KR101445458B1 - １Ｈ-이미다조［４,５-ｃ］퀴놀리논 유도체 - Google Patents
１Ｈ-이미다조［４,５-ｃ］퀴놀리논 유도체 Download PDFInfo
- Publication number
- KR101445458B1 KR101445458B1 KR1020127000098A KR20127000098A KR101445458B1 KR 101445458 B1 KR101445458 B1 KR 101445458B1 KR 1020127000098 A KR1020127000098 A KR 1020127000098A KR 20127000098 A KR20127000098 A KR 20127000098A KR 101445458 B1 KR101445458 B1 KR 101445458B1
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- quinolin
- dihydro
- imidazo
- pyrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *c(c(I=N)c1)c(*)c(nc2*)c1c(*)c2[N+]([O-])=O Chemical compound *c(c(I=N)c1)c(*)c(nc2*)c1c(*)c2[N+]([O-])=O 0.000 description 29
- YRTIPZUNGYBTAI-UHFFFAOYSA-O CC(C(C[NH2+]C)C1=Cc2c(cc(cc3)-c(cn4)ccc4OCC[O](Cc4ccccc4)=C)c3ncc2N(C)C1=O)=N Chemical compound CC(C(C[NH2+]C)C1=Cc2c(cc(cc3)-c(cn4)ccc4OCC[O](Cc4ccccc4)=C)c3ncc2N(C)C1=O)=N YRTIPZUNGYBTAI-UHFFFAOYSA-O 0.000 description 1
- VOMUOHJLYTYKLU-UHFFFAOYSA-O CC(C(N(c1c(cc(cc2)-c(cc3)cnc3-[n]3nccc3)c2ncc1N1C)C1=O)=C=[NH2+])=N Chemical compound CC(C(N(c1c(cc(cc2)-c(cc3)cnc3-[n]3nccc3)c2ncc1N1C)C1=O)=C=[NH2+])=N VOMUOHJLYTYKLU-UHFFFAOYSA-O 0.000 description 1
- LDNRGBSBPGMGPI-UHFFFAOYSA-O CC(C(N(c1c(cc(cc2)-c3ccccc3)c2ncc1N1)C1=O)=C[NH2+]C)NC Chemical compound CC(C(N(c1c(cc(cc2)-c3ccccc3)c2ncc1N1)C1=O)=C[NH2+]C)NC LDNRGBSBPGMGPI-UHFFFAOYSA-O 0.000 description 1
- YWRBLSYOLXMZGA-UHFFFAOYSA-N CC1(C)OB(c2c[n](CCOC3OCCCC3)nc2)OC1(C)C Chemical compound CC1(C)OB(c2c[n](CCOC3OCCCC3)nc2)OC1(C)C YWRBLSYOLXMZGA-UHFFFAOYSA-N 0.000 description 1
- UMNHNYSMUMUXMG-UHFFFAOYSA-N CC1(C)OB(c2ccc(N3CCC3)nc2)OC1(C)C Chemical compound CC1(C)OB(c2ccc(N3CCC3)nc2)OC1(C)C UMNHNYSMUMUXMG-UHFFFAOYSA-N 0.000 description 1
- MDQFPCPLPMLWQE-UHFFFAOYSA-O CCC(CC)CC1=C(C)NCC(c(ccc2ncc3N4C)cc2c3N(C(C(C)=N)=C[NH2+]C)C4=O)=C1 Chemical compound CCC(CC)CC1=C(C)NCC(c(ccc2ncc3N4C)cc2c3N(C(C(C)=N)=C[NH2+]C)C4=O)=C1 MDQFPCPLPMLWQE-UHFFFAOYSA-O 0.000 description 1
- IPRBGSHKJYVKMQ-UHFFFAOYSA-N CCC(CC1)N=C(C)C1N(c(c(cc(cc1)-c2cncc(OC3CCC3)c2)c1nc1)c1N1C)C1=O Chemical compound CCC(CC1)N=C(C)C1N(c(c(cc(cc1)-c2cncc(OC3CCC3)c2)c1nc1)c1N1C)C1=O IPRBGSHKJYVKMQ-UHFFFAOYSA-N 0.000 description 1
- ZIRKWXVVWHTKJA-UHFFFAOYSA-O CCN(C)C(C[NH2+]C=C(C(C)=N)N(c1c(cc(cc2)-c3ccccc3)c2ncc1N1C)C1=O)=O Chemical compound CCN(C)C(C[NH2+]C=C(C(C)=N)N(c1c(cc(cc2)-c3ccccc3)c2ncc1N1C)C1=O)=O ZIRKWXVVWHTKJA-UHFFFAOYSA-O 0.000 description 1
- QZWGMFPVRXMGNO-UHFFFAOYSA-N CCNC(c1cc(S2OC(C)(C)C(C)(C)O2)cnc1NC)=O Chemical compound CCNC(c1cc(S2OC(C)(C)C(C)(C)O2)cnc1NC)=O QZWGMFPVRXMGNO-UHFFFAOYSA-N 0.000 description 1
