BRPI0614099B8 - uso de um composto derivado de quinolina, sua combinação, composição farmacêutica, uso da referida combinação, produto e o referido composto - Google Patents
uso de um composto derivado de quinolina, sua combinação, composição farmacêutica, uso da referida combinação, produto e o referido compostoInfo
- Publication number
- BRPI0614099B8 BRPI0614099B8 BRPI0614099A BRPI0614099A BRPI0614099B8 BR PI0614099 B8 BRPI0614099 B8 BR PI0614099B8 BR PI0614099 A BRPI0614099 A BR PI0614099A BR PI0614099 A BRPI0614099 A BR PI0614099A BR PI0614099 B8 BRPI0614099 B8 BR PI0614099B8
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- compound
- hydrogen
- combination
- het
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
uso de um composto derivado de quinolina, sua combinação, composição farmacêutica, uso da referida combinação, produto e o referido composto. a presente invenção refere-se ao uso de um composto para a fabricação de um medicamento para o tratamento de uma infecção bacteriana desde que a infecção bacteriana seja diferente de uma infecção micobacteriana, o referido composto sendo um composto de fórmula (la) (ia) ou (ib), (ib) um sal de adição de ácido ou de base farmaceuticamente aceitável do mesmo, uma amina quaternária do mesmo, uma forma estereoquimicamente isomérica do mesmo, uma forma tautomérica do mesmo ou uma forma n-óxido do mesmo, em que r1 é hidrogênio, halo, haloalquila, ciano, hidróxi, ar, het, alquila, alquilóxi, alquiltio, alquiloxialquila, alquiltioalquila, ar-alquila ou di (ar) alquila; p é 1, 2, 3 ou 4; r2 é hidrogênio, hidróxi, tio, alquilóxi, alquiloxialquilóxi, alquiltio, mono ou di (alquil) amino ou um radical de fórmula (ii) (ii); r3 é alquila, ar, ar-alquila, het ou het-alquila; r4 é hidrogênio, alquila ou benzila; r5 é hidrogênio, halo, haloalquila, hidróxi, ar, alquila, alquilóxi, alquiltio, alquiloxialquila, alquiltioalquila, ar-alquila ou di (ar) alquila; ou dois radicais r5 vicinais podem ser tomados juntos para formar juntos com o anel fenila aos quais eles são fixados uma naftila; r é 1, 2, 3, 4 ou 5; r6 é hidrogênio, alquila, ar ou het; r7 é hidrogênio ou alquila; r8 é oxo; ou r7 e r8 juntos formam o radical -ch=ch-n=; z é ch2 ou c(=o).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05107155 | 2005-08-03 | ||
| EP05107155.3 | 2005-08-03 | ||
| PCT/EP2006/064847 WO2007014934A2 (en) | 2005-08-03 | 2006-07-31 | Quinoline derivatives as antibacterial agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0614099A2 BRPI0614099A2 (pt) | 2011-03-09 |
| BRPI0614099B1 BRPI0614099B1 (pt) | 2019-11-12 |
| BRPI0614099B8 true BRPI0614099B8 (pt) | 2021-05-25 |
Family
ID=35768115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0614099A BRPI0614099B8 (pt) | 2005-08-03 | 2006-07-31 | uso de um composto derivado de quinolina, sua combinação, composição farmacêutica, uso da referida combinação, produto e o referido composto |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US8691800B2 (pt) |
| EP (1) | EP1912649B1 (pt) |
| JP (1) | JP5208739B2 (pt) |
| KR (1) | KR101413094B1 (pt) |
| CN (1) | CN101277698B (pt) |
| AP (1) | AP2483A (pt) |
| AR (1) | AR054888A1 (pt) |
| AU (1) | AU2006274873B2 (pt) |
| BR (1) | BRPI0614099B8 (pt) |
| CA (1) | CA2615900C (pt) |
| CY (1) | CY1113535T1 (pt) |
| DK (1) | DK1912649T3 (pt) |
| EA (1) | EA014834B1 (pt) |
| ES (1) | ES2397358T3 (pt) |
| HK (1) | HK1124232A1 (pt) |
| HR (1) | HRP20120910T1 (pt) |
| IL (1) | IL189140A (pt) |
| JO (1) | JO2837B1 (pt) |
| ME (1) | ME01485B (pt) |
| MX (1) | MX2008001601A (pt) |
| MY (1) | MY147637A (pt) |
| NO (1) | NO342328B1 (pt) |
| NZ (1) | NZ566012A (pt) |
| PL (1) | PL1912649T3 (pt) |
| PT (1) | PT1912649E (pt) |
| RS (1) | RS52606B (pt) |
| SI (1) | SI1912649T1 (pt) |
