ZA200807862B - Azolopyrimidines as inhibitors of cannabinoid 1 activity - Google Patents
Azolopyrimidines as inhibitors of cannabinoid 1 activityInfo
- Publication number
- ZA200807862B ZA200807862B ZA200807862A ZA200807862A ZA200807862B ZA 200807862 B ZA200807862 B ZA 200807862B ZA 200807862 A ZA200807862 A ZA 200807862A ZA 200807862 A ZA200807862 A ZA 200807862A ZA 200807862 B ZA200807862 B ZA 200807862B
- Authority
- ZA
- South Africa
- Prior art keywords
- azolopyrimidines
- cannabinoid
- inhibitors
- activity
- Prior art date
Links
- KCTZOTUQSGYWLV-UHFFFAOYSA-N N1C=NC=C2N=CC=C21 Chemical class N1C=NC=C2N=CC=C21 KCTZOTUQSGYWLV-UHFFFAOYSA-N 0.000 title 1
- 229930003827 cannabinoid Natural products 0.000 title 1
- 239000003557 cannabinoid Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/02—Nasal agents, e.g. decongestants
-
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78831006P | 2006-03-30 | 2006-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200807862B true ZA200807862B (en) | 2009-06-24 |
Family
ID=38294112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200807862A ZA200807862B (en) | 2006-03-30 | 2008-09-12 | Azolopyrimidines as inhibitors of cannabinoid 1 activity |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8722691B2 (https=) |
| EP (1) | EP1999132B1 (https=) |
| JP (1) | JP5253374B2 (https=) |
| KR (1) | KR100997601B1 (https=) |
| CN (1) | CN101454327A (https=) |
| AU (1) | AU2007239033B2 (https=) |
| BR (1) | BRPI0710107A2 (https=) |
| CA (1) | CA2645967C (https=) |
| CR (1) | CR10309A (https=) |
| EC (1) | ECSP088852A (https=) |
| ES (1) | ES2388881T3 (https=) |
| GT (1) | GT200800198A (https=) |
| MA (1) | MA30339B1 (https=) |
| MX (1) | MX2008012400A (https=) |
| NO (1) | NO20084489L (https=) |
| PL (1) | PL1999132T3 (https=) |
| PT (1) | PT1999132E (https=) |
| RU (1) | RU2424242C2 (https=) |
| TN (1) | TNSN08373A1 (https=) |
| WO (1) | WO2007120454A1 (https=) |
| ZA (1) | ZA200807862B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101686989B (zh) * | 2007-06-21 | 2016-10-19 | 卡拉治疗学股份有限公司 | 取代的咪唑并杂环 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| MX2010005028A (es) | 2007-11-05 | 2010-05-27 | Schering Corp | Moduladores de gamma secretasa. |
| EP2227471A1 (en) | 2007-12-11 | 2010-09-15 | Schering Corporation | Gamma secretase modulators |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| HUE035333T2 (en) * | 2013-05-02 | 2018-05-02 | Hoffmann La Roche | Pyrrolo [2,3-d] pyrimidine derivatives as CB2 receptor agonists |
| MA45442A (fr) * | 2016-06-23 | 2019-05-01 | Hoffmann La Roche | Dérivés de [1,2,3]triazolo[4,5-d]pyrimidine ayant une affinité pour le récepteur cannabinoïde de type 2 |
| US20180072741A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyrimidine compounds and uses thereof |
| WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| CN115819417A (zh) | 2016-09-09 | 2023-03-21 | 因赛特公司 | 作为hpk1调节剂的吡唑并吡啶衍生物及其用于治疗癌症的用途 |
| TWI800498B (zh) * | 2016-12-21 | 2023-05-01 | 義大利商吉斯藥品公司 | 作為Rho-激酶抑制劑之雙環二氫嘧啶-羧醯胺衍生物 |
| WO2018152220A1 (en) | 2017-02-15 | 2018-08-23 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| US10722495B2 (en) | 2017-09-08 | 2020-07-28 | Incyte Corporation | Cyanoindazole compounds and uses thereof |
| EP3755703B1 (en) | 2018-02-20 | 2022-05-04 | Incyte Corporation | N-(phenyl)-2-(phenyl)pyrimidine-4-carboxamide derivatives and related compounds as hpk1 inhibitors for treating cancer |
| US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
| US10752635B2 (en) | 2018-02-20 | 2020-08-25 | Incyte Corporation | Indazole compounds and uses thereof |
| US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
| US20200035118A1 (en) | 2018-07-27 | 2020-01-30 | Joseph Pandolfino | Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes |
