KR101203124B1 - 응고 장애 치료용 물질 및 치료 방법 - Google Patents

응고 장애 치료용 물질 및 치료 방법 Download PDF

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Publication number
KR101203124B1
KR101203124B1 KR1020067022954A KR20067022954A KR101203124B1 KR 101203124 B1 KR101203124 B1 KR 101203124B1 KR 1020067022954 A KR1020067022954 A KR 1020067022954A KR 20067022954 A KR20067022954 A KR 20067022954A KR 101203124 B1 KR101203124 B1 KR 101203124B1
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KR
South Korea
Prior art keywords
formula
compound
another aspect
provides
halogen
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KR1020067022954A
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English (en)
Korean (ko)
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KR20060133081A (ko
Inventor
파스칼 드루즈갈라
시루스 벡커
Original Assignee
아메데온, 인코포레이티드
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Priority claimed from US10/822,129 external-priority patent/US7145020B2/en
Application filed by 아메데온, 인코포레이티드 filed Critical 아메데온, 인코포레이티드
Publication of KR20060133081A publication Critical patent/KR20060133081A/ko
Application granted granted Critical
Publication of KR101203124B1 publication Critical patent/KR101203124B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
KR1020067022954A 2004-04-08 2005-04-08 응고 장애 치료용 물질 및 치료 방법 KR101203124B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US56112104P 2004-04-08 2004-04-08
US10/822,129 2004-04-08
US10/822,129 US7145020B2 (en) 2001-04-24 2004-04-08 Materials and methods for treating coagulation disorders
US60/561,121 2004-04-08
PCT/US2005/012091 WO2005100336A1 (en) 2004-04-08 2005-04-08 Materials and methods for treating coagulation disorders

Publications (2)

Publication Number Publication Date
KR20060133081A KR20060133081A (ko) 2006-12-22
KR101203124B1 true KR101203124B1 (ko) 2012-11-20

Family

ID=34965219

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020067022954A KR101203124B1 (ko) 2004-04-08 2005-04-08 응고 장애 치료용 물질 및 치료 방법

Country Status (18)

