KR100911623B1 - 비만, 고지혈 또는 당뇨의 예방 또는 치료용 분획물 - Google Patents
비만, 고지혈 또는 당뇨의 예방 또는 치료용 분획물 Download PDFInfo
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- KR100911623B1 KR100911623B1 KR1020080045952A KR20080045952A KR100911623B1 KR 100911623 B1 KR100911623 B1 KR 100911623B1 KR 1020080045952 A KR1020080045952 A KR 1020080045952A KR 20080045952 A KR20080045952 A KR 20080045952A KR 100911623 B1 KR100911623 B1 KR 100911623B1
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- juniper
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- dichloromethane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/326—Foods, ingredients or supplements having a functional effect on health having effect on cardiovascular health
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/3262—Foods, ingredients or supplements having a functional effect on health having an effect on blood cholesterol
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/328—Foods, ingredients or supplements having a functional effect on health having effect on glycaemic control and diabetes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- General Health & Medical Sciences (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
Description
화학식 | C15H26O |
분자량 | 222 |
온도 | 200±2 K |
파장 | 0.71073 Å |
결정형태 | 사방정계 |
스페이스 그룹 | P212121 |
단위셀 디멘젼 | a = 6.0454± 7 Å α= 90° b = 19.291± 2 Å β = 90° c = 25.910± 3 Å γ = 90° |
부피 | 3021.6±6 Å3 |
Z | 4 |
밀도(calculated) | 1.079 Mg/m3 |
흡광계수 | 0.066 mm-1 |
F(OOO) | 1096 |
결정크기 | 0.25 x 0.22 x 0.19 mm3 |
데이터 수집 세타 범위 | 1.32 to 28.31° |
인덱스 범위 | -5≤h≤8, -25≤k≤25, -34≤l≤34 |
수집 리플렉션 | 22764 |
독립 리플렉션 | 7468 [R(int) = 0.1648] |
세타에 대한 컴플리트니스 = 28.31o | 99.8% |
흡광 보정 | None |
리파인먼트 방법 | 풀-매트릭스 리스트-스퀘어 온 F2 |
데이터/리스트레인트/파라미터 | 7468 / 0 / 328 |
굿니스-오브-피트 온 F2 | 0.903 |
최종 R 인덱스 [I>2시그마(I)] | R1 = 0.0814, wR2 = 0.1885 |
R 인덱스 (모든 데이터) | R1 = 0.2732, wR2 = 0.2773 |
절대구조 파라미터 | -3(3) |
최대 회절 피크 및 홀 | 0.298 및 -0.228 e.Å-3 |
No. | Retention time (min.) | 이름 (CAS No.) | Quality (피크순도) | 구조식 | 함량 (%) |
1 | 13.18 | (-)-α-Cedrene (469-61-4) | 97% | (C15H24) | 5.9 |
2 | 13.40 | γ-Muurolene (30021-74-0) | 97 | (C15H24) | 0.9 |
3 | 13.69 | Thujopsene (470-40-6) | 99 | (C15H24) | 0.3 |
4 | 16.70 | Globulol (51371-47-2) | 55 | (C15H26O) | 0.5 |
