KR101108222B1 - 진통 작용을 가진 인다졸아마이드 - Google Patents

진통 작용을 가진 인다졸아마이드 Download PDF

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Publication number
KR101108222B1
KR101108222B1 KR1020057014055A KR20057014055A KR101108222B1 KR 101108222 B1 KR101108222 B1 KR 101108222B1 KR 1020057014055 A KR1020057014055 A KR 1020057014055A KR 20057014055 A KR20057014055 A KR 20057014055A KR 101108222 B1 KR101108222 B1 KR 101108222B1
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KR
South Korea
Prior art keywords
acid
methyl
pharmaceutically acceptable
formula
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020057014055A
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English (en)
Korean (ko)
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KR20050101541A (ko
Inventor
마리아 알레산드라 알리시
니콜라 카졸라
안젤로 구글리엘모티
구이도 푸로티
쥬세페 루나
로렌조 폴렌자니
Original Assignee
아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이
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Application filed by 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 filed Critical 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이
Publication of KR20050101541A publication Critical patent/KR20050101541A/ko
Application granted granted Critical
Publication of KR101108222B1 publication Critical patent/KR101108222B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020057014055A 2003-02-18 2004-01-26 진통 작용을 가진 인다졸아마이드 Expired - Fee Related KR101108222B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2003A000287 2003-02-18
IT000287A ITMI20030287A1 (it) 2003-02-18 2003-02-18 Indazolammidi dotate di attivita' analgesica metodo, per
PCT/EP2004/000647 WO2004074275A1 (en) 2003-02-18 2004-01-26 Indazolamides with analgesic activity

Publications (2)

Publication Number Publication Date
KR20050101541A KR20050101541A (ko) 2005-10-24
KR101108222B1 true KR101108222B1 (ko) 2012-02-08

Family

ID=32894157

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057014055A Expired - Fee Related KR101108222B1 (ko) 2003-02-18 2004-01-26 진통 작용을 가진 인다졸아마이드

Country Status (22)

Country Link
US (2) US7632849B2 (https=)
EP (1) EP1594859B1 (https=)
JP (1) JP4724651B2 (https=)
KR (1) KR101108222B1 (https=)
CN (2) CN101139341B (https=)
AR (1) AR043186A1 (https=)
AT (1) ATE471934T1 (https=)
AU (1) AU2004213104B2 (https=)
CA (1) CA2511984C (https=)
DE (1) DE602004027792D1 (https=)
DK (1) DK1594859T3 (https=)
EA (1) EA009077B1 (https=)
ES (1) ES2345983T3 (https=)
GE (1) GEP20074075B (https=)
IL (1) IL169285A (https=)
IT (1) ITMI20030287A1 (https=)
MX (1) MXPA05008730A (https=)
PL (1) PL215870B1 (https=)
PT (1) PT1594859E (https=)
SI (1) SI1594859T1 (https=)
UA (1) UA79537C2 (https=)
WO (1) WO2004074275A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
WO2005123718A2 (en) * 2004-06-15 2005-12-29 Pfizer Japan Inc. Benzimidazolone carboxylic acid derivatives
CN102046240B (zh) * 2008-03-25 2014-06-25 阿费克蒂斯药品公司 新的p2x7r拮抗剂及其应用
US8815892B2 (en) 2008-03-25 2014-08-26 Affectis Pharmaceuticals Ag P2X7R antagonists and their use
WO2010118921A1 (en) * 2009-04-14 2010-10-21 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
CA2860250C (en) * 2012-02-21 2020-11-10 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
RS54539B1 (sr) 2012-02-21 2016-06-30 Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A. Upotreba 1h-indazol-3-karboksamidnih jedinjenja kao inhibitora kinaze 3-beta glikogen sintetaze
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
JP6064062B2 (ja) 2013-03-15 2017-01-18 ファイザー・インク Ａｍｐｋを活性化させるインダゾール化合物
PT3790873T (pt) 2018-05-07 2022-05-11 Acraf Compostos de 1h-indazole-3-carboxamida como inibidores da glicogénio sintase cinase 3 beta
CN109336890B (zh) * 2018-11-17 2020-03-20 重庆文理学院 一种吲唑类衍生物的合成方法及抗肿瘤应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0732333A1 (en) 1995-03-16 1996-09-18 Eli Lilly And Company Indazolecarboxamides
EP0908459A1 (en) 1997-10-07 1999-04-14 Eli Lilly And Company 5-HT4 Agonists and antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705175A (en) * 1969-04-01 1972-12-05 Egyt Gyogyszervegyeszeti Gyar Indazole-3-carboxylic amides
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
EP0829474B1 (en) * 1995-05-31 2003-04-09 Nisshin Seifun Group Inc. Indazole derivatives having monocyclic amino group
EP0802067B1 (en) * 1995-11-08 2002-04-24 Toray Industries, Inc. Direct drawing type waterless planographic original form plate
JP3911297B2 (ja) 1996-08-16 2007-05-09 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー Ｎ―［（１―ｎブチル―４―ピペリジル）メチル］―３，４―ジヒドロ―２Ｈ―［１，３］オキサジノ［３，２―ａ］インドール―１０―カルボキシアミドおよび塩ならびに製造における中間体
IT1291569B1 (it) 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
DE69940951D1 (de) * 1998-04-21 2009-07-16 Bristol Myers Squibb Pharma Co Nd wachstumshemmende mittel
US6407103B2 (en) * 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0732333A1 (en) 1995-03-16 1996-09-18 Eli Lilly And Company Indazolecarboxamides
EP0908459A1 (en) 1997-10-07 1999-04-14 Eli Lilly And Company 5-HT4 Agonists and antagonists

Also Published As

Publication number Publication date
CN100347168C (zh) 2007-11-07
JP4724651B2 (ja) 2011-07-13
DK1594859T3 (da) 2010-10-11
PL377236A1 (pl) 2006-01-23
ITMI20030287A1 (it) 2004-08-19
GEP20074075B (en) 2007-03-26
AU2004213104B2 (en) 2010-07-08
MXPA05008730A (es) 2005-09-20
US8519139B2 (en) 2013-08-27
CN101139341B (zh) 2010-12-08
PT1594859E (pt) 2010-07-23
KR20050101541A (ko) 2005-10-24
US20100048907A1 (en) 2010-02-25
US7632849B2 (en) 2009-12-15
ES2345983T3 (es) 2010-10-07
US20060052417A1 (en) 2006-03-09
EP1594859B1 (en) 2010-06-23
CA2511984C (en) 2011-01-18
HK1079199A1 (en) 2006-03-31
AR043186A1 (es) 2005-07-20
PL215870B1 (pl) 2014-02-28
UA79537C2 (en) 2007-06-25
CN1742004A (zh) 2006-03-01
EA200501164A1 (ru) 2005-12-29
CA2511984A1 (en) 2004-09-02
IL169285A (en) 2012-08-30
JP2006517932A (ja) 2006-08-03
CN101139341A (zh) 2008-03-12
DE602004027792D1 (de) 2010-08-05
EP1594859A1 (en) 2005-11-16
WO2004074275A1 (en) 2004-09-02
ATE471934T1 (de) 2010-07-15
EA009077B1 (ru) 2007-10-26
SI1594859T1 (sl) 2010-10-29
AU2004213104A1 (en) 2004-09-02

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