KR101065885B1 - 벤즈이미다졸 화합물의 합성 방법 - Google Patents

벤즈이미다졸 화합물의 합성 방법 Download PDF

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Publication number
KR101065885B1
KR101065885B1 KR1020057006554A KR20057006554A KR101065885B1 KR 101065885 B1 KR101065885 B1 KR 101065885B1 KR 1020057006554 A KR1020057006554 A KR 1020057006554A KR 20057006554 A KR20057006554 A KR 20057006554A KR 101065885 B1 KR101065885 B1 KR 101065885B1
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KR
South Korea
Prior art keywords
water
reaction
toluene
organic solvent
ethyl acetate
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Expired - Fee Related
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KR1020057006554A
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English (en)
Korean (ko)
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KR20050050145A (ko
Inventor
앤더스 구스타브슨
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아스트라제네카 아베
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
KR1020057006554A 2002-10-18 2003-10-15 벤즈이미다졸 화합물의 합성 방법 Expired - Fee Related KR101065885B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0203092A SE0203092D0 (en) 2002-10-18 2002-10-18 Method for the synthesis of a benzimidazole compound
SE0203092-2 2002-10-18

Publications (2)

Publication Number Publication Date
KR20050050145A KR20050050145A (ko) 2005-05-27
KR101065885B1 true KR101065885B1 (ko) 2011-09-19

Family

ID=20289310

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057006554A Expired - Fee Related KR101065885B1 (ko) 2002-10-18 2003-10-15 벤즈이미다졸 화합물의 합성 방법

Country Status (31)

Country Link
US (2) US7227024B2 (https=)
EP (1) EP1556370B1 (https=)
JP (1) JP4551221B2 (https=)
KR (1) KR101065885B1 (https=)
CN (2) CN100374436C (https=)
AR (1) AR041639A1 (https=)
AT (1) ATE398118T1 (https=)
AU (1) AU2003269773B2 (https=)
BR (1) BR0315254A (https=)
CA (1) CA2501542C (https=)
CY (1) CY1108255T1 (https=)
DE (1) DE60321588D1 (https=)
DK (1) DK1556370T3 (https=)
ES (1) ES2306883T3 (https=)
IL (1) IL167795A (https=)
IS (1) IS2590B (https=)
MX (1) MXPA05003994A (https=)
MY (1) MY133573A (https=)
NO (1) NO330785B1 (https=)
NZ (1) NZ539370A (https=)
PL (1) PL376819A1 (https=)
PT (1) PT1556370E (https=)
RU (1) RU2324691C2 (https=)
SA (1) SA03240344B1 (https=)
SE (1) SE0203092D0 (https=)
SI (1) SI1556370T1 (https=)
TW (1) TWI310382B (https=)
UA (1) UA79147C2 (https=)
UY (1) UY28025A1 (https=)
WO (1) WO2004035565A1 (https=)
ZA (1) ZA200502577B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0203092D0 (en) 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
US8691995B2 (en) 2004-12-16 2014-04-08 Cipla Limited Process
WO2010134099A1 (en) 2009-05-21 2010-11-25 Cadila Healthcare Limited One pot process for preparing omeprazole and related compounds
CN102884178B (zh) 2009-12-08 2014-12-03 科德克希思公司 拉唑化合物的合成
HUE037616T2 (hu) 2010-12-08 2018-09-28 Codexis Inc Biokatalizátorok és eljárások armodafinil szintéziséhez
CN103570681A (zh) * 2012-07-24 2014-02-12 江苏柯菲平医药有限公司 一种埃索美拉唑关键中间体的制备方法
CN103232389A (zh) * 2013-05-08 2013-08-07 浙江新三和医药化工股份有限公司 2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐的制备方法
CN103524494A (zh) * 2013-11-07 2014-01-22 安徽国星生物化学有限公司 含甲基吡啶基团的巯基咪唑类衍生物及合成方法
CN108251466B (zh) * 2016-12-28 2021-07-02 浙江京新药业股份有限公司 一种酶法合成埃索美拉唑的方法
CN107400118B (zh) * 2017-08-29 2020-07-28 信泰制药（苏州）有限公司 埃索美拉唑中间体的制备方法
CN111943883A (zh) * 2020-08-21 2020-11-17 抚州三和医药化工有限公司 一种奥美氯化物的生产工艺
KR20220084718A (ko) 2020-12-14 2022-06-21 메디케어제약 주식회사 기능성 소화 불량을 동반한 위식도 역류 질환을 치료하는 약제학적 복합제제
KR20230090184A (ko) 2021-12-14 2023-06-21 메디케어제약 주식회사 에스오메프라졸 및 레바미피드를 포함하는 약제학적 복합제제

