KR101444090B1 - 이소프레노이드 변형 효소를 코드화하는 폴리뉴클레오티드및 그것의 사용방법 - Google Patents
이소프레노이드 변형 효소를 코드화하는 폴리뉴클레오티드및 그것의 사용방법 Download PDFInfo
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- KR101444090B1 KR101444090B1 KR1020087002992A KR20087002992A KR101444090B1 KR 101444090 B1 KR101444090 B1 KR 101444090B1 KR 1020087002992 A KR1020087002992 A KR 1020087002992A KR 20087002992 A KR20087002992 A KR 20087002992A KR 101444090 B1 KR101444090 B1 KR 101444090B1
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- Prior art keywords
- isoprenoid
- nucleic acid
- delete delete
- host cell
- nucleotide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
- C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
- C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69706705P | 2005-07-05 | 2005-07-05 | |
| US60/697,067 | 2005-07-05 | ||
| PCT/US2006/025572 WO2007005604A2 (en) | 2005-07-05 | 2006-06-29 | Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137011897A Division KR101487304B1 (ko) | 2005-07-05 | 2006-06-29 | 이소프레노이드 변형 효소를 코드화하는 폴리뉴클레오티드 및 그것의 사용방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20080031054A KR20080031054A (ko) | 2008-04-07 |
| KR101444090B1 true KR101444090B1 (ko) | 2014-09-26 |
Family
ID=37605033
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087002992A Active KR101444090B1 (ko) | 2005-07-05 | 2006-06-29 | 이소프레노이드 변형 효소를 코드화하는 폴리뉴클레오티드및 그것의 사용방법 |
| KR1020137011897A Active KR101487304B1 (ko) | 2005-07-05 | 2006-06-29 | 이소프레노이드 변형 효소를 코드화하는 폴리뉴클레오티드 및 그것의 사용방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137011897A Active KR101487304B1 (ko) | 2005-07-05 | 2006-06-29 | 이소프레노이드 변형 효소를 코드화하는 폴리뉴클레오티드 및 그것의 사용방법 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8163980B2 (enExample) |
| EP (2) | EP1919514B1 (enExample) |
| JP (1) | JP2009504138A (enExample) |
| KR (2) | KR101444090B1 (enExample) |
| CN (4) | CN103667370B (enExample) |
| AP (1) | AP3827A (enExample) |
| BR (1) | BRPI0612411B8 (enExample) |
| CA (1) | CA2613469C (enExample) |
| DK (1) | DK1919514T3 (enExample) |
| ES (2) | ES2386554T3 (enExample) |
| IL (1) | IL188376A (enExample) |
| MX (1) | MX2008000200A (enExample) |
| PL (1) | PL1919514T3 (enExample) |
| PT (1) | PT1919514E (enExample) |
| SG (1) | SG176459A1 (enExample) |
| SI (1) | SI1919514T1 (enExample) |
| WO (1) | WO2007005604A2 (enExample) |
| ZA (1) | ZA200800889B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006014837A1 (en) * | 2004-07-27 | 2006-02-09 | The Regents Of The University Of California | Genetically modified host cells and use of same for producing isoprenoid compounds |
| EP1919514B1 (en) * | 2005-07-05 | 2012-05-16 | The Regents of the University of California | Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof |
| EP2024504B2 (en) | 2006-05-26 | 2022-12-14 | Amyris, Inc. | Production of isoprenoids |
| DK3020799T3 (da) | 2006-09-26 | 2020-09-21 | Amyris Biotechnologies Inc | Fremstilling af isoprenoider og isoprenoid-prækursorer |
| CN101835901B (zh) | 2007-06-01 | 2013-03-06 | 蓝宝石能源公司 | 遗传修饰的光合生物的高通量筛选 |
| EP2203542A1 (en) | 2007-09-11 | 2010-07-07 | Sapphire Energy, Inc. | Methods of producing organic products with photosynthetic organisms and products and compositions thereof |
| EP2444415A1 (en) * | 2010-10-20 | 2012-04-25 | Genoplante-Valor | 1-Deoxy-D-xylulose 5-phosphate synthase alleles responsible for enhanced terpene biosynthesis |
| JP5993019B2 (ja) * | 2011-11-01 | 2016-09-14 | フイルメニツヒ ソシエテ アノニムFirmenich Sa | シトクロムp450及びテルペンの酵素的酸化のためのそれらの使用 |
| JP5827601B2 (ja) * | 2012-07-04 | 2015-12-02 | 住友ゴム工業株式会社 | 特定の蛋白質の発現を光応答転写因子により調整する方法、光応答転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法 |
| HK1207097A1 (en) * | 2012-09-07 | 2016-01-22 | Sanofi | Fusion proteins for treating a metabolic syndrome |
| PL224377B1 (pl) * | 2012-11-02 | 2016-12-30 | Inst Biochemii I Biofizyki Polskiej Akademii Nauk | Szczep Trichoderma atroviride, sposób otrzymywania i zastosowanie szczepu Trichoderma atroviride jako środka biobójczego |
| CA2924541A1 (en) * | 2013-09-19 | 2015-03-26 | Firmenich Sa | Method for producing fragrant alcohols |
