CA2571904A1 - System and method of detecting pathogens - Google Patents

System and method of detecting pathogens Download PDF

Info

Publication number
CA2571904A1
CA2571904A1 CA002571904A CA2571904A CA2571904A1 CA 2571904 A1 CA2571904 A1 CA 2571904A1 CA 002571904 A CA002571904 A CA 002571904A CA 2571904 A CA2571904 A CA 2571904A CA 2571904 A1 CA2571904 A1 CA 2571904A1
Authority
CA
Canada
Prior art keywords
pathogen
sample
detection
pathogens
host
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002571904A
Other languages
English (en)
French (fr)
Inventor
Michael Mordinson Greenberg
Kevin Charles Kain
Warren Che Wor Chan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FIO Corp
Original Assignee
FIO Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002536698A external-priority patent/CA2536698A1/en
Application filed by FIO Corp filed Critical FIO Corp
Priority to CA002571904A priority Critical patent/CA2571904A1/en
Priority to PCT/CA2007/000211 priority patent/WO2007093043A1/en
Priority to JP2008554569A priority patent/JP5114432B2/ja
Priority to CN2007800056984A priority patent/CN101384725B/zh
Priority to HK09108325.0A priority patent/HK1128735B/xx
Priority to CA002636489A priority patent/CA2636489C/en
Priority to KR1020087022364A priority patent/KR101431843B1/ko
Priority to US12/279,639 priority patent/US20100021937A1/en
Priority to KR1020147000928A priority patent/KR101518765B1/ko
Priority to MX2008010541A priority patent/MX2008010541A/es
Priority to EP07719377A priority patent/EP1994166A4/en
Priority to BRPI0708468-4A priority patent/BRPI0708468A2/pt
Priority to CA2580589A priority patent/CA2580589C/en
Publication of CA2571904A1 publication Critical patent/CA2571904A1/en
Priority to CA2668779A priority patent/CA2668779C/en
Priority to CN200780051507.8A priority patent/CN101680893B/zh
Priority to PCT/CA2007/002317 priority patent/WO2008074146A1/en
Priority to US12/520,295 priority patent/US9360476B2/en
Priority to JP2009541715A priority patent/JP5680303B2/ja
Priority to BRPI0720707-7A2A priority patent/BRPI0720707A2/pt
Priority to EP07855599A priority patent/EP2115471A4/en
Priority to ZA2008/07871A priority patent/ZA200807871B/en
Priority to ZA200904969A priority patent/ZA200904969B/xx
Priority to US15/184,519 priority patent/US20160299137A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6489Photoluminescence of semiconductors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00Information retrieval; Database structures therefor; File system structures therefor
    • G06F16/20Information retrieval; Database structures therefor; File system structures therefor of structured data, e.g. relational data
    • G06F16/29Geographical information databases
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16ZINFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR
    • G16Z99/00Subject matter not provided for in other main groups of this subclass
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04WWIRELESS COMMUNICATION NETWORKS
    • H04W4/00Services specially adapted for wireless communication networks; Facilities therefor
    • H04W4/02Services making use of location information
    • H04W4/021Services related to particular areas, e.g. point of interest [POI] services, venue services or geofences
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/02Identification, exchange or storage of information
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/02Identification, exchange or storage of information
