KR101262764B1 - New process technology for effective manufacture of red-ginseng extraction and concentration - Google Patents

Abstract

PURPOSE: A manufacturing method of red ginseng concentrate is provided to improve extraction efficiency without destroying ginsenoside Rg1 and Rb1 by conducting extract and concentrating processes combining ultra sound extraction falling film type concentration of red ginseng powder multiple times. CONSTITUTION: Raw red ginseng powder and 8 times the amount of 70% alcohol are mixed. The mixture is extracted at 50-65 deg. C in the ultra sound scanning condition. Extract residues and an extract are separated, and the separated extract is concentrated by falling film type concentration to obtain first extract concentrate. 8 times the amount of 50% alcohol is added to the extract residues, and extracted at 50-65 deg. C in the ultra sound scanning condition. The extract residue and the extraction are separated, and the separated extract is concentrated by second falling film type concentration to obtain extract concentrate. Purified water and alpha-amylase is added to the extract residues, for extracting at 50-65 deg. C in the ultra sound scanning condition. The extract is concentrated by falling film type concentration to obtain third extract concentrate. [Reference numerals] (AA) Raw red ginseng powder; (BB) 70% ethanol; (CC) First extraction of ultrasound scanning; (DD) First extract liquid; (EE,II) Extraction residues; (FF) 50% ethanol; (GG) Second extraction of ultrasound scanning; (HH) Second extract liquid; (JJ) Refined water; (KK) Alpha-amylase; (LL) Third extraction of ultrasound scanning; (MM) Third extract liquid; (NN) Extraction residues; (OO) Falling film type concentration; (PP) First red ginseng extract concentrated liquid(first process); (QQ) Second red ginseng extract concentrated liquid(second process); (RR) Third red ginseng extract concentrated liquid(third process); (SS) Valve; (TT) Total red ginseng extract concentrated liquid(final product)

Description

New process technology for effective manufacture of red-ginseng extraction and concentration}

The present invention relates to a novel manufacturing method for efficiently preparing red ginseng extract concentrate from red ginseng, specifically, the extraction process of red ginseng powder using ultrasonic wave and starch degrading enzyme and the falling film type (falling film type) concentration process. The present invention relates to a method for efficiently preparing red ginseng extract concentrate without destroying the active ingredient of red ginseng.

Ginseng is botanically belonging to the genus Araliaceae, Panax ginseng, and has been used as a mysterious medicine for thousands of years along with red ginseng produced by steaming, drying and processing fresh ginseng. Efficacy includes central nervous system disease, anti-anxiety, nervous system, drug addiction, vascular effect, alcohol detoxification, lipid metabolism and fatigue recovery, antidiabetic, hyperlipidemia, antiviral, immune enhancement, sexual function improvement, anticancer and cancer prevention effect. In particular, panaxadiol (PD) -based saponin represented by ginsenoside Rb ₁ exhibits an inhibitory effect on the central nervous system, and exhibits mental stability, nerve relaxation, analgesic, anticancer, anticonvulsion, blood pressure lowering action, and the like. Panaxatriol (PT) -based saponins represented by Rg ₁ are known to exhibit anti-fatigue effects on the central nervous system [Latest Ginseng Research, Korea Ginseng Society, 2007].

In general, ginseng and red ginseng are marketed as herbal medicines or teas in the form of circular form itself, powders and concentrates. Currently, the use of red ginseng concentrates is widely used in nutritional supplements, cosmetics, pharmaceutical raw materials and health functional foods. Therefore, since the demand is rapidly increasing, the efficient manufacturing process technology of red ginseng concentrate has a great influence on the industrial competitiveness according to product quality and production cost.

