KR101264444B1 - 록사핀 유사체 및 이것의 사용 방법 - Google Patents

록사핀 유사체 및 이것의 사용 방법 Download PDF

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Publication number
KR101264444B1
KR101264444B1 KR1020077009122A KR20077009122A KR101264444B1 KR 101264444 B1 KR101264444 B1 KR 101264444B1 KR 1020077009122 A KR1020077009122 A KR 1020077009122A KR 20077009122 A KR20077009122 A KR 20077009122A KR 101264444 B1 KR101264444 B1 KR 101264444B1
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KR
South Korea
Prior art keywords
sleep
hydrogen
compound
compounds
formula
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Expired - Fee Related
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KR1020077009122A
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English (en)
Korean (ko)
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KR20070060126A (ko
Inventor
데일 엠. 에드가
데이비드 지. 항고어
카즈미 시오사키
마이클 솔로몬
제임스 에프. 화이트
Original Assignee
히프니언 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020077009122A 2004-09-21 2005-09-21 록사핀 유사체 및 이것의 사용 방법 Expired - Fee Related KR101264444B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61184904P 2004-09-21 2004-09-21
US60/611,849 2004-09-21
US67319805P 2005-04-19 2005-04-19
US60/673,198 2005-04-19

Publications (2)

Publication Number Publication Date
KR20070060126A KR20070060126A (ko) 2007-06-12
KR101264444B1 true KR101264444B1 (ko) 2013-05-20

Family

ID=36090680

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077009122A Expired - Fee Related KR101264444B1 (ko) 2004-09-21 2005-09-21 록사핀 유사체 및 이것의 사용 방법

Country Status (19)

Country Link
US (3) US7592333B2 (enExample)
EP (1) EP1804804B1 (enExample)
JP (1) JP5049129B2 (enExample)
KR (1) KR101264444B1 (enExample)
AT (1) ATE542536T1 (enExample)
AU (1) AU2005286713B2 (enExample)
BR (1) BRPI0515518A (enExample)
CA (1) CA2580250C (enExample)
CY (1) CY1112590T1 (enExample)
DK (1) DK1804804T3 (enExample)
EA (1) EA012610B1 (enExample)
ES (1) ES2378452T3 (enExample)
MA (1) MA28985B1 (enExample)
MX (1) MX2007003032A (enExample)
NO (1) NO20071604L (enExample)
NZ (1) NZ553900A (enExample)
PL (1) PL1804804T3 (enExample)
PT (1) PT1804804E (enExample)
WO (1) WO2006034414A2 (enExample)