    • B01L2300/025Displaying results or values with integrated means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Databases & Information Systems (AREA)
  • Organic Chemistry (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Data Mining & Analysis (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Signal Processing (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
CA002571904A 2006-02-15 2006-12-19 System and method of detecting pathogens Abandoned CA2571904A1 (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
CA002571904A CA2571904A1 (en) 2006-02-15 2006-12-19 System and method of detecting pathogens
BRPI0708468-4A BRPI0708468A2 (pt) 2006-02-15 2007-02-13 método de detecção de patógenos utilizando micropérolas conjugadas com moléculas de bioreconhecimento
MX2008010541A MX2008010541A (es) 2006-02-15 2007-02-13 Metodo para detectar patogenos utilizando microgranulos conjugados a moleculas de biorreconocimiento.
EP07719377A EP1994166A4 (en) 2006-02-15 2007-02-13 METHOD FOR DETECTING DISEASES OF DISEASES USING MICRO BEAM CONJUGATED TO BIO-IDENTIFICATION MOLECULES
JP2008554569A JP5114432B2 (ja) 2006-02-15 2007-02-13 生体物質認識分子に結合したマイクロビーズを用いた病原体検出システム及び方法
CN2007800056984A CN101384725B (zh) 2006-02-15 2007-02-13 检测病原体的系统
HK09108325.0A HK1128735B (en) 2006-02-15 2007-02-13 A system for detecting pathogens
CA002636489A CA2636489C (en) 2006-02-15 2007-02-13 System and method of detecting pathogens
KR1020087022364A KR101431843B1 (ko) 2006-02-15 2007-02-13 생체인식 분자에 접합된 마이크로비드를 사용하여 병원체를검출하는 방법
US12/279,639 US20100021937A1 (en) 2006-02-15 2007-02-13 Method for detecting pathogens using microbeads conjugated to biorecognition molecules
KR1020147000928A KR101518765B1 (ko) 2006-02-15 2007-02-13 생체인식 분자에 접합된 마이크로비드를 사용하여 병원체를 검출하는 방법
PCT/CA2007/000211 WO2007093043A1 (en) 2006-02-15 2007-02-13 Method for detecting pathogens using microbeads conjugated to biorecognition molecules
CA2580589A CA2580589C (en) 2006-12-19 2007-03-02 Microfluidic detection system
CA2668779A CA2668779C (en) 2006-12-19 2007-12-19 Microfluidic system and method to test for target molecules in a biological sample
EP07855599A EP2115471A4 (en) 2006-12-19 2007-12-19 MICROFLUIDIC SYSTEM AND METHOD FOR TESTING TARGET MOLECULES IN A BIOLOGICAL SAMPLE
BRPI0720707-7A2A BRPI0720707A2 (pt) 2006-12-19 2007-12-19 Sistema de teste para uso com um tampão para testar a presença de moléculas alvo de um ou mais tipos de alvo em uma amostra de teste biológico; sistema de teste para testar a presença de moléculas alvo de um ou mais tipos de alvo em uma amostra de teste biológico; e método de focalização de moléculas para facilitar um teste da presença de moléculas alvo de um ou mais tipos de alvo de uma amostra de teste biológico.
CN200780051507.8A CN101680893B (zh) 2006-12-19 2007-12-19 用于测试生物样本中的目标分子的微观流体系统和方法
PCT/CA2007/002317 WO2008074146A1 (en) 2006-12-19 2007-12-19 Microfluidic system and method to test for target molecules in a biological sample
US12/520,295 US9360476B2 (en) 2006-12-19 2007-12-19 Microfluidic system and method to test for target molecules in a biological sample
JP2009541715A JP5680303B2 (ja) 2006-12-19 2007-12-19 生物学的サンプル中の標的分子を試験するためのマイクロ流体システムおよび方法
ZA2008/07871A ZA200807871B (en) 2006-02-15 2008-09-12 Method for detecting pathogens using microbeads conjugated to biorecognition molecules
ZA200904969A ZA200904969B (en) 2006-12-19 2009-07-16 Microfluidic system and method to test for target molecules in a biological sample
US15/184,519 US20160299137A1 (en) 2006-02-15 2016-06-16 Method for detecting pathogens using microbeads conjugated to biorecognition molecules

