CN101454327A - 作为大麻素1活性抑制剂的吡咯并嘧啶类化合物 - Google Patents

作为大麻素1活性抑制剂的吡咯并嘧啶类化合物 Download PDF

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Publication number
CN101454327A
CN101454327A CNA2007800198186A CN200780019818A CN101454327A CN 101454327 A CN101454327 A CN 101454327A CN A2007800198186 A CNA2007800198186 A CN A2007800198186A CN 200780019818 A CN200780019818 A CN 200780019818A CN 101454327 A CN101454327 A CN 101454327A
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Prior art keywords
phenyl
dihydro
chloro
pyrimidin
pyrazolo
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CNA2007800198186A
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Chinese (zh)
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贺晓晖
杨鲲泳
刘宏
D·A·埃里斯
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IRM LLC
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IRM LLC
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    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Animal Behavior & Ethology (AREA)
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  • Obesity (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
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CNA2007800198186A 2006-03-30 2007-03-30 作为大麻素1活性抑制剂的吡咯并嘧啶类化合物 Pending CN101454327A (zh)

Applications Claiming Priority (2)

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US78831006P 2006-03-30 2006-03-30
US60/788,310 2006-03-30

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CN101454327A true CN101454327A (zh) 2009-06-10

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US (1) US8722691B2 (https=)
EP (1) EP1999132B1 (https=)
JP (1) JP5253374B2 (https=)
KR (1) KR100997601B1 (https=)
CN (1) CN101454327A (https=)
AU (1) AU2007239033B2 (https=)
BR (1) BRPI0710107A2 (https=)
CA (1) CA2645967C (https=)
CR (1) CR10309A (https=)
EC (1) ECSP088852A (https=)
ES (1) ES2388881T3 (https=)
GT (1) GT200800198A (https=)
MA (1) MA30339B1 (https=)
MX (1) MX2008012400A (https=)
NO (1) NO20084489L (https=)
PL (1) PL1999132T3 (https=)
PT (1) PT1999132E (https=)
RU (1) RU2424242C2 (https=)
TN (1) TNSN08373A1 (https=)
WO (1) WO2007120454A1 (https=)
ZA (1) ZA200807862B (https=)

Cited By (2)

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CN105164133A (zh) * 2013-05-02 2015-12-16 豪夫迈·罗氏有限公司 作为CB2受体激动剂的吡咯并[2，3-d]嘧啶衍生物
CN110062758A (zh) * 2016-12-21 2019-07-26 奇斯药制品公司 作为rho-激酶抑制剂的二环二氢嘧啶-甲酰胺衍生物

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CN101686989B (zh) * 2007-06-21 2016-10-19 卡拉治疗学股份有限公司 取代的咪唑并杂环
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
MX2010005028A (es) 2007-11-05 2010-05-27 Schering Corp Moduladores de gamma secretasa.
EP2227471A1 (en) 2007-12-11 2010-09-15 Schering Corporation Gamma secretase modulators
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
MA45442A (fr) * 2016-06-23 2019-05-01 Hoffmann La Roche Dérivés de [1,2,3]triazolo[4,5-d]pyrimidine ayant une affinité pour le récepteur cannabinoïde de type 2
US20180072741A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyrimidine compounds and uses thereof
WO2018049214A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer
CN115819417A (zh) 2016-09-09 2023-03-21 因赛特公司 作为hpk1调节剂的吡唑并吡啶衍生物及其用于治疗癌症的用途
WO2018152220A1 (en) 2017-02-15 2018-08-23 Incyte Corporation Pyrazolopyridine compounds and uses thereof
US10722495B2 (en) 2017-09-08 2020-07-28 Incyte Corporation Cyanoindazole compounds and uses thereof
EP3755703B1 (en) 2018-02-20 2022-05-04 Incyte Corporation N-(phenyl)-2-(phenyl)pyrimidine-4-carboxamide derivatives and related compounds as hpk1 inhibitors for treating cancer
US10745388B2 (en) 2018-02-20 2020-08-18 Incyte Corporation Indazole compounds and uses thereof
US10752635B2 (en) 2018-02-20 2020-08-25 Incyte Corporation Indazole compounds and uses thereof
US11299473B2 (en) 2018-04-13 2022-04-12 Incyte Corporation Benzimidazole and indole compounds and uses thereof
US20200035118A1 (en) 2018-07-27 2020-01-30 Joseph Pandolfino Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes
US10897925B2 (en) 2018-07-27 2021-01-26 Joseph Pandolfino Articles and formulations for smoking products and vaporizers
US10899755B2 (en) 2018-08-08 2021-01-26 Incyte Corporation Benzothiazole compounds and uses thereof
WO2020068729A1 (en) 2018-09-25 2020-04-02 Incyte Corporation Pyrazolo[4,3-d]pyrimidine compounds as alk2 abd/or fgfr modulators
BR112022002059A2 (pt) 2019-08-06 2022-06-07 Incyte Corp Formas sólidas de um inibidor de hpk1