| TW (1) | TWI385168B (pt) |
| UA (1) | UA95911C2 (pt) |
| WO (1) | WO2007014934A2 (pt) |
| ZA (1) | ZA200801106B (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2837B1 (en) | 2005-08-03 | 2014-09-15 | جانسن فارمسيتكا ان في | Quinoline derivatives acting as antibacterial agents |
| JO3271B1 (ar) * | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
| JO2683B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JP5246715B2 (ja) | 2009-01-27 | 2013-07-24 | 独立行政法人科学技術振興機構 | 蛋白質架橋阻害剤およびその用途 |
| CN104254527B (zh) | 2012-04-27 | 2017-05-31 | 詹森药业有限公司 | 抗菌的喹啉衍生物 |
| CN104254528B (zh) | 2012-04-27 | 2017-06-06 | 詹森药业有限公司 | 抗菌的喹啉衍生物 |
| KR102355154B1 (ko) * | 2016-03-07 | 2022-01-26 | 더 글로벌 얼라이언스 포 티비 드러그 디벨롭먼트, 잉크. | 항박테리아 화합물 및 그의 용도 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0936866A4 (en) * | 1996-10-28 | 2001-04-11 | Dept Of The Army Us Government | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING ANTIBIOTIC RESIST INFECTIONS |
| US6103905A (en) * | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| GB0101577D0 (en) * | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
| AR040336A1 (es) * | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
| CN1325475C (zh) * | 2002-07-25 | 2007-07-11 | 詹森药业有限公司 | 喹啉衍生物及其作为分枝杆菌抑制剂的应用 |
| ES2306082T3 (es) * | 2004-01-23 | 2008-11-01 | Janssen Pharmaceutica Nv | Quinolinas sustituidas y su utilizacion como inhibidores micobacterianos. |
| JO2837B1 (en) | 2005-08-03 | 2014-09-15 | جانسن فارمسيتكا ان في | Quinoline derivatives acting as antibacterial agents |
-
2006
- 2006-07-18 JO JO2006234A patent/JO2837B1/en active
- 2006-07-31 US US11/997,015 patent/US8691800B2/en active Active
- 2006-07-31 AU AU2006274873A patent/AU2006274873B2/en active Active
- 2006-07-31 WO PCT/EP2006/064847 patent/WO2007014934A2/en active Application Filing
- 2006-07-31 RS RS20120577A patent/RS52606B/en unknown
- 2006-07-31 AP AP2008004320A patent/AP2483A/xx active
- 2006-07-31 ME MEP-2012-146A patent/ME01485B/me unknown
- 2006-07-31 CN CN2006800367813A patent/CN101277698B/zh active Active
- 2006-07-31 DK DK06792614.7T patent/DK1912649T3/da active
- 2006-07-31 BR BRPI0614099A patent/BRPI0614099B8/pt active IP Right Grant
- 2006-07-31 NZ NZ566012A patent/NZ566012A/en unknown
- 2006-07-31 KR KR1020087005063A patent/KR101413094B1/ko active IP Right Grant
- 2006-07-31 JP JP2008524502A patent/JP5208739B2/ja active Active
- 2006-07-31 EP EP06792614A patent/EP1912649B1/en active Active
- 2006-07-31 CA CA2615900A patent/CA2615900C/en active Active
- 2006-07-31 ES ES06792614T patent/ES2397358T3/es active Active
- 2006-07-31 EA EA200800513A patent/EA014834B1/ru unknown
- 2006-07-31 SI SI200631469T patent/SI1912649T1/sl unknown
- 2006-07-31 MX MX2008001601A patent/MX2008001601A/es active IP Right Grant
- 2006-07-31 UA UAA200800827A patent/UA95911C2/ru unknown
- 2006-07-31 PL PL06792614T patent/PL1912649T3/pl unknown
- 2006-07-31 PT PT67926147T patent/PT1912649E/pt unknown
- 2006-08-01 MY MYPI20063725A patent/MY147637A/en unknown
- 2006-08-02 TW TW095128222A patent/TWI385168B/zh active
- 2006-08-02 AR ARP060103370A patent/AR054888A1/es unknown
-
2008
- 2008-01-31 IL IL189140A patent/IL189140A/en active IP Right Grant
- 2008-02-01 ZA ZA200801106A patent/ZA200801106B/xx unknown
- 2008-02-29 NO NO20081068A patent/NO342328B1/no unknown
-
2009
- 2009-02-05 HK HK09101043.6A patent/HK1124232A1/xx unknown
-
2012
- 2012-11-13 HR HRP20120910TT patent/HRP20120910T1/hr unknown
-
2013
- 2013-01-08 CY CY20131100015T patent/CY1113535T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/11/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/11/2019, OBSERVADAS AS CONDICOES LEGAIS |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 31/07/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |