprises an amino acid, a first composition comprising a peptide or protein consisting of two or more amino acids; And a second composition comprising a compound capable of forming a chemical bond between amino acids constituting the protein or peptide, wherein the cosmetic composition for damage recovery or strengthening of hair or skin is provided.

More preferred cosmetics according to the present invention comprise a first composition and a second composition, which are separated from each other, wherein the first composition comprises a protein, peptide or amino acid obtained from or synthesized from copper, plants, microorganisms or the like in a cosmetically available solvent. It is preferable that it is a liquid which melt | dissolved or disperse | distributed. These first agents also include pH adjusters, penetration aids and thickeners, stabilizers, surfactants, conditioning agents, cosmetics, fragrances, and preservatives for the formulation of these proteins, peptides and amino acids to effectively penetrate hair or skin. It may further include various cosmetic formulation agents such as dyes and pigments, metal ion sequestrants. The second agent, which is the second composition, is capable of forming a bond between the proteins, peptides and amino acids that have penetrated into the hair or skin in the first agent and the amino acids contained in the hair or skin, or were originally present in the hair or skin. It is possible to form bonds between amino acids and includes compounds capable of penetration into hair or skin.

Compounds that play a role in forming bonds between amino acids included in the second agent include glyoxal, methyl glyoxal, diacetyl, acetoin, acetol, acetol, Carbonyl compounds, such as dehydroxyacetone, acetaldehyde, and glycoaldehyde, threose, dehydroascobic acid, and cyclotene ), Oxalic acid, formaldehyde, glyceraldehydes, glutaraldehyde, etc. may be used alone or in combination, and these compounds may be used cosmetically. It is used in the form of a solution dissolved or dispersed in.

In addition, as in the first agent, in the second agent, pH adjusters, penetration aids, and thickeners, stabilizers, surfactants, conditioning agents, appearance agents, etc., for the formulation of products to effectively bind the proteins, peptides and amino acids can be achieved. Various cosmetic formulations may also additionally be included, such as enhancers, perfumes, preservatives, dyes and pigments, metal ion sequestrants and the like.

Among the amino acids, proteins and peptides which are essential components of the first agent, the most preferable component is a peptide composed of several to several tens of amino acids, preferably an average molecular weight of about 120 to 2000 Daltons, more preferably an average molecular weight of about 120 to 1000 Daltons And most preferably oligopeptides having an average molecular weight of about 120 to 500 Daltons. In another aspect preferred peptides are oligopeptides consisting of 1-18 amino acids, more preferably 1-9 amino acids, most preferably 1-5 amino acids.

Peptides of this size were most effective in penetrating into hair and repairing damage to hair. From these results, there are differences depending on the extent of damage and treatment conditions due to the histological characteristics of the hair and skin, but the maximum molecular weight that these peptides can penetrate into the hair is about 2000. It is difficult to penetrate into tissues and is therefore less desirable for hair restoration and strengthening.

In addition, as in the present invention, the peptide used as a role of reinforcing hepatitis in damaged hair tissue preferably includes lysine. Most of the compounds that form the amino acid residue bonds of the second agent have the property of forming a bond primarily to amino acids, in particular lysine. In the case of peptides composed of two or more amino acids, at least one lysine Including lysine residues can form more bonds.

The application of the cosmetic according to the present invention is to treat the first agent solution to hair or skin first to infiltrate amino acids, peptides or proteins, and then to treat the second agent solution to form bonds between amino acids. In the middle of the use of the first and second solutions, it may not be necessary to clean it, but it is usually necessary to simply clean it to prevent the reaction from occurring outside of the hair or skin and to effectively prevent the second from inside the hair or skin. It is more advantageous to infiltrate the liquid solution.

The present invention provides a cosmetic that can repair and strengthen damaged hair or skin due to physical / chemical factors, and a method of treating hair or skin, and thus the cosmetic according to the present invention includes providing a volume feeling through increasing thickness. It can provide various beneficial properties such as conditioning effects such as gloss, moisturizing, smoothing, and softening of hair and skin, styling of hair, antistatic, and the like.

