KR101133084B1 - 장기간 순환성 비-페길레이티드 리포좀 - Google Patents

장기간 순환성 비-페길레이티드 리포좀 Download PDF

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Publication number
KR101133084B1
KR101133084B1 KR1020057012107A KR20057012107A KR101133084B1 KR 101133084 B1 KR101133084 B1 KR 101133084B1 KR 1020057012107 A KR1020057012107 A KR 1020057012107A KR 20057012107 A KR20057012107 A KR 20057012107A KR 101133084 B1 KR101133084 B1 KR 101133084B1
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KR
South Korea
Prior art keywords
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liposome
doxorubicin
liposomes
composition
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KR1020057012107A
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English (en)
Korean (ko)
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KR20050088233A (ko
Inventor
궈탐 비노드 다프타리
스리칸트 안나파 파아이
산기타 하누르메쉬 리반카르
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자이더스 비에스브이 파마 프라이빗 리미티드
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Publication of KR20050088233A publication Critical patent/KR20050088233A/ko
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Publication of KR101133084B1 publication Critical patent/KR101133084B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020057012107A 2002-12-31 2003-12-31 장기간 순환성 비-페길레이티드 리포좀 KR101133084B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1101/MUM/02 2002-12-31
IN1101MU2002 2002-12-31
PCT/IN2003/000424 WO2004058140A2 (fr) 2002-12-31 2003-12-31 Liposomes non-peg a longue circulation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020117014172A Division KR101171045B1 (ko) 2002-12-31 2003-12-31 장기간 순환성 비-페길레이테드 리포좀을 함유하는 조성물 및 그의 제조방법

Publications (2)

Publication Number Publication Date
KR20050088233A KR20050088233A (ko) 2005-09-02
KR101133084B1 true KR101133084B1 (ko) 2012-04-04

Family

ID=32500467

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020057012107A KR101133084B1 (ko) 2002-12-31 2003-12-31 장기간 순환성 비-페길레이티드 리포좀
KR1020117014172A KR101171045B1 (ko) 2002-12-31 2003-12-31 장기간 순환성 비-페길레이테드 리포좀을 함유하는 조성물 및 그의 제조방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020117014172A KR101171045B1 (ko) 2002-12-31 2003-12-31 장기간 순환성 비-페길레이테드 리포좀을 함유하는 조성물 및 그의 제조방법

Country Status (19)

Country Link
EP (1) EP1435231B8 (fr)
JP (1) JP5355842B2 (fr)
KR (2) KR101133084B1 (fr)
CN (1) CN1756533B (fr)
AT (1) ATE453381T1 (fr)
AU (1) AU2003303368B2 (fr)
BR (1) BR0317882A (fr)
CA (1) CA2511464C (fr)
DE (1) DE60330745D1 (fr)
DK (1) DK1435231T3 (fr)
EA (1) EA008930B1 (fr)
ES (1) ES2337563T3 (fr)
HK (1) HK1089946A1 (fr)
IL (1) IL169364A (fr)
MX (1) MXPA05007102A (fr)
NZ (1) NZ540778A (fr)
PT (1) PT1435231E (fr)
WO (1) WO2004058140A2 (fr)
ZA (1) ZA200504850B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008250518B2 (en) * 2007-05-16 2013-09-12 Ktb Tumorforschungsgesellschaft Mbh Low-viscous anthracycline formulation
US9968583B2 (en) 2009-03-30 2018-05-15 Eisai R & D Management Co., Ltd. Method of manufacture of liposome composition
PE20120923A1 (es) * 2009-03-30 2012-08-27 Eisai Randd Man Co Ltd Composiciones farmaceuticas comprendiendo liposomas que contiene eribulina o una sal del mismo
WO2012118376A1 (fr) * 2011-03-01 2012-09-07 To-Bbb Holding B.V. Chargement liposomal actif avancé de substances médiocrement solubles dans l'eau
CN107106703A (zh) * 2014-11-25 2017-08-29 纳米生物技术公司 药物组合物、其制备和用途
CA3038657A1 (fr) * 2016-09-27 2018-04-05 Vertex Pharmaceuticals Incorporated Methode de traitement du cancer utilisant une combinaison d'agents endommageant l'adn et d'inhibiteurs de la dna-pk
US11083705B2 (en) 2019-07-26 2021-08-10 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
CN116570775A (zh) * 2023-05-16 2023-08-11 万瑞飞鸿(北京)医疗器材有限公司 一种药物涂层、血管支架及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000061075A (ko) * 1999-03-23 2000-10-16 린 중친 리포솜의 응집을 방지하기 위한 방법 및 조성물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
WO1985000968A1 (fr) * 1983-09-06 1985-03-14 Health Research, Inc. Procede d'administration de liposomes servant a diminuer la toxicite d'un medicament antitumoral
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
CA1270198C (fr) * 1984-08-08 1990-06-12 Marcel B Bally Encapsulation d'agents antineoplastiques dans des liposones
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
CA1338702C (fr) * 1987-03-05 1996-11-12 Lawrence D. Mayer Formulations d'agents liposomiques-antineoplasiques a faible teneur en medicaments-lipides
JPH0720857B2 (ja) 1988-08-11 1995-03-08 テルモ株式会社 リポソームおよびその製法
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
US6132763A (en) 1988-10-20 2000-10-17 Polymasc Pharmaceuticals Plc Liposomes
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
ES2208946T3 (es) * 1996-08-23 2004-06-16 Sequus Pharmaceuticals, Inc. Liposomas que contienen un compuesto de cisplatino.
DK1121102T3 (da) * 1998-09-16 2003-08-11 Alza Corp Liposomindesluttede topoisomeraseinhibitorer
GB0111279D0 (en) * 2001-05-10 2001-06-27 Nycomed Imaging As Radiolabelled liposomes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000061075A (ko) * 1999-03-23 2000-10-16 린 중친 리포솜의 응집을 방지하기 위한 방법 및 조성물

Also Published As

Publication number Publication date
JP5355842B2 (ja) 2013-11-27
EA200500850A1 (ru) 2006-02-24
PT1435231E (pt) 2010-04-08
EP1435231A1 (fr) 2004-07-07
ES2337563T3 (es) 2010-04-27
AU2003303368B2 (en) 2010-06-17
HK1089946A1 (en) 2006-12-15
EA008930B1 (ru) 2007-08-31
KR20110075051A (ko) 2011-07-05
KR101171045B1 (ko) 2012-08-03
CN1756533A (zh) 2006-04-05
WO2004058140A2 (fr) 2004-07-15
DE60330745D1 (de) 2010-02-11
IL169364A0 (en) 2007-07-04
ATE453381T1 (de) 2010-01-15
KR20050088233A (ko) 2005-09-02
EP1435231B1 (fr) 2009-12-30
ZA200504850B (en) 2006-08-30
JP2006513189A (ja) 2006-04-20
AU2003303368A1 (en) 2004-07-22
MXPA05007102A (es) 2005-08-26
CA2511464C (fr) 2011-08-23
CN1756533B (zh) 2010-06-16
DK1435231T3 (da) 2010-04-26
WO2004058140B1 (fr) 2004-12-16
IL169364A (en) 2012-05-31
EP1435231B8 (fr) 2010-03-03
CA2511464A1 (fr) 2004-07-15
NZ540778A (en) 2008-04-30
WO2004058140A3 (fr) 2004-10-28
BR0317882A (pt) 2005-12-13

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