KR101431843B1 - 생체인식 분자에 접합된 마이크로비드를 사용하여 병원체를검출하는 방법 - Google Patents

생체인식 분자에 접합된 마이크로비드를 사용하여 병원체를검출하는 방법 Download PDF

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KR101431843B1
KR101431843B1 KR1020087022364A KR20087022364A KR101431843B1 KR 101431843 B1 KR101431843 B1 KR 101431843B1 KR 1020087022364 A KR1020087022364 A KR 1020087022364A KR 20087022364 A KR20087022364 A KR 20087022364A KR 101431843 B1 KR101431843 B1 KR 101431843B1
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pathogen
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detection
host
pathogens
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KR20090003220A (ko
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마이클 모르딘손 그린버그
워렌 체 워 찬
케빈 찰스 카인
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피오 코포레이션
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KR1020087022364A 2006-02-15 2007-02-13 생체인식 분자에 접합된 마이크로비드를 사용하여 병원체를검출하는 방법 Expired - Fee Related KR101431843B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CA002536698A CA2536698A1 (en) 2006-02-15 2006-02-15 System and method of detecting, identifying and characterizing pathogensand characterizing hosts
CA2,536,698 2006-02-15
CA002571904A CA2571904A1 (en) 2006-02-15 2006-12-19 System and method of detecting pathogens
CA2,571,904 2006-12-19
PCT/CA2007/000211 WO2007093043A1 (en) 2006-02-15 2007-02-13 Method for detecting pathogens using microbeads conjugated to biorecognition molecules

Related Child Applications (1)

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KR1020147000928A Division KR101518765B1 (ko) 2006-02-15 2007-02-13 생체인식 분자에 접합된 마이크로비드를 사용하여 병원체를 검출하는 방법

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Publication Number Publication Date
KR20090003220A KR20090003220A (ko) 2009-01-09
KR101431843B1 true KR101431843B1 (ko) 2014-08-25

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KR1020087022364A Expired - Fee Related KR101431843B1 (ko) 2006-02-15 2007-02-13 생체인식 분자에 접합된 마이크로비드를 사용하여 병원체를검출하는 방법
KR1020147000928A Expired - Fee Related KR101518765B1 (ko) 2006-02-15 2007-02-13 생체인식 분자에 접합된 마이크로비드를 사용하여 병원체를 검출하는 방법

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US (2) US20100021937A1 (https=)
EP (1) EP1994166A4 (https=)
JP (1) JP5114432B2 (https=)
KR (2) KR101431843B1 (https=)
BR (1) BRPI0708468A2 (https=)
CA (2) CA2571904A1 (https=)
MX (1) MX2008010541A (https=)
WO (1) WO2007093043A1 (https=)
ZA (1) ZA200807871B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
JP5507454B2 (ja) * 2007-07-09 2014-05-28 フィオ コーポレイション 試験サンプル中の標的分子の蛍光検出の向上のためのシステムおよび方法
CN102024090A (zh) * 2009-09-14 2011-04-20 深圳市嘉实特科技有限公司 一种乙肝指标数据处理装置、检测设备及检测系统
US20120035279A1 (en) * 2010-08-06 2012-02-09 Miller Jeffrey E Protocol for screening travelers
GB2500168A (en) * 2012-01-14 2013-09-18 Cosmos Wathingira Ngumi A cleaning device for identifying microscopic objects
EP2831577B1 (en) * 2012-03-28 2018-08-08 Purdue Research Foundation Methods and systems useful for foodborne pathogen detection
KR101836075B1 (ko) * 2013-12-27 2018-03-08 가부시키가이샤 아이피 솔루션즈 정보 입력 보조 시트
EP3213081A4 (en) * 2014-10-30 2018-08-15 Sightline Innovation Inc. System, method and apparatus for pathogen detection
US10185807B2 (en) * 2014-11-18 2019-01-22 Mastercard International Incorporated System and method for conducting real time active surveillance of disease outbreak
ES2876039T3 (es) 2015-11-10 2021-11-11 Illumina Inc Generación inercial de gotitas y encapsulación de partículas
US10132752B2 (en) 2017-01-27 2018-11-20 The United States Of America, As Represented By The Secretary Of The Navy Hand-held laser biosensor
US11328826B2 (en) 2018-06-12 2022-05-10 Clarius Mobile Health Corp. System architecture for improved storage of electronic health information, and related methods
CN110489586A (zh) * 2019-01-07 2019-11-22 公安部第一研究所 一种样品检测数据库分级匹配的方法
CN111307826B (zh) * 2020-03-03 2023-03-31 桂林电子科技大学 一种瓶内粉末中异物在线视觉检测设备及方法
US10991185B1 (en) 2020-07-20 2021-04-27 Abbott Laboratories Digital pass verification systems and methods
WO2024227081A1 (en) * 2023-04-27 2024-10-31 S D Systems, Inc. Systems, methods, and compositions for the detection of microbes
KR20250132854A (ko) * 2024-02-29 2025-09-05 고려대학교 산학협력단 타겟과 결합된 아이디-마이크로파티클를 이용한 병렬 약물스크리닝 방법
CN121384916B (zh) * 2025-12-26 2026-04-10 首都医科大学附属北京中医医院 基于光谱的呼吸道分泌物中感染标志物检测方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020164271A1 (en) 2001-05-02 2002-11-07 Ho Winston Z. Wavelength-coded bead for bioassay and signature recogniton
WO2003003015A2 (en) * 2001-06-28 2003-01-09 Advanced Research And Technology Institute, Inc. Methods of preparing multicolor quantum dot tagged beads and conjugates thereof