- IUAYLJIEHYDJLS-UHFFFAOYSA-O CCOc1cncc(-c(ccc2ncc3N4C)cc2c3N(C(C[NH2+]C)C(C)=N)C4=O)c1 Chemical compound CCOc1cncc(-c(ccc2ncc3N4C)cc2c3N(C(C[NH2+]C)C(C)=N)C4=O)c1 IUAYLJIEHYDJLS-UHFFFAOYSA-O 0.000 description 1
- GRFCJZIHPOHZAL-UHFFFAOYSA-O CC[NH2+]C=C(C(C)=N)N(c(c(cc(cc1)-c(cc2OCC)ccc2OCC)c1nc1)c1N1C)C1=O Chemical compound CC[NH2+]C=C(C(C)=N)N(c(c(cc(cc1)-c(cc2OCC)ccc2OCC)c1nc1)c1N1C)C1=O GRFCJZIHPOHZAL-UHFFFAOYSA-O 0.000 description 1
- AHOJCZFQXZGFMZ-UHFFFAOYSA-O C[NH2+]C=C(C(Cl)=N)N(c1c(cc(C2C=NC(OC)=C(COC)C2)cc2)c2ncc1N1C)C1=O Chemical compound C[NH2+]C=C(C(Cl)=N)N(c1c(cc(C2C=NC(OC)=C(COC)C2)cc2)c2ncc1N1C)C1=O AHOJCZFQXZGFMZ-UHFFFAOYSA-O 0.000 description 1
- DOAAPYLUVPPLPI-UHFFFAOYSA-N Cc1n[n](C)c(N(c(c2nc(-c3ccc(C)c(OC)c3)ccc2nc2)c2N2C)C2=O)c1 Chemical compound Cc1n[n](C)c(N(c(c2nc(-c3ccc(C)c(OC)c3)ccc2nc2)c2N2C)C2=O)c1 DOAAPYLUVPPLPI-UHFFFAOYSA-N 0.000 description 1
- PFEQWFLEEJGWPM-UHFFFAOYSA-N Cc1n[n](C)cc1N(C1c2cc(-c3cccc(S(N4CCCC4)=O)c3)ccc2N=CC1N1C)C1=O Chemical compound Cc1n[n](C)cc1N(C1c2cc(-c3cccc(S(N4CCCC4)=O)c3)ccc2N=CC1N1C)C1=O PFEQWFLEEJGWPM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18414109P | 2009-06-04 | 2009-06-04 | |
| US61/184,141 | 2009-06-04 | ||
| PCT/EP2010/057719 WO2010139731A1 (en) | 2009-06-04 | 2010-06-02 | 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20120034710A KR20120034710A (ko) | 2012-04-12 |
| KR101445458B1 true KR101445458B1 (ko) | 2014-10-07 |
Family
ID=42697442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127000098A Expired - Fee Related KR101445458B1 (ko) | 2009-06-04 | 2010-06-02 | １Ｈ-이미다조［４,５-ｃ］퀴놀리논 유도체 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US8476294B2 (enExample) |
| EP (1) | EP2438064A1 (enExample) |
| JP (1) | JP5596137B2 (enExample) |
| KR (1) | KR101445458B1 (enExample) |
| CN (1) | CN102574845B (enExample) |
| AR (1) | AR076949A1 (enExample) |
| AU (1) | AU2010255727B2 (enExample) |
| BR (1) | BRPI1010621A2 (enExample) |
| CA (1) | CA2763821A1 (enExample) |
| CL (1) | CL2011003052A1 (enExample) |
| CO (1) | CO6470887A2 (enExample) |
| CR (1) | CR20110608A (enExample) |
| CU (1) | CU24064B1 (enExample) |
| DO (1) | DOP2011000373A (enExample) |
| EA (1) | EA020715B1 (enExample) |
| EC (1) | ECSP11011500A (enExample) |
| GE (1) | GEP20156267B (enExample) |
| IL (1) | IL216452A0 (enExample) |
| MA (1) | MA33332B1 (enExample) |
| MX (1) | MX2011012943A (enExample) |
| NI (1) | NI201100209A (enExample) |
| NZ (1) | NZ596487A (enExample) |
| PE (1) | PE20120224A1 (enExample) |
| SG (1) | SG176572A1 (enExample) |
| TN (1) | TN2011000626A1 (enExample) |
