KR101262300B1 - 형질전환 식물 유래의 고병원성 조류독감 바이러스 단백질 백신 및 그 제조방법 - Google Patents

형질전환 식물 유래의 고병원성 조류독감 바이러스 단백질 백신 및 그 제조방법 Download PDF

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KR101262300B1
KR101262300B1 KR1020100096488A KR20100096488A KR101262300B1 KR 101262300 B1 KR101262300 B1 KR 101262300B1 KR 1020100096488 A KR1020100096488 A KR 1020100096488A KR 20100096488 A KR20100096488 A KR 20100096488A KR 101262300 B1 KR101262300 B1 KR 101262300B1
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protein
hemagglutinin
virus
plant
present
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KR20110037880A (ko
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황인환
성영철
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헬릭스 주식회사
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Priority to PCT/KR2010/006821 priority Critical patent/WO2011043584A2/ko
Priority to CN2010800563463A priority patent/CN102770016A/zh
Priority to US13/500,762 priority patent/US20120219580A1/en
Priority to EP10822229.0A priority patent/EP2486791A4/en
Priority to IN3330DEN2012 priority patent/IN2012DN03330A/en
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Assigned to 주식회사 바이오앱 reassignment 주식회사 바이오앱 권리의 전부이전등록 Assignors: 포항공과대학교 산학협력단
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
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  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
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  • Epidemiology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020100096488A 2009-10-06 2010-10-04 형질전환 식물 유래의 고병원성 조류독감 바이러스 단백질 백신 및 그 제조방법 Active KR101262300B1 (ko)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN2010800563463A CN102770016A (zh) 2009-10-06 2010-10-06 来源于转基因植物的高致病性禽流感病毒蛋白疫苗及其制备方法
US13/500,762 US20120219580A1 (en) 2009-10-06 2010-10-06 Highly pathogenic avian influenza virus protein vaccine derived from transgenic plant, and preparing method thereof
EP10822229.0A EP2486791A4 (en) 2009-10-06 2010-10-06 PROTEIN VACCINE PREVENTED FROM TRANSGENIC PLANTS AGAINST HIGH DENSITY PATHOGENIC BIRD VEGETABLE VIRUSES AND MANUFACTURING METHOD THEREFOR
IN3330DEN2012 IN2012DN03330A (https=) 2009-10-06 2010-10-06
PCT/KR2010/006821 WO2011043584A2 (ko) 2009-10-06 2010-10-06 형질전환 식물 유래의 고병원성 조류독감 바이러스 단백질 백신 및 그 제조방법

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Application Number Priority Date Filing Date Title
KR20090094627 2009-10-06
KR1020090094627 2009-10-06

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KR20110037880A KR20110037880A (ko) 2011-04-13
KR101262300B1 true KR101262300B1 (ko) 2013-05-20

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US (1) US20120219580A1 (https=)
EP (1) EP2486791A4 (https=)
KR (1) KR101262300B1 (https=)
CN (1) CN102770016A (https=)
IN (1) IN2012DN03330A (https=)
WO (1) WO2011043584A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150141329A (ko) * 2014-06-10 2015-12-18 포항공과대학교 산학협력단 인플루엔자 a 바이러스 h5n1의 헤마글루티닌을 발현하는 식물체 및 사포닌을 포함하는 경구용 인플루엔자 a 바이러스 h5n1 백신 조성물
WO2020059962A1 (ko) * 2018-09-19 2020-03-26 주식회사 바이오앱 Bip 단편을 포함하는 재조합 벡터 및 상기 벡터를 이용한 재조합 단백질의 제조 방법

