MXPA05008730A - Indazolamidas con actividad analgesica. - Google Patents

Indazolamidas con actividad analgesica.

Info

Publication number
MXPA05008730A
MXPA05008730A MXPA05008730A MXPA05008730A MXPA05008730A MX PA05008730 A MXPA05008730 A MX PA05008730A MX PA05008730 A MXPA05008730 A MX PA05008730A MX PA05008730 A MXPA05008730 A MX PA05008730A MX PA05008730 A MXPA05008730 A MX PA05008730A
Authority
MX
Mexico
Prior art keywords
carbon atoms
methyl
pharmaceutically acceptable
acid
compound
Prior art date
Application number
MXPA05008730A
Other languages
English (en)
Spanish (es)
Inventor
Polenzani Lorenzo
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of MXPA05008730A publication Critical patent/MXPA05008730A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MXPA05008730A 2003-02-18 2004-01-26 Indazolamidas con actividad analgesica. MXPA05008730A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000287A ITMI20030287A1 (it) 2003-02-18 2003-02-18 Indazolammidi dotate di attivita' analgesica metodo, per
PCT/EP2004/000647 WO2004074275A1 (en) 2003-02-18 2004-01-26 Indazolamides with analgesic activity

Publications (1)

Publication Number Publication Date
MXPA05008730A true MXPA05008730A (es) 2005-09-20

Family

ID=32894157

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05008730A MXPA05008730A (es) 2003-02-18 2004-01-26 Indazolamidas con actividad analgesica.

Country Status (22)

Country Link
US (2) US7632849B2 (https=)
EP (1) EP1594859B1 (https=)
JP (1) JP4724651B2 (https=)
KR (1) KR101108222B1 (https=)
CN (2) CN101139341B (https=)
AR (1) AR043186A1 (https=)
AT (1) ATE471934T1 (https=)
AU (1) AU2004213104B2 (https=)
CA (1) CA2511984C (https=)
DE (1) DE602004027792D1 (https=)
DK (1) DK1594859T3 (https=)
EA (1) EA009077B1 (https=)
ES (1) ES2345983T3 (https=)
GE (1) GEP20074075B (https=)
IL (1) IL169285A (https=)
IT (1) ITMI20030287A1 (https=)
MX (1) MXPA05008730A (https=)
PL (1) PL215870B1 (https=)
PT (1) PT1594859E (https=)
SI (1) SI1594859T1 (https=)
UA (1) UA79537C2 (https=)
WO (1) WO2004074275A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
WO2005123718A2 (en) * 2004-06-15 2005-12-29 Pfizer Japan Inc. Benzimidazolone carboxylic acid derivatives
CN102046240B (zh) * 2008-03-25 2014-06-25 阿费克蒂斯药品公司 新的p2x7r拮抗剂及其应用
US8815892B2 (en) 2008-03-25 2014-08-26 Affectis Pharmaceuticals Ag P2X7R antagonists and their use
WO2010118921A1 (en) * 2009-04-14 2010-10-21 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
CA2860250C (en) * 2012-02-21 2020-11-10 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
RS54539B1 (sr) 2012-02-21 2016-06-30 Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A. Upotreba 1h-indazol-3-karboksamidnih jedinjenja kao inhibitora kinaze 3-beta glikogen sintetaze
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
JP6064062B2 (ja) 2013-03-15 2017-01-18 ファイザー・インク Ampkを活性化させるインダゾール化合物
PT3790873T (pt) 2018-05-07 2022-05-11 Acraf Compostos de 1h-indazole-3-carboxamida como inibidores da glicogénio sintase cinase 3 beta
CN109336890B (zh) * 2018-11-17 2020-03-20 重庆文理学院 一种吲唑类衍生物的合成方法及抗肿瘤应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705175A (en) * 1969-04-01 1972-12-05 Egyt Gyogyszervegyeszeti Gyar Indazole-3-carboxylic amides
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
EP0829474B1 (en) * 1995-05-31 2003-04-09 Nisshin Seifun Group Inc. Indazole derivatives having monocyclic amino group
EP0802067B1 (en) * 1995-11-08 2002-04-24 Toray Industries, Inc. Direct drawing type waterless planographic original form plate
JP3911297B2 (ja) 1996-08-16 2007-05-09 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー N―[(1―nブチル―4―ピペリジル)メチル]―3,4―ジヒドロ―2H―[1,3]オキサジノ[3,2―a]インドール―10―カルボキシアミドおよび塩ならびに製造における中間体
IT1291569B1 (it) 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
DE69940951D1 (de) * 1998-04-21 2009-07-16 Bristol Myers Squibb Pharma Co Nd wachstumshemmende mittel
US6407103B2 (en) * 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses

Also Published As

Publication number Publication date
CN100347168C (zh) 2007-11-07
JP4724651B2 (ja) 2011-07-13
DK1594859T3 (da) 2010-10-11
PL377236A1 (pl) 2006-01-23
ITMI20030287A1 (it) 2004-08-19
GEP20074075B (en) 2007-03-26
AU2004213104B2 (en) 2010-07-08
US8519139B2 (en) 2013-08-27
CN101139341B (zh) 2010-12-08
PT1594859E (pt) 2010-07-23
KR20050101541A (ko) 2005-10-24
US20100048907A1 (en) 2010-02-25
US7632849B2 (en) 2009-12-15
ES2345983T3 (es) 2010-10-07
US20060052417A1 (en) 2006-03-09
EP1594859B1 (en) 2010-06-23
CA2511984C (en) 2011-01-18
HK1079199A1 (en) 2006-03-31
AR043186A1 (es) 2005-07-20
PL215870B1 (pl) 2014-02-28
UA79537C2 (en) 2007-06-25
CN1742004A (zh) 2006-03-01
EA200501164A1 (ru) 2005-12-29
CA2511984A1 (en) 2004-09-02
KR101108222B1 (ko) 2012-02-08
IL169285A (en) 2012-08-30
JP2006517932A (ja) 2006-08-03
CN101139341A (zh) 2008-03-12
DE602004027792D1 (de) 2010-08-05
EP1594859A1 (en) 2005-11-16
WO2004074275A1 (en) 2004-09-02
ATE471934T1 (de) 2010-07-15
EA009077B1 (ru) 2007-10-26
SI1594859T1 (sl) 2010-10-29
AU2004213104A1 (en) 2004-09-02

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