KR100983450B1 - 식품보충제에 대한 개별적 다양성 평가의 모델로서 전혈내의 생체 외 유전자 발현 - Google Patents

식품보충제에 대한 개별적 다양성 평가의 모델로서 전혈내의 생체 외 유전자 발현 Download PDF

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KR100983450B1
KR100983450B1 KR1020077027182A KR20077027182A KR100983450B1 KR 100983450 B1 KR100983450 B1 KR 100983450B1 KR 1020077027182 A KR1020077027182 A KR 1020077027182A KR 20077027182 A KR20077027182 A KR 20077027182A KR 100983450 B1 KR100983450 B1 KR 100983450B1
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whole blood
mrna
vitamin
blood
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KR20080019590A (ko
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마사토 미츠하시
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히다치 가세고교 가부시끼가이샤
히타치케미컬 리서치센터 인코포레이티드
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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KR1020077027182A 2005-04-28 2006-04-28 식품보충제에 대한 개별적 다양성 평가의 모델로서 전혈내의 생체 외 유전자 발현 Expired - Fee Related KR100983450B1 (ko)

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US67558005P 2005-04-28 2005-04-28
US60/675,580 2005-04-28

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KR20080019590A KR20080019590A (ko) 2008-03-04
KR100983450B1 true KR100983450B1 (ko) 2010-09-20

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US (1) US20080206761A1 (https=)
EP (1) EP1888089B9 (https=)
JP (1) JP4945554B2 (https=)
KR (1) KR100983450B1 (https=)
CN (1) CN101166537B (https=)
AT (1) ATE512234T1 (https=)
WO (1) WO2006116721A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008503206A (ja) * 2004-05-25 2008-02-07 日立化成工業株式会社 癌感受性を測定する方法
CN101044249B (zh) * 2004-10-20 2012-09-05 日立化成工业株式会社 通过定量mRNA定制给药的方法
JP4800384B2 (ja) * 2005-06-08 2011-10-26 ヒタチ ケミカル リサーチ センター インコーポレイテッド 腫瘍細胞及び刺激された白血球におけるｍＲＮＡの発現プロファイルに基づく腫瘍性疾患に対する免疫応答を予測する方法
JP2009536021A (ja) * 2006-04-07 2009-10-08 日立化成工業株式会社 関節リウマチの患者の末梢血白血球におけるＦＣ受容体媒介性腫瘍壊死因子スーパーファミリ及びケモカインのｍＲＮＡ発現の増大
ATE518011T1 (de) * 2006-04-07 2011-08-15 Hitachi Chemical Co Ltd Erhöhte expression von t- zellenrezeptorvermittelter tumornekrosefaktorsuperfamilie und chemokin-mrna in peripheren blut leukozyten bei patienten mit morbus& xa;crohn
US20090298071A1 (en) * 2006-05-08 2009-12-03 Masato Mitsuhashi Method for testing drug sensitivity in solid tumors by quantifying mrna expression in thinly-sliced tumor tissue
JP2011502535A (ja) 2007-11-14 2011-01-27 日立化成工業株式会社 末梢血白血球における、Ｆｃ受容体を介した腫瘍壊死因子スーパーファミリーｍＲＮＡ発現
US20090215064A1 (en) * 2008-02-27 2009-08-27 Hitachi Chemical Co., Ltd. Quantitative assessment of individual cancer susceptibility by measuring dna damage-induced mrna in whole blood
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy
WO2011140125A1 (en) 2010-05-07 2011-11-10 Hitachi Chemical Co., Ltd. Methods of characterizing host responsiveness to interferon by ex vivo induction of interferon-responsive markers
EP2734233B1 (en) * 2011-07-18 2017-11-01 Hitachi Chemical Co., Ltd. Methods of predicting host responsiveness to cancer immunotherapies by ex vivo induction of leukocyte-function-associated mrnas
KR20230109779A (ko) 2013-03-27 2023-07-20 세다르스-신나이 메디칼 센터 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전
EP3022295A4 (en) 2013-07-19 2017-03-01 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
DE112016003948T5 (de) 2015-08-31 2018-05-09 City Of Sapporo Molekulare verfahren zum beurteilen einer urothelialen erkrankung
KR20240095481A (ko) 2016-03-17 2024-06-25 세다르스-신나이 메디칼 센터 Rnaset2를 통한 염증성 장 질환의 진단 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020006613A1 (en) 1998-01-20 2002-01-17 Shyjan Andrew W. Methods and compositions for the identification and assessment of cancer therapies