| TW (1) | TWI464168B (enExample) |
| UA (1) | UA106074C2 (enExample) |
| UY (1) | UY32682A (enExample) |
| WO (1) | WO2010139731A1 (enExample) |
| ZA (1) | ZA201108439B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010035744A1 (de) * | 2010-08-28 | 2012-03-01 | Merck Patent Gmbh | Imidazolonylchinoline |
| US20130310374A1 (en) * | 2010-12-06 | 2013-11-21 | Piramal Enterprises Limited` | Substituted Imidazoquinoline Derivatives |
| JO3003B1 (ar) | 2011-01-14 | 2016-09-05 | Lilly Co Eli | مركب أيميدازو [4، 5 -c ] كينولين-2- واحد واستخدامه كمثبط كيناز PI3/mtor |
| WO2013071698A1 (zh) * | 2011-11-17 | 2013-05-23 | 山东轩竹医药科技有限公司 | 三环类PI3K和/或mTOR抑制剂 |
| WO2014141118A1 (en) * | 2013-03-14 | 2014-09-18 | Piramal Enterprises Limited | Imidazo[4,5-c]quinoline derivatives and uses thereof |
| CN105121411B (zh) | 2013-04-15 | 2017-10-10 | 杜邦公司 | 杀真菌酰胺 |
| JP6576929B2 (ja) * | 2013-09-11 | 2019-09-18 | メルク パテント ゲーエムベーハー | ヘテロ環化合物 |
| EP3053926B1 (en) | 2013-09-30 | 2018-08-08 | Shanghai Yingli Pharmaceutical Co. Ltd. | Fused pyrimidine compound, intermediate, preparation method therefor, and composition and application thereof |
| US10989719B2 (en) * | 2013-10-11 | 2021-04-27 | National University Corporation Tokyo Medical And Dental University | Methods for treating spinocerebellar ataxia type I using RPA1 |
| US10047084B2 (en) | 2013-11-20 | 2018-08-14 | Beijing Forelandpharma Co. Ltd. | Imidazolone derivatives, pharmaceutical compositions and uses thereof |
| NO2714752T3 (enExample) | 2014-05-08 | 2018-04-21 | ||
| CN106414429B (zh) | 2014-06-03 | 2020-01-03 | 爱杜西亚药品有限公司 | 吡唑化合物及其作为t型钙通道阻断剂的用途 |
| RS62082B1 (sr) | 2015-04-02 | 2021-08-31 | Merck Patent Gmbh | Imidazolonilhinolini i njihova primena kao inhibitora atm kinaze |
| GB201516504D0 (en) | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| GB201519568D0 (en) * | 2015-11-05 | 2015-12-23 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| CN110023312A (zh) | 2016-10-13 | 2019-07-16 | 由卫生与公众服务部部长代表的美利坚合众国 | 阻止疟疾寄生虫传播的化合物和方法 |
| MX388586B (es) | 2016-12-16 | 2025-03-20 | Idorsia Pharmaceuticals Ltd | Combinacion farmaceutica que comprende un bloqueador del canal de calcio de tipo t. |
| CA3050348A1 (en) | 2017-02-06 | 2018-08-09 | Idorsia Pharmaceuticals Ltd | A novel process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes |
| JOP20190209A1 (ar) * | 2017-03-16 | 2019-09-12 | Astrazeneca Ab | مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان |
| WO2019126731A1 (en) | 2017-12-22 | 2019-06-27 | Petra Pharma Corporation | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| KR20220068243A (ko) * | 2019-09-23 | 2022-05-25 | 난징 젱시앙 파마슈티칼스 컴퍼니 리미티드 | 포스포디에스테라제 억제제 및 용도 |