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA002536698A CA2536698A1 (en) 2006-02-15 2006-02-15 System and method of detecting, identifying and characterizing pathogensand characterizing hosts
CA2,536,698 2006-02-15
CA002571904A CA2571904A1 (en) 2006-02-15 2006-12-19 System and method of detecting pathogens

Publications (1)

Publication Number Publication Date
CA2571904A1 true CA2571904A1 (en) 2007-08-15

Family

ID=38371145

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002571904A Abandoned CA2571904A1 (en) 2006-02-15 2006-12-19 System and method of detecting pathogens
CA002636489A Expired - Fee Related CA2636489C (en) 2006-02-15 2007-02-13 System and method of detecting pathogens

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002636489A Expired - Fee Related CA2636489C (en) 2006-02-15 2007-02-13 System and method of detecting pathogens

Country Status (9)

Country Link
US (2) US20100021937A1 (https=)
EP (1) EP1994166A4 (https=)
JP (1) JP5114432B2 (https=)
KR (2) KR101431843B1 (https=)
BR (1) BRPI0708468A2 (https=)
CA (2) CA2571904A1 (https=)
MX (1) MX2008010541A (https=)
WO (1) WO2007093043A1 (https=)
ZA (1) ZA200807871B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
JP5507454B2 (ja) * 2007-07-09 2014-05-28 フィオ コーポレイション 試験サンプル中の標的分子の蛍光検出の向上のためのシステムおよび方法
CN102024090A (zh) * 2009-09-14 2011-04-20 深圳市嘉实特科技有限公司 一种乙肝指标数据处理装置、检测设备及检测系统
US20120035279A1 (en) * 2010-08-06 2012-02-09 Miller Jeffrey E Protocol for screening travelers
GB2500168A (en) * 2012-01-14 2013-09-18 Cosmos Wathingira Ngumi A cleaning device for identifying microscopic objects
EP2831577B1 (en) * 2012-03-28 2018-08-08 Purdue Research Foundation Methods and systems useful for foodborne pathogen detection
KR101836075B1 (ko) * 2013-12-27 2018-03-08 가부시키가이샤 아이피 솔루션즈 정보 입력 보조 시트
EP3213081A4 (en) * 2014-10-30 2018-08-15 Sightline Innovation Inc. System, method and apparatus for pathogen detection
US10185807B2 (en) * 2014-11-18 2019-01-22 Mastercard International Incorporated System and method for conducting real time active surveillance of disease outbreak
ES2876039T3 (es) 2015-11-10 2021-11-11 Illumina Inc Generación inercial de gotitas y encapsulación de partículas
US10132752B2 (en) 2017-01-27 2018-11-20 The United States Of America, As Represented By The Secretary Of The Navy Hand-held laser biosensor
US11328826B2 (en) 2018-06-12 2022-05-10 Clarius Mobile Health Corp. System architecture for improved storage of electronic health information, and related methods
CN110489586A (zh) * 2019-01-07 2019-11-22 公安部第一研究所 一种样品检测数据库分级匹配的方法
CN111307826B (zh) * 2020-03-03 2023-03-31 桂林电子科技大学 一种瓶内粉末中异物在线视觉检测设备及方法
US10991185B1 (en) 2020-07-20 2021-04-27 Abbott Laboratories Digital pass verification systems and methods
WO2024227081A1 (en) * 2023-04-27 2024-10-31 S D Systems, Inc. Systems, methods, and compositions for the detection of microbes
KR20250132854A (ko) * 2024-02-29 2025-09-05 고려대학교 산학협력단 타겟과 결합된 아이디-마이크로파티클를 이용한 병렬 약물스크리닝 방법
CN121384916B (zh) * 2025-12-26 2026-04-10 首都医科大学附属北京中医医院 基于光谱的呼吸道分泌物中感染标志物检测方法

