KR101068180B1 - 세로토닌성 및/또는 노르에피네프린성 활성을 갖는 치환된펜에틸아민 - Google Patents

세로토닌성 및/또는 노르에피네프린성 활성을 갖는 치환된펜에틸아민 Download PDF

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KR101068180B1
KR101068180B1 KR1020087015962A KR20087015962A KR101068180B1 KR 101068180 B1 KR101068180 B1 KR 101068180B1 KR 1020087015962 A KR1020087015962 A KR 1020087015962A KR 20087015962 A KR20087015962 A KR 20087015962A KR 101068180 B1 KR101068180 B1 KR 101068180B1
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KR20080073361A (ko
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토마스 지 간트
세피어 사샤르
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오스펙스 파마슈티칼스, 인코포레이티드
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
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    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
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  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020087015962A 2005-12-01 2006-11-30 세로토닌성 및/또는 노르에피네프린성 활성을 갖는 치환된펜에틸아민 Expired - Fee Related KR101068180B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74131505P 2005-12-01 2005-12-01
US60/741,315 2005-12-01
US84136606P 2006-08-30 2006-08-30
US60/841,366 2006-08-30

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KR20080073361A KR20080073361A (ko) 2008-08-08
KR101068180B1 true KR101068180B1 (ko) 2011-09-28

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US (9) US7456317B2 (enExample)
EP (2) EP2998288B1 (enExample)
JP (1) JP5302005B2 (enExample)
KR (1) KR101068180B1 (enExample)
AU (1) AU2006320655A1 (enExample)
BR (1) BRPI0620587A2 (enExample)
CA (1) CA2631581C (enExample)
DK (1) DK1954669T3 (enExample)
EA (1) EA200801488A1 (enExample)
ES (1) ES2549079T3 (enExample)
HU (1) HUE027865T2 (enExample)
IL (1) IL191847A0 (enExample)
MA (1) MA30088B1 (enExample)
NZ (1) NZ568720A (enExample)
PL (1) PL1954669T3 (enExample)
PT (1) PT1954669E (enExample)
SI (1) SI1954669T1 (enExample)
WO (1) WO2007064697A1 (enExample)

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US8586760B2 (en) * 2009-06-15 2013-11-19 Auspex Pharmaceuticals, Inc. Aminothiazole modulators of beta-3-adrenoreceptor
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CN104059030B (zh) 2014-05-30 2016-05-04 镇江圣安医药有限公司 [(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途
WO2017079102A1 (en) 2015-11-03 2017-05-11 Albert Einstein College Of Medicine, Inc. Use of 13c derivatization reagents for gas or liquid chromatography-mass spectroscopy chemical identification and quantification
WO2020114853A1 (en) 2018-12-03 2020-06-11 H. Lundbeck A/S Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine
CN115667217A (zh) 2020-05-19 2023-01-31 赛本爱尔兰有限公司 氘化的色胺衍生物和使用方法
CN120917022A (zh) 2023-03-23 2025-11-07 葛兰素史密斯克莱知识产权(第3号)有限公司 氘代p2x3调节剂

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