JP4724651B2 - 鎮痛作用を有するインダゾールアミド - Google Patents

鎮痛作用を有するインダゾールアミド Download PDF

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Publication number
JP4724651B2
JP4724651B2 JP2006501608A JP2006501608A JP4724651B2 JP 4724651 B2 JP4724651 B2 JP 4724651B2 JP 2006501608 A JP2006501608 A JP 2006501608A JP 2006501608 A JP2006501608 A JP 2006501608A JP 4724651 B2 JP4724651 B2 JP 4724651B2
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JP
Japan
Prior art keywords
indazole
methyl
group
formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2006501608A
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English (en)
Japanese (ja)
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JP2006517932A5 (https=
JP2006517932A (ja
Inventor
アレッサンドラ アリシ マリア
カッツォーラ ニコラ
ググリエルモッティ アンジェロ
フルロッティ グイド
ルナ ジュセッペ
ポレンツァーニ ロレンツォ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Angelini Acraf SpA
Original Assignee
Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
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Publication of JP2006517932A publication Critical patent/JP2006517932A/ja
Publication of JP2006517932A5 publication Critical patent/JP2006517932A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2006501608A 2003-02-18 2004-01-26 鎮痛作用を有するインダゾールアミド Expired - Fee Related JP4724651B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000287A ITMI20030287A1 (it) 2003-02-18 2003-02-18 Indazolammidi dotate di attivita' analgesica metodo, per
ITMI2003A000287 2003-02-18
PCT/EP2004/000647 WO2004074275A1 (en) 2003-02-18 2004-01-26 Indazolamides with analgesic activity

Publications (3)

Publication Number Publication Date
JP2006517932A JP2006517932A (ja) 2006-08-03
JP2006517932A5 JP2006517932A5 (https=) 2007-05-31
JP4724651B2 true JP4724651B2 (ja) 2011-07-13

Family

ID=32894157

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006501608A Expired - Fee Related JP4724651B2 (ja) 2003-02-18 2004-01-26 鎮痛作用を有するインダゾールアミド

Country Status (22)

Country Link
US (2) US7632849B2 (https=)
EP (1) EP1594859B1 (https=)
JP (1) JP4724651B2 (https=)
KR (1) KR101108222B1 (https=)
CN (2) CN100347168C (https=)
AR (1) AR043186A1 (https=)
AT (1) ATE471934T1 (https=)
AU (1) AU2004213104B2 (https=)
CA (1) CA2511984C (https=)
DE (1) DE602004027792D1 (https=)
DK (1) DK1594859T3 (https=)
EA (1) EA009077B1 (https=)
ES (1) ES2345983T3 (https=)
GE (1) GEP20074075B (https=)
IL (1) IL169285A (https=)
IT (1) ITMI20030287A1 (https=)
MX (1) MXPA05008730A (https=)
PL (1) PL215870B1 (https=)
PT (1) PT1594859E (https=)
SI (1) SI1594859T1 (https=)
UA (1) UA79537C2 (https=)
WO (1) WO2004074275A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
CA2569654C (en) * 2004-06-15 2010-12-21 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
US8815892B2 (en) 2008-03-25 2014-08-26 Affectis Pharmaceuticals Ag P2X7R antagonists and their use
BRPI0910034B1 (pt) * 2008-03-25 2022-02-08 Affectis Pharmaceuticals Ag Antagonistas do p2x7r e composições farmacêuticas que os compreendem
AU2010237302A1 (en) * 2009-04-14 2011-12-01 Affectis Pharmaceuticals Ag Novel P2X7R antagonists and their use
BR112014018657B1 (pt) 2012-02-21 2022-08-02 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A Compostos de 1h-indazol-3-carboxamida
AU2013224302B2 (en) 2012-02-21 2017-03-30 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP2970177A1 (en) 2013-03-15 2016-01-20 Pfizer Inc. Indole compounds that activate ampk
ES2913975T3 (es) 2018-05-07 2022-06-07 Acraf Compuestos de 1H-indazol-3-carboxamida como inhibidores de la glucógeno sintasa cinasa-3 beta
CN109336890B (zh) * 2018-11-17 2020-03-20 重庆文理学院 一种吲唑类衍生物的合成方法及抗肿瘤应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705175A (en) * 1969-04-01 1972-12-05 Egyt Gyogyszervegyeszeti Gyar Indazole-3-carboxylic amides
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
IL117438A (en) 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
DE69627323T2 (de) * 1995-05-31 2004-01-15 Nisshin Seifun Group Inc Indazolderivate mit einer cyclischen aminogruppe
AU7507196A (en) * 1995-11-08 1997-05-29 Toray Industries, Inc. Direct drawing type waterless planographic original form plate
JP3911297B2 (ja) 1996-08-16 2007-05-09 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー Ｎ―［（１―ｎブチル―４―ピペリジル）メチル］―３，４―ジヒドロ―２Ｈ―［１，３］オキサジノ［３，２―ａ］インドール―１０―カルボキシアミドおよび塩ならびに製造における中間体
IT1291569B1 (it) 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
US6407103B2 (en) * 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses
JP4665239B2 (ja) * 1998-04-21 2011-04-06 アゲンニクス アーゲー 抗癌剤および抗増殖性薬剤としての５−アミノインデノ［１，２−ｃ］ピラゾール−４−オン

Also Published As

Publication number Publication date
AR043186A1 (es) 2005-07-20
CN101139341A (zh) 2008-03-12
WO2004074275A1 (en) 2004-09-02
EA009077B1 (ru) 2007-10-26
HK1079199A1 (en) 2006-03-31
EP1594859A1 (en) 2005-11-16
GEP20074075B (en) 2007-03-26
US20100048907A1 (en) 2010-02-25
EP1594859B1 (en) 2010-06-23
US20060052417A1 (en) 2006-03-09
CA2511984A1 (en) 2004-09-02
IL169285A (en) 2012-08-30
PL377236A1 (pl) 2006-01-23
KR20050101541A (ko) 2005-10-24
AU2004213104A1 (en) 2004-09-02
UA79537C2 (en) 2007-06-25
CN101139341B (zh) 2010-12-08
DE602004027792D1 (de) 2010-08-05
KR101108222B1 (ko) 2012-02-08
US8519139B2 (en) 2013-08-27
EA200501164A1 (ru) 2005-12-29
SI1594859T1 (sl) 2010-10-29
US7632849B2 (en) 2009-12-15
ES2345983T3 (es) 2010-10-07
CA2511984C (en) 2011-01-18
CN100347168C (zh) 2007-11-07
ATE471934T1 (de) 2010-07-15
DK1594859T3 (da) 2010-10-11
MXPA05008730A (es) 2005-09-20
JP2006517932A (ja) 2006-08-03
ITMI20030287A1 (it) 2004-08-19
PL215870B1 (pl) 2014-02-28
CN1742004A (zh) 2006-03-01
PT1594859E (pt) 2010-07-23
AU2004213104B2 (en) 2010-07-08

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