However, in general, the manufacturing technology for producing high quality without destroying the inherent effective ingredients of red ginseng in the manufacturing process and the manufacturing technology for improving the production yield are in contradiction with the applied process conditions. For example, in the red ginseng concentrate process In order not to destroy the active ingredients of red ginseng, cold extraction and concentration should be carried out, polar solvents and acids should not be used, and the extraction and concentration will be necessary to exclude pressurization and harsh conditions. In order to improve the performance, it is common to apply the opposite conditions. In general, red ginseng concentrate is prepared by the natural circulation method, which is difficult to work under vacuum for long concentration and processing time due to foaming by saponin (ginsenoside), an active ingredient of red ginseng. There is a disadvantage, and there is a problem of using a silicone-based synthetic antifoam to solve this.

Due to the above problems, a manufacturing technique has been developed that simplifies the manufacturing process and introduces a low temperature extraction method so that red ginseng concentrate can be produced at high quality and low cost. However, stirring method, extraction and concentration time in the extraction and concentration process are still developed. As there are many problems such as the concentration, the concentration method, and the use of the antifoaming agent, there is a need for a lot of process development.

As a prior art related to the red ginseng extract concentrate manufacturing process, for example, in Korean Patent Publication No. 10-0355521, ginseng is heat-treated to produce red ginseng in order to maximize the yield of the red ginseng extract concentrate and extracted using the red ginseng Korean Patent Publication No. 10-0744433 discloses red ginseng powder with 60% alcohol-water extraction solvent at a temperature of 75 ° C. to 85 ° C. for 1 hour to maintain the inherent efficacy of red ginseng. The method of extracting three times by heating the above is presented, and in Korean Patent Publication No. 10-0517128, red ginseng powder is extracted with 0 ~ 60% alcohol-water extraction solvent to maintain the efficacy of red ginseng as it is and increase the yield. Extraction at temperature of 40 ℃ ~ 90 ℃ for 3 ~ 7 hours, especially adjusted to pH 9 ~ 11 using 1N NaOH to improve extraction yield, conversion of extraction solvent using ether The Korean Patent Application Publication No. 10-0854685 discloses a red ginseng extract with 5-6 times purified water at a temperature of 80 ° C. to 95 ° C. in order to maximize the yield of the red ginseng extract concentrate. A method of extracting 4 times by heating for more than 9 hours is proposed, and in Korean Unexamined Patent Publication No. 10-2011-0113424, in order to prevent the destruction of active ingredients of red ginseng in the extraction process and to maximize the extraction yield, Discloses a technique for extracting by applying the low temperature extraction step consisting of 60 ℃ ~ 80 ℃ and the high temperature extraction step consisting of 80 ℃ ~ 100 ℃ sequentially, and in Korea Patent Publication No. 10-1079693 to improve the yield In order to shorten the time, the process of grinding red ginseng into red ginseng powder and separating the extraction foil and extract liquid using screw decanter are performed in a continuous process. The present invention discloses a technique for controlling extraction with alkaline water to increase the content of ginsenosides Rg1 and Rb1, which are active ingredients of red ginseng, without destroying them during the extraction process, and disclosed in Korean Patent Publication No. 10 -2012-0018400 discloses a technique for applying photosensing to a natural circulation concentrate solution and an additional device in order to solve the problem of the loss of centrifuge containing red ginseng components in the manufacture of red ginseng concentrate to improve the yield.

The prior art is a manufacturing technology that simplifies the manufacturing process and introduced a low temperature extraction method to enable the high quality, low cost production of red ginseng extract concentrate, but still stirring method, extraction and concentration time, concentration method and antifoaming agent in the extraction and concentration process Problems such as use.

In order to solve the above problems of the prior art, the present invention does not destroy the active ingredients of red ginseng by applying the extraction process of red ginseng powder using ultrasonic and starch degrading enzyme and the falling film type (falling film type) concentration process. The present invention was completed by developing a novel red ginseng powder extraction technology to maximize the yield in a short time.

The present invention aims at the preparation of a novel red ginseng extract concentrate for the efficient production of red ginseng extract concentrate, and more specifically, combining the ultrasonic extraction of red ginseng powder and the concentration of falling oil film (falling film type). The extraction concentration process was performed several times to improve the extraction efficiency without destroying the axial phase taxosides Rg ₁ and Rb ₁ , and in the final extraction step, the starch of the extract was decomposed to increase the extraction yield by adding alpha-amylase, a starch degrading enzyme. It is an object of the present invention to provide a method for producing red ginseng extract concentrate.