Hereinafter, examples and the like will be described in detail to help understand the present invention. However, the embodiments according to the present invention may be modified in many different forms, and the scope of the present invention should not be construed as being limited to the following examples. Embodiments of the present invention are provided to more fully describe the present invention to those skilled in the art.

<Production of Example 1-6 and Comparative Example 1-2>

The first composition was prepared by dissolving polypeptides having various molecular weights in distilled water in the composition of Table 1 below, and adjusting the pH of the contents to about 7.8-8.0 with sodium citrate, and glyoxal and methylglycol in distilled water. After dissolving oxal, glutaraldehyde, and the like, the second composition was prepared by using citric acid and sodium citrate so that the pH of the content was about 5.0-5.5.

Ingredient (% by weight) Example Comparative example One 2 3 4 5 6 One 2 The first Distilled water to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 Sodium citrate 0.25 0.25 0.25 0.25 0.25 0.25 0.25 0.25 Peptide 1
(MW approximately 500 Da) One One One Peptide 3
(MW approximately 1000 Da) One One One Peptide 4
(MW approximately 5000Da) One Second Distilled water to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 Citric acid 0.17 0.17 0.17 0.17 0.17 0.17 0.17 0.17 Sodium citrate 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Glyoxal One One One One Methylglyoxal One One Glutaraldehyde One One

<Hair tensile strength test method and result of Example 1-6 and Comparative Example 1-2>

The influence on the hair tensile strength of Example 1-6 and Comparative Example 1-2 was evaluated. Using a commercially available bleaching agent, bleaching twice, using a 12cm, 3g hairtress made of the same hair in a damaged state, first measuring the tensile strength of 100 strands of hair, and averaging 100 average values based on the initial hair tensile strength (100). 15 minutes of each hairdresser was infiltrated into the first agent to infiltrate the peptide therein, and then lightly rinsed with running water after 15 minutes of soaking in the second agent, lightly rinsed with running water, and the hair was dried using a hair dryer. Ten strands of the treated hair were taken to measure tensile strength, and the average value of 100 hairs was taken as the hair tensile strength value after treatment. The treatment of the data determined the rate of increase in the tensile strength of the hair after treatment against the average value of the tensile strength of 100 hairs before the treatment. The device was measured using Diastron's tensile strength measuring device, the results are shown in Table 2, the unit of Table 2 is cN (1gf = 0.98cN).

Example Comparative example One 2 3 4 5 6 One 2 Before processing (initial) 141 139 142 138 139 142 141 140 After treatment 161 165 166 168 169 175 149 145 Change rate 14.2 18.7 16.9 21.7 21.6 23.2 5.7 3.6

As a result of the hair tensile strength test, after the peptide treatment having the molecular weight of 500Da and 1000Da capable of infiltrating the hair of Example 1-6, a very excellent tensile strength was treated with amino acid binding compounds such as glyoxal, methylglyoxal, and glutaaldehyde. It was confirmed that it showed an effect of increasing the strength, on the contrary, when treating a peptide having a molecular weight of 5000Da, which is difficult to penetrate hair, it showed a relatively low tensile strength increase rate, and a comparative example in which glyoxal was treated after the first agent treatment containing no peptide. In case of 2, the tensile strength increase rate was very low.

Claims (6)

Glyoxal, methyl glyoxal, diacetyl, acetoin, acetol, and dihydroxy, which are chemical compounds that can form chemical bonds between amino acids that make up proteins or peptides Acetone (dehydroxyacetone), acetaldehyde, carbonyl, threose, dehydroascobic acid, degloascobic acid, cyclotene, oxalic acid, pollum Hair or skin damage recovery or strengthening cosmetics, characterized in that it comprises any one or more selected from the group consisting of aldehyde (formaldehyde), glyceraldehyde (glyceraldehydes) and glutaraldehyde (glutaraldehyde). delete delete delete delete The cosmetic according to claim 1, wherein the peptide has an average molecular weight of 120 to 2000 Daltons.