KR100997601B1 - 카나비노이드 1 활성의 억제제로서의 아졸로피리미딘 - Google Patents

카나비노이드 1 활성의 억제제로서의 아졸로피리미딘 Download PDF

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Publication number
KR100997601B1
KR100997601B1 KR1020087023736A KR20087023736A KR100997601B1 KR 100997601 B1 KR100997601 B1 KR 100997601B1 KR 1020087023736 A KR1020087023736 A KR 1020087023736A KR 20087023736 A KR20087023736 A KR 20087023736A KR 100997601 B1 KR100997601 B1 KR 100997601B1
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South Korea
Prior art keywords
phenyl
chlorophenyl
pyrimidin
oxo
dihydropyrazolo
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Korean (ko)
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KR20080113387A (ko
Inventor
샤오후이 헤
쿤용 양
홍 리우
데이비드 아처 엘리스
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아이알엠 엘엘씨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P11/02—Nasal agents, e.g. decongestants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P3/06—Antihyperlipidemics
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
KR1020087023736A 2006-03-30 2007-03-30 카나비노이드 1 활성의 억제제로서의 아졸로피리미딘 Expired - Fee Related KR100997601B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78831006P 2006-03-30 2006-03-30
US60/788,310 2006-03-30

Publications (2)

Publication Number Publication Date
KR20080113387A KR20080113387A (ko) 2008-12-30
KR100997601B1 true KR100997601B1 (ko) 2010-11-30

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KR1020087023736A Expired - Fee Related KR100997601B1 (ko) 2006-03-30 2007-03-30 카나비노이드 1 활성의 억제제로서의 아졸로피리미딘

Country Status (21)

Country Link
US (1) US8722691B2 (https=)
EP (1) EP1999132B1 (https=)
JP (1) JP5253374B2 (https=)
KR (1) KR100997601B1 (https=)
CN (1) CN101454327A (https=)
AU (1) AU2007239033B2 (https=)
BR (1) BRPI0710107A2 (https=)
CA (1) CA2645967C (https=)
CR (1) CR10309A (https=)
EC (1) ECSP088852A (https=)
ES (1) ES2388881T3 (https=)
GT (1) GT200800198A (https=)
MA (1) MA30339B1 (https=)
MX (1) MX2008012400A (https=)
NO (1) NO20084489L (https=)
PL (1) PL1999132T3 (https=)
PT (1) PT1999132E (https=)
RU (1) RU2424242C2 (https=)
TN (1) TNSN08373A1 (https=)
WO (1) WO2007120454A1 (https=)
ZA (1) ZA200807862B (https=)

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EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
MX2010005028A (es) 2007-11-05 2010-05-27 Schering Corp Moduladores de gamma secretasa.
EP2227471A1 (en) 2007-12-11 2010-09-15 Schering Corporation Gamma secretase modulators
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
HUE035333T2 (en) * 2013-05-02 2018-05-02 Hoffmann La Roche Pyrrolo [2,3-d] pyrimidine derivatives as CB2 receptor agonists
MA45442A (fr) * 2016-06-23 2019-05-01 Hoffmann La Roche Dérivés de [1,2,3]triazolo[4,5-d]pyrimidine ayant une affinité pour le récepteur cannabinoïde de type 2
US20180072741A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyrimidine compounds and uses thereof
WO2018049214A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer
CN115819417A (zh) 2016-09-09 2023-03-21 因赛特公司 作为hpk1调节剂的吡唑并吡啶衍生物及其用于治疗癌症的用途
TWI800498B (zh) * 2016-12-21 2023-05-01 義大利商吉斯藥品公司 作為Rho-激酶抑制劑之雙環二氫嘧啶-羧醯胺衍生物
WO2018152220A1 (en) 2017-02-15 2018-08-23 Incyte Corporation Pyrazolopyridine compounds and uses thereof
US10722495B2 (en) 2017-09-08 2020-07-28 Incyte Corporation Cyanoindazole compounds and uses thereof
EP3755703B1 (en) 2018-02-20 2022-05-04 Incyte Corporation N-(phenyl)-2-(phenyl)pyrimidine-4-carboxamide derivatives and related compounds as hpk1 inhibitors for treating cancer
US10745388B2 (en) 2018-02-20 2020-08-18 Incyte Corporation Indazole compounds and uses thereof
US10752635B2 (en) 2018-02-20 2020-08-25 Incyte Corporation Indazole compounds and uses thereof
US11299473B2 (en) 2018-04-13 2022-04-12 Incyte Corporation Benzimidazole and indole compounds and uses thereof
US20200035118A1 (en) 2018-07-27 2020-01-30 Joseph Pandolfino Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes
US10897925B2 (en) 2018-07-27 2021-01-26 Joseph Pandolfino Articles and formulations for smoking products and vaporizers
US10899755B2 (en) 2018-08-08 2021-01-26 Incyte Corporation Benzothiazole compounds and uses thereof
WO2020068729A1 (en) 2018-09-25 2020-04-02 Incyte Corporation Pyrazolo[4,3-d]pyrimidine compounds as alk2 abd/or fgfr modulators
BR112022002059A2 (pt) 2019-08-06 2022-06-07 Incyte Corp Formas sólidas de um inibidor de hpk1

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AU2007239033A1 (en) 2007-10-25
NO20084489L (no) 2008-12-19
CN101454327A (zh) 2009-06-10
KR20080113387A (ko) 2008-12-30
GT200800198A (es) 2009-04-29
EP1999132A1 (en) 2008-12-10
ECSP088852A (es) 2008-11-27
MX2008012400A (es) 2008-10-10
WO2007120454A1 (en) 2007-10-25
ES2388881T3 (es) 2012-10-19
CA2645967A1 (en) 2007-10-25
US20090247556A1 (en) 2009-10-01
TNSN08373A1 (en) 2009-12-29
CR10309A (es) 2008-12-03
BRPI0710107A2 (pt) 2011-08-02
PT1999132E (pt) 2012-10-02
EP1999132B1 (en) 2012-07-18
RU2424242C2 (ru) 2011-07-20
US8722691B2 (en) 2014-05-13
HK1122034A1 (en) 2009-05-08
JP2009532360A (ja) 2009-09-10
JP5253374B2 (ja) 2013-07-31
MA30339B1 (fr) 2009-04-01
ZA200807862B (en) 2009-06-24
CA2645967C (en) 2011-05-24
PL1999132T3 (pl) 2012-12-31
RU2008142832A (ru) 2010-05-10
AU2007239033B2 (en) 2011-12-15

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