| US10897925B2 (en) | 2018-07-27 | 2021-01-26 | Joseph Pandolfino | Articles and formulations for smoking products and vaporizers |
| US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
| WO2020068729A1 (en) | 2018-09-25 | 2020-04-02 | Incyte Corporation | Pyrazolo[4,3-d]pyrimidine compounds as alk2 abd/or fgfr modulators |
| BR112022002059A2 (pt) | 2019-08-06 | 2022-06-07 | Incyte Corp | Formas sólidas de um inibidor de hpk1 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2789079B3 (fr) * | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
| US7145012B2 (en) | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| US7141669B2 (en) | 2003-04-23 | 2006-11-28 | Pfizer Inc. | Cannabiniod receptor ligands and uses thereof |
| WO2005049615A1 (en) * | 2003-11-21 | 2005-06-02 | Pfizer Products Inc. | Pyrazolo`1,5-a!`1,3,5! triazin -4-one derivatives as cb1 receptor antagonists |
| WO2005061505A1 (en) | 2003-12-16 | 2005-07-07 | Pfizer Products Inc. | Bicyclic imidazolyl pyrimidin-4-one cannabinoid receptor ligands and uses thereof |
| TW200528455A (en) | 2003-12-19 | 2005-09-01 | Bristol Myers Squibb Co | Azabicyclic heterocycles as cannabinoid receptor modulators |
| AR051596A1 (es) * | 2004-10-26 | 2007-01-24 | Irm Llc | Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios |
-
2007
- 2007-03-30 WO PCT/US2007/007989 patent/WO2007120454A1/en not_active Ceased
- 2007-03-30 RU RU2008142832/04A patent/RU2424242C2/ru not_active IP Right Cessation
- 2007-03-30 AU AU2007239033A patent/AU2007239033B2/en not_active Ceased
- 2007-03-30 EP EP07754503A patent/EP1999132B1/en not_active Not-in-force
- 2007-03-30 MX MX2008012400A patent/MX2008012400A/es active IP Right Grant
- 2007-03-30 CA CA2645967A patent/CA2645967C/en not_active Expired - Fee Related
- 2007-03-30 BR BRPI0710107-4A patent/BRPI0710107A2/pt not_active IP Right Cessation
- 2007-03-30 PT PT07754503T patent/PT1999132E/pt unknown
- 2007-03-30 PL PL07754503T patent/PL1999132T3/pl unknown
- 2007-03-30 ES ES07754503T patent/ES2388881T3/es active Active
- 2007-03-30 CN CNA2007800198186A patent/CN101454327A/zh active Pending
- 2007-03-30 JP JP2009503047A patent/JP5253374B2/ja not_active Expired - Fee Related
- 2007-03-30 US US12/295,555 patent/US8722691B2/en not_active Expired - Fee Related
- 2007-03-30 KR KR1020087023736A patent/KR100997601B1/ko not_active Expired - Fee Related
-
2008
- 2008-09-12 ZA ZA200807862A patent/ZA200807862B/xx unknown
- 2008-09-22 CR CR10309A patent/CR10309A/es not_active Application Discontinuation
- 2008-09-24 TN TNP2008000373A patent/TNSN08373A1/en unknown
- 2008-09-29 GT GT200800198A patent/GT200800198A/es unknown
- 2008-10-17 MA MA31300A patent/MA30339B1/fr unknown
- 2008-10-24 NO NO20084489A patent/NO20084489L/no not_active Application Discontinuation
- 2008-10-30 EC EC2008008852A patent/ECSP088852A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007239033A1 (en) | 2007-10-25 |
| NO20084489L (no) | 2008-12-19 |
| CN101454327A (zh) | 2009-06-10 |
| KR20080113387A (ko) | 2008-12-30 |
| GT200800198A (es) | 2009-04-29 |
| EP1999132A1 (en) | 2008-12-10 |
| ECSP088852A (es) | 2008-11-27 |
| MX2008012400A (es) | 2008-10-10 |
| WO2007120454A1 (en) | 2007-10-25 |
| ES2388881T3 (es) | 2012-10-19 |
| KR100997601B1 (ko) | 2010-11-30 |
| CA2645967A1 (en) | 2007-10-25 |
| US20090247556A1 (en) | 2009-10-01 |
| TNSN08373A1 (en) | 2009-12-29 |
| CR10309A (es) | 2008-12-03 |
| BRPI0710107A2 (pt) | 2011-08-02 |
| PT1999132E (pt) | 2012-10-02 |
| EP1999132B1 (en) | 2012-07-18 |
| RU2424242C2 (ru) | 2011-07-20 |
| US8722691B2 (en) | 2014-05-13 |
| HK1122034A1 (en) | 2009-05-08 |
| JP2009532360A (ja) | 2009-09-10 |
| JP5253374B2 (ja) | 2013-07-31 |
| MA30339B1 (fr) | 2009-04-01 |
| CA2645967C (en) | 2011-05-24 |
| PL1999132T3 (pl) | 2012-12-31 |
| RU2008142832A (ru) | 2010-05-10 |
| AU2007239033B2 (en) | 2011-12-15 |
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