| JP6475336B2 (ja) * | 2014-08-21 | 2019-02-27 | チュン−アン ユニヴァーシティ インダストリー−アカデミー コーポレーション ファウンデーションChung−Ang University Industry−Academy Cooperation Foundation | rDNA NTS基盤の遺伝子多重挿入カセットセット、及びそれを用いたGRAS等級の組換え酵母菌株 |
| US11697830B2 (en) * | 2015-04-15 | 2023-07-11 | Ramon Gonzalez | Iterative platform for the synthesis of alpha functionalized products |
| WO2016168681A1 (en) * | 2015-04-15 | 2016-10-20 | William Marsh Rice University | Iterative platform for the synthesis of alpha functionalized products |
| CN105274109B (zh) * | 2015-10-30 | 2017-12-29 | 上海交通大学 | 一种调控基因在非分泌型腺毛中表达的启动子及其应用 |
| CN105177007B (zh) * | 2015-10-30 | 2017-11-10 | 上海交通大学 | 一种调控基因在非分泌型腺毛中表达的启动子及其应用 |
| CN105483236A (zh) * | 2015-12-26 | 2016-04-13 | 吉林省农业科学院 | 转基因植物中cry1C基因的LAMP检测引物组、试剂盒及检测方法 |
| CN105567685B (zh) * | 2016-01-18 | 2018-07-13 | 上海交通大学 | AaPDR3基因启动子及其应用 |
| US10787674B2 (en) * | 2016-09-20 | 2020-09-29 | 22Nd Century Limited, Llc | Trichome specific promoters for the manipulation of cannabinoids and other compounds in grandular trichomes |
| WO2018111194A1 (en) * | 2016-12-16 | 2018-06-21 | Temasek Life Sciences Laboratory Limited | Targets for improving terpene production in rhodosporidium toruloides |
| MX2019011323A (es) | 2017-03-24 | 2020-01-27 | Trait Biosciences Inc | Biosintesis y aislamiento in vivo de alto nivel de cannabinoides solubles en agua en sistemas de plantas. |
| US11905543B2 (en) | 2017-07-11 | 2024-02-20 | Trait Biosceinces, Inc. | In vivo generation of water-soluble acetylated cannabinoid glycoside compounds in plant cell suspension cultures |
| CN111465700A (zh) | 2017-07-11 | 2020-07-28 | 特征生物科学公司 | 在酵母和植物细胞悬浮培养物中产生水溶性大麻素化合物和材料组合物 |
| US11946059B2 (en) | 2017-07-11 | 2024-04-02 | Trait Biosciences, Inc. | In vivo generation of water-soluble cannabinoids in plant cell suspension cultures |
| CN113302298B (zh) | 2018-11-09 | 2025-02-25 | 银杏生物制品公司 | 罗汉果甙的生物合成 |
| US20230066313A1 (en) * | 2020-01-23 | 2023-03-02 | Amyris, Inc. | Amorpha-4,11-diene 12-monooxygenase variants and uses thereof |
| CN111621508B (zh) * | 2020-06-11 | 2022-07-01 | 云南中烟工业有限责任公司 | 烟草萜类合成酶NtTPS7基因及其载体与应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998059042A1 (en) | 1997-06-24 | 1998-12-30 | Washington State University Research Foundation | Recombinant materials and methods for the production of limonene hydroxylases |
| US20040162420A1 (en) | 2002-10-16 | 2004-08-19 | U.S. Smokeless Tobacco Company | Cloning of cytochrome p450 genes from nicotiana |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5451513A (en) | 1990-05-01 | 1995-09-19 | The State University of New Jersey Rutgers | Method for stably transforming plastids of multicellular plants |
| NZ249808A (en) * | 1992-03-27 | 1996-09-25 | Int Flower Dev Pty Ltd | Genetic sequence encoding flavonoid pathway enzymes and their uses |
| FR2689905B1 (fr) * | 1992-04-13 | 1995-07-13 | Orsan | Procede de clonage d'une sequence d'adn codant pour une nadph cytochrome p450 reductase et sequences d'adn codant pour une nadph-cytochrome p450 reductase, notamment de plantes. |
| US5576198A (en) | 1993-12-14 | 1996-11-19 | Calgene, Inc. | Controlled expression of transgenic constructs in plant plastids |
| US5545818A (en) | 1994-03-11 | 1996-08-13 | Calgene Inc. | Expression of Bacillus thuringiensis cry proteins in plant plastids |
| US5545817A (en) | 1994-03-11 | 1996-08-13 | Calgene, Inc. | Enhanced expression in a plant plastid |
| DK0796341T3 (da) | 1994-12-09 | 1999-06-14 | Imp College Innovations Ltd | Identifikation af gener, som tillader tilpasning af en mikroorganisme til en særlig omgivelse |
| AR011182A1 (es) * | 1997-03-07 | 2000-08-02 | Syngenta Participations Ag | Molecula de adn, monooxigenasa de citocromo p450, codificada por dicha molecula, un metodo para el aislamiento de una molecula de adnc, un metodo parala produccion de una monooxigenasa de citocromo p450 recombinante purificada, una planta transgenica, un metodo para obtener dicha planta, el uso de d |
| US6900012B1 (en) | 1997-06-03 | 2005-05-31 | The University Of Chicago | Plant artificial chromosome compositions and methods |