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244630A (en) * 1988-04-22 1993-09-14 Abbott Laboratories Device for performing solid-phase diagnostic assay
ES2066851T3 (es) * 1988-05-24 1995-03-16 Anagen Uk Ltd Particulas atraibles magneticamente y metodo de preparacion.
US5120662A (en) * 1989-05-09 1992-06-09 Abbott Laboratories Multilayer solid phase immunoassay support and method of use
US5824506A (en) * 1994-08-15 1998-10-20 Genelabs Diagnostics Pte. Ltd. Dengue virus peptides and methods
US6103379A (en) * 1994-10-06 2000-08-15 Bar-Ilan University Process for the preparation of microspheres and microspheres made thereby
US6340588B1 (en) * 1995-04-25 2002-01-22 Discovery Partners International, Inc. Matrices with memories
US6022500A (en) * 1995-09-27 2000-02-08 The United States Of America As Represented By The Secretary Of The Army Polymer encapsulation and polymer microsphere composites
WO1997014028A2 (en) * 1995-10-11 1997-04-17 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5837442A (en) * 1995-11-29 1998-11-17 Roche Molecular Systems, Inc. Oligonucleotide primers for amplifying HCV nucleic acid
US5885470A (en) * 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US6405936B1 (en) * 1996-05-13 2002-06-18 Universidad De Sevilla Stabilized capillary microjet and devices and methods for producing same
US6197835B1 (en) * 1996-05-13 2001-03-06 Universidad De Sevilla Device and method for creating spherical particles of uniform size
ES2140998B1 (es) * 1996-05-13 2000-10-16 Univ Sevilla Procedimiento de atomizacion de liquidos.
US5800690A (en) * 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US5714390A (en) * 1996-10-15 1998-02-03 Bio-Tech Imaging, Inc. Cartridge test system for the collection and testing of blood in a single step
US5817458A (en) * 1996-10-15 1998-10-06 The Avriel Group, Amcas Division Inc. Reagent system for detecting HIV-infected peripheral blood lymphocytes in whole blood
US5786219A (en) * 1996-10-28 1998-07-28 Molecular Probes, Inc. Microspheres with fluorescent spherical zones
US5959291A (en) * 1997-06-27 1999-09-28 Caliper Technologies Corporation Method and apparatus for measuring low power signals
US6066243A (en) * 1997-07-22 2000-05-23 Diametrics Medical, Inc. Portable immediate response medical analyzer having multiple testing modules
EP0919568A1 (en) * 1997-12-01 1999-06-02 Sorin Diagnostics S.r.l. Escape mutant of the surface antigen of hepatitis B virus
EP1044370B1 (en) * 1997-12-30 2017-08-23 Caliper Life Sciences, Inc. Software for the display of chromatographic separation data
WO1999036564A1 (en) * 1998-01-16 1999-07-22 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US6100541A (en) * 1998-02-24 2000-08-08 Caliper Technologies Corporation Microfluidic devices and systems incorporating integrated optical elements
US20020081729A1 (en) * 1998-03-27 2002-06-27 Martin C. Peters Controlled release of tissue culture supplements
CA2268997C (en) * 1998-05-05 2005-03-22 National Research Council Of Canada Quantum dot infrared photodetectors (qdip) and methods of making the same
JP4215397B2 (ja) * 1998-05-14 2009-01-28 ルミネックス コーポレイション 多重分析物診断システム
US6617583B1 (en) * 1998-09-18 2003-09-09 Massachusetts Institute Of Technology Inventory control
US7079241B2 (en) * 2000-04-06 2006-07-18 Invitrogen Corp. Spatial positioning of spectrally labeled beads
EP1115888B1 (en) * 1998-09-24 2008-03-12 Indiana University Research and Technology Corporation Water-soluble luminescent quantum dots and bioconjugates thereof
US6319607B1 (en) * 1998-11-10 2001-11-20 Bio-Pixels Ltd. Purification of functionalized fluorescent nanocrystals
US6114038A (en) * 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