As a solution to the manufacturing method of the red ginseng extract concentrate for achieving the object of the present invention, extraction by ultrasonic injection of the red ginseng powder pulverized raw red ginseng and extraction by falling concentrated film type (falling film type; Falling Film type) concentration The extraction step of the first step to the third step of performing the concentration step three times, and at the same time, the extraction step of the third step, which is the final extraction and concentration step comprises an extraction concentration step of extracting by adding alpha-amylase, The method for preparing red ginseng extract concentrate according to the present invention extracts red ginseng whose process yield is increased without destroying ginsenosides Rg ₁ and Rb _{1, which} are inherent pharmacological ingredients of red ginseng, by short time and low temperature extraction and concentration conditions. A concentrated liquid is produced.

In general, when acid treatment, high temperature treatment or prolonged processing conditions are applied in red ginseng extract concentration process, ginsenosides Rg ₁ and Rb _{1, which} are inherent pharmacological components of ginseng, are destroyed [see Fig. 1]. While the inherent aroma and taste are lost, the process yield is significantly decreased when low temperature treatment and short time process conditions are applied in order to preserve the ginsenoside and maintain the intrinsic taste and aroma. [Latest Ginseng Research, Consideration Ginseng Society, 2007].

[Figure 1]

When explaining the solution to the manufacturing method of the red ginseng extract concentrate according to the present invention in more detail, a) a raw material mixture of 70% alcohol of 8 times compared to the raw red ginseng powder and the raw red ginseng powder of 50 ~ 65 ℃ A first step of extracting the extraction residue and the extract from the temperature range and ultrasonic scanning conditions, and concentrating the separated extract by falling film type (falling film type) concentration to obtain a first extract concentrate;

 b) Add 50% alcohol 8 times more than the raw red ginseng powder to the extraction residue of the first step, extract it under the temperature range of 50-65 ℃ and ultrasonic scanning conditions to separate the extraction residue and the extract, A second step of obtaining the second extraction concentrate by concentrating the extract by dropping film type (falling film type) concentration (extracting and concentrating under the same conditions as the first step); and

c) 8 times more purified water and alpha-amylase than the raw red ginseng powder are added to the extraction residue of the second step, extracted under the temperature range of 50-65 ° C. and ultrasonic scanning conditions to separate the extraction residue and the extract, and And a third step of concentrating the extract by falling oil type (falling film type) concentration (extracting and concentrating under the same conditions as the first step) to obtain an extract concentrate three times.

Red ginseng used in the present invention is not limited in kind, but the sum of the content of ginsenoside Rg ₁ and Rb ₁ is more than 4mg / g, the dry raw material suitable for the specifications of the ginseng industry law of 15% by weight or less Red ginseng is used, and if the moisture content is more than 15% by weight, the grinding time is long or the grinding is not performed smoothly. Therefore, the present invention uses raw red ginseng in the range of 12 to 15% by weight. Use red ginseng powder ground to 5mesh ~ 30mesh.

According to the use of the red ginseng powder pulverized into the 5 mesh ~ 30 mesh when the ultrasonic injection in the extraction step has the advantage of widening the specific surface area of the red ginseng to increase the efficiency of extraction to excellent, and the extraction step of each process of the present invention is ultrasonic It is effective to increase the extraction efficiency without the fluidity of the extract by stirring in the extractor by the injection, the ultrasonic scanning condition is preferably in the frequency range of 25kHz ~ 60kHz, maximizing the extraction efficacy of red ginseng powder, and injecting 30kHz ultrasound It is more preferable.