| EP4142710B1 (en) | 2020-09-21 | 2024-01-31 | Wei Zhong | Substituted 1-(3,3-difluoropiperidin-4-yl)-imidazo[4,5-c] quinolin-2-one compounds with blood-brain barrier penetrable capability |
| CN115136336A (zh) * | 2021-01-26 | 2022-09-30 | 京东方科技集团股份有限公司 | 量子点发光器件、显示装置和制作方法 |
| CN116768928A (zh) * | 2023-06-15 | 2023-09-19 | 上海毕臣生化科技有限公司 | 一种3-叔丁基-5-硼酸酯基吡啶的合成方法 |
| CN117384154A (zh) * | 2023-09-04 | 2024-01-12 | 广州医科大学 | 一种吡咯并喹啉酮化合物、合成方法及其应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003097641A2 (en) * | 2002-05-21 | 2003-11-27 | Novartis Ag | 1h-imidazo[4,5-c] quinoline derivatives in the treatment of protein kinase dependent diseases |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1687305E (pt) | 2003-11-21 | 2008-10-17 | Novartis Ag | Derivados de 1h-imidazoquinolina como inibidores de proteína quinase |
| AR046845A1 (es) | 2003-11-21 | 2005-12-28 | Novartis Ag | Derivados de 1h-imidazo[4,5-c]quinolina para tratamiento de enfermedades dependientes de las proteino-quinasas |
| CN101056877B (zh) | 2004-09-14 | 2010-06-09 | 诺华疫苗和诊断公司 | 咪唑并喹啉化合物 |
| GB0510390D0 (en) * | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| KR20080083270A (ko) | 2005-11-04 | 2008-09-17 | 콜레이 파마시티컬 그룹, 인코포레이티드 | 하이드록시 및 알콕시 치환된 1에이치 이미다조퀴놀린 및방법 |
| KR20140091718A (ko) | 2006-11-20 | 2014-07-22 | 노파르티스 아게 | 2-메틸-2-［4-(3-메틸-2-옥소-8-퀴놀린-3-일-2,3-디히드로-이미다조［4,5-ｃ］퀴놀린-1-일)-페닐］-프로피오니트릴의 염 및 결정 형태 |
| AU2008218806B2 (en) * | 2007-02-20 | 2011-12-01 | Novartis Ag | Imidazoquinolines as dual lipid kinase and mTOR inhibitors |
| PL2182948T3 (pl) * | 2007-07-24 | 2013-07-31 | Novartis Ag | Zastosowanie imidazochinolin do leczenia chorób EGFR-zależnych albo chorób wykazujących nabytą oporność wobec środków ukierunkowanych na członków rodziny EGFR |
| US20090082387A1 (en) | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched nvp-bez234 |
| KR20100126553A (ko) | 2008-03-26 | 2010-12-01 | 노파르티스 아게 | Ｖｅｇｆ-유도성 혈관신생 과정의 유력한 조절제로서의 이미다조퀴놀린 및 피리미딘 유도체 |
| US20110212053A1 (en) | 2008-06-19 | 2011-09-01 | Dapeng Qian | Phosphatidylinositol 3 kinase inhibitors |
| WO2010038165A1 (en) * | 2008-09-30 | 2010-04-08 | Pfizer Inc. | Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions |
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|---|---|---|---|---|
| WO2003097641A2 (en) * | 2002-05-21 | 2003-11-27 | Novartis Ag | 1h-imidazo[4,5-c] quinoline derivatives in the treatment of protein kinase dependent diseases |
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