KR100874392B1 - Ｌｐａ 수용체 아고니스트 및 안타고니스트, 및 사용 방법 - Google Patents

Ｌｐａ 수용체 아고니스트 및 안타고니스트, 및 사용 방법 Download PDF

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KR100874392B1
KR100874392B1 KR1020027012236A KR20027012236A KR100874392B1 KR 100874392 B1 KR100874392 B1 KR 100874392B1 KR 1020027012236 A KR1020027012236 A KR 1020027012236A KR 20027012236 A KR20027012236 A KR 20027012236A KR 100874392 B1 KR100874392 B1 KR 100874392B1
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compound
lpa
edg
delete delete
alkyl
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KR20020082890A (ko
Inventor
디. 밀러듀안
티지이가버
티. 달톤제임스
엠. 사다비닛
비. 엘로드돈
수히핑
엘. 베이커다니엘
왕딘
릴리엄캐롤리
제이. 피셔데이비드
비랙터마스
뉴서노라
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유니버시티 오브 테네시 리서치 파운데이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4028—Esters of poly(thio)phosphonic acids containing no further substituents than -PO3H2 groups in free or esterified form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/093—Polyol derivatives esterified at least twice by phosphoric acid groups
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
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    • C07F9/094—Esters of phosphoric acids with arylalkanols
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/17—Esters of thiophosphoric acids with hydroxyalkyl compounds without further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl

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  • Molecular Biology (AREA)
  • Biochemistry (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020027012236A 2000-03-17 2001-03-19 Ｌｐａ 수용체 아고니스트 및 안타고니스트, 및 사용 방법 Expired - Fee Related KR100874392B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19037000P 2000-03-17 2000-03-17
US60/190,370 2000-03-17
PCT/US2001/008729 WO2001071022A2 (en) 2000-03-17 2001-03-19 Lpa receptor agonists and antagonists and methods of use

Publications (2)

Publication Number Publication Date
KR20020082890A KR20020082890A (ko) 2002-10-31
KR100874392B1 true KR100874392B1 (ko) 2008-12-17

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US (2) US6875757B2 (https=)
EP (2) EP1263752B1 (https=)
JP (1) JP2004506604A (https=)
KR (1) KR100874392B1 (https=)
AT (1) ATE380187T1 (https=)
AU (1) AU4926301A (https=)
CA (1) CA2402038C (https=)
CY (1) CY1107214T1 (https=)
DE (1) DE60131730T2 (https=)
DK (1) DK1263752T3 (https=)
ES (1) ES2298227T3 (https=)
PT (1) PT1263752E (https=)
WO (1) WO2001071022A2 (https=)

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CA2669102A1 (en) 2006-11-21 2008-05-29 University Of Virginia Patent Foundation Tetralin analogs having sphingosine 1-phosphate agonist activity
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DK1263752T3 (da) 2008-04-14
ATE380187T1 (de) 2007-12-15
AU4926301A (en) 2001-10-03
EP1263752A4 (en) 2003-07-30
CA2402038C (en) 2011-03-15
PT1263752E (pt) 2008-03-18
JP2004506604A (ja) 2004-03-04
EP1263752B1 (en) 2007-12-05
US6875757B2 (en) 2005-04-05
DE60131730T2 (de) 2008-11-20
EP1918287A2 (en) 2008-05-07
US20030027800A1 (en) 2003-02-06
WO2001071022A2 (en) 2001-09-27
CA2402038A1 (en) 2001-09-27
DE60131730D1 (de) 2008-01-17
EP1918287A3 (en) 2008-08-20
KR20020082890A (ko) 2002-10-31
ES2298227T3 (es) 2008-05-16
CY1107214T1 (el) 2012-11-21
EP1263752A2 (en) 2002-12-11
US20050261252A1 (en) 2005-11-24
WO2001071022A3 (en) 2002-04-04

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