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244630A (en) * 1988-04-22 1993-09-14 Abbott Laboratories Device for performing solid-phase diagnostic assay
ES2066851T3 (es) * 1988-05-24 1995-03-16 Anagen Uk Ltd Particulas atraibles magneticamente y metodo de preparacion.
US5120662A (en) * 1989-05-09 1992-06-09 Abbott Laboratories Multilayer solid phase immunoassay support and method of use
US5824506A (en) * 1994-08-15 1998-10-20 Genelabs Diagnostics Pte. Ltd. Dengue virus peptides and methods
US6103379A (en) * 1994-10-06 2000-08-15 Bar-Ilan University Process for the preparation of microspheres and microspheres made thereby
US6340588B1 (en) * 1995-04-25 2002-01-22 Discovery Partners International, Inc. Matrices with memories
US6022500A (en) * 1995-09-27 2000-02-08 The United States Of America As Represented By The Secretary Of The Army Polymer encapsulation and polymer microsphere composites
WO1997014028A2 (en) * 1995-10-11 1997-04-17 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5837442A (en) * 1995-11-29 1998-11-17 Roche Molecular Systems, Inc. Oligonucleotide primers for amplifying HCV nucleic acid
US5885470A (en) * 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US6405936B1 (en) * 1996-05-13 2002-06-18 Universidad De Sevilla Stabilized capillary microjet and devices and methods for producing same
US6197835B1 (en) * 1996-05-13 2001-03-06 Universidad De Sevilla Device and method for creating spherical particles of uniform size
ES2140998B1 (es) * 1996-05-13 2000-10-16 Univ Sevilla Procedimiento de atomizacion de liquidos.
US5800690A (en) * 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US5714390A (en) * 1996-10-15 1998-02-03 Bio-Tech Imaging, Inc. Cartridge test system for the collection and testing of blood in a single step
US5817458A (en) * 1996-10-15 1998-10-06 The Avriel Group, Amcas Division Inc. Reagent system for detecting HIV-infected peripheral blood lymphocytes in whole blood
US5786219A (en) * 1996-10-28 1998-07-28 Molecular Probes, Inc. Microspheres with fluorescent spherical zones
US5959291A (en) * 1997-06-27 1999-09-28 Caliper Technologies Corporation Method and apparatus for measuring low power signals
US6066243A (en) * 1997-07-22 2000-05-23 Diametrics Medical, Inc. Portable immediate response medical analyzer having multiple testing modules
EP0919568A1 (en) * 1997-12-01 1999-06-02 Sorin Diagnostics S.r.l. Escape mutant of the surface antigen of hepatitis B virus
EP1044370B1 (en) * 1997-12-30 2017-08-23 Caliper Life Sciences, Inc. Software for the display of chromatographic separation data
WO1999036564A1 (en) * 1998-01-16 1999-07-22 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US6100541A (en) * 1998-02-24 2000-08-08 Caliper Technologies Corporation Microfluidic devices and systems incorporating integrated optical elements
US20020081729A1 (en) * 1998-03-27 2002-06-27 Martin C. Peters Controlled release of tissue culture supplements
CA2268997C (en) * 1998-05-05 2005-03-22 National Research Council Of Canada Quantum dot infrared photodetectors (qdip) and methods of making the same
JP4215397B2 (ja) * 1998-05-14 2009-01-28 ルミネックス コーポレイション 多重分析物診断システム
US6617583B1 (en) * 1998-09-18 2003-09-09 Massachusetts Institute Of Technology Inventory control
US7079241B2 (en) * 2000-04-06 2006-07-18 Invitrogen Corp. Spatial positioning of spectrally labeled beads
EP1115888B1 (en) * 1998-09-24 2008-03-12 Indiana University Research and Technology Corporation Water-soluble luminescent quantum dots and bioconjugates thereof
US6319607B1 (en) * 1998-11-10 2001-11-20 Bio-Pixels Ltd. Purification of functionalized fluorescent nanocrystals
US6114038A (en) * 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
