KR100995790B1 - 신규한 4-아미노-티에노[3,2-ｃ]피리딘-7-카르복실산아미드 - Google Patents

신규한 4-아미노-티에노[3,2-ｃ]피리딘-7-카르복실산아미드 Download PDF

Info

Publication number
KR100995790B1
KR100995790B1 KR1020087003603A KR20087003603A KR100995790B1 KR 100995790 B1 KR100995790 B1 KR 100995790B1 KR 1020087003603 A KR1020087003603 A KR 1020087003603A KR 20087003603 A KR20087003603 A KR 20087003603A KR 100995790 B1 KR100995790 B1 KR 100995790B1
Authority
KR
South Korea
Prior art keywords
thieno
pyridine
carboxylic acid
phenoxymethyl
amino
Prior art date
Application number
KR1020087003603A
Other languages
English (en)
Korean (ko)
Other versions
KR20080027945A (ko
Inventor
킨-천 룩
리 어파슬 맥더모트
파멜라 로렌 로스만
피터 마이클 우브컬리치
주밍 장
Original Assignee
에프. 호프만-라 로슈 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에프. 호프만-라 로슈 아게 filed Critical 에프. 호프만-라 로슈 아게
Publication of KR20080027945A publication Critical patent/KR20080027945A/ko
Application granted granted Critical
Publication of KR100995790B1 publication Critical patent/KR100995790B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020087003603A 2005-08-16 2005-08-16 신규한 4-아미노-티에노[3,2-ｃ]피리딘-7-카르복실산아미드 KR100995790B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2005/054022 WO2007019884A1 (fr) 2005-08-16 2005-08-16 Nouveaux amides de l'acide 4-amino-thiéno[3,2-c]pyridine-7-carboxylique

Publications (2)

Publication Number Publication Date
KR20080027945A KR20080027945A (ko) 2008-03-28
KR100995790B1 true KR100995790B1 (ko) 2010-11-22

Family

ID=35159670

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087003603A KR100995790B1 (ko) 2005-08-16 2005-08-16 신규한 4-아미노-티에노[3,2-ｃ]피리딘-7-카르복실산아미드

Country Status (9)

Country Link
EP (1) EP1917015A1 (fr)
JP (1) JP2009504692A (fr)
KR (1) KR100995790B1 (fr)
AU (1) AU2005335661A1 (fr)
BR (1) BRPI0520482A2 (fr)
CA (1) CA2619459A1 (fr)
IL (1) IL189181A0 (fr)
MX (1) MX2008002060A (fr)
WO (1) WO2007019884A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0616239A2 (pt) * 2005-09-15 2011-06-14 Hoffmann La Roche derivados de Ácido 4-amino-tieno[3,2-c]piridina-7-carboxÍlico, formulaÇço farmacÊutica contendo os mesmos bem como seus usos
AR070317A1 (es) * 2008-02-06 2010-03-31 Osi Pharm Inc Furo (3,2-c) piridina y tieno (3,2-c) piridinas
US20120189641A1 (en) 2009-02-25 2012-07-26 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
EP2401614A1 (fr) 2009-02-27 2012-01-04 OSI Pharmaceuticals, LLC Méthodes d'identification d'agents qui inhibent les cellules cancéreuses mésenchymateuses ou leur formation
WO2010099138A2 (fr) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Procédés pour l'identification d'agents qui inhibent les cellules tumorales de type mésenchymateuses ou leur formation
WO2012149014A1 (fr) 2011-04-25 2012-11-01 OSI Pharmaceuticals, LLC Utilisation de signatures de gènes de tem dans la découverte de médicaments contre le cancer, diagnostics et traitement du cancer
WO2013152252A1 (fr) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Polythérapie antinéoplasique

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232320B1 (en) * 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
US7199119B2 (en) * 2002-10-31 2007-04-03 Amgen Inc. Antiinflammation agents
JP2006528685A (ja) * 2003-05-06 2006-12-21 スミスクライン ビーチャム コーポレーション 新規化合物
US20050026944A1 (en) * 2003-07-24 2005-02-03 Patrick Betschmann Thienopyridine and furopyridine kinase inhibitors
US20050020619A1 (en) * 2003-07-24 2005-01-27 Patrick Betschmann Thienopyridine kinase inhibitors

Also Published As

Publication number Publication date
BRPI0520482A2 (pt) 2009-05-12
CA2619459A1 (fr) 2007-02-22
IL189181A0 (en) 2008-06-05
WO2007019884A1 (fr) 2007-02-22
JP2009504692A (ja) 2009-02-05
MX2008002060A (es) 2008-04-16
AU2005335661A1 (en) 2007-02-22
KR20080027945A (ko) 2008-03-28
EP1917015A1 (fr) 2008-05-07

Similar Documents

Publication Publication Date Title
US20050256154A1 (en) 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides
CN104169283B (zh) 作为parp抑制剂的稠合的四元或五元环吡啶并酞嗪酮类化合物
US7084270B2 (en) Pyrimido compounds having antiproliferative activity
EP2081923B1 (fr) Amides substitués, procédé de production et d'utilisation desdits amides
KR100995790B1 (ko) 신규한 4-아미노-티에노[3,2-ｃ]피리딘-7-카르복실산아미드
CN103703004B (zh) 作为parp抑制剂的稠合的四环或五环的二氢二氮杂*并咔唑酮
CA2621830C (fr) Derives d'acide 4-amino-thieno[3,2-c]pyridine-7-carboxylique
MXPA05006437A (es) Derivados de piridino[2,3-d]pirimidina como inhibidores selectivos de kdr y fgfr.
Hou et al. Design, synthesis and biological evaluation of novel 7-amino-[1, 2, 4] triazolo [4, 3-f] pteridinone, and 7-aminotetrazolo [1, 5-f] pteridinone derivative as potent antitumor agents
CN102858770A (zh) 双环化合物及其作为c-SRC/JAK激酶双重抑制剂的用途
MXPA03002294A (es) Compuestos de pirazol utiles como inhibidores de proteina cinasa.
CN107176932B (zh) 苯并恶嗪酮衍生物及其制备方法和用途
CN103974955A (zh) 嘧啶并-哒嗪酮化合物及其用途
WO2019154395A1 (fr) Composé de tétrahydroisoquinoléine, son procédé de préparation, composition pharmaceutique le contenant et utilisation associée
CN115353508B (zh) 5-吡啶-1h-吲唑类化合物、药物组合物和应用
BR112014019402B1 (pt) Composto 2-aril-benzofuran-7-carboxamida, ou sal farmacologicamente aceitável do mesmo e método para a preparação do composto
JP5469604B2 (ja) 新規テトラヒドロ融合ピリジン
CN101189243A (zh) 取代的杂环及其作为chk1、pdk1和pak抑制剂的应用
CN107200716B (zh) 苯并噁嗪类化合物及其制备方法与应用
CN108329232B (zh) 酰肼类衍生物及其应用
CN111247137A (zh) 一种嘧啶类化合物、其制备方法及其医药用途
CN109134433A (zh) 一种抑制rock的化合物及其应用
CN108239081A (zh) 一种抑制rock的化合物及其应用
RU2346946C2 (ru) Производные 1, 3, 4-триазафеналена и 1, 3, 4, 6-тетраазафеналена, обладающие свойствами ингибитора эпидермального фактора роста тирозинкиназы
CN110229146B (zh) 组蛋白去乙酰化酶抑制剂及其制备方法与用途

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
LAPS Lapse due to unpaid annual fee