5 | 18.37 | 1-(1-Cyclohexen-1-yl)pyrrolidine (1125-99-1) | 58 | (C10H17N) | 0.8 |
No . | Retention time ( min .) | 이름 ( CAS No .) | Quality (피크순도) | 구조식 | 함량 (%) |
6 | 18.89 | Juniperanol | 99 | (C15H26O) | 49.8 |
7 | 19.09 | α- Cedrene oxide | 99 | (C15H24O) | 0.6 |
8 | 19.46 | ()-α- Cedrene (469-61-4) | 89 | (C15H24) | 0.4 |
9 | 19.63 | (98205-48-2) | 53 | ND | 1.8 |
No . | Retention time( min .) | 이름 ( CAS No .) | Quality ( 피크순도 ) | 구조식 | 함량 (%) |
10 | 19.93 | 2-[5- methyl -5-(4- methyl -1- cyclohex -3- enyl ) oxolan -2- yl ] propan -2- ol (26184-88-3) | 58 | (C15H26O2) | 0.5 |
11 | 20.04 | 1,4- Trans -1,7- trans - acorenone (5956-05-8) | 98 | - | 0.5 |
12 | 20.20 | Cedr -8- en -15- ol (21441-72-5) | 96 | (C15H24O) | 1.0 |
13 | 20.38 | Salvialane | 92 | - | 0.8 |
14 | 20.63 | α- Cadinol (481-34-5) | 38 | (C15H26O) | 0.7 |
15 | 20.75 | Levomenol (23089-26-1) | 90 | (C15H26O) | 0.6 |
No . | Retention time( min .) | 이름 ( CAS No .) | Quality ( 피크순도 ) | 구조식 | 함량 (%) |
16 | 21.09 | 8- Cedren -13- ol (18319-35-2) | 97 | (C15H24O) | 0.5 |
17 | 21.17 | Cedr -8- en -15- ol (21441-72-5) | 97 | (C15H24O) | 0.7 |
18 | 21.32 | Thujopsene (= Widdrene ) (38609-30-2) | 93 | (C15H24) | 0.7 |
19 | 21.53 | α- Guaiene (3691-12-1) | 74 | (C15H24) | 1.5 |
No . | Retention time( min .) | 이름 ( CAS No .) | Quality ( 피크순도 ) | 구조식 | 함량 (%) |
20 | 23.68 | β- Caryophyllene (87-44-5) | 90 | (C15H24) | 0.2 |
21 | 23.98 | Nootkatone (4674-50-4) | 99 | (C15H22O) | 2.9 |
No . | Retention time( min .) | 이름 ( CAS No .) | Quality ( 피크순도 ) | 구조식 | 함량 (%) |
22 | 26.20 | Germacrene B (15423-57-1) | 27 | (C15H24) | 0.4 |
23 | 36.23 | Ferruginol (514-62-5) | 94 | (C20H30O) | 0.4 |
24 | 40.73 | Di (2- ethylhexyl ) phthalate (117-81-7) | 91 | (C28H38O4) | 12.2 |
25 | 40.93 | Podocarpa-8,11,13-trien-3-one, 12-hydroxy-13-isopropyl- 2(1H)-Phenanthrenone, 3,4,4a,9,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-, (4aS-trans)- (472-37-7) | 99 | (C20H28O2) | 0.6 |
No . | Retention time( min .) | 이름 ( CAS No .) | Quality ( 피크순도 ) | 구조식 | 함량 (%) |
1 | 16.70 | Globulol (51371-47-2) | 64 | (C15H26O) | 0.8 |
2 | 18.84 | Juniperanol | 97 | (C15H26O) | 56.8 |
3 | 18.92 | Epicedrol (α-Cedrol) (19903-73-2) | 99 | (C15H26O) | 24.1 |
4 | 19.14 | Epicedrol (19903-73-2) | 99 | 상동 | 0.8 |
