KR101286216B1 - 샘플을 분석하는 방법 및 이를 위한 장치 - Google Patents

샘플을 분석하는 방법 및 이를 위한 장치 Download PDF

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KR101286216B1
KR101286216B1 KR1020077005978A KR20077005978A KR101286216B1 KR 101286216 B1 KR101286216 B1 KR 101286216B1 KR 1020077005978 A KR1020077005978 A KR 1020077005978A KR 20077005978 A KR20077005978 A KR 20077005978A KR 101286216 B1 KR101286216 B1 KR 101286216B1
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KR20070050085A (ko
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콜린 블랙모어
패트릭 코트니
알리스테어 피치
샤브 라다
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퍼킨엘머 싱가포르 피티이 리미티드
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458Fluorescence microscopy
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432Quenching

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
KR1020077005978A 2004-09-01 2005-08-17 샘플을 분석하는 방법 및 이를 위한 장치 Expired - Lifetime KR101286216B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0419325.6 2004-09-01
GBGB0419325.6A GB0419325D0 (en) 2004-09-01 2004-09-01 A method of analysing a sample including fluorescent labels and apparatus therefor
GB0512811A GB2418018B (en) 2004-09-01 2005-06-23 A method of analysing a sample including fluorescent labels and apparatus therefor
GB0512811.1 2005-06-23
PCT/GB2005/003226 WO2006024819A2 (en) 2004-09-01 2005-08-17 A method of analysing a sample and apparatus therefor

Publications (2)

Publication Number Publication Date
KR20070050085A KR20070050085A (ko) 2007-05-14
KR101286216B1 true KR101286216B1 (ko) 2013-07-15

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KR1020077005978A Expired - Lifetime KR101286216B1 (ko) 2004-09-01 2005-08-17 샘플을 분석하는 방법 및 이를 위한 장치

Country Status (6)

Country Link
EP (1) EP1784633B1 (https=)
JP (1) JP5318413B2 (https=)
KR (1) KR101286216B1 (https=)
AU (1) AU2005279041B2 (https=)
CA (1) CA2576804C (https=)
WO (1) WO2006024819A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4855139B2 (ja) 2006-05-18 2012-01-18 オリンパス株式会社 顕微鏡装置および細胞観察方法
US8664589B2 (en) * 2011-12-29 2014-03-04 Electro Scientific Industries, Inc Spectroscopy data display systems and methods
WO2014168734A1 (en) * 2013-03-15 2014-10-16 Cedars-Sinai Medical Center Time-resolved laser-induced fluorescence spectroscopy systems and uses thereof
WO2017173315A1 (en) 2016-04-01 2017-10-05 Black Light Surgical, Inc. Systems, devices, and methods for time-resolved fluorescent spectroscopy
DE102016109303A1 (de) * 2016-05-20 2017-11-23 Friedrich-Schiller-Universität Jena Lasermikroskop mit Ablationsfunktion
JP6033980B1 (ja) * 2016-06-01 2016-11-30 株式会社片岡製作所 細胞処理システム
JP6541160B2 (ja) * 2017-02-13 2019-07-10 株式会社片岡製作所 細胞処理装置および対象物の処理方法
JP6532063B2 (ja) 2017-02-13 2019-06-19 株式会社片岡製作所 細胞処理装置
JP6574028B1 (ja) 2018-06-29 2019-09-11 株式会社片岡製作所 細胞処理装置および細胞のレーザ処理方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11503824A (ja) * 1995-03-07 1999-03-30 ソイニ,エルッキ 生物特異性アッセイ法
JP2004347608A (ja) * 1995-01-16 2004-12-09 Erkki Soini フロー蛍光法及び装置

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629687A (en) * 1982-07-29 1986-12-16 Board Of Trustees Of Michigan State University Positive selection sorting of cells
US5932872A (en) * 1994-07-01 1999-08-03 Jeffrey H. Price Autofocus system for scanning microscopy having a volume image formation
EP0977981B1 (en) * 1997-04-25 2003-07-09 Universiteit van Amsterdam Photobleachable luminescent layers for calibration and standardization in optical microscopy
JP3735190B2 (ja) * 1997-10-28 2006-01-18 オリンパス株式会社 走査型サイトメータ
JPH11271220A (ja) * 1998-03-24 1999-10-05 Olympus Optical Co Ltd 走査型顕微鏡の測定パラメータ決定方法
AU5223899A (en) * 1998-07-27 2000-02-21 Ljl Biosystems, Inc. Apparatus and methods for spectroscopic measurements
JP3678397B2 (ja) * 1998-12-15 2005-08-03 富士写真フイルム株式会社 撮影システム
US20030026762A1 (en) * 1999-05-05 2003-02-06 Malmros Mark K. Bio-spectral imaging system and methods for diagnosing cell disease state
WO2000071028A1 (en) * 1999-05-26 2000-11-30 Photogen, Inc. Improved methods and apparatus for multi-photon photo-activation and detection of molecular agents
DE60005138T2 (de) * 2000-04-06 2004-06-03 Europäisches Laboratorium für Molekularbiologie Rechnergesteuertes Mikroskop
EP1351048A4 (en) * 2000-12-14 2007-02-28 Olympus Corp FLUOROMETRIC ANALYZER AND FLUOROMETRIC ANALYSIS
JP3734769B2 (ja) * 2001-11-09 2006-01-11 アイダエンジニアリング株式会社 蛍光強度測定方法および装置
GB0224067D0 (en) * 2002-10-16 2002-11-27 Perkinelmer Uk Ltd Improvements in and relating to imaging
US7271886B2 (en) * 2002-11-18 2007-09-18 Panomics, Inc. Uncaging device

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004347608A (ja) * 1995-01-16 2004-12-09 Erkki Soini フロー蛍光法及び装置
JPH11503824A (ja) * 1995-03-07 1999-03-30 ソイニ,エルッキ 生物特異性アッセイ法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Howell, J. L. et al. BioTechniques, 2002, Vol. 32, No. 1, pages 80-87. *
Koster, M. et al. Current Opinion in Biotechnology, 2005, Vol. 16, pages 28-34. *

Also Published As

Publication number Publication date
KR20070050085A (ko) 2007-05-14
EP1784633A2 (en) 2007-05-16
CA2576804C (en) 2013-10-15
AU2005279041B2 (en) 2011-04-07
WO2006024819A2 (en) 2006-03-09
CA2576804A1 (en) 2006-03-09
JP2008511824A (ja) 2008-04-17
WO2006024819A8 (en) 2006-09-08
EP1784633B1 (en) 2011-11-09
JP5318413B2 (ja) 2013-10-16
WO2006024819A3 (en) 2006-05-18
AU2005279041A1 (en) 2006-03-09

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