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FR2789079B3 (fr) * 1999-02-01 2001-03-02 Sanofi Synthelabo Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
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WO2005049615A1 (en) * 2003-11-21 2005-06-02 Pfizer Products Inc. Pyrazolo`1,5-a!`1,3,5! triazin -4-one derivatives as cb1 receptor antagonists
WO2005061505A1 (en) 2003-12-16 2005-07-07 Pfizer Products Inc. Bicyclic imidazolyl pyrimidin-4-one cannabinoid receptor ligands and uses thereof
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105164133A (zh) * 2013-05-02 2015-12-16 豪夫迈·罗氏有限公司 作为CB2受体激动剂的吡咯并[2，3-d]嘧啶衍生物
CN105164133B (zh) * 2013-05-02 2018-02-13 豪夫迈·罗氏有限公司 作为CB2受体激动剂的吡咯并[2，3‑d]嘧啶衍生物
CN110062758A (zh) * 2016-12-21 2019-07-26 奇斯药制品公司 作为rho-激酶抑制剂的二环二氢嘧啶-甲酰胺衍生物
KR20190092439A (ko) * 2016-12-21 2019-08-07 키에시 파르마슈티시 엣스. 피. 에이. Rho-키나아제 억제제로서 바이사이클릭 다이하이드로피리미딘-카복스아마이드 유도체
CN110062758B (zh) * 2016-12-21 2023-01-17 奇斯药制品公司 作为rho-激酶抑制剂的二环二氢嘧啶-甲酰胺衍生物
KR102559612B1 (ko) 2016-12-21 2023-07-26 키에시 파르마슈티시 엣스. 피. 에이. Rho-키나아제 억제제로서 바이사이클릭 다이하이드로피리미딘-카복스아마이드 유도체

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NO20084489L (no) 2008-12-19
KR20080113387A (ko) 2008-12-30
GT200800198A (es) 2009-04-29
EP1999132A1 (en) 2008-12-10
ECSP088852A (es) 2008-11-27
MX2008012400A (es) 2008-10-10
WO2007120454A1 (en) 2007-10-25
ES2388881T3 (es) 2012-10-19
KR100997601B1 (ko) 2010-11-30
CA2645967A1 (en) 2007-10-25
US20090247556A1 (en) 2009-10-01
TNSN08373A1 (en) 2009-12-29
CR10309A (es) 2008-12-03
BRPI0710107A2 (pt) 2011-08-02
PT1999132E (pt) 2012-10-02
EP1999132B1 (en) 2012-07-18
RU2424242C2 (ru) 2011-07-20
US8722691B2 (en) 2014-05-13
HK1122034A1 (en) 2009-05-08
JP2009532360A (ja) 2009-09-10
JP5253374B2 (ja) 2013-07-31
MA30339B1 (fr) 2009-04-01
ZA200807862B (en) 2009-06-24
CA2645967C (en) 2011-05-24
PL1999132T3 (pl) 2012-12-31
RU2008142832A (ru) 2010-05-10
AU2007239033B2 (en) 2011-12-15

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