US6576155B1 (en) * 1998-11-10 2003-06-10 Biocrystal, Ltd. Fluorescent ink compositions comprising functionalized fluorescent nanocrystals
US6309701B1 (en) * 1998-11-10 2001-10-30 Bio-Pixels Ltd. Fluorescent nanocrystal-labeled microspheres for fluorescence analyses
US6333110B1 (en) * 1998-11-10 2001-12-25 Bio-Pixels Ltd. Functionalized nanocrystals as visual tissue-specific imaging agents, and methods for fluorescence imaging
US6261779B1 (en) * 1998-11-10 2001-07-17 Bio-Pixels Ltd. Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system
WO2000028598A1 (en) * 1998-11-10 2000-05-18 Biocrystal Limited Methods for identification and verification
GB9827748D0 (en) * 1998-12-18 1999-02-10 Secr Defence Improvements in avalanche photo-diodes
CA2359039A1 (en) * 1999-01-29 2000-08-03 Toshio Miyata Meg-4 protein
ATE556149T1 (de) * 1999-02-23 2012-05-15 Caliper Life Sciences Inc Manipulation von mikropartikeln in mikrofluidischen systemen
US20010055764A1 (en) * 1999-05-07 2001-12-27 Empedocles Stephen A. Microarray methods utilizing semiconductor nanocrystals
AU4701200A (en) * 1999-05-07 2000-11-21 Quantum Dot Corporation A method of detecting an analyte using semiconductor nanocrystals
JP3815969B2 (ja) * 1999-05-12 2006-08-30 アクララ バイオサイエンシーズ, インコーポレイテッド 微量流体デバイスにおける多重方式蛍光検出
EP1179087B1 (en) * 1999-05-17 2019-03-27 Caliper Life Sciences, Inc. Focusing of microparticles in microfluidic systems
US6592821B1 (en) * 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US20020051971A1 (en) * 1999-05-21 2002-05-02 John R. Stuelpnagel Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6353475B1 (en) * 1999-07-12 2002-03-05 Caliper Technologies Corp. Light source power modulation for use with chemical and biochemical analysis
WO2001013119A1 (en) * 1999-08-17 2001-02-22 Luminex Corporation Encapsulation of fluorescent particles
US7037416B2 (en) * 2000-01-14 2006-05-02 Caliper Life Sciences, Inc. Method for monitoring flow rate using fluorescent markers
US20020009728A1 (en) * 2000-01-18 2002-01-24 Quantum Dot Corporation Oligonucleotide-tagged semiconductor nanocrystals for microarray and fluorescence in situ hybridization
US20030099940A1 (en) * 2000-02-16 2003-05-29 Empedocles Stephen A. Single target counting assays using semiconductor nanocrystals
JP2004500109A (ja) * 2000-03-22 2004-01-08 クァンタム・ドット・コーポレイション ビーズベースの核酸アッセイにおける半導体ナノクリスタルの使用方法
WO2001078087A2 (en) * 2000-04-06 2001-10-18 Luminex Corporation Magnetically-responsive microspheres
US6548264B1 (en) * 2000-05-17 2003-04-15 University Of Florida Coated nanoparticles
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US6494830B1 (en) * 2000-06-22 2002-12-17 Guidance Interactive Technologies, Inc. Handheld controller for monitoring/using medical parameters
JP2002000271A (ja) * 2000-06-28 2002-01-08 Sanyo Electric Co Ltd 微生物分析システム及び方法並びにデータベース
WO2002007064A2 (en) * 2000-07-17 2002-01-24 Labnetics, Inc. Method and apparatus for the processing of remotely collected electronic information characterizing properties of biological entities
US20020182609A1 (en) * 2000-08-16 2002-12-05 Luminex Corporation Microsphere based oligonucleotide ligation assays, kits, and methods of use, including high-throughput genotyping
US20020048425A1 (en) * 2000-09-20 2002-04-25 Sarnoff Corporation Microfluidic optical electrohydrodynamic switch
JP2004510678A (ja) * 2000-10-04 2004-04-08 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー コロイドナノ結晶の合成
US6649138B2 (en) * 2000-10-13 2003-11-18 Quantum Dot Corporation Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
US6937323B2 (en) * 2000-11-08 2005-08-30 Burstein Technologies, Inc. Interactive system for analyzing biological samples and processing related information and the use thereof