The extraction solvent according to the present invention uses 70% alcohol, 50% alcohol and purified water sequentially in each process, but uses the same amount, that is, 8 times compared to the raw red ginseng powder, and extracts in the third process according to the present invention. The step is the final extraction of ginsenoside Rb ₁ + Rg ₁ from the raw red ginseng. The final extraction process is used to decompose the starch of the extract residue and to increase the yield of the extract concentrate. The extraction is performed by adding amylase, and the addition ratio of alpha-amylase is preferably extracted by adding it within the range of 0.1 to 1% by weight relative to the raw red ginseng powder.

In addition, the falling oil film type (falling film type) concentration technology employed together in the first to third processes of the present invention flows the liquid to be processed from above the heating part of the evaporator (concentrator) to allow the evaporation tube. A thin film is formed on the wall to flow down and evaporates moisture under low temperature and reduced pressure conditions. It is a concentration technique widely applied to heat-sensitive fruit juice, etc. In the present invention, it is 140 ° C. to 160 ° C. Falling film type (falling film type) concentration process is carried out under the concentration range of 1 ~ 10mmHg and vacuum degree, the concentration production efficiency is preferably 500 ~ 800ℓ / hr.

The present invention has the advantage that it can be rapidly concentrated at low temperature without using any antifoaming agent in the concentration process of the iris extract by applying the falling film type (falling film type) concentration process described above.

The manufacturing method of the red ginseng extract concentrate according to the present invention is an efficient process for preparing the extract concentrate under low temperature conditions in a short time while the whole process is simple, and the resulting red ginseng extract concentrate is preserved intact in its own flavor or color, and red ginseng Acidic polysaccharides, water-soluble proteins, peptides and amino acid derivatives, and polyacetylene-based components, which are inherent pharmacological components, are extracted in high yield, and in particular, the degree of destruction of ginsenosides Rg ₁ and Rb ₁ , which are the criteria for pharmacologically active ingredients, are extracted. It is characterized in that the red ginseng extract concentrate with increased process yield is low.

In addition, in general, when the red ginseng extract is concentrated, a lot of bubbles due to ginsenosides occur, and the silicone antifoaming agent is openly used, whereas the falling film type (falling film type) concentration technology of the present invention is an antifoaming agent. It can be concentrated quickly at low temperature without any use of it, which also saves energy and is environmentally friendly.

Therefore, since the manufacturing method of the red ginseng extract concentrate according to the present invention can reduce the production cost due to the simple manufacturing process, it is highly competitive in the health functional food, pharmaceutical material or red ginseng concentrate market, so that customers can provide high quality low price products. There are advantages to it.

1 is a process diagram schematically showing a method for producing a red ginseng extract concentrate that repeats the first step second step and the third step according to the present invention by one extractor and a drop film type thickener.
Figure 2 is a process diagram schematically showing a method for producing a red ginseng extract concentrate that performs the first step second step and the third step according to the present invention by connecting three extractors and a drop film type thickener in sequence.
3 is a reference diagram schematically showing a known falling film thickener (falling film evaporator) employed in the present invention.
4 is a graph showing the extraction efficiency and the concentration yield of the ginsenoside Rg ₁ + Rb ₁ according to the ultrasonic frequency change of the present invention
5 is a graph showing the extraction efficiency and the concentration yield change of ginsenoside Rg ₁ + Rb _{1 with} the addition amount of alpha-amylase of the present invention
Figure 6 is a graph showing the change in the content of ginsenoside Rg ₁ + Rb ₁ according to the temperature conditions change in the falling oil film concentration process of the present invention

Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples, and the present invention is not limited by the following description. In addition, all the parts and percentage units used by this invention are shown by weight unless there is particular notice.

And ginsenosides Rb _{1 in} Examples and Test Examples of the present invention. And the content analysis of Rg ₁ is prepared according to the pretreatment method of the food industry, respectively, and then HPLC (High Performance Liquid Chromatography) equipped with UVD (Ultra Visible Detector) shown in the [Table 1] and [Table 2] Analysis was carried out by the analysis conditions and the content calculation formula.