Country Link
US (1) US7285671B2 (US07981874-20110719-C00313.png)
EP (1) EP1735296B1 (US07981874-20110719-C00313.png)
JP (1) JP5036532B2 (US07981874-20110719-C00313.png)
KR (1) KR101203124B1 (US07981874-20110719-C00313.png)
AT (1) ATE451361T1 (US07981874-20110719-C00313.png)
AU (1) AU2005233614C1 (US07981874-20110719-C00313.png)
BR (1) BRPI0508392A (US07981874-20110719-C00313.png)
CA (1) CA2559568C (US07981874-20110719-C00313.png)
CY (1) CY1109763T1 (US07981874-20110719-C00313.png)
DE (1) DE602005018181D1 (US07981874-20110719-C00313.png)
DK (1) DK1735296T3 (US07981874-20110719-C00313.png)
ES (2) ES2436298T3 (US07981874-20110719-C00313.png)
HK (2) HK1105200A1 (US07981874-20110719-C00313.png)
IL (1) IL178122A (US07981874-20110719-C00313.png)
NO (1) NO338837B1 (US07981874-20110719-C00313.png)
PT (1) PT1735296E (US07981874-20110719-C00313.png)
RU (1) RU2495034C2 (US07981874-20110719-C00313.png)
WO (1) WO2005100336A1 (US07981874-20110719-C00313.png)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4662690B2 (ja) * 2001-04-24 2011-03-30 アリックス セラピューティクス 抗凝血薬として用いるクマリン誘導体
DK2161261T3 (da) * 2004-04-08 2013-11-04 Armetheon Inc Materialer og fremgangsmåder til behandling af koagulationslidelser
JP5302005B2 (ja) * 2005-12-01 2013-10-02 オースペックス・ファーマシューティカルズ・インコーポレイテッド セロトニン作動性および／またはノルエピネフリン作動性の活性を有する置換フェネチルアミン
CN101188435B (zh) * 2007-01-08 2011-03-16 中兴通讯股份有限公司 一种比特交织装置与方法
US20110053933A1 (en) 2008-03-26 2011-03-03 Daiichi Sankyo Company, Limited Hydroxyquinoxalinecarboxamide derivative
US9549912B2 (en) 2009-11-23 2017-01-24 Armetheon, Inc. Methods for treating atrial fibrillation
US20110136779A1 (en) * 2009-11-23 2011-06-09 Milner Peter G Methods for stroke reduction in atrial fibrillation patients
WO2011072275A2 (en) * 2009-12-11 2011-06-16 Nono, Inc. Agents and methods for treating ischemic and other diseases
EP2533637B1 (en) * 2010-02-12 2014-03-26 N30 Pharmaceuticals, Inc. Chromone inhibitors of s-nitrosoglutathione reductase
ES2565345T3 (es) 2010-02-12 2016-04-04 Nivalis Therapeutics, Inc. Nuevos inhibidores de la reductasa de s-nitrosoglutatión
US9561227B2 (en) 2014-01-15 2017-02-07 Southern Methodist University Inhibitors of multidrug resistance transporter P-glycoprotein
US11013739B2 (en) 2014-01-15 2021-05-25 Southern Methodist University Inhibitors of multidrug resistance transporter p-glycoprotein
US11234978B2 (en) 2014-01-15 2022-02-01 Southern Methodist University Inhibitors of multidrug resistance transporter P-glycoprotein
US10292982B2 (en) 2014-01-15 2019-05-21 Southern Methodist University Inhibitors of multidrug resistance transporter P-glycoprotein
CN114524791B (zh) * 2022-01-26 2024-01-26 江苏慧聚药业股份有限公司 替卡法林的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001072667A2 (fr) * 2000-03-29 2001-10-04 Warner-Lambert Company Modification de la chimioselectivite lors de l'oxydation de composes organiques azotes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL108459A0 (en) * 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
US5510375A (en) * 1993-11-19 1996-04-23 Warner-Lambert Company Coumarin derivatives as protease inhibitors and antiviral agents
GB9324517D0 (en) * 1993-11-30 1994-01-19 Octel Chem Ltd Process for the preparation of substituted 4-hydroxycoumarins
FR2749585B1 (fr) * 1996-06-11 1998-08-14 Hoechst Marion Roussel Inc Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
US7145020B2 (en) * 2001-04-24 2006-12-05 Aryx Therapeutics Materials and methods for treating coagulation disorders
JP4662690B2 (ja) * 2001-04-24 2011-03-30 アリックス セラピューティクス 抗凝血薬として用いるクマリン誘導体
US6608097B2 (en) * 2001-10-10 2003-08-19 Aryx Therapeutics Materials and methods for the treatment of hypertension and angina
US7179838B2 (en) * 2002-07-30 2007-02-20 New Century Pharmaceuticals, Inc. Coumarin analog compounds for safer anticoagulant treatment

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001072667A2 (fr) * 2000-03-29 2001-10-04 Warner-Lambert Company Modification de la chimioselectivite lors de l'oxydation de composes organiques azotes

Also Published As

Publication number Publication date
CA2559568A1 (en) 2005-10-27
US20060287388A1 (en) 2006-12-21
IL178122A0 (en) 2006-12-31
ATE451361T1 (de) 2009-12-15
RU2008120295A (ru) 2009-11-27
KR20060133081A (ko) 2006-12-22
CA2559568C (en) 2013-05-28
AU2005233614A1 (en) 2005-10-27
WO2005100336A1 (en) 2005-10-27
EP1735296A1 (en) 2006-12-27
ES2436298T3 (es) 2013-12-30
HK1105200A1 (en) 2008-02-06
DE602005018181D1 (de) 2010-01-21
NO20065079L (no) 2006-11-03
HK1138265A1 (en) 2010-08-20
JP2007532575A (ja) 2007-11-15
DK1735296T3 (da) 2010-02-01
AU2005233614C1 (en) 2012-07-19
EP1735296B1 (en) 2009-12-09
CY1109763T1 (el) 2014-09-10
NO338837B1 (no) 2016-10-24
BRPI0508392A (pt) 2007-08-07
IL178122A (en) 2013-01-31
AU2005233614B2 (en) 2011-11-24
ES2340690T3 (es) 2010-06-08
RU2495034C2 (ru) 2013-10-10
PT1735296E (pt) 2010-02-09
JP5036532B2 (ja) 2012-09-26
US7285671B2 (en) 2007-10-23

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