KR100884500B1 - 수베로일아닐리드 하이드록삼산의 제형 및 이의 제조방법 - Google Patents

수베로일아닐리드 하이드록삼산의 제형 및 이의 제조방법 Download PDF

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Publication number
KR100884500B1
KR100884500B1 KR1020077003998A KR20077003998A KR100884500B1 KR 100884500 B1 KR100884500 B1 KR 100884500B1 KR 1020077003998 A KR1020077003998 A KR 1020077003998A KR 20077003998 A KR20077003998 A KR 20077003998A KR 100884500 B1 KR100884500 B1 KR 100884500B1
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South Korea
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active ingredient
delete delete
crystalline
particle size
saha
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Expired - Fee Related
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KR20070062505A (ko
Inventor
지아니 차우 웡
아론 에스 코테
에릭 에이 디네만
킴벌리 갤러허
크레이그 이케다
져스틴 모세르
파볼 라즈니아크
로버트 에이 리드
신디 스타벅
시엔-신 퉁
칭시 왕
벤자민 맥스 코헨
빈센트 알 카포다노
브라이언 셀
토마스 에이 밀러
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머크 앤드 캄파니 인코포레이티드
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Application filed by 머크 앤드 캄파니 인코포레이티드 filed Critical 머크 앤드 캄파니 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020077003998A 2005-05-20 2006-05-16 수베로일아닐리드 하이드록삼산의 제형 및 이의 제조방법 Expired - Fee Related KR100884500B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68287505P 2005-05-20 2005-05-20
US60/682,875 2005-05-20
US69312805P 2005-06-23 2005-06-23
US60/693,128 2005-06-23

Related Child Applications (1)

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KR1020087030074A Division KR100993135B1 (ko) 2005-05-20 2006-05-16 수베로일아닐리드 하이드록삼산의 제형 및 이의 제조방법

Publications (2)

Publication Number Publication Date
KR20070062505A KR20070062505A (ko) 2007-06-15
KR100884500B1 true KR100884500B1 (ko) 2009-02-20

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KR1020077003998A Expired - Fee Related KR100884500B1 (ko) 2005-05-20 2006-05-16 수베로일아닐리드 하이드록삼산의 제형 및 이의 제조방법
KR1020087030074A Expired - Fee Related KR100993135B1 (ko) 2005-05-20 2006-05-16 수베로일아닐리드 하이드록삼산의 제형 및 이의 제조방법

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US (4) US8093295B2 (enrdf_load_stackoverflow)
EP (2) EP1853245A2 (enrdf_load_stackoverflow)
JP (2) JP5264174B2 (enrdf_load_stackoverflow)
KR (2) KR100884500B1 (enrdf_load_stackoverflow)
AR (1) AR055953A1 (enrdf_load_stackoverflow)
AU (3) AU2006249440C1 (enrdf_load_stackoverflow)
BR (1) BRPI0605893A (enrdf_load_stackoverflow)
CA (1) CA2580367C (enrdf_load_stackoverflow)
CR (1) CR8912A (enrdf_load_stackoverflow)
DO (1) DOP2006000113A (enrdf_load_stackoverflow)
EC (1) ECSP077263A (enrdf_load_stackoverflow)
IL (1) IL181070A0 (enrdf_load_stackoverflow)
MA (1) MA28804B1 (enrdf_load_stackoverflow)
MX (1) MX2007002047A (enrdf_load_stackoverflow)
MY (1) MY144613A (enrdf_load_stackoverflow)
NI (1) NI200700031A (enrdf_load_stackoverflow)
NZ (2) NZ553204A (enrdf_load_stackoverflow)
PE (1) PE20061390A1 (enrdf_load_stackoverflow)
TW (2) TWI415603B (enrdf_load_stackoverflow)
WO (2) WO2006127319A2 (enrdf_load_stackoverflow)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI415603B (zh) * 2005-05-20 2013-11-21 Merck Sharp & Dohme １，８－辛二醯基苯胺羥胺酸（ｓｕｂｅｒｏｙｌａｎｉｌｉｄｅ ｈｙｄｒｏｘａｍｉｃ ａｃｉｄ）之調配物及其製配方法
AU2009305214B2 (en) 2008-10-15 2015-06-25 Generics [Uk] Limited Process for the preparation of vorinostat
JP2012509929A (ja) * 2008-11-26 2012-04-26 ジェネリクス・（ユーケー）・リミテッド 多型
EP2362870A2 (en) * 2008-11-26 2011-09-07 Generics [UK] Limited Novel processes and pure polymorphs
US20110313044A1 (en) * 2010-06-18 2011-12-22 Urquima S.A. Polymorphs of Suberoylanilide Hydroxamic Acid
EP3484470A4 (en) 2016-07-13 2020-02-26 Technion Research & Development Foundation Limited INHIBITORS OF HISTONE DEACETYLASE 4 CYTOPLASMIC COMPLEX FOR THE TREATMENT OR PREVENTION OF VASCULAR OR VALVULAR CALCIFICATION
CN107362148B (zh) * 2017-07-27 2020-04-21 东曜药业有限公司 一种治疗肿瘤的药物组合物及其制备方法和应用
EP4007585A4 (en) 2019-08-02 2023-11-08 OneHealthCompany, Inc. TREATMENT OF CANCER IN DOGS

