KR100868959B1 - 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물 - Google Patents

알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물 Download PDF

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KR100868959B1
KR100868959B1 KR1020060139200A KR20060139200A KR100868959B1 KR 100868959 B1 KR100868959 B1 KR 100868959B1 KR 1020060139200 A KR1020060139200 A KR 1020060139200A KR 20060139200 A KR20060139200 A KR 20060139200A KR 100868959 B1 KR100868959 B1 KR 100868959B1
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South Korea
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pyran
tetrahydro
alpha
triazole
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Korean (ko)
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KR20080062973A (ko
Inventor
강창율
김상희
윤현준
이윤숙
이규아
이태호
백동재
조민재
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재단법인서울대학교산학협력재단
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Priority to PCT/KR2007/006889 priority patent/WO2008082156A1/en
Priority to CNA2007800486889A priority patent/CN101573369A/zh
Priority to US12/521,487 priority patent/US8883746B2/en
Priority to EP07851806A priority patent/EP2102225A4/en
Priority to CN201210275308.8A priority patent/CN102816189B/zh
Priority to JP2009543946A priority patent/JP5167273B2/ja
Publication of KR20080062973A publication Critical patent/KR20080062973A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • General Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
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  • Diabetes (AREA)
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  • Obesity (AREA)
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  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020060139200A 2006-12-30 2006-12-30 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물 Expired - Fee Related KR100868959B1 (ko)

Priority Applications (7)

Application Number Priority Date Filing Date Title
KR1020060139200A KR100868959B1 (ko) 2006-12-30 2006-12-30 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물
CNA2007800486889A CN101573369A (zh) 2006-12-30 2007-12-27 α-半乳糖神经酰胺衍生物、其药物可接受的盐、制备方法和含有其作为活性成分的用于免疫佐剂的药物组合物
US12/521,487 US8883746B2 (en) 2006-12-30 2007-12-27 α-galactosylceramide derivatives, pharmaceutically acceptable salts thereof, preparation method and pharmaceutical composition for the immune adjuvant containing the same as an active ingredient
EP07851806A EP2102225A4 (en) 2006-12-30 2007-12-27 ALPHA-GALACTOSYL CERAMIDE DERIVATIVES, PHARMACEUTICALALLY SALTS THEREOF, METHOD OF MANUFACTURE AND PHARMACEUTICAL COMPOSITION FOR IMMUNADJUVANS CONTAINING THEM AS AN ACTIVE SUBSTANCE
PCT/KR2007/006889 WO2008082156A1 (en) 2006-12-30 2007-12-27 Alpha-galactosylceramide derivatives, pharmaceutically acceptable salts thereof, preparation method and pharmaceutical composition for the immune adjuvant containing the same as an active ingredient
CN201210275308.8A CN102816189B (zh) 2006-12-30 2007-12-27 α-半乳糖神经酰胺衍生物、其药物可接受的盐、制备方法和含有其作为活性成分的用于免疫佐剂的药物组合物
JP2009543946A JP5167273B2 (ja) 2006-12-30 2007-12-27 αガラクトシルセラミド誘導体、その薬学的に許容可能な塩、その製造方法及びそれを有効成分として含む免疫補助用薬学的組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020060139200A KR100868959B1 (ko) 2006-12-30 2006-12-30 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물

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KR20080062973A KR20080062973A (ko) 2008-07-03
KR100868959B1 true KR100868959B1 (ko) 2008-11-17

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KR1020060139200A Expired - Fee Related KR100868959B1 (ko) 2006-12-30 2006-12-30 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물

Country Status (6)