In addition, the analysis of the content of benzopyrene in the examples and test examples of the present invention were prepared by analytical samples according to the pretreatment method of the food industry, and then analyzed by HPLC (High Performance Liquid Chromatography) equipped with FLD (Fluorescence Detector).

The analysis conditions are as shown in the following [Table 3], the content calculation formula was the peak area method using the internal standard according to the method of the Food Code.

And the raw red ginseng used in the embodiment of the present invention is a raw red ginseng (6 years old domestic) for manufacturing red ginseng concentrate prepared directly by the applicant company of the present invention (Daedong Korea Ginseng Co., Ltd.), meets the standards of the ginseng industry law, The sum of the contents of the senoside Rg ₁ and Rb ₁ is more than 4mg / g, and the moisture content is produced to meet the specification of less than 15wt%.

≪ Example 1 >

102 kg of the red ginseng raw material was put into a grinder and crushed into 10mesh to prepare 100 kg of red ginseng powder, and then the pulverized red ginseng powder was prepared using an extractor equipped with an ultrasonic generator and a falling film evaporator. Extraction and concentration was performed three times in.

A) Preparation of Red Ginseng Extract Concentrate (Phase 1) by the First Step

After extracting the extraction solvent 70% alcohol 800ℓ and the red ginseng powder 100kg into the extractor equipped with the ultrasonic generator, the extraction was performed while scanning the ultrasonic wave of extraction temperature 55 ℃, extraction time 2 hours, frequency 30kHz to extract the primary extract from the extractor. After the separation, the first extract was put into a falling film evaporator and the first extract of red ginseng with 60% solids was extracted at a concentration of 150 ° C, a vacuum pressure of 5mmHg, a production flow rate of 500ℓ / hr and a process time of 30 minutes. A concentrate was obtained.

B) Preparation of Red Ginseng Extract Concentrate (Second Time) by the Second Step

After separating the primary extract in the first step, the extraction solvent 50% alcohol 800ℓ is added to the remaining residue, extraction is carried out while scanning the ultrasonic wave of the extraction temperature 60 ℃, extraction time 2 hours, frequency 30kHz 2 After extracting the secondary extract, the secondary extract was added to the falling film evaporator, and the concentration of 155 ℃, vacuum pressure of 5mmHg, concentration of the concentrate production flow of 500ℓ / hr, and processing time of 30 minutes were obtained. The red ginseng extract concentrate was prepared.

C) Preparation of Red Ginseng Extract Concentrate (No. 3) by the Third Step

After separating the secondary extract in the second step, 800 liters of purified water was added to the remaining extraction residue as an extraction solvent, and the extraction temperature was 65 ° C and extraction time under the condition that 0.5 wt% of alpha-amylase was added to the amount of red ginseng powder used. Extraction was carried out by scanning ultrasonic waves at a frequency of 30 kHz for 3 hours to separate the tertiary extract from the extractor. Then, the tertiary extract was added to a falling film evaporator, and the condensation temperature was 160 ° C., the vacuum pressure was 5 mmHg, and the concentrate was concentrated. A red ginseng extract concentrate of 60% solids was prepared under a production flow rate of 500 l / hr and a process time of 30 minutes.

≪ Comparative Example 1 &

For the comparative test, red ginseng powder having the same conditions as in <Example 1>, and using the ultrasonic extraction and the conventional extraction method without the alpha-amylase and batch circulating vacuum concentration method three times Extracted and concentrated to prepare a red ginseng extract concentrate, the process conditions are as follows.

1) Preparation of Red Ginseng Extract Concentrate

After extracting the extraction solvent 70% alcohol 800ℓ and the red ginseng powder 100kg into the extractor, the extraction was carried out at an extraction temperature of 70 ℃, extraction time 8 hours to put the primary extract separated from the extractor into a batch circulating vacuum concentrator Then, the first concentrated red ginseng extract concentrate was prepared at a concentration temperature of 220 ° C., a vacuum pressure of 5 mmHg, and a process time of 2 hours.