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997002260A1 (en) * 1995-07-03 1997-01-23 Asahi Kasei Kogyo Kabushiki Kaisha 1-(5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrates

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4619997A (en) * 1984-09-06 1986-10-28 The Upjohn Company Substituted 2-pyridylmethylthio and sulfinyl-benzimidazoles as gastric antisecretory agents
SE9002043D0 (sv) 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
WO1993006097A1 (en) * 1991-09-20 1993-04-01 Merck & Co., Inc. Novel process for the preparation of anti-ulcer agents
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
SE9704183D0 (sv) * 1997-11-14 1997-11-14 Astra Ab New process
SI20019A (sl) * 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
SE0203092D0 (en) 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997002260A1 (en) * 1995-07-03 1997-01-23 Asahi Kasei Kogyo Kabushiki Kaisha 1-(5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrates

Also Published As

Publication number Publication date
TW200500357A (en) 2005-01-01
ZA200502577B (en) 2005-10-12
UA79147C2 (en) 2007-05-25
JP4551221B2 (ja) 2010-09-22
US7683178B2 (en) 2010-03-23
PL376819A1 (pl) 2006-01-09
WO2004035565A8 (en) 2005-05-19
MY133573A (en) 2007-11-30
CA2501542A1 (en) 2004-04-29
CN100374436C (zh) 2008-03-12
PT1556370E (pt) 2008-08-06
CN101230057A (zh) 2008-07-30
AU2003269773A1 (en) 2004-05-04
AR041639A1 (es) 2005-05-26
CY1108255T1 (el) 2014-02-12
EP1556370A1 (en) 2005-07-27
WO2004035565A1 (en) 2004-04-29
DK1556370T3 (da) 2008-09-01
KR20050050145A (ko) 2005-05-27
BR0315254A (pt) 2005-08-23
CN1705656A (zh) 2005-12-07
RU2005109270A (ru) 2006-01-20
TWI310382B (en) 2009-06-01
ATE398118T1 (de) 2008-07-15
JP2006505567A (ja) 2006-02-16
NO20052158L (no) 2005-05-02
SA03240344B1 (ar) 2008-09-14
RU2324691C2 (ru) 2008-05-20
SI1556370T1 (sl) 2008-10-31
MXPA05003994A (es) 2005-06-22
CA2501542C (en) 2011-12-06
ES2306883T3 (es) 2008-11-16
NZ539370A (en) 2006-11-30
HK1078852A1 (en) 2006-03-24
EP1556370B1 (en) 2008-06-11
SE0203092D0 (en) 2002-10-18
IS2590B (is) 2010-02-15
IL167795A (en) 2011-02-28
CN101230057B (zh) 2011-09-14
UY28025A1 (es) 2004-05-31
IS7834A (is) 2005-05-03
US7227024B2 (en) 2007-06-05
US20080004447A1 (en) 2008-01-03
US20060084811A1 (en) 2006-04-20
DE60321588D1 (de) 2008-07-24
AU2003269773B2 (en) 2007-02-01
NO330785B1 (no) 2011-07-18

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