KR20110006060A - 항염 활성이 탁월한 금은화 추출 정제물을 제조하는 제조방법 및 이를 유효성분으로 함유하는 염증성 질환의 예방 및 치료용 조성물 - Google Patents
항염 활성이 탁월한 금은화 추출 정제물을 제조하는 제조방법 및 이를 유효성분으로 함유하는 염증성 질환의 예방 및 치료용 조성물 Download PDFInfo
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- KR20110006060A KR20110006060A KR1020090063514A KR20090063514A KR20110006060A KR 20110006060 A KR20110006060 A KR 20110006060A KR 1020090063514 A KR1020090063514 A KR 1020090063514A KR 20090063514 A KR20090063514 A KR 20090063514A KR 20110006060 A KR20110006060 A KR 20110006060A
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- extraction
- extract
- gold
- water
- purified
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Abstract
Description
실험군 | 용량 (mg/kg) |
부종 증가율(%) | ||||
0.5 | 1 | 2 | 4 | 6(h) | ||
대조군 | 0 | 22.1±2.4 | 27.5±3.1 | 40.6±3.5 | 62.5±3.5 | 55.2±4.9 |
HI-37 | 30 | 17.8±1.0 (19.7) |
23.8±2.9 (13.4) |
33.2±2.9 (18.4) |
43.2±3.2** (31.0) |
41.7±3.7* (24.4) |
100 | 18.1±1.9 (18.1) |
21.6±2.0 (21.6) |
33.4±1.7 (17.9) |
41.8±1.4** (33.1) |
43.8±1.6 (20.5) |
|
300 | 19.2±1.2 (13.2) |
23.4±1.7 (14.8) |
35.9±2.7 (11.8) |
50.0±3.3* (20.0) |
50.1±2.9 (9.2) |
|
600 | 11.9±1.4** (46.3) |
16.6±1.6** (39.7) |
25.4±2.1** (37.5) |
36.2±2.5** (42.0) |
36.7±1.8** (33.5) |
|
디클로페낙 | 25 | 14.5±2.6* | 17.7±1.6* | 21.4±2.6** | 30.0±1.5** | 31.2±2.5** |
부종 증가율은 각 군당 8-10 마리 흰쥐의 평균± 표준오차 값으로 나타내었고, 유의성 평가는 대조군에 대한 각 실험군을 two-way anova를 시행하여 P=0.05 수준에서 유의성이 인정되는 경우 Dunnett's t-test로 실험군간 차이를 비교하였으며, *P<0.05 및 **P<0.01로 표시하였다. |
Claims (6)
- 금은화를 그 중량의 10 내지 20배(v/w)의 정제수를 포함한 물, C1 내지 C4의 저급 알콜 또는 이들의 혼합용매로부터 선택되어진 용매를 가하여 1시간 내지 24시간 동안 열수추출, 냉침추출, 환류냉각추출 또는 초음파추출 등의 추출방법을 사용하여 1회 내지 5회 반복 추출하는 제 1단계; 상기 추출물을 일정량의 정제수로 용해시키고 동량의 노르말 헥산, 에틸아세테이트, 클로로포름, 노르말 부탄올 등의 유기용매를 순차적으로 극성을 올려 1회 내지 5회 분획한 후, 유기용매 가용부를 제거하는 제 2단계; 제거 후 남은 수가용성 분획을 일정량의 정제수에 용해시켜, 그 중량의 10 내지 15배(w/w)의 미세다공 비이온 흡착제 수지 또는 역상 칼럼에 사용되는 수지에 흡착시켜 용출하는 제 3단계의 공정을 포함하는 제조공정으로 항염증 활성이 증진된 금은화 추출 정제물을 제조하는 제조방법.
- 금은화를 그 중량의 10 내지 20배(v/w)의 정제수를 포함한 물, C1 내지 C4의 저급 알콜 또는 이들의 혼합용매로부터 선택되어진 용매를 가하여 1시간 내지 24시간 동안 열수추출, 냉침추출, 환류냉각추출 또는 초음파추출 등의 추출방법을 사용하여 1회 내지 5회 반복 추출하는 제 1단계; 상기 추출물을 일정량의 정제수로 용해시켜, 그 중량의 10 내지 15배(w/w)의 미세다공 비이온 흡착제 수지 또는 역상 칼럼에 사용되는 수지에 흡착시켜 용출하는 제 2단계의 공정을 포함하는 제조공정으로 항염증 활성이 증진된 금은화 추출 정제물을 제조하는 제조방법.