US6573128B1 (en) * 2000-11-28 2003-06-03 Cree, Inc. Epitaxial edge termination for silicon carbide Schottky devices and methods of fabricating silicon carbide devices incorporating same
US20020083888A1 (en) * 2000-12-28 2002-07-04 Zehnder Donald A. Flow synthesis of quantum dot nanocrystals
AU2002309528A1 (en) * 2001-04-02 2002-10-15 Therasense, Inc. Blood glucose tracking apparatus and methods
JP2002311027A (ja) * 2001-04-09 2002-10-23 Hitachi Software Eng Co Ltd ビーズ、ビーズ製造方法、フローサイトメータ及びプログラム
US20020164271A1 (en) 2001-05-02 2002-11-07 Ho Winston Z. Wavelength-coded bead for bioassay and signature recogniton
US7319012B2 (en) * 2001-05-30 2008-01-15 Gene Therapy Systems, Inc. Protein arrays and methods and systems for producing the same
US6845327B2 (en) * 2001-06-08 2005-01-18 Epocal Inc. Point-of-care in-vitro blood analysis system
US6905885B2 (en) * 2001-06-12 2005-06-14 The Regents Of The University Of California Portable pathogen detection system
WO2003003015A2 (en) * 2001-06-28 2003-01-09 Advanced Research And Technology Institute, Inc. Methods of preparing multicolor quantum dot tagged beads and conjugates thereof
US7044911B2 (en) * 2001-06-29 2006-05-16 Philometron, Inc. Gateway platform for biological monitoring and delivery of therapeutic compounds
JP4567436B2 (ja) * 2001-07-20 2010-10-20 ライフ テクノロジーズ コーポレーション 発光ナノ粒子およびそれらの調製方法
US7060227B2 (en) * 2001-08-06 2006-06-13 Sau Lan Tang Staats Microfluidic devices with raised walls
DK2184346T3 (en) * 2001-09-06 2017-06-26 Rapid Micro Biosystems Inc Rapid detection of replicating cells
US7214428B2 (en) * 2001-09-17 2007-05-08 Invitrogen Corporation Highly luminescent functionalized semiconductor nanocrystals for biological and physical applications
US7195913B2 (en) * 2001-10-05 2007-03-27 Surmodics, Inc. Randomly ordered arrays and methods of making and using
US7312071B2 (en) * 2001-12-06 2007-12-25 Arbor Vita Corporation Effective monitoring system for anthrax smallpox, or other pathogens
US7457731B2 (en) * 2001-12-14 2008-11-25 Siemens Medical Solutions Usa, Inc. Early detection of disease outbreak using electronic patient data to reduce public health threat from bio-terrorism
WO2003057011A2 (en) * 2002-01-04 2003-07-17 Canswers Llc Systems and methods for predicting disease behavior
US7689899B2 (en) * 2002-03-06 2010-03-30 Ge Corporate Financial Services, Inc. Methods and systems for generating documents
US20030194350A1 (en) * 2002-04-11 2003-10-16 Siemens Information And Communication Networks Public health threat surveillance system
US20050227252A1 (en) * 2002-08-20 2005-10-13 Moon John A Diffraction grating-based encoded articles for multiplexed experiments
JP4073323B2 (ja) * 2003-01-23 2008-04-09 日立ソフトウエアエンジニアリング株式会社 機能性ビーズ、その読み取り方法および読み取り装置
US20050014134A1 (en) * 2003-03-06 2005-01-20 West Jason Andrew Appleton Viral identification by generation and detection of protein signatures
CA2534402C (en) * 2003-08-04 2013-06-25 Emory University Porous materials embedded with nanospecies, methods of fabrication thereof, and methods of use thereof
US8346482B2 (en) * 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
US20060292039A1 (en) * 2003-09-05 2006-12-28 Kazuhiro Iida Measuring system
EP1711517A4 (en) * 2004-01-21 2008-02-13 Univ Utah Res Found MUTANT NAv1.7 SODIUM CHANNEL AND ASSOCIATED METHODS
JP2008514955A (ja) * 2004-09-28 2008-05-08 シンギュレックス・インコーポレイテッド サンプル分析システムおよび方法
WO2006058334A2 (en) * 2004-11-29 2006-06-01 Perkinelmer Life And Analytical Sciences Prticle-based multiplex assay for identifying glycosylation
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system