5 | 19.63 | 1- Methyl -4-((S)-6- methylhept -5- en -2- yl )- benzene (644-30-4) | 46 | (C15H22) | 1.5 |
6 | 20.19 | Cedr -8- en -15- ol (21441-72-5) | 96 | (C15H24O) | 1.1 |
7 | 21.47 | Trimethyldodecapentaene (73368-16-8) | 51 | (C15H22) | 2.5 |
8 | 21.54 | 1,1,3α,7- Tetramethyl - 1α,2,3,3α,4,5,6,7β- octahydro -1H- cyclopropa [a] naphthalene (489-29-2) | 83 | (C15H24) | 2.5 |
No . | Retention time ( min .) | 이름 ( CAS No .) | Quality (피크순도) | 구조식 | 함량 (%) |
9 | 22.58 | (131613-25-7) | 43 | ND | 1.1 |
10 | 23.22 | 7,8- dimethoxy -2,2- dimethyl - chromene (67015-35-4) | 83 | (C13H16O3) | 1.1 |
11 | 23.78 | (129286-32-4) | 83 | ND | 1.6 |
12 | 23.87 | (111935-68-3) | 30 | ND | 1.2 |
13 | 23.98 | Nootkatone (4674-50-4) | 99 | (C15H22O) | 1.8 |
14 | 40.65 | Di (2- ethylhexyl ) phthalate (117-81-7) | 91 | (C28H38O4) | 3.1 |
항목 | 지방함량 | ||||
시료농도 (㎍/㎖) | 0 | 10 | 50 | 100 | 250 |
FR1B | +4 | +2 | +1 | +1 | +1 |
성분 | 고지방식이대조군 (g/kg diet) | FR1B군 (g/kg diet) |
카제인 | 200 | 200 |
DL-메티오닌 | 3 | 3 |
옥수수 전분 | 111 | 109 |
수크로오스 | 370 | 370 |
셀룰로오스 | 50 | 50 |
옥수수유 | 30 | 30 |
라드 | 170 | 170 |
비타민 복합물 | 12 | 12 |
미네랄 복합물 | 42 | 42 |
콜린 비타르트레이트 | 2 | 2 |
콜레스테롤 | 10 | 10 |
tert-부티하이드로퀴논 | 0.04 | 0.04 |
FR1B | - | 5 |
총합(g) | 1,000 | 1,000 |
지방(% 칼로리) | 39.0 | 39.0 |
총 열량, kJ/kg diet | 19,315 | 19,315 |
지표 | 고지방식이대조군 | FR1B군 |
혈장 | ||
총 콜레스테롤(mmol/L) | 4.09 ± 0.34 | 2.34 ± 0.19* |
트리글라이세리드(mmol/L) | 1.21 ± 0.07 | 0.67 ± 0.05* |
HDL-콜레스테롤(mmol/L) | 1.16 ± 0.12 | 1.06 ± 0.07 |
LDL+VLDL-콜레스테롤 (mmol/L) | 2.68 ± 0.37 | 1.30 ± 0.14* |
유리지방산(μEq/L) | 914.6 ± 73.4 | 871 ± 70.3 |
포도당(mmol/L) | 9.05 ± 0.92 | 7.57 ± 0.56* |
인슐린(ng/mL) | 0.66 ± 0.08 | 0.38 ± 0.03* |
IRI | 0.79 ± 0.198 | 0.37 ± 0.09* |
간 | ||
콜레스테롤(μmol/g) | 65.3 ± 1.17 | 51.5 ± 3.23* |
트리글라이세리드(μmol/g) | 47.6 ± 1.89 | 31.5 ± 0.88* |
Claims (19)
- 제 1 항에 있어서, 상기 향나무는 눈향나무, 둥근향나무, 뚝향나무, 섬향나무, 가시향나무, 자단향 또는 노송나무인 것을 특징으로 하는 조성물.
- 제 2 항에 있어서, 상기 향나무는 노송나무인 것을 특징으로 하는 조성물.
- 제 1 항에 있어서, 상기 향나무 추출물은 향나무 목질 추출물인 것을 특징으로 하는 조성물.
- 삭제
- 삭제
- 제 1 항에 있어서, 상기 다공성 흡착물은 실리카, 제올라이트, 활성 알루미나, 활성 탄소, 아가로스, 덱스트란 또는 셀룰로오스인 것을 특징으로 하는 조성물.
- 제 7 항에 있어서, 상기 다공성 흡착물은 실리카인 것을 특징으로 하는 조성물.
- 삭제
- 삭제
- 삭제
- 제 1 항에 있어서, 상기 분획용매로서 (ⅰ) 디클로로메탄:(ⅱ) 메탄올의 중량비율은 99:1 ~ 60:40인 것을 특징으로 하는 조성물.
- 제 12 항에 있어서, 상기 분획용매로서 (ⅰ) 디클로로메탄:(ⅱ) 메탄올의 중량비율은 99:1 ~ 90:10인 것을 특징으로 하는 조성물.