B) Preparation of the 2nd red ginseng extract concentrate

The primary extract was separated and the extraction solvent 50% alcohol 800ℓ was added to the remaining residue in the extractor, and the extraction was performed at an extraction temperature of 75 ° C. and extraction time of 8 hours to batch the secondary extract separated from the extractor. The red ginseng extract concentrate was prepared in a circulating vacuum concentrator, and the second concentrated red ginseng extract was 60% solid under a concentration temperature of 225 ° C, a vacuum pressure of 5 mmHg, and a process time of 2 hours.

C) Preparation of red ginseng extract concentrate

The secondary extract was separated and 800 liters of purified water was added to the extraction residue remaining in the extractor as an extraction solvent, and the extraction was performed at an extraction temperature of 80 ° C. and an extraction time of 8 hours. The red ginseng extract concentrate having a solid content of 60% was prepared at a concentration of 230 ° C., a vacuum pressure of 5 mmHg, and a process time of 2 hours.

&Lt; Test Example 1 >

Ginsenoside Rb ₁ of the red ginseng extract concentrate prepared by <Example 1> and <Comparative Example 1> And the test analysis on the content, color, and flavor of Rg ₁ and the results are shown in Table 4 below, and to compare the process efficiency of <Example 1> and <Comparative Example 1><Example1> The comparison table of extraction temperature and extraction time of <Comparative Example 1> is shown in [Table 5] below.

According to the results shown in [Table 4] of the red ginseng concentrate obtained in each extraction concentration in the <Example 1> and <Comparative Example 1> (conventional extraction concentration method) of the preparation method of the red ginseng extract concentrate of the present invention the binary comparing the total amount of ginsenoside Rb ₁ + Rg individually content and a ginsenoside Rb ₁ + Rg ₁ obtained in the overall process of Figure _1, obtained in the first step and the extract concentration step of the second process Rb ₁ + Rg the content of _1, but appears to be a of <example 1> extract concentration process according to the invention increases relative to <Comparative example 1>, the extract concentration step of the third step <example 1> the <Comparative example 1> The total content of Rb ₁ + Rg ₁ according to the overall extraction and concentration process of the first to third process is compared to that of <Example 1>, which is a manufacturing method of the red ginseng extract concentrate according to the present invention. Example 1> shows increased results compared to conventional extraction and concentration methods There.

According to the results shown in [Table 4], in the manufacturing method of the red ginseng extract concentrate according to the present invention, ginsenosides Rb ₁ + Rg ₁ contained in the raw red ginseng by ultrasonic irradiation are the first and second steps. Compared with the extraction concentration process, more than 97.8% is extracted. In Comparative Example 1 (conventional extraction concentration method), ginsenoside Rb ₁ + Rg ₁ is about 83% in the first and second extraction concentration processes. The extraction concentration method according to the present invention from the point that is extracted is confirmed that the ginsenoside Rb ₁ + Rg ₁ contained in the raw material red ginseng by ultrasonic irradiation is mostly extracted in the extraction concentration step of the first to second steps Can be.

In the final extraction process of the third process, the decomposing ginsenoside Rb ₁ + Rg ₁ contained in the raw red ginseng was almost completely extracted, and alpha-amylase was added to the residue to extract the residue. It can be confirmed that a higher yield of red ginseng extract concentrate can be obtained from raw red ginseng without affecting the decomposition of ginsenosides Rb ₁ + Rg ₁ by decomposing and extracting starch.

As shown in Table 5 above, the conditions according to the extraction concentration step of the first step to the third step for <Example 1> and <Comparative Example 1> (conventional extraction concentration method) according to the present invention are integrated. When comparing the process efficiency by total (total), the extraction temperature and extraction time in <Example 1> compared to <Comparative Example 1>, respectively, lower temperature and shorter extraction time [extraction time is <Comparative Example 1> It is shown that the process time is reduced by more than 3.4 times compared to Example 1>, and the concentration temperature and the concentration time are also lower than those of <Example 1> and <Comparative Example 1>. It was found that <Example 1> was shown to shorten the process time by about 4 times compared to <Comparative Example 1>.