- 금은화를 그 중량의 10 내지 20배(v/w)의 정제수를 포함한 물, C1 내지 C4의 저급 알콜 또는 이들의 혼합용매로부터 선택되어진 용매를 가하여 1시간 내지 24시간 동안 열수추출, 냉침추출, 환류냉각추출 또는 초음파추출 등의 추출방법을 사용하여 1회 내지 5회 반복 추출하는 제 1단계; 상기 추출물을 일정량의 정제수로 용해시키고 노르말헥산, 에틸아세테이트, 클로로포름, 노르말부탄올 등의 동량의 유기용매를 순차적으로 극성을 올려 1회 내지 5회 분획한 후, 유기용매 가용부를 제거하는 제 2단계의 공정을 포함하는 제조공정으로 항염증 활성이 증진된 금은화 추출 정제물을 제조하는 제조방법.
- 상기 제 1항 내지 제 3항 중 어느 한 항의 제조방법으로 수득한 금은화 추출 정제물을 유효성분으로 함유하는 염증성 질환의 예방 및 치료용 약학조성물.
- 제 4항에 있어서, 상기 염증성 질환은 척추염, 요도염, 방광염, 신염, 신우 신염, 혈관염, 비염, 인후염, 편도염, 급성통증 또는 염증성 장질환인 약학조성물.
- 상기 제 1항 내지 제 3항 중 어느 한 항의 제조방법으로 수득한 금은화 추출 정제물을 유효성분으로 함유하는 염증성 질환의 예방 및 개선용 건강기능식품.
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Cited By (5)
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CN102697956A (zh) * | 2012-05-09 | 2012-10-03 | 徐东波 | 一种治疗脉管炎的中药 |
WO2013162135A1 (en) * | 2012-04-27 | 2013-10-31 | Huons Co., Ltd. | A method for preparing a purified extract of lonicera japonica thunberg and the composition comprising the same for preventing and treating sepsis and septic shock. |
CN105148090A (zh) * | 2015-10-16 | 2015-12-16 | 张永波 | 一种咽喉、肺部疾病护理用中药制剂 |
US9498506B2 (en) | 2013-09-24 | 2016-11-22 | H&K Bioscience Co., Ltd. | Pharmaceutical composition for preventing or treating thyroid diseases, comprising extract from Lonicera caerulea L. var. edulis fruits as active ingredient |
KR20210045964A (ko) * | 2018-11-14 | 2021-04-27 | 경희대학교 산학협력단 | 항산화 및 항비만 활성 증진을 위한 금은화 가공방법 |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2013162135A1 (en) * | 2012-04-27 | 2013-10-31 | Huons Co., Ltd. | A method for preparing a purified extract of lonicera japonica thunberg and the composition comprising the same for preventing and treating sepsis and septic shock. |
JP2015530968A (ja) * | 2012-04-27 | 2015-10-29 | ヒュオンス カンパニー リミテッド | 金銀花精製抽出物の製造方法及びそれを含む敗血症及び敗血症性ショックの予防及び治療用組成物 |
EP2841081A4 (en) * | 2012-04-27 | 2015-12-16 | Huons Co Ltd | PROCESS FOR THE PREPARATION OF A PURIFIED EXTRACT OF LONICERA JAPONICA THUNBERG AND A COMPOSITION COMPRISING THE SAME FOR PREVENTING AND TREATING SEPTICEMIA AND SEPTIC SHOCK |
CN102697956A (zh) * | 2012-05-09 | 2012-10-03 | 徐东波 | 一种治疗脉管炎的中药 |
US9498506B2 (en) | 2013-09-24 | 2016-11-22 | H&K Bioscience Co., Ltd. | Pharmaceutical composition for preventing or treating thyroid diseases, comprising extract from Lonicera caerulea L. var. edulis fruits as active ingredient |
CN105148090A (zh) * | 2015-10-16 | 2015-12-16 | 张永波 | 一种咽喉、肺部疾病护理用中药制剂 |
KR20210045964A (ko) * | 2018-11-14 | 2021-04-27 | 경희대학교 산학협력단 | 항산화 및 항비만 활성 증진을 위한 금은화 가공방법 |
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