Country Link
US (1) US8883746B2 (enExample)
EP (1) EP2102225A4 (enExample)
JP (1) JP5167273B2 (enExample)
KR (1) KR100868959B1 (enExample)
CN (2) CN101573369A (enExample)
WO (1) WO2008082156A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8916164B2 (en) 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
PT2231145E (pt) 2007-12-05 2014-12-23 Wittycell Utilização de glicosilceramidas para aumentar a resposta imunitária a antigénios
US7928077B2 (en) * 2008-07-11 2011-04-19 Academia Sinica Alpha-galactosyl ceramide analogs and their use as immunotherapies
JP5809560B2 (ja) * 2008-10-08 2015-11-11 アビヴァックス インフルエンザに対して使用するためのワクチン組成物
KR20110045545A (ko) * 2009-10-27 2011-05-04 서울대학교산학협력단 신규 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 면역보조용 약학적 조성물
US8853173B2 (en) 2010-02-05 2014-10-07 Riken Synthetic glycolipid and use thereof
ES2654382T3 (es) 2011-01-05 2018-02-13 National Taiwan University Método para la preparación de glucoesfingolípidos
KR101307331B1 (ko) * 2012-02-01 2013-09-10 서울대학교산학협력단 신규 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 면역보조용 약학적 조성물
US10227290B2 (en) * 2012-02-07 2019-03-12 The Regents Of The University Of California Glycosphingolipids for use in modulating immune responses
EP2881400A4 (en) * 2012-08-03 2016-02-24 Riken HYDROXYLATED KRN7000 ANALOGON AND USE THEREOF
KR101969129B1 (ko) * 2012-08-03 2019-04-15 (주)스파크바이오파마 알파-갈락토실세라마이드 유사체, 이의 제조방법 및 이를 포함하는 면역조절 이상으로 인한 질환의 치료 또는 예방용 약학적 조성물
US20150224129A1 (en) 2012-10-03 2015-08-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza with invariant nkt cell agonists
CA2925878A1 (en) 2012-10-12 2014-04-17 The Brigham And Women's Hospital, Inc. Glycosphingolipids and methods of use thereof
WO2017163808A1 (ja) * 2016-03-22 2017-09-28 学校法人慶應義塾 化合物又はその塩、ナチュラルキラーｔ細胞活性化剤、及び医薬組成物
WO2017207040A1 (en) 2016-06-01 2017-12-07 Vib Vzw ANTI-CANCER THERAPY USING A LEPTIN ANTAGONIST AND AN iNKT-CELL ACTIVATOR
EP4174074A1 (en) 2021-10-29 2023-05-03 Consejo Superior de Investigaciones Científicas (CSIC) Multiantennary glycolipid mimetics
CN115286667B (zh) * 2022-08-02 2024-03-26 华中农业大学 一种α-半乳糖基神经酰胺类似物及其制备方法和应用
WO2025035125A1 (en) * 2023-08-10 2025-02-13 The Curators Of The University Of Missouri Suppression of type 1 diabetes by intrathymic il-4

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060052316A1 (en) * 2004-08-27 2006-03-09 Porcelli Steven A Ceramide derivatives as modulators of immunity and autoimmunity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61502124A (ja) * 1984-05-09 1986-09-25 ジ　オ−ストラリアン　ナシヨナル　ユニヴア−シテイ− 免疫応答の調節方法
JPH0559081A (ja) * 1991-08-29 1993-03-09 Kirin Brewery Co Ltd 新規スフインゴ糖脂質、その製造法および使用
US5936076A (en) * 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
ES2235324T3 (es) * 1997-04-10 2005-07-01 Kirin Beer Kabushiki Kaisha Empleo de a-glicosilceramidas para la obtencion de un agente terapeutico para enfermedades autoinmunes.
EP1437358B1 (en) * 2001-08-16 2006-10-18 Daiichi Asubio Pharma Co., Ltd. Novel glycolipid and remedial agent for autoimmune disease containing the same as active ingredient
CA2493690C (en) * 2002-06-13 2011-11-08 New York University Synthetic c-glycolipid and its use for treating cancer, infectious diseases and autoimmune diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060052316A1 (en) * 2004-08-27 2006-03-09 Porcelli Steven A Ceramide derivatives as modulators of immunity and autoimmunity

Also Published As

Publication number Publication date
CN101573369A (zh) 2009-11-04
JP5167273B2 (ja) 2013-03-21
US8883746B2 (en) 2014-11-11
EP2102225A1 (en) 2009-09-23
WO2008082156A1 (en) 2008-07-10
KR20080062973A (ko) 2008-07-03
EP2102225A4 (en) 2011-12-14
US20100104590A1 (en) 2010-04-29
CN102816189B (zh) 2015-05-20
JP2010514758A (ja) 2010-05-06
CN102816189A (zh) 2012-12-12

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