The results shown in the above [Table 5] shows that the manufacturing method of the red acid extract concentrate according to the present invention can concentrate the red ginseng extract in a short time at low temperature compared to the conventional extract concentrate technique by employing a falling film concentration technique. In addition, the red ginseng extract concentrate according to the present invention can be produced while maintaining the efficacy, color and fragrance of red ginseng as it is. It can be seen that it is a new and excellent technology suitable for manufacturing with high yield.

<Example 2>

Preparation of the red ginseng extract concentrate of <Example 1> for the test of the extraction efficiency of ginsenoside Rg ₁ + Rb ₁ and the yield change of the extract concentrate in relation to the ultrasonic injection in the preparation method of the red ginseng extract concentrate according to the present invention In the example, red ginseng extract concentrate was prepared under the same conditions as in <Example 1> except that the frequency of the ultrasonic wave was changed to 25 kHz, 30 kHz, 35 kHz, 40 kHz, 50 kHz, and 60 kHz only in the first step. The ginsenoside Rg ₁ + Rb ₁ extraction efficiency and extract concentrate yield change are shown in FIG. 3.

Referring to FIG. 3, it can be seen that the change in the content of ginsenoside Rg ₁ + Rb _{1 in} the red ginseng extract concentrate showed an inflection point of the rising curve at 30 kHz and then a downward curve while the ultrasonic frequency was changed from 25 kHz to 60 kHz. In addition, the red ginseng extraction process by ultrasonic scanning was analyzed at 30 kHz as the most preferable frequency by showing the equilibrium curve after the inflection point of the rising curve at 30 kHz.

<Example 3>

Red ginseng extract of <Example 1> for a test for the extraction efficiency of ginsenoside Rg ₁ + Rb ₁ and the change of extract concentrate yield in relation to the addition of alpha-amylase in the preparation method of the red ginseng extract concentrate according to the present invention In the preparation example of the concentrate, the same conditions as in <Example 1> except that the amount of alpha-amylase was changed to 0%, 0.1%, 0.3%, 0.5%, 0.75%, and 1% relative to the amount of raw red ginseng in the third step only. Red ginseng extract concentrate was prepared under the conditions, and ginsenoside Rg ₁ + Rb ₁ extraction efficiency and extract concentrate yield change according to the change in the amount of alpha-amylase were shown in FIG. 4.

Referring to FIG. 4, while the amount of alpha-amylase was changed from 0% to 1% compared to the amount of raw red ginseng, the content of ginsenoside Rg ₁ + Rb ₁ in the red ginseng concentrate obtained was decreased 0.5 of the amount of alpha-amylase. Changes in yields of red ginseng extract concentrates showed an equilibrium curve after the addition of alpha-amylase at 0.5%, with the inflection point of the rising curve at 0.5%. to increase the yield of the concentrate, but binary while also, and that the can know true the least destructive ginsenosides Rg content of ₁ + Rb ₁ serves to ginsenoside Rg ₁ + reduce the content of Rb ₁ number of red ginseng extract concentrate yield The optimum condition of the amount of alpha-amylase added to maximize the weight of the raw red ginseng was found to be 0.5% most preferred. In addition, in order to increase the amount of ginsenoside Rg ₁ + Rb ₁ of the red ginseng extract concentrate and increase the yield of the red ginseng concentrate according to the results of [Figure 2], ultrasonic injection was performed as in the first and second steps of the present invention. It can be recognized that the ginsenoside Rg ₁ + Rb ₁ contained in the raw red ginseng should be obtained as much as possible.

<Example 4>

In the preparation method of the red ginseng extract concentrate according to the present invention for the test of the change in the content of ginsenoside Rg ₁ + Rb ₁ contained in the red ginseng extract concentrate in connection with the adoption of the falling film concentration technology <Example In the preparation example of the red ginseng extract concentrate of 1>, the temperature change was changed to 130 ° C, 140 ° C, 150 ° C, 160 ° C, 170 ° C, 180 ° C, 190 ° C, and 200 ° C by the falling film concentration conditions of the first step. , Except that it is different from 210 ℃ red ginseng extract concentrate was prepared under the same conditions as in <Example 1>, and the results for the ginsenoside Rg ₁ + Rb ₁ content change is shown in FIG.

