KR101090672B1 - 항염 활성이 탁월한 금은화 추출 정제물을 제조하는 제조방법 및 이를 유효성분으로 함유하는 염증성 질환의 예방 및 치료용 조성물 - Google Patents
항염 활성이 탁월한 금은화 추출 정제물을 제조하는 제조방법 및 이를 유효성분으로 함유하는 염증성 질환의 예방 및 치료용 조성물 Download PDFInfo
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- KR101090672B1 KR101090672B1 KR1020090063514A KR20090063514A KR101090672B1 KR 101090672 B1 KR101090672 B1 KR 101090672B1 KR 1020090063514 A KR1020090063514 A KR 1020090063514A KR 20090063514 A KR20090063514 A KR 20090063514A KR 101090672 B1 KR101090672 B1 KR 101090672B1
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- extract
- water
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- silver
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Abstract
Description
실험군 | 용량 (mg/kg) |
부종 증가율(%) | ||||
0.5 | 1 | 2 | 4 | 6(h) | ||
대조군 | 0 | 22.1±2.4 | 27.5±3.1 | 40.6±3.5 | 62.5±3.5 | 55.2±4.9 |
HI-37 | 30 | 17.8±1.0 (19.7) |
23.8±2.9 (13.4) |
33.2±2.9 (18.4) |
43.2±3.2** (31.0) |
41.7±3.7* (24.4) |
100 | 18.1±1.9 (18.1) |
21.6±2.0 (21.6) |
33.4±1.7 (17.9) |
41.8±1.4** (33.1) |
43.8±1.6 (20.5) |
|
300 | 19.2±1.2 (13.2) |
23.4±1.7 (14.8) |
35.9±2.7 (11.8) |
50.0±3.3* (20.0) |
50.1±2.9 (9.2) |
|
600 | 11.9±1.4** (46.3) |
16.6±1.6** (39.7) |
25.4±2.1** (37.5) |
36.2±2.5** (42.0) |
36.7±1.8** (33.5) |
|
디클로페낙 | 25 | 14.5±2.6* | 17.7±1.6* | 21.4±2.6** | 30.0±1.5** | 31.2±2.5** |
부종 증가율은 각 군당 8-10 마리 흰쥐의 평균± 표준오차 값으로 나타내었고, 유의성 평가는 대조군에 대한 각 실험군을 two-way anova를 시행하여 P=0.05 수준에서 유의성이 인정되는 경우 Dunnett's t-test로 실험군간 차이를 비교하였으며, *P<0.05 및 **P<0.01로 표시하였다. |
Claims (6)
- 삭제
- 삭제
- 삭제
- 금은화를 그 중량의 10 내지 20배(v/w)의 정제수를 포함한 물 또는 물 및 에탄올 혼합용매를 가하여 1시간 내지 24시간 동안 환류냉각추출 방법을 사용하여 2회 내지 5회 반복 추출하는 제 1단계; 상기 추출물을 정제수로 용해시키고 동량의 노르말 헥산, 에틸아세테이트, 클로로포름 및 노르말 부탄올을 이용하여 2회 내지 5회 분획한 후, 유기용매 가용부를 제거하는 제 2단계; 제거 후 남은 수 가용성 분획을 정제수에 용해시켜, 그 중량의 10 내지 15배(w/w)의 미세다공 비이온 흡착제 수지 또는 역상 칼럼에 사용되는 수지에 흡착시켜 용출하는 제 3단계의 공정으로 제조된 금은화 추출 정제물을 유효성분으로 함유하는 인후염, 편도염, 급성통증 또는 염증성 장질환의 예방 및 치료용 약학조성물.
- 삭제
- 금은화를 그 중량의 10 내지 20배(v/w)의 정제수를 포함한 물 또는 물 및 에탄올 혼합용매를 가하여 1시간 내지 24시간 동안 환류냉각추출 방법을 사용하여 2회 내지 5회 반복 추출하는 제 1단계; 상기 추출물을 정제수로 용해시키고 동량의 노르말 헥산, 에틸아세테이트, 클로로포름 및 노르말 부탄올을 이용하여 2회 내지 5회 분획한 후, 유기용매 가용부를 제거하는 제 2단계; 제거 후 남은 수 가용성 분획을 정제수에 용해시켜, 그 중량의 10 내지 15배(w/w)의 미세다공 비이온 흡착제 수지 또는 역상 칼럼에 사용되는 수지에 흡착시켜 용출하는 제 3단계의 공정으로 제조된 금은화 추출 정제물을 유효성분으로 함유하는 인후염, 편도염, 급성통증 또는 염증성 장질환의 예방 및 개선용 건강기능식품.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020090063514A KR101090672B1 (ko) | 2009-07-13 | 2009-07-13 | 항염 활성이 탁월한 금은화 추출 정제물을 제조하는 제조방법 및 이를 유효성분으로 함유하는 염증성 질환의 예방 및 치료용 조성물 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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KR1020090063514A KR101090672B1 (ko) | 2009-07-13 | 2009-07-13 | 항염 활성이 탁월한 금은화 추출 정제물을 제조하는 제조방법 및 이를 유효성분으로 함유하는 염증성 질환의 예방 및 치료용 조성물 |
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