KR101413094B1 - 항박테리아제로서의 퀴놀린 유도체 - Google Patents

항박테리아제로서의 퀴놀린 유도체 Download PDF

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Publication number
KR101413094B1
KR101413094B1 KR1020087005063A KR20087005063A KR101413094B1 KR 101413094 B1 KR101413094 B1 KR 101413094B1 KR 1020087005063 A KR1020087005063 A KR 1020087005063A KR 20087005063 A KR20087005063 A KR 20087005063A KR 101413094 B1 KR101413094 B1 KR 101413094B1
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South Korea
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alkyl
formula
compound
compounds
halo
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KR1020087005063A
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English (en)
Korean (ko)
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KR20080039961A (ko
Inventor
코엔라드 요제프 로데비이크 마르셀 안드리스
아닐 코울
제롬 에밀 조지 귈레몽
엘리자베스 테레즈 쟌느 파스퀴어
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얀센 파마슈티카 엔.브이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020087005063A 2005-08-03 2006-07-31 항박테리아제로서의 퀴놀린 유도체 Expired - Fee Related KR101413094B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05107155 2005-08-03
EP05107155.3 2005-08-03
PCT/EP2006/064847 WO2007014934A2 (en) 2005-08-03 2006-07-31 Quinoline derivatives as antibacterial agents

Publications (2)

Publication Number Publication Date
KR20080039961A KR20080039961A (ko) 2008-05-07
KR101413094B1 true KR101413094B1 (ko) 2014-07-01

Family

ID=35768115

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087005063A Expired - Fee Related KR101413094B1 (ko) 2005-08-03 2006-07-31 항박테리아제로서의 퀴놀린 유도체

Country Status (30)

Country Link
US (1) US8691800B2 (https=)
EP (1) EP1912649B1 (https=)
JP (1) JP5208739B2 (https=)
KR (1) KR101413094B1 (https=)
CN (1) CN101277698B (https=)
AP (1) AP2483A (https=)
AR (1) AR054888A1 (https=)
AU (1) AU2006274873B2 (https=)
BR (1) BRPI0614099B8 (https=)
CA (1) CA2615900C (https=)
CY (1) CY1113535T1 (https=)
DK (1) DK1912649T3 (https=)
EA (1) EA014834B1 (https=)
ES (1) ES2397358T3 (https=)
HR (1) HRP20120910T1 (https=)
IL (1) IL189140A (https=)
JO (1) JO2837B1 (https=)
ME (1) ME01485B (https=)
MX (1) MX2008001601A (https=)
MY (1) MY147637A (https=)
NO (1) NO342328B1 (https=)
NZ (1) NZ566012A (https=)
PL (1) PL1912649T3 (https=)
PT (1) PT1912649E (https=)
RS (1) RS52606B (https=)
SI (1) SI1912649T1 (https=)
TW (1) TWI385168B (https=)
UA (1) UA95911C2 (https=)
WO (1) WO2007014934A2 (https=)
ZA (1) ZA200801106B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2837B1 (en) 2005-08-03 2014-09-15 جانسن فارمسيتكا ان في Quinoline derivatives acting as antibacterial agents
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO3271B1 (ar) * 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
JP5246715B2 (ja) * 2009-01-27 2013-07-24 独立行政法人科学技術振興機構 蛋白質架橋阻害剤およびその用途
CN104254527B (zh) 2012-04-27 2017-05-31 詹森药业有限公司 抗菌的喹啉衍生物
ES2607879T3 (es) 2012-04-27 2017-04-04 Janssen Pharmaceutica N.V. Derivados de quinolina antibacterianos
BR122023025283A2 (pt) * 2016-03-07 2024-02-20 Global Alliance For Tb Drug Development Inc Compostos antibacterianos e seus usos

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011436A1 (en) 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018326A1 (en) * 1996-10-28 1998-05-07 Department Of The Army, U.S. Government Compounds, compositions and methods for treating antibiotic-resistant infections
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
GB0101577D0 (en) * 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
EA011359B1 (ru) * 2004-01-23 2009-02-27 Янссен Фармацевтика Н.В. Замещенные хинолины и их применение в качестве микобактериальных ингибиторов
JO2837B1 (en) 2005-08-03 2014-09-15 جانسن فارمسيتكا ان في Quinoline derivatives acting as antibacterial agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011436A1 (en) 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors

Also Published As

Publication number Publication date
ZA200801106B (en) 2009-09-30
HK1124232A1 (zh) 2009-07-10
JP2009503021A (ja) 2009-01-29
ES2397358T3 (es) 2013-03-06
EP1912649A2 (en) 2008-04-23
JP5208739B2 (ja) 2013-06-12
KR20080039961A (ko) 2008-05-07
NO342328B1 (no) 2018-05-07
PT1912649E (pt) 2013-01-14
IL189140A (en) 2014-07-31
DK1912649T3 (da) 2013-01-21
WO2007014934A2 (en) 2007-02-08
TWI385168B (zh) 2013-02-11
BRPI0614099B8 (pt) 2021-05-25
NO20081068L (no) 2008-02-29
CN101277698B (zh) 2011-06-22
AR054888A1 (es) 2007-07-25
CA2615900C (en) 2014-12-09
EA014834B1 (ru) 2011-02-28
ME01485B (me) 2014-04-20
EP1912649B1 (en) 2012-10-10
PL1912649T3 (pl) 2013-03-29
US20080227775A1 (en) 2008-09-18
AU2006274873A1 (en) 2007-02-08
CY1113535T1 (el) 2016-06-22
RS52606B (sr) 2013-04-30
BRPI0614099B1 (pt) 2019-11-12
WO2007014934A3 (en) 2007-04-05
AU2006274873B2 (en) 2012-12-13
IL189140A0 (en) 2008-08-07
AP2483A (en) 2012-10-01
SI1912649T1 (sl) 2013-01-31
EA200800513A1 (ru) 2008-06-30
MY147637A (en) 2012-12-31
UA95911C2 (ru) 2011-09-26
TW200800971A (en) 2008-01-01
CA2615900A1 (en) 2007-02-08
US8691800B2 (en) 2014-04-08
HRP20120910T1 (hr) 2012-12-31
MX2008001601A (es) 2008-02-19
CN101277698A (zh) 2008-10-01
WO2007014934A8 (en) 2007-05-18
JO2837B1 (en) 2014-09-15
BRPI0614099A2 (pt) 2011-03-09
NZ566012A (en) 2011-02-25

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