US6576155B1 (en) * 1998-11-10 2003-06-10 Biocrystal, Ltd. Fluorescent ink compositions comprising functionalized fluorescent nanocrystals
US6309701B1 (en) * 1998-11-10 2001-10-30 Bio-Pixels Ltd. Fluorescent nanocrystal-labeled microspheres for fluorescence analyses
US6333110B1 (en) * 1998-11-10 2001-12-25 Bio-Pixels Ltd. Functionalized nanocrystals as visual tissue-specific imaging agents, and methods for fluorescence imaging
US6261779B1 (en) * 1998-11-10 2001-07-17 Bio-Pixels Ltd. Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system
WO2000028598A1 (en) * 1998-11-10 2000-05-18 Biocrystal Limited Methods for identification and verification
GB9827748D0 (en) * 1998-12-18 1999-02-10 Secr Defence Improvements in avalanche photo-diodes
CA2359039A1 (en) * 1999-01-29 2000-08-03 Toshio Miyata Meg-4 protein
ATE556149T1 (de) * 1999-02-23 2012-05-15 Caliper Life Sciences Inc Manipulation von mikropartikeln in mikrofluidischen systemen
US20010055764A1 (en) * 1999-05-07 2001-12-27 Empedocles Stephen A. Microarray methods utilizing semiconductor nanocrystals
AU4701200A (en) * 1999-05-07 2000-11-21 Quantum Dot Corporation A method of detecting an analyte using semiconductor nanocrystals
JP3815969B2 (ja) * 1999-05-12 2006-08-30 アクララ バイオサイエンシーズ， インコーポレイテッド 微量流体デバイスにおける多重方式蛍光検出
EP1179087B1 (en) * 1999-05-17 2019-03-27 Caliper Life Sciences, Inc. Focusing of microparticles in microfluidic systems
US6592821B1 (en) * 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US20020051971A1 (en) * 1999-05-21 2002-05-02 John R. Stuelpnagel Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6353475B1 (en) * 1999-07-12 2002-03-05 Caliper Technologies Corp. Light source power modulation for use with chemical and biochemical analysis
WO2001013119A1 (en) * 1999-08-17 2001-02-22 Luminex Corporation Encapsulation of fluorescent particles
US7037416B2 (en) * 2000-01-14 2006-05-02 Caliper Life Sciences, Inc. Method for monitoring flow rate using fluorescent markers
US20020009728A1 (en) * 2000-01-18 2002-01-24 Quantum Dot Corporation Oligonucleotide-tagged semiconductor nanocrystals for microarray and fluorescence in situ hybridization
US20030099940A1 (en) * 2000-02-16 2003-05-29 Empedocles Stephen A. Single target counting assays using semiconductor nanocrystals
JP2004500109A (ja) * 2000-03-22 2004-01-08 クァンタム・ドット・コーポレイション ビーズベースの核酸アッセイにおける半導体ナノクリスタルの使用方法
WO2001078087A2 (en) * 2000-04-06 2001-10-18 Luminex Corporation Magnetically-responsive microspheres
US6548264B1 (en) * 2000-05-17 2003-04-15 University Of Florida Coated nanoparticles
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US6494830B1 (en) * 2000-06-22 2002-12-17 Guidance Interactive Technologies, Inc. Handheld controller for monitoring/using medical parameters
JP2002000271A (ja) * 2000-06-28 2002-01-08 Sanyo Electric Co Ltd 微生物分析システム及び方法並びにデータベース
WO2002007064A2 (en) * 2000-07-17 2002-01-24 Labnetics, Inc. Method and apparatus for the processing of remotely collected electronic information characterizing properties of biological entities
US20020182609A1 (en) * 2000-08-16 2002-12-05 Luminex Corporation Microsphere based oligonucleotide ligation assays, kits, and methods of use, including high-throughput genotyping
US20020048425A1 (en) * 2000-09-20 2002-04-25 Sarnoff Corporation Microfluidic optical electrohydrodynamic switch
JP2004510678A (ja) * 2000-10-04 2004-04-08 ザ　ボード　オブ　トラスティーズ　オブ　ザ　ユニバーシティ　オブ　アーカンソー コロイドナノ結晶の合成
US6649138B2 (en) * 2000-10-13 2003-11-18 Quantum Dot Corporation Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
US6937323B2 (en) * 2000-11-08 2005-08-30 Burstein Technologies, Inc. Interactive system for analyzing biological samples and processing related information and the use thereof