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US20040122101A1 (en) * 2002-03-04 2004-06-24 Miller Thomas A. Polymorphs of suberoylanilide hydroxamic acid

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WO2003075839A2 (en) * 2002-03-04 2003-09-18 Aton Pharma, Inc. Methods of inducing terminal differentiation
US20040122101A1 (en) * 2002-03-04 2004-06-24 Miller Thomas A. Polymorphs of suberoylanilide hydroxamic acid

Also Published As

Publication number Publication date
EP1853245A2 (en) 2007-11-14
US20100112046A1 (en) 2010-05-06
EP2292221A2 (en) 2011-03-09
CA2580367C (en) 2012-08-21
TWI415603B (zh) 2013-11-21
PE20061390A1 (es) 2007-01-15
NI200700031A (es) 2008-03-03
AU2010201359A1 (en) 2010-04-29
MY144613A (en) 2011-10-04
AU2006249440C1 (en) 2009-08-13
NZ594669A (en) 2013-02-22
AU2009201652A1 (en) 2009-05-21
AU2009201652B2 (en) 2011-10-06
BRPI0605893A (pt) 2007-12-18
WO2006127321A3 (en) 2007-03-22
KR20080113135A (ko) 2008-12-26
TW200727892A (en) 2007-08-01
KR20070062505A (ko) 2007-06-15
AR055953A1 (es) 2007-09-12
EP2292221A3 (en) 2011-08-10
TW201034660A (en) 2010-10-01
NZ553204A (en) 2011-09-30
WO2006127319A2 (en) 2006-11-30
AU2006249440B2 (en) 2009-03-12
JP5264174B2 (ja) 2013-08-14
JP2011251985A (ja) 2011-12-15
AU2009201650B2 (en) 2011-09-15
AU2009201650A1 (en) 2009-05-21
DOP2006000113A (es) 2006-10-31
US8288440B2 (en) 2012-10-16
IL181070A0 (en) 2007-07-04
ECSP077263A (enrdf_load_stackoverflow) 2007-04-26
US8093295B2 (en) 2012-01-10
US8450372B2 (en) 2013-05-28
US20100113829A1 (en) 2010-05-06
US20100119596A1 (en) 2010-05-13
JP2008519081A (ja) 2008-06-05
CA2580367A1 (en) 2006-11-30
KR100993135B1 (ko) 2010-11-10
US20080132575A1 (en) 2008-06-05
MX2007002047A (es) 2007-04-12
WO2006127319A3 (en) 2007-03-29
TWI365068B (en) 2012-06-01
JP5308486B2 (ja) 2013-10-09
MA28804B1 (fr) 2007-08-01
CR8912A (es) 2008-02-21
AU2006249440A1 (en) 2006-11-30
WO2006127321A2 (en) 2006-11-30

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