Also Published As

Publication number Publication date
JP5114432B2 (ja) 2013-01-09
BRPI0708468A2 (pt) 2011-05-31
KR101518765B1 (ko) 2015-05-11
JP2009526973A (ja) 2009-07-23
WO2007093043A1 (en) 2007-08-23
KR20090003220A (ko) 2009-01-09
US20100021937A1 (en) 2010-01-28
MX2008010541A (es) 2008-11-18
US20160299137A1 (en) 2016-10-13
ZA200807871B (en) 2009-12-30
KR20140053953A (ko) 2014-05-08
CA2636489C (en) 2009-12-29
EP1994166A4 (en) 2009-12-02
HK1128735A1 (en) 2009-11-06
KR101431843B1 (ko) 2014-08-25
EP1994166A1 (en) 2008-11-26
CA2636489A1 (en) 2007-08-23

Similar Documents

Publication Publication Date Title
CA2636489C (en) System and method of detecting pathogens
US11130994B2 (en) Automated, cloud-based, point-of-care (POC) pathogen and antibody array detection system and method
CN101672779B (zh) 用于在生物样品中进行稀有事件分析的高灵敏度多参数方法
Glynn et al. CD4 counting technologies for HIV therapy monitoring in resource-poor settings–state-of-the-art and emerging microtechnologies
US11789020B2 (en) Neutralizing antibody testing and treatment
US20210115496A1 (en) Methods and Devices for Real-Time Diagnostic Testing (RDT) for Ebola and other Infectious Diseases
JP2018512871A (ja) 標準物質として外部生体分子を用いた生体分子分析方法およびそのキット
US20060088895A1 (en) Systems, methods and reagents for the detection of biological and chemical agents using dynamic surface generation and imaging
CN106434996A (zh) 一种检测鲍曼不动杆菌dna的试剂盒及检测方法
Martín-Ramírez et al. Usefulness of a commercial LAMP assay for detection of malaria infection, including Plasmodium knowlesi cases, in returning travelers in Spain
CN101384725B (zh) 检测病原体的系统
Abdelrazik et al. Evaluation of pooling strategy of SARS-CoV-2 RT-PCR in limited resources setting in Egypt at low prevalence
US20220244258A1 (en) Assay For Neutralizing Antibody Testing And Treatment
Mirza et al. Advancements in rapid and affordable diagnostic testing for respiratory infectious diseases: Evaluation of aptamer beacon technology for rapid and sensitive detection of SAR-CoV-2 in breath condensate
CN112782401A (zh) 一种体外快速检测新型冠状病毒的方法及应用
Ehtesabi et al. Smartphone-based corona virus detection using saliva: a mini-review
HK1128735B (en) A system for detecting pathogens
Burg et al. From Concept to Commercialization: High-Throughput Optical Modulation Biosensing for Detecting Low Concentrations of Biomarkers
US20220252588A1 (en) Neutralizing antibody testing and treatment
US20220205998A1 (en) Assay for neutralizing antibody testing and treatment
Cole et al. Multicolor flow cytometry and high-dimensional data analysis to probe complex questions in vaccinology
Dixit et al. Redefining Diagnostic Detection: Molecular Diagnostics to LFA technologies
Hertzog et al. ANTIBODY TITER ASSESSMENT BY IMAGE CYTOMETRY
Emanuel Biological detectors: market survey
Schaudies State of the art for autonomous detection systems using immunoassays and protein signatures

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20170515