KR101168211B1 - （ｓ）－３－［（１－디메틸아미노）에틸］－페닐－ｎ－에틸－ｎ－메틸－카바메이트의 제조를 위한 효과적인 방법 - Google Patents

（ｓ）－３－［（１－디메틸아미노）에틸］－페닐－ｎ－에틸－ｎ－메틸－카바메이트의 제조를 위한 효과적인 방법 Download PDF

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KR101168211B1
KR101168211B1 KR1020077009495A KR20077009495A KR101168211B1 KR 101168211 B1 KR101168211 B1 KR 101168211B1 KR 1020077009495 A KR1020077009495 A KR 1020077009495A KR 20077009495 A KR20077009495 A KR 20077009495A KR 101168211 B1 KR101168211 B1 KR 101168211B1
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formula
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reaction
ethyl
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KR20070083814A (ko
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밀린드 모레쉬와르 가르푸레
바부라오 마니크라오 바왈
비랄 비핀브하이 샤흐
우메쉬 레와지 조페
사티쉬 라만랄 메타
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엠큐어 파마슈티컬즈 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020077009495A 2004-11-08 2005-10-29 （ｓ）－３－［（１－디메틸아미노）에틸］－페닐－ｎ－에틸－ｎ－메틸－카바메이트의 제조를 위한 효과적인 방법 Expired - Fee Related KR101168211B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1207MU2004 2004-11-08
IN1207/MUM/2004 2004-11-08
PCT/IB2005/003237 WO2006048720A1 (en) 2004-11-08 2005-10-29 An efficient method for preparation of (s)-3-[(1-dimethyl amino)ethyl]-phenyl-n-ethyl-n-methyl-carbamate

Publications (2)

Publication Number Publication Date
KR20070083814A KR20070083814A (ko) 2007-08-24
KR101168211B1 true KR101168211B1 (ko) 2012-07-25

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KR1020077009495A Expired - Fee Related KR101168211B1 (ko) 2004-11-08 2005-10-29 （ｓ）－３－［（１－디메틸아미노）에틸］－페닐－ｎ－에틸－ｎ－메틸－카바메이트의 제조를 위한 효과적인 방법

Country Status (6)

Country Link
EP (1) EP1856036B1 (enExample)
JP (2) JP4954886B2 (enExample)
KR (1) KR101168211B1 (enExample)
ES (1) ES2615487T3 (enExample)
RU (1) RU2393148C2 (enExample)
WO (1) WO2006048720A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1856036B1 (en) * 2004-11-08 2016-12-14 Emcure Pharmaceuticals Limited An efficient method for preparation of (s)-3-[(1-dimethyl amino)ethyl]-phenyl-n-ethyl-n-methyl-carbamate
ES2267399B1 (es) * 2005-08-04 2008-02-01 Ragactives, S.L. Procedimiento para la obtencion de carbamatos de fenilo.
US7767843B2 (en) * 2006-03-02 2010-08-03 Apotex Pharmachem Inc. Process for the preparation of phenylcarbamates
ATE472523T1 (de) * 2006-08-17 2010-07-15 Alembic Ltd Verbessertes verfahren zur herstellung von rivastigmin
WO2008037433A1 (en) 2006-09-29 2008-04-03 Synthon B.V. Process for making aminoalkylphenyl carbamates and intermediates therefor
WO2008110339A2 (en) * 2007-03-09 2008-09-18 Synthon B.V. Polymorphs of rivastigmine hydrogentartrate
WO2009086705A1 (zh) * 2008-01-10 2009-07-16 Shanghai Institute Of Pharmaceutical Industry 利凡斯的明的制备方法、其中间体以及中间体的制备方法
US8420846B2 (en) 2008-08-25 2013-04-16 Jubilant Life Sciences Limited Process for producing (S)-3-[(1-dimethylamino)ethyl] phenyl-N-ethyl-N-methyl-carbamate via novel intermediates
GB0823554D0 (en) * 2008-12-24 2009-01-28 Novartis Ag Process for the preparation of optically active compounds using transfer hydrogenation
CN103664703A (zh) * 2013-12-18 2014-03-26 成都医路康医学技术服务有限公司 一种酒石酸卡巴拉汀的合成工艺
CN103664702A (zh) * 2013-12-18 2014-03-26 成都医路康医学技术服务有限公司 一种卡巴拉汀的生产工艺
CN104987294B (zh) * 2015-07-27 2017-08-15 浙江京新药业股份有限公司 一种3‑[1‑(二甲基氨基)乙基]苯酚的制备方法
CN105439906A (zh) * 2015-12-08 2016-03-30 哈药集团三精制药有限公司 一种重酒石酸卡巴拉汀的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004037771A1 (en) 2002-10-24 2004-05-06 Zentiva, A.S. A method of production of (-)-(s)-3-[1-(dimethylamino)ethyl]phenyl-n-ethyl-n-methylcarbamate

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS495325B1 (enExample) * 1965-09-29 1974-02-06
IL74497A (en) * 1985-03-05 1990-02-09 Proterra Ag Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
HU201906B (en) * 1987-03-04 1991-01-28 Sandoz Ag Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them
JPH07119189B2 (ja) * 1989-09-28 1995-12-20 北陸製薬株式会社 光学活性なベンジルアルコール誘導体及びその用途
SE8904064D0 (sv) * 1989-12-01 1989-12-01 Astra Ab Improved method of preparing an intermediate for the manufacture of bambuterol
JP3705657B2 (ja) * 1996-09-05 2005-10-12 信越化学工業株式会社 Ｎ，ｎ−ジアルキルカルバミン酸２−ニトロベンジルエステル類の製造方法
US6479495B1 (en) * 1997-09-29 2002-11-12 Aventis Pharmaceuticals Inc. Aminoalkylphenol derivatives and related compounds
AU2001291077A1 (en) * 2000-09-21 2002-04-02 Teva Pharmaceuticals Industries Ltd. N-disubstituted carbamoyloxy flavones
EP1689704A2 (en) * 2003-10-21 2006-08-16 CoLucid Pharmaceuticals, Inc. Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents
EP1856036B1 (en) * 2004-11-08 2016-12-14 Emcure Pharmaceuticals Limited An efficient method for preparation of (s)-3-[(1-dimethyl amino)ethyl]-phenyl-n-ethyl-n-methyl-carbamate

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004037771A1 (en) 2002-10-24 2004-05-06 Zentiva, A.S. A method of production of (-)-(s)-3-[1-(dimethylamino)ethyl]phenyl-n-ethyl-n-methylcarbamate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. Labeled Comp. and Radiopharm. 1997, 39(8), 651-668

Also Published As

Publication number Publication date
EP1856036A1 (en) 2007-11-21
JP2012072171A (ja) 2012-04-12
KR20070083814A (ko) 2007-08-24
WO2006048720A1 (en) 2006-05-11
JP2008519023A (ja) 2008-06-05
EP1856036B1 (en) 2016-12-14
ES2615487T3 (es) 2017-06-07
RU2007115398A (ru) 2008-12-20
WO2006048720B1 (en) 2006-07-06
JP4954886B2 (ja) 2012-06-20
RU2393148C2 (ru) 2010-06-27

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