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US7355042B2 (en) * 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
US20050250767A1 (en) * 2003-01-23 2005-11-10 Weiner David M Use of N-desmethylclozapine to treat human neuropsychiatric disease
US20050085463A1 (en) * 2003-01-23 2005-04-21 Weiner David M. Use of N-desmethylclozapine to treat human neuropsychiatric disease
MXPA05007784A (es) * 2003-01-23 2005-09-30 Acadia Pharm Inc Empleo de la n-desmetilclozapina para tratar las enfermedades neuropsiquiatricas humanas.
PT1696931E (pt) * 2003-12-22 2009-06-12 Acadia Pharm Inc Análogos diaril[a,d]ciclo-hepteno substituídos com amino utilizados como agonistas muscarínicos e métodos de tratamento de perturbações neuropsiquiátricas
MXPA06011320A (es) * 2004-04-01 2007-03-21 Acadia Pharm Inc Metodo de sintesis y aislamiento de n-desmetilclozapina solida y sus formas cristalinas.
WO2006049734A2 (en) * 2004-10-29 2006-05-11 Hypnion, Inc. Quetiapine analogs and methods of use thereof
WO2007053618A1 (en) * 2005-10-31 2007-05-10 Acadia Pharmaceuticals Inc. Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders
US7762006B2 (en) * 2006-06-14 2010-07-27 Siestamed, Technologies Medical equipment drying device
RU2459811C2 (ru) * 2006-10-28 2012-08-27 Метилджен Инк. Ингибиторы гистоновой деацетилазы
BRPI0808828A8 (pt) * 2007-03-15 2017-11-28 Aryx Therapeutics Inc Compostos de dibenzo[b,f][1,4]oxazapina
US8827979B2 (en) 2007-03-19 2014-09-09 Insuline Medical Ltd. Drug delivery device
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
EP2231229A1 (en) 2007-12-18 2010-09-29 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
CN102245137A (zh) 2008-11-07 2011-11-16 茵苏莱恩医药有限公司 用于药物递送的装置和方法
WO2014116684A1 (en) * 2013-01-22 2014-07-31 Edward Roberts Non-peptidic neuropeptide y receptor modulators
CN107635549A (zh) 2015-03-26 2018-01-26 杰奎琳·M·艾弗森 抑制与宿醉相关的症状的方法和组合物
AU2020370063B2 (en) * 2019-10-21 2025-10-23 Alairion, Inc. 3-(4-(11H-dibenzo[b,e][1,4]azepin-6-yl)piperazin-1-yl)- and 3-(4-(dibenzo[b,f][1,4]oxazepin/thiazepin/diazepin-11-yl)piperazin-1-yl)-propanoic acid derivatives as H1 and 5-HT2A-receptor modulators for the treatment of sleep disorders
WO2025076527A1 (en) * 2023-10-07 2025-04-10 Inspire Medical Systems, Inc. Pulmonary therapy for sleep disordered breathing care

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187021A1 (en) 2001-10-16 2003-10-02 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators

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NL140242B (nl) 1963-03-01 1973-11-15 Wander Ag Dr A Werkwijze voor het bereiden van op de 11-plaats door een basische groep gesubstitueerde dibenz (b.f.)(1.4) oxazepinen.
US3928356A (en) 1967-10-06 1975-12-23 Fujisawa Pharmaceutical Co 10-{8 4-({107 -Hydroxy alkyl)-1-piperazimyl{9 -dibenzo (h,f) oxofins and thiepins and acetyl esters thereof
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US4072756A (en) 1973-05-17 1978-02-07 Sandoz Ltd. Tricyclo piperidino ketones and soporific compositions thereof
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JPH04211071A (ja) * 1990-03-05 1992-08-03 Hokuriku Seiyaku Co Ltd 多環式化合物
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Also Published As

Publication number Publication date
MX2007003032A (es) 2007-05-21
MA28985B1 (fr) 2007-11-01
US7592333B2 (en) 2009-09-22
NZ553900A (en) 2010-10-29
EP1804804B1 (en) 2012-01-25
WO2006034414A2 (en) 2006-03-30
EA200700702A1 (ru) 2007-10-26
PT1804804E (pt) 2012-03-30
US20090186872A1 (en) 2009-07-23
WO2006034414A3 (en) 2006-09-08
CY1112590T1 (el) 2016-02-10
JP5049129B2 (ja) 2012-10-17
NO20071604L (no) 2007-06-20
EA012610B1 (ru) 2009-10-30
PL1804804T3 (pl) 2012-08-31
AU2005286713A1 (en) 2006-03-30
EP1804804A2 (en) 2007-07-11
AU2005286713B2 (en) 2010-10-28
CA2580250A1 (en) 2006-03-30
DK1804804T3 (da) 2012-02-20
EP1804804A4 (en) 2010-11-24
CA2580250C (en) 2013-05-14
US20060063928A1 (en) 2006-03-23
ES2378452T3 (es) 2012-04-12
US8101596B2 (en) 2012-01-24
US20060063755A1 (en) 2006-03-23
KR20070060126A (ko) 2007-06-12
BRPI0515518A (pt) 2008-07-29
ATE542536T1 (de) 2012-02-15
JP2008513510A (ja) 2008-05-01

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