| US6080849A (en) | 1997-09-10 | 2000-06-27 | Vion Pharmaceuticals, Inc. | Genetically modified tumor-targeted bacteria with reduced virulence |
| EP0982404A1 (en) * | 1998-08-27 | 2000-03-01 | Wallaart, Thorvald Eelco | DNA encoding amorpha-4,11-diene synthase |
| US6645747B1 (en) | 1999-09-21 | 2003-11-11 | E. I. Du Pont De Nemours And Company | Cis-prenyltransferases from plants |
| US6369212B1 (en) | 2000-02-07 | 2002-04-09 | Korea Kumbo Petrochemical Co., Ltd. | Cytochrome P450 gene highly expressed in the incompatible interaction |
| WO2002053746A1 (fr) * | 2000-12-28 | 2002-07-11 | Toyota Jidosha Kabushiki Kaisha | Procédé de production d'alcool prényle |
| GB0105924D0 (en) | 2001-03-09 | 2001-04-25 | Microscience Ltd | Promoter |
| ATE513046T1 (de) | 2001-03-09 | 2011-07-15 | Univ Kentucky Res Found | Cytochrom p450s und verwendungen davon |
| AUPR446701A0 (en) * | 2001-04-18 | 2001-05-17 | Gene Stream Pty Ltd | Transgenic mammals for pharmacological and toxicological studies |
| US7214507B2 (en) * | 2001-09-17 | 2007-05-08 | Plant Research International B.V. | Plant enzymes for bioconversion |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| US7192751B2 (en) * | 2001-12-06 | 2007-03-20 | The Regents Of The University Of California | Biosynthesis of amorpha-4,11-diene |
| US6733996B2 (en) | 2002-08-26 | 2004-05-11 | Trustees Of Dartmouth College | Methods for regulating gene expression using light |
| EP1919514B1 (en) * | 2005-07-05 | 2012-05-16 | The Regents of the University of California | Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof |
| CA2630305A1 (en) * | 2005-10-24 | 2007-05-03 | National Research Council Of Canada | A novel gene encoding amorphadiene hydroxylase and a process to produce artemisinic alcohol therewith |
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2006
- 2006-06-29 EP EP06785959A patent/EP1919514B1/en active Active
- 2006-06-29 ES ES06785959T patent/ES2386554T3/es active Active
- 2006-06-29 KR KR1020087002992A patent/KR101444090B1/ko active Active
- 2006-06-29 CA CA2613469A patent/CA2613469C/en active Active
- 2006-06-29 KR KR1020137011897A patent/KR101487304B1/ko active Active
- 2006-06-29 PL PL06785959T patent/PL1919514T3/pl unknown
- 2006-06-29 AP AP2013006962A patent/AP3827A/en active
- 2006-06-29 CN CN201310335874.8A patent/CN103667370B/zh active Active
- 2006-06-29 SI SI200631367T patent/SI1919514T1/sl unknown
- 2006-06-29 CN CN2006800246664A patent/CN101495499B/zh active Active
- 2006-06-29 BR BRPI0612411A patent/BRPI0612411B8/pt active IP Right Grant
- 2006-06-29 DK DK06785959.5T patent/DK1919514T3/da active
- 2006-06-29 CN CN201710271576.5A patent/CN106939323B/zh active Active
- 2006-06-29 MX MX2008000200A patent/MX2008000200A/es active IP Right Grant
- 2006-06-29 US US11/917,875 patent/US8163980B2/en active Active
- 2006-06-29 ZA ZA200800889A patent/ZA200800889B/xx unknown
- 2006-06-29 SG SG2011081403A patent/SG176459A1/en unknown
- 2006-06-29 PT PT06785959T patent/PT1919514E/pt unknown
- 2006-06-29 CN CN201610412819.8A patent/CN105950667A/zh active Pending
- 2006-06-29 ES ES12158465.0T patent/ES2621657T3/es active Active
- 2006-06-29 JP JP2008519611A patent/JP2009504138A/ja not_active Withdrawn
- 2006-06-29 WO PCT/US2006/025572 patent/WO2007005604A2/en not_active Ceased
- 2006-06-29 EP EP12158465.0A patent/EP2489672B1/en active Active
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2007
- 2007-12-24 IL IL188376A patent/IL188376A/en active IP Right Grant
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2012
- 2012-03-21 US US13/426,387 patent/US8759632B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998059042A1 (en) | 1997-06-24 | 1998-12-30 | Washington State University Research Foundation | Recombinant materials and methods for the production of limonene hydroxylases |
| US20040162420A1 (en) | 2002-10-16 | 2004-08-19 | U.S. Smokeless Tobacco Company | Cloning of cytochrome p450 genes from nicotiana |
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