- 삭제
- 제 1 항 또는 제 14 항에 있어서, 상기 분획물은 에피세드롤(epicedrol)을 포함하는 것을 특징으로 하는 조성물.
- 제 15 항에 있어서, 상기 분획물은 누트카톤(nootkatone), 세드르-8-엔-15-올(cedr-8-en-15-ol), 글로불롤(globulol), 1-메틸-4-((S)-6-메틸헵트-5-엔-2-일)-벤젠[1-Methyl-4-((S)-6-methylhept-5-en-2-yl)-benzene], 트리메틸도데카펜타엔(Trimethyldodecapentaene), 1,1,3α,7-테트라메틸-1α,2,3,3α,4,5,6,7β-옥타하이드로-1H-사이클로프로파[a]나프탈렌[1,1,3α,7-Tetramethyl-1α,2,3,3α,4,5,6,7β-octahydro-1H-cyclopropa[a]naphthalene], 7,8-다이메톡시-2,2-다이메틸-크로멘(7,8-dimothoxy-2,2-dimethyl-chromene) 및 다이(2-에틸헥시)프탈레이트[Di(2-ethylhexyl) phthalate]로 구성된 군으로부터 선택되는 최소 1종의 성분을 추가적으로 포함하는 것을 특징으로 하는 조성물.
- 제 1 항에 있어서, 상기 조성물은 약제학적 조성물인 것을 특징으로 하는 조성물.
- 제 1 항에 있어서, 상기 조성물은 식품 조성물인 것을 특징으로 하는 조성물.
- 제 1 항에 있어서, 상기 조성물은 UCP2(uncoupling protein 2) 또는 UCP3(uncoupling protein 3) 단백질의 발현량을 증가시키는 것을 특징으로 하는 조성물.
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WO2011118953A2 (en) * | 2010-03-25 | 2011-09-29 | Dong-A Pharm.Co., Ltd. | Composition for the prevention or treatment of obesity or lipid related metabolic deseases |
WO2014077487A1 (ko) * | 2012-11-19 | 2014-05-22 | 목포대학교산학협력단 | 칠면초를 포함하는 당뇨병 예방 또는 개선용 조성물 |
CN103877129A (zh) * | 2012-12-19 | 2014-06-25 | 财团法人工业技术研究院 | 抑制血管新生之医药组合物与圆柏萃取物用于制造抑制血管新生之药物的用途 |
KR20190140407A (ko) * | 2018-06-11 | 2019-12-19 | 주식회사 인투바이오 | 떡버들, 눈향나무 및 함박꽃나무 혼합추출물을 함유하는 화장료 조성물 |
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WO2011118953A3 (en) * | 2010-03-25 | 2012-01-12 | Dong-A Pharm.Co., Ltd. | Composition for the prevention or treatment of obesity or lipid related metabolic deseases |
WO2014077487A1 (ko) * | 2012-11-19 | 2014-05-22 | 목포대학교산학협력단 | 칠면초를 포함하는 당뇨병 예방 또는 개선용 조성물 |
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CN103877129A (zh) * | 2012-12-19 | 2014-06-25 | 财团法人工业技术研究院 | 抑制血管新生之医药组合物与圆柏萃取物用于制造抑制血管新生之药物的用途 |
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KR20190140407A (ko) * | 2018-06-11 | 2019-12-19 | 주식회사 인투바이오 | 떡버들, 눈향나무 및 함박꽃나무 혼합추출물을 함유하는 화장료 조성물 |
KR102220580B1 (ko) * | 2018-06-11 | 2021-02-25 | 주식회사 인투바이오 | 떡버들, 눈향나무 및 함박꽃나무 혼합추출물을 함유하는 화장료 조성물 |
KR102372666B1 (ko) * | 2021-02-02 | 2022-03-10 | (주)한국메디칼컨설팅 | 새싹보리 추출물을 포함하는 비만억제조성물 제조방법 |
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