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925572A (en) * 1987-10-20 1990-05-15 Pall Corporation Device and method for depletion of the leukocyte content of blood and blood components
US4880548A (en) * 1988-02-17 1989-11-14 Pall Corporation Device and method for separating leucocytes from platelet concentrate
DE68921918T2 (de) * 1988-05-09 1995-09-07 Univ Temple Verfahren zur Voraussage der Wirksamkeit einer antineoplastichen Behandlung bei einzelnen Patienten.
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5474909A (en) * 1992-08-07 1995-12-12 Anticancer, Inc. Noncolorimetric histoculture method for predicting drug response of tumors
US7625697B2 (en) * 1994-06-17 2009-12-01 The Board Of Trustees Of The Leland Stanford Junior University Methods for constructing subarrays and subarrays made thereby
US5491063A (en) * 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
DE69739909D1 (de) * 1996-03-26 2010-07-29 Michael S Kopreski Methoden aus plasma oder serum extrahierte extrazelluraere rna zur diagnoseüberwachung oder evaluation von krebs verwenden
US5683698A (en) 1996-08-02 1997-11-04 New England Deaconess Hospital Formulation for alleviating symptoms associated with arthritis
US7514232B2 (en) * 1996-12-06 2009-04-07 Becton, Dickinson And Company Method for detecting T cell response to specific antigens in whole blood
AU768189B2 (en) * 1999-06-15 2003-12-04 Nutri-Logics, Inc. Nutrient formulations for disease reduction, and related treatment and component screening methods
US6692916B2 (en) * 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US20020048566A1 (en) * 2000-09-14 2002-04-25 El-Deiry Wafik S. Modulation of cellular apoptosis and methods for treating cancer
ATE480618T1 (de) * 2000-10-31 2010-09-15 Hitachi Chemical Res Ct Inc Methode für das sammeln und das verwenden von kern-mrna
US20020182274A1 (en) 2001-03-21 2002-12-05 Kung-Ming Lu Methods for inhibiting cancer growth, reducing infection and promoting general health with a fermented soy extract
US7767390B2 (en) * 2001-11-20 2010-08-03 Oncomedx, Inc. Methods for evaluating drug-resistance gene expression in the cancer patient
FI20020078A7 (fi) * 2002-01-15 2003-07-16 Danisco Immuunijärjestelmän stimulointi polydextroosilla
US6878518B2 (en) * 2002-01-22 2005-04-12 The Trustees Of The University Of Pennsylvania Methods for determining steroid responsiveness
JP2005525114A (ja) * 2002-04-24 2005-08-25 ヒタチ ケミカル リサーチ センター インコーポレイテッド 全血からのｍＲＮＡをハイスループットに定量するための装置および方法
US7745180B2 (en) * 2002-04-24 2010-06-29 Hitachi Chemical Co., Ltd. Device and method for high-throughput quantification of mRNA from whole blood
WO2004012755A1 (en) * 2002-08-05 2004-02-12 The Wistar Institute Methods for regulating brca1-brca2-containing complex activity
GB0219642D0 (en) * 2002-08-23 2002-10-02 Gauthier Pierre Method and device for preparing tissues sections
AU2002953533A0 (en) * 2002-12-24 2003-01-16 Arthron Limited Fc receptor modulating compounds and compositions
JP2008503206A (ja) * 2004-05-25 2008-02-07 日立化成工業株式会社 癌感受性を測定する方法
JP4800384B2 (ja) * 2005-06-08 2011-10-26 ヒタチ ケミカル リサーチ センター インコーポレイテッド 腫瘍細胞及び刺激された白血球におけるｍＲＮＡの発現プロファイルに基づく腫瘍性疾患に対する免疫応答を予測する方法
EP1945814A2 (en) * 2005-09-27 2008-07-23 Source MDX Gene expression profiling for identification monitoring and treatment of rheumatoid arthritis
ATE518011T1 (de) * 2006-04-07 2011-08-15 Hitachi Chemical Co Ltd Erhöhte expression von t- zellenrezeptorvermittelter tumornekrosefaktorsuperfamilie und chemokin-mrna in peripheren blut leukozyten bei patienten mit morbus& xa;crohn
JP2009536021A (ja) * 2006-04-07 2009-10-08 日立化成工業株式会社 関節リウマチの患者の末梢血白血球におけるＦＣ受容体媒介性腫瘍壊死因子スーパーファミリ及びケモカインのｍＲＮＡ発現の増大
US20090298071A1 (en) * 2006-05-08 2009-12-03 Masato Mitsuhashi Method for testing drug sensitivity in solid tumors by quantifying mrna expression in thinly-sliced tumor tissue
JP2011502535A (ja) * 2007-11-14 2011-01-27 日立化成工業株式会社 末梢血白血球における、Ｆｃ受容体を介した腫瘍壊死因子スーパーファミリーｍＲＮＡ発現
US20090215064A1 (en) * 2008-02-27 2009-08-27 Hitachi Chemical Co., Ltd. Quantitative assessment of individual cancer susceptibility by measuring dna damage-induced mrna in whole blood

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020006613A1 (en) 1998-01-20 2002-01-17 Shyjan Andrew W. Methods and compositions for the identification and assessment of cancer therapies

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CN101166537B (zh) 2013-01-23
EP1888089B1 (en) 2011-06-08
JP4945554B2 (ja) 2012-06-06
CN101166537A (zh) 2008-04-23
JP2008538930A (ja) 2008-11-13
EP1888089A4 (en) 2009-01-07
US20080206761A1 (en) 2008-08-28
WO2006116721A1 (en) 2006-11-02
EP1888089B9 (en) 2012-08-08
KR20080019590A (ko) 2008-03-04
EP1888089A1 (en) 2008-02-20
ATE512234T1 (de) 2011-06-15

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