US6573128B1 (en) * 2000-11-28 2003-06-03 Cree, Inc. Epitaxial edge termination for silicon carbide Schottky devices and methods of fabricating silicon carbide devices incorporating same
US20020083888A1 (en) * 2000-12-28 2002-07-04 Zehnder Donald A. Flow synthesis of quantum dot nanocrystals
AU2002309528A1 (en) * 2001-04-02 2002-10-15 Therasense, Inc. Blood glucose tracking apparatus and methods
JP2002311027A (ja) * 2001-04-09 2002-10-23 Hitachi Software Eng Co Ltd ビーズ、ビーズ製造方法、フローサイトメータ及びプログラム
US7319012B2 (en) * 2001-05-30 2008-01-15 Gene Therapy Systems, Inc. Protein arrays and methods and systems for producing the same
US6845327B2 (en) * 2001-06-08 2005-01-18 Epocal Inc. Point-of-care in-vitro blood analysis system
US6905885B2 (en) * 2001-06-12 2005-06-14 The Regents Of The University Of California Portable pathogen detection system
US7044911B2 (en) * 2001-06-29 2006-05-16 Philometron, Inc. Gateway platform for biological monitoring and delivery of therapeutic compounds
JP4567436B2 (ja) * 2001-07-20 2010-10-20 ライフ テクノロジーズ コーポレーション 発光ナノ粒子およびそれらの調製方法
US7060227B2 (en) * 2001-08-06 2006-06-13 Sau Lan Tang Staats Microfluidic devices with raised walls
DK2184346T3 (en) * 2001-09-06 2017-06-26 Rapid Micro Biosystems Inc Rapid detection of replicating cells
US7214428B2 (en) * 2001-09-17 2007-05-08 Invitrogen Corporation Highly luminescent functionalized semiconductor nanocrystals for biological and physical applications
US7195913B2 (en) * 2001-10-05 2007-03-27 Surmodics, Inc. Randomly ordered arrays and methods of making and using
US7312071B2 (en) * 2001-12-06 2007-12-25 Arbor Vita Corporation Effective monitoring system for anthrax smallpox, or other pathogens
US7457731B2 (en) * 2001-12-14 2008-11-25 Siemens Medical Solutions Usa, Inc. Early detection of disease outbreak using electronic patient data to reduce public health threat from bio-terrorism
WO2003057011A2 (en) * 2002-01-04 2003-07-17 Canswers Llc Systems and methods for predicting disease behavior
US7689899B2 (en) * 2002-03-06 2010-03-30 Ge Corporate Financial Services, Inc. Methods and systems for generating documents
US20030194350A1 (en) * 2002-04-11 2003-10-16 Siemens Information And Communication Networks Public health threat surveillance system
US20050227252A1 (en) * 2002-08-20 2005-10-13 Moon John A Diffraction grating-based encoded articles for multiplexed experiments
JP4073323B2 (ja) * 2003-01-23 2008-04-09 日立ソフトウエアエンジニアリング株式会社 機能性ビーズ、その読み取り方法および読み取り装置
US20050014134A1 (en) * 2003-03-06 2005-01-20 West Jason Andrew Appleton Viral identification by generation and detection of protein signatures
CA2534402C (en) * 2003-08-04 2013-06-25 Emory University Porous materials embedded with nanospecies, methods of fabrication thereof, and methods of use thereof
US8346482B2 (en) * 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
US20060292039A1 (en) * 2003-09-05 2006-12-28 Kazuhiro Iida Measuring system
EP1711517A4 (en) * 2004-01-21 2008-02-13 Univ Utah Res Found MUTANT NAv1.7 SODIUM CHANNEL AND ASSOCIATED METHODS
JP2008514955A (ja) * 2004-09-28 2008-05-08 シンギュレックス・インコーポレイテッド サンプル分析システムおよび方法
WO2006058334A2 (en) * 2004-11-29 2006-06-01 Perkinelmer Life And Analytical Sciences Prticle-based multiplex assay for identifying glycosylation
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020164271A1 (en) 2001-05-02 2002-11-07 Ho Winston Z. Wavelength-coded bead for bioassay and signature recogniton
WO2003003015A2 (en) * 2001-06-28 2003-01-09 Advanced Research And Technology Institute, Inc. Methods of preparing multicolor quantum dot tagged beads and conjugates thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Lab on a Chip, 5권,11호, 1327-30면(2005.11.) *

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