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KR101535704B1 (ko) * 2012-12-28 2015-07-27 한국생명공학연구원 항원성 단백질 고정화를 통한 돈단독 백신 제조방법
US9624272B2 (en) 2013-03-14 2017-04-18 University Of Washington Through Its Center For Commercialization Polypeptides for treating and/or limiting influenza infection
US10344293B2 (en) * 2016-05-12 2019-07-09 Bio Applications Inc. Vaccine composition for classical swine fever from plant and manufacturing method thereof
EA201892385A1 (ru) 2016-06-03 2019-06-28 Санофи Пастер Инк. Модификация сконструированных полипептидов гемагглютинина вируса гриппа
CN107058377A (zh) * 2017-06-16 2017-08-18 深圳惠升生物科技有限公司 植物作为宿主在表达中东呼吸综合征的疫苗中的应用
KR102128453B1 (ko) * 2018-03-23 2020-07-01 주식회사 젠바디 황열 바이러스 유래 ns1 단백질, 이에 특이적으로 결합하는 단일클론항체 및 이의 용도
GB2578163A (en) * 2018-10-19 2020-04-22 Univ Pretoria Plant produced avian influenza antigens and their uses in diagnostic assays and devices
KR102317403B1 (ko) * 2019-01-28 2021-10-29 주식회사 바이오앱 당화된 Ag85A 단백질을 포함하는 결핵 예방용 백신 조성물 및 이의 제조방법
KR102209198B1 (ko) * 2019-04-02 2021-02-02 주식회사 바이오앱 식물에서의 발현이 최적화된 재조합 이리신 유전자 및 이를 이용한 재조합 이리신 단백질의 생산 방법

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KR100769584B1 (ko) 2004-07-30 2007-10-23 학교법인 포항공과대학교 셀룰로오스의 자가가수분해를 위한 셀룰라아제 발현형질전환 식물체 및 이를 이용한 수용성 당의 생산방법

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WO2008054540A2 (en) * 2006-05-18 2008-05-08 Pharmexa Inc. Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions
CN1884517B (zh) * 2006-06-08 2010-06-30 武汉禾元生物科技有限公司 利用谷物非储藏蛋白为融合载体在胚乳表达多肽的方法及应用
US8158264B2 (en) 2006-10-20 2012-04-17 3M Innovative Properties Company Method for easy-to-clean substrates and articles therefrom
CN101284130B (zh) * 2007-04-09 2011-12-14 生宝生物科技股份有限公司 利用逆向基因工程技术开发蛋白质疫苗与禽流感疫苗的方法
KR101161622B1 (ko) * 2009-08-31 2012-07-04 헬릭스 주식회사 번역 효율 증진용 ｄｎａ 단편 및 이를 포함하는 재조합 벡터

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KR100769584B1 (ko) 2004-07-30 2007-10-23 학교법인 포항공과대학교 셀룰로오스의 자가가수분해를 위한 셀룰라아제 발현형질전환 식물체 및 이를 이용한 수용성 당의 생산방법

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150141329A (ko) * 2014-06-10 2015-12-18 포항공과대학교 산학협력단 인플루엔자 a 바이러스 h5n1의 헤마글루티닌을 발현하는 식물체 및 사포닌을 포함하는 경구용 인플루엔자 a 바이러스 h5n1 백신 조성물
KR101602562B1 (ko) * 2014-06-10 2016-03-10 포항공과대학교 산학협력단 인플루엔자 a 바이러스 h5n1의 헤마글루티닌을 발현하는 식물체 및 사포닌을 포함하는 경구용 인플루엔자 a 바이러스 h5n1 백신 조성물
WO2020059962A1 (ko) * 2018-09-19 2020-03-26 주식회사 바이오앱 Bip 단편을 포함하는 재조합 벡터 및 상기 벡터를 이용한 재조합 단백질의 제조 방법
US11434496B2 (en) 2018-09-19 2022-09-06 Bioapplications Inc. Recombinant vector comprising BiP fragment and preparation method of recombinant proteins using thereof

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Publication number Publication date
EP2486791A4 (en) 2013-06-12
US20120219580A1 (en) 2012-08-30
WO2011043584A2 (ko) 2011-04-14
CN102770016A (zh) 2012-11-07
WO2011043584A3 (ko) 2011-10-20
EP2486791A2 (en) 2012-08-15
KR20110037880A (ko) 2011-04-13
IN2012DN03330A (https=) 2015-10-23
WO2011043584A9 (ko) 2011-09-01

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