Referring to FIG. 5, the content change of ginsenoside Rg ₁ + Rb ₁ of the red ginseng concentrate obtained during the temperature condition of Falling Film concentration from 130 ° C. to 210 ° C. in the red ginseng extract concentration process It can be seen that after the temperature condition has an inflection point at 150 ℃, it shows a falling curve, the ginsenoside Rg ₁ + Rb ₁ is gradually destroyed by the concentration temperature, the concentration temperature conditions are below 150 ℃ It can be seen that the senoside Rg ₁ + Rb ₁ is the maximum temperature which does not break down. In addition, in the case of the extraction concentration process, since the process time is longer when the falling oil concentration temperature is lower than 140 ° C, the temperature condition of the falling oil concentration that has optimum process efficiency without destroying ginsenoside Rg ₁ + Rb ₁ is 150. C is most preferred.

In addition, in Example 1 of the present invention described above, each extraction concentration process was repeatedly performed by an apparatus for manufacturing a single red ginseng extract concentrate consisting of an extractor equipped with an ultrasonic generator and a falling film evaporator. If necessary, as shown in FIG. 2, a combination of three red ginseng extract concentrates, each consisting of an extractor equipped with an ultrasonic generator and a falling film evaporator, sequentially combines the first to third processes. The process may be carried out in a continuous process.

Claims (8)

a) Extracting the raw material mixture containing 70% alcohol 8 times more than the raw red ginseng powder and raw red ginseng powder under the temperature range of 50-65 ℃ and ultrasonic scanning conditions, separating the extraction residue and extract, and dropping the separated extract A first step of obtaining a first extract concentrate by concentrating by concentration of a falling film type,
b) Add 50% alcohol 8 times more than the raw red ginseng powder to the extraction residue of the first step, extract it under the temperature range of 50-65 ℃ and ultrasonic scanning conditions to separate the extraction residue and the extract, A second process of concentrating the extract by falling film type concentration to obtain a second extract concentrate; and
c) 8 times more purified water and alpha-amylase than the raw red ginseng powder are added to the extraction residue of the second step, and extracted under the temperature range of 50-65 ° C. and ultrasonic scanning conditions to separate the extraction residue and the extract, and And a third step of concentrating one extract by falling film type concentration to obtain a third extract concentrate. The method according to claim 1, wherein the ultrasonic scanning of the first step to the third step is a frequency of 25 ~ 60kHz range manufacturing method of red ginseng extract concentrate. The method according to claim 2, wherein the ultrasonic scanning of the first to the third step is in the frequency range of 30 kHz, and extracted for 1 to 3 hours. The red ginseng concentrate according to any one of claims 1 to 3, wherein the falling film type concentration of the first to third steps is performed at a concentration temperature of 140 to 160 ° C, a vacuum pressure of 1 to 10 mmHg, and a solid content of 60% or more. The production method of red ginseng extract concentrate, characterized in that concentrated to the production rate 500 ~ 800ℓ / hr. The method according to any one of claims 1 to 3, wherein the alpha-amylase is added in an amount of 0.1 to 1 wt% based on the amount of the raw red ginseng powder. Red ginseng extract concentrate, which is produced by the production method according to any one of claims 1 to 3. According to claim 6, Falling film type (Falling Film type) concentration of the first step to the third step of the red ginseng concentrate production rate of 500 ~ 800l / hr of the concentration temperature 140 ~ 160 ℃, vacuum pressure 1 ~ 10mmHg and solid content 60% or more. Red ginseng extract concentrate, characterized in that concentrated under the conditions. The red ginseng extract concentrate according to claim 6, wherein the alpha-amylase is added in a range of 0.1 to 1 wt% based